46,188 results match your criteria lipase

Lipolytic enzymes and free fatty acids at the endothelial interface.

Atherosclerosis 2021 May 28;329:1-8. Epub 2021 May 28.

Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address:

Lipids released from circulating lipoproteins by intravascular action of lipoprotein lipase (LpL) reach parenchymal cells in tissues with a non-fenestrated endothelium by transfer through or around endothelial cells. The actions of LpL are controlled at multiple sites, its synthesis and release by myocytes and adipocytes, its transit and association with the endothelial cell luminal surface, and finally its activation and inhibition by a number of proteins and by its product non-esterified fatty acids. Multiple pathways mediate endothelial transit of lipids into muscle and adipose tissues. Read More

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Cola nitida infusion modulates cardiometabolic activities linked to cardiomyopathy in diabetic rats.

Food Chem Toxicol 2021 Jun 12:112335. Epub 2021 Jun 12.

Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.

This study investigated the therapeutic mechanism of Cola nitida seeds on diabetic cardiomyopathy in hearts of diabetic rats. Type 2 diabetic (T2D) rats were treated with C. nitida infusion at 150 and 300 mg/kg body weight (bw). Read More

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Eruptive xanthoma model reveals endothelial cells internalize and metabolize chylomicrons, leading to extravascular triglyceride accumulation.

J Clin Invest 2021 Jun;131(12)

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.

Although tissue uptake of fatty acids from chylomicrons is primarily via lipoprotein lipase (LpL) hydrolysis of triglycerides (TGs), studies of patients with genetic LpL deficiency suggest additional pathways deliver dietary lipids to tissues. Despite an intact endothelial cell (EC) barrier, hyperchylomicronemic patients accumulate chylomicron-derived lipids within skin macrophages, leading to the clinical finding eruptive xanthomas. We explored whether an LpL-independent pathway exists for transfer of circulating lipids across the EC barrier. Read More

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Nutritional targeting modification of silkworm pupae oil catalyzed by a smart hydrogel immobilized lipase.

Food Funct 2021 Jun 15. Epub 2021 Jun 15.

Jiangsu Key Laboratory Sericutural Biology and Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212100, China. and Attached Silkworm Medicine Factory, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, Jiangsu 212100, China and Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agricultural and Rural Affairs, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, Jiangsu 212100, China.

To prepare a nutritional supplement using silkworm pupae oil (SPO) as a feedstock, a microfluidic reactor with a smart hydrogel immobilized lipase was first constructed to reduce the relative content of palmitic acid at sn-1,3 and improve the nutritional function. The effects of flow rate, reaction temperature, and substrate molar ratio were investigated. In vitro digestion and pH-stat models were employed to analyze the digestion feature after the modification of SPO, while HPLC-ELSD, zeta potential, DSC, and TGA were used to evaluate the nutritional function. Read More

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A Fatal Case of Hypertriglyceridemia-Induced Acute Pancreatitis in a Patient With Diabetic Ketoacidosis.

Cureus 2021 May 11;13(5):e14968. Epub 2021 May 11.

Pulmonary and Critical Care, Richmond University Medical Center, Staten Island, USA.

Diabetic ketoacidosis (DKA) with coexisting hypertriglyceridemia-induced acute pancreatitis is a rare yet potentially life-threatening condition. This report describes a patient with no history of diabetes who presented with DKA and coexisting acute pancreatitis secondary to severe hypertriglyceridemia. The patient did not respond to standard DKA management or plasmapheresis, developed acute respiratory distress syndrome (ARDS), and eventually expired. Read More

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High Drying Temperature Accelerates Sunflower Seed Deterioration by Regulating the Fatty Acid Metabolism, Glycometabolism, and Abscisic Acid/Gibberellin Balance.

Front Plant Sci 2021 28;12:628251. Epub 2021 May 28.

Institute of Crop and Nuclear Technology Utilization, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.

Sunflower seed storage is accompanied by the loss of seed vigor. Seed drying is a key link between seed harvest and seed storage; however, to date, the effect of seed drying on sunflower seed deterioration during storage remains unclear. The present study performed hot air drying for sunflower seeds with an initial moisture content of 30% to examine the manner in which drying temperature (35, 40, 45, 50, and 55°C) affects the drying performance and seed vigor following storage process (6 and 12 months). Read More

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Identifying Anti-Oxidant Biosynthesis Genes in Pearl Millet [ (L.) R. Br.] Using Genome-Wide Association Analysis.

Front Plant Sci 2021 28;12:599649. Epub 2021 May 28.

Institute of Biological Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, United Kingdom.

Pearl millet [ (L.) R Br.] is an important staple food crop in the semi-arid tropics of Asia and Africa. Read More

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Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis.

Front Endocrinol (Lausanne) 2021 27;12:668396. Epub 2021 May 27.

Diabetes Center, University of California, San Francisco, San Francisco, CA, United States.

In mammals, myeloid cells help maintain the homeostasis of peripheral metabolic tissues, and their immunologic dysregulation contributes to the progression of obesity and associated metabolic disease. There is accumulating evidence that innate immune cells also serve as functional regulators within the mediobasal hypothalamus (MBH), a critical brain region controlling both energy and glucose homeostasis. Specifically, microglia, the resident parenchymal myeloid cells of the CNS, play important roles in brain physiology and pathology. Read More

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Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters.

J Nat Med 2021 Jun 12. Epub 2021 Jun 12.

School of Pharmacy, Guangxi University of Chinese Medicine, No. 13, Wuhe Avenue, Qingxiu District, Nanning, 530200, Guangxi, China.

While the underlying mechanism remains unknown, Rubus chingii var. suavissimus (S. K. Read More

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Metabolomics of extracellular compounds and parasitic enzymes of Beauveria bassiana associated with biological control of whiteflies (Bemisia tabaci).

Pestic Biochem Physiol 2021 Jul 21;176:104877. Epub 2021 May 21.

Department of Biotechnology, College of Agriculture, Junagadh Agricultural University, Junagadh 362 001, Gujarat, India.

The Beauveria spp. were isolated from soil and insect cadavers of crop rhizosphere and characterized for parasitic enzyme activity and virulence against whiteflies (Bemisia tabaci). The colony morphology and molecular identification using ITS specific marker were carried out and confirmed entomopathogenic fungi as Beauveria bassiana. Read More

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Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study.

Mov Disord 2021 Jun 12. Epub 2021 Jun 12.

Clinical Research Center Core Facility, Hannover Medical School, Hannover, Germany.

Background: Modulation of the endocannabinoid system via monoacylglycerol lipase inhibition with Lu AG06466 (formerly known as ABX-1431) has previously been shown to reduce tics in patients with Tourette syndrome.

Objective: The aim of this study was to evaluate the efficacy and safety of Lu AG06466 in reducing tics, premonitory urges, and comorbidities in patients with Tourette syndrome.

Methods: This was a 12-week, multicenter, randomized, placebo-controlled, double-blind clinical trial of Lu AG06466 given at two dose levels in 49 adults with Tourette syndrome. Read More

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Synthesis of lipophilic arbutin ester by enzymatic transesterification in high pressure carbon dioxide.

Kuan-Ju Liu

Enzyme Microb Technol 2021 Aug 13;148:109818. Epub 2021 May 13.

Department of Food Science, National Penghu University of Science and Technology, Makung City, Penghu, 880011, Taiwan, ROC. Electronic address:

In this study, a novel one-step enzymatic acylation was developed for the synthesis of hydrophobic arbutin ester, by using supercritical carbon dioxide (SC-CO) as the reaction solvent. Immobilized Novozym 435 from Candida antarctica was identified as the best biocatalyst for producing arbutin palmitate through transesterification between arbutin and palmitic acid ethyl ester in SC-CO. A transesterification yield of 85. Read More

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Ternary biogenic silica/magnetite/graphene oxide composite for the hyperactivation of Candida rugosa lipase in the esterification production of ethyl valerate.

Enzyme Microb Technol 2021 Aug 24;148:109807. Epub 2021 Apr 24.

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310, Johor Bahru, Johor, Malaysia; Enzyme Technology and Green Synthesis Group, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310, Johor Bahru, Johor, Malaysia.

Oil palm leaves (OPL) silica (SiO) can replace the energy-intensive, commercially produced SiO. Moreover, the agronomically sourced biogenic SiO is more biocompatible and cost-effective enzyme support, which properties could be improved by the addition of magnetite (FeO) and graphene oxide (GO) to yield better ternary support to immobilize enzymes, i.e. Read More

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Effect of the acyl-group length on the chemoselectivity of the lipase-catalyzed acylation of propranolol-a computational study.

J Mol Model 2021 Jun 11;27(7):198. Epub 2021 Jun 11.

Grupo de Bioquímica Teórica, Universidad Industrial de Santander, Cra. 27 Calle 9, Bucaramanga, Colombia.

The selective N-acylation of 1,2-amino alcohols has been proposed to occur through the proton shuttle mechanism. However, the O-acetylation of propranolol catalyzed by Candida antarctica lipase B is an exception. We investigated the relation between the chemoselectivity of this reaction and the acyl group length. Read More

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Free Fatty Acid Increases the Expression of NLRP3-Caspase1 in Adipose Tissue Macrophages in Obese Severe Acute Pancreatitis.

Dig Dis Sci 2021 Jun 10. Epub 2021 Jun 10.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei Province, China.

Background And Aims: Obesity is an important risk factor for severe acute pancreatitis. The necrosis of epididymal adipose tissue occurs in severe acute pancreatitis. Adipose tissue macrophages play an important role in metabolic related inflammation. Read More

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Physiological Characteristics and Comparative Secretome Analysis of Grown on Glucose, Rice Straw, Sawdust, Wheat Grain, and MIX Substrates.

Front Microbiol 2021 25;12:636344. Epub 2021 May 25.

Institute of Vegetable, Wuhan Academy of Agricultural Sciences, Wuhan, China.

Morels ( sp.) are economically important edible macro-fungi, which can grow on various synthetic or semi-synthetic media. However, the complex nutritional metabolism and requirements of these fungi remain ill-defined. Read More

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Finite-temperature effect in the O-acylation of (R,S)-propranolol catalyzed by Candida antarctica lipase B.

J Mol Graph Model 2021 May 31;107:107951. Epub 2021 May 31.

Grupo de Bioquímica Teórica, Universidad Industrial de Santander, Cra 27 Calle 9, Bucaramanga, Colombia. Electronic address:

CalB is a triacylglycerol hydrolase (E.C.3. Read More

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Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Jun 7:158988. Epub 2021 Jun 7.

LANEH, School of Life Sciences, East China Normal University, Shanghai, China. Electronic address:

Neutral lipases-mediated lipolysis and acid lipases-moderated lipophagy are two main processes for degradation of lipid droplets (LDs). However, the individual and interactive roles of these metabolic pathways are not well known across vertebrates. This study explored the roles of lipolysis and lipophagy from the aspect of neutral and acid lipases in zebrafish. Read More

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Functional Annotation of circRNAs in Tea Leaves after Infection by the Tea Leaf Spot Pathogen, Lasiodiplodia theobromae.

Phytopathology 2021 Jun 10. Epub 2021 Jun 10.

Guizhou University, 71206, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Huaxi District, Guiyang, Guizhou Province of China, Guiyang, China, 550025;

Tea leaf spot, caused by Lasiodiplodia theobromae, is an important disease that can seriously decrease the production and quality of tea (Camellia sinensis [L.] Kuntze) leaves. The analysis of circular RNA (circRNA) in tea leaves after infection by the pathogen could improve understanding about the mechanism of host-pathogen interactions. Read More

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A phase I trial of sorafenib with whole brain radiotherapy (WBRT) in breast cancer patients with brain metastases and a correlative study of FLT-PET brain imaging.

Breast Cancer Res Treat 2021 Jun 10. Epub 2021 Jun 10.

Breast Cancer Medicine Service, Evelyn Lauder Breast Center, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY, 10065, USA.

Purpose: Sorafenib has demonstrated anti-tumor efficacy and radiosensitizing activity preclinically and in breast cancer. We examined sorafenib in combination with whole brain radiotherapy (WBRT) and explored the [18F] 3'deoxy-3'-fluorothymidine (FLT)-PET as a novel brain imaging modality in breast cancer brain metastases.

Methods: A phase I trial of WBRT + sorafenib was conducted using a 3 + 3 design with safety-expansion cohort. Read More

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Consuming Different Structural Parts of Bamboo Induce Gut Microbiome Changes in Captive Giant Pandas.

Curr Microbiol 2021 Jun 9. Epub 2021 Jun 9.

Chengdu Research Base of Giant Panda Breeding, Chengdu, 610081, China.

Giant pandas consume different structural parts of bamboo (shoots, leaves and culms) during different seasons. Previous research showed different bamboo parts have varying nutritional content and that a long-term diet consisting of a single part of bamboo resulted in remarkable metabolic changes within captive giant pandas. However, the effects on the gut microbiome of giant pandas, as a result of a single bamboo part diet, have not been investigated. Read More

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Synergetic Action of Forskolin and Mevastatin Induce Normalization of Lipids Profile in Dyslipidemic Rats through Adenosine Monophosphate Kinase Upregulation.

Biomed Res Int 2021 19;2021:6687551. Epub 2021 May 19.

Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

In the present study, we examined the synergetic effect of forskolin and mevastatin administration on lipid profile and lipid metabolism in omental adipose tissue in dyslipidemic rats. The study was conducted on forty male albino rats. The rats were randomly classified into four main groups of ten animals in each group as follows: , served as control nontreated; , rats that received Triton WR 1339 (500 mg/kg); , rats that received Triton WR 1339 with forskolin (100% FSK extract 0. Read More

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Docosahexaenoic acid-enriched phospholipids and eicosapentaenoic acid-enriched phospholipids inhibit tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes by activating sirtuin 1 pathways.

Food Funct 2021 Jun;12(11):4783-4796

Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, No. 44 Wenhuaxi Road, Jinan, Shandong 250012, China.

Some chronic diseases such as cancer-associated cachexia (CAC) and obesity are associated with the overproduction of tumor necrosis factor-alpha (TNF-α) that stimulates excess lipolysis in adipocytes. Our previous studies have shown that docosahexaenoic acid-enriched phospholipids (DHA-PL) and eicosapentaenoic acid-enriched phospholipids (EPA-PL) ameliorated CAC and obesity-related metabolic disorders. To identify the molecular mechanisms involved, we examined the impact and the associated signaling pathways of DHA-PL and EPA-PL on TNF-α-induced lipolysis in 3T3-L1 adipocytes. Read More

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Self-assembling peptide hydrogel SPG-178 as a pancreatic fistula-preventing agent.

Langenbecks Arch Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2, Suita, Osaka, 565-0871, Japan.

Purpose: Pancreatic fistula (PF) is a common and challenging complication after pancreatic surgery. The aim of this study was to investigate the efficacy of a new method for preventing PF utilizing self-assembling peptide hydrogel SPG-178 as a preclinical study.

Methods: The degradability of SPG-178 was confirmed by mixing it with protease. Read More

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Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity.

Nat Commun 2021 06 7;12(1):3335. Epub 2021 Jun 7.

Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany.

Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 "helper" NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). The mechanism of RNL/EDS1 family protein cooperation is not understood. Read More

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cAMP Signaling-Mediated Phosphorylation of Diacylglycerol Lipase α Regulates Interaction With Ankyrin-G and Dendritic Spine Morphology.

Biol Psychiatry 2021 Mar 26. Epub 2021 Mar 26.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Psychiatry and Behavioral Sciences, and Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Center for Autism and Neurodevelopment, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

Background: Diacylglycerol lipase α (DAGLα), a major biosynthetic enzyme for endogenous cannabinoid signaling, has emerged as a risk gene in multiple psychiatric disorders. However, its role in the regulation of dendritic spine plasticity is unclear.

Methods: DAGLα wild-type or point mutants were overexpressed in primary cortical neurons or human embryonic kidney 293T cells. Read More

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Microbial halophilic lipases: A review.

J Basic Microbiol 2021 Jun 7. Epub 2021 Jun 7.

College of Bioengineering, Sichuan University of Science and Engineering, Zigong, China.

Microbial lipases are commercially significant due to their versatile catalytic function of hydrolysis triacylglycerol. Among these, lipases from extremophiles are optimal for industrial application. Halophilic microorganisms living in a high salinity environment, such as the ocean, salt lakes, salt wells, and so on, produce halophilic lipases. Read More

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Triblock polyester thermoplastic elastomers with semi-aromatic polymer end blocks by ring-opening copolymerization.

Chem Sci 2020 May 4;11(25):6567-6581. Epub 2020 May 4.

Oxford Chemistry, Chemistry Research Laboratory 12 Mansfield Road Oxford OX1 3TA UK

Thermoplastic elastomers benefit from high elasticity and straightforward (re)processability; they are widely used across a multitude of sectors. Currently, the majority derive from oil, do not degrade or undergo chemical recycling. Here a new series of ABA triblock polyesters are synthesized and show high-performances as degradable thermoplastic elastomers; their composition is poly(cyclohexene--phthalate)--poly(ε-decalactone)--poly(cyclohexene--phthalate) {PE-PDL-PE}. Read More

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Effect of eggplant () on the metabolic syndrome: A review.

Iran J Basic Med Sci 2021 Apr;24(4):420-427

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Metabolic syndrome (MetS), also known as syndrome X, is a significant risk factor for cardiovascular disease incidence and mortality. Increasing age, obesity, physical inactivity, smoking, and positive family history are the risk factors associated with MetS, which increases the risk of diabetes, cardiovascular disease, hypertension, hyperlipidemia, and obesity. Chemical compounds in the treatment of metabolic complications are associated with a lack of efficacy and severe side effects. Read More

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Interactive Gene Expression Between JEF-290 and Longhorned Tick at Early Stage of Infection.

Front Physiol 2021 19;12:643389. Epub 2021 May 19.

Department of Agricultural Biology, College of Agriculture and Life Sciences, Jeonbuk National University, Jeonju, South Korea.

The longhorned tick, (Acari: Ixodidae), is a hard tick and a vector for severe fever with thrombocytopenia syndrome (SFTS) virus. The number of patients infected with SFTS is rapidly increasing. Recently, the invertebrate pathogen JEF-290 was reported to be useful to control the tick as an alternative to chemical acaricides, which are not easily applicable in human living areas where the tick is widely spread. Read More

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