10,652 results match your criteria linking number


Evolution of disability pension after renal transplantation: methods and results of a database linkage study of the Swiss Transplant Cohort Study and Swiss Disability Insurance.

Swiss Med Wkly 2021 Sep 23;151:w30027. Epub 2021 Sep 23.

Basel University, Switzerland.

Aims: In Switzerland, certain patients with disabilities and reduced working ability are entitled to a disability pension granted by the Swiss Federal Social Insurance Office (FSIO). The aim was to assess the evolution of disability pension and work capacity after kidney transplantation and thereby pilot the procedures linking FSIO data with Swiss Transplant Cohort Study (STCS) data.

Methods: The current study pilot tested the record linkage of FSIO data with data from the STCS in a single-centre, observational setting. Read More

View Article and Full-Text PDF
September 2021

Integrative Analysis of DNA Methylation and microRNA Expression Reveals Mechanisms of Racial Heterogeneity in Hepatocellular Carcinoma.

Front Genet 2021 7;12:708326. Epub 2021 Sep 7.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, United States.

Pathologic alterations in epigenetic regulation have long been considered a hallmark of many cancers, including hepatocellular carcinoma (HCC). In a healthy individual, the relationship between DNA methylation and microRNA (miRNA) expression maintains a fine balance; however, disruptions in this harmony can aid in the genesis of cancer or the propagation of existing cancers. The balance between DNA methylation and microRNA expression and its potential disturbance in HCC can vary by race. Read More

View Article and Full-Text PDF
September 2021

Influence of pre-existing multimorbidity on receiving a hip arthroplasty: cohort study of 28 025 elderly subjects from UK primary care.

BMJ Open 2021 Sep 23;11(9):e046713. Epub 2021 Sep 23.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK

The median age for total hip arthroplasty (THA) is over 70 years with the corollary that many individuals have multiple multimorbidities. Despite the predicted improvement in quality of life, THA might be denied even to those with low levels of multimorbidity.

Objective: To evaluate how pre-existing levels of multimorbidity influence the likelihood and timing of THA. Read More

View Article and Full-Text PDF
September 2021

Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England.

BMJ Open 2021 Sep 23;11(9):e046712. Epub 2021 Sep 23.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK

Total hip arthroplasty (THA) surgery for elderly people with multimorbidity increases the risk of serious health hazards including mortality. Whether such background morbidity reduces the clinical benefit is less clear.

Objective: To evaluate how pre-existing health status, using multiple approaches, influences risks of, and quality of life benefits from, THA. Read More

View Article and Full-Text PDF
September 2021

Narrowing the Early Mathematics Gap: A Play-Based Intervention to Promote Low-Income Preschoolers' Number Skills.

J Numer Cogn 2017 30;3(3):559-581. Epub 2018 Jan 30.

Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.

Preschoolers from low-income households lag behind preschoolers from middle-income households on numerical skills that underlie later mathematics achievement. However, it is unknown whether these gaps exist on parallel measures of symbolic and non-symbolic numerical skills. Experiment 1 indicated preschoolers from low-income backgrounds were less accurate than peers from middle-income backgrounds on a measure of symbolic magnitude comparison, but they performed equivalently on a measure of non-symbolic magnitude comparison. Read More

View Article and Full-Text PDF
January 2018

Branched Methoxydiphenylamine-Substituted Carbazole Derivatives for Efficient Perovskite Solar Cells: Bigger Is Not Always Better.

Chem Mater 2021 Sep 19;33(17):7017-7027. Epub 2021 Aug 19.

Group for Molecular Engineering of Functional Material, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, CH-1951 Sion, Switzerland.

A set of novel branched molecules bearing a different number of 3,6-bis(4,4'-dimethoxydiphenylamino)carbazole-based (Cz-OMeDPA) periphery arms linked together by aliphatic chains have been developed, and their performance has been tested in perovskite solar cells (PSCs). Electrical and photovoltaic properties have been evaluated with respect to the number of Cz-OMeDPA moieties and the nature of the linking aliphatic chain. The isolated compounds possess sufficient thermal stability and are amorphous having high glass-transition temperatures (>120 °C) minimizing the risk of direct layer crystallization. Read More

View Article and Full-Text PDF
September 2021

Shift work, inflammation and musculoskeletal pain-The HUNT Study.

Occup Med (Lond) 2021 Sep 22. Epub 2021 Sep 22.

Section for Clinical Neurophysiology, Department of Neurology, Oslo University Hospital-Ullevål, Oslo 0424, Norway.

Background: Studies have indicated that shift work, in particular night work, is associated with chronic musculoskeletal pain but the mechanisms are unclear. It has been suggested that sleep disturbance, a common complaint among shift and night workers, may induce low-grade inflammation as well as heightened pain sensitivity.

Aims: Firstly, this study was aimed to examine the cross-sectional associations between shift work, C-reactive protein (CRP) level and chronic musculoskeletal pain, and secondly, to analyse CRP as a mediator between shift work and chronic musculoskeletal pain. Read More

View Article and Full-Text PDF
September 2021

Linking Central Gene Expression Patterns and Mental States Using Transcriptomics and Large-Scale Meta-Analysis of fMRI Data: A Tutorial and Example Using the Oxytocin Signaling Pathway.

Methods Mol Biol 2022 ;2384:127-137

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, University of Oslo, and Oslo University Hospital, Oslo, Norway.

The measurement of gene expression levels in the human brain can help accelerate our understanding of complex mental states and psychiatric illnesses. Mental states are typically associated with whole-brain networks; however, gene expression levels from postmortem brain samples have traditionally been measured in a limited number of brain regions due to resource limitations. The recent availability of whole-brain gene expression data from the Allen Human Brain Atlas (AHBA) provides the opportunity to generate gene expression patterns for over 20,000 genes. Read More

View Article and Full-Text PDF
January 2022

Mental health in the second year of the COVID-19 pandemic: protocol for a nationally representative multilevel survey in Serbia.

BMJ Open 2021 Sep 21;11(9):e053835. Epub 2021 Sep 21.

Department of Psychology, Univerzitet u Beogradu Filozofski Fakultet, Belgrade, Serbia

Introduction: The COVID-19 pandemic is likely to have a prolonged impact on mental health (MH); however, the long-term MH effects of the COVID-19 pandemic remain unknown. The Serbian national survey-CoV2Soul.RS-was launched to document the MH status of the Serbian population following the COVID-19 pandemic and to contribute to an international evidence base about MH prevalence rates during different phases of the pandemic. Read More

View Article and Full-Text PDF
September 2021

Developmental pathways linking the quality and intensity of organized afterschool activities in middle school to academic performance in high school.

J Adolesc 2021 Sep 20;92:152-164. Epub 2021 Sep 20.

University of California, Irvine, USA. Electronic address:

Introduction: Adolescents' organized afterschool activities have been linked to their academic performance, but processes contributing to these relations are not well understood. This study tested two pathways linking activity intensity and activity quality in 6th grade to high school academic performance: adolescents' activities in 9th grade and adolescents' academic skills in 9th grade.

Methods: Data were from the Study of Early Child Care and Youth Development, a longitudinal study conducted at 10 sites in the United States. Read More

View Article and Full-Text PDF
September 2021

Putting DNA to Work as Generic Polymeric Materials.

Angew Chem Int Ed Engl 2021 Sep 20. Epub 2021 Sep 20.

Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Micro-Nano Research and Diagnosis Center, CHINA.

DNA is a true polymer that stores the genetic information for an organism. With its amazing biological and polymeric characters, DNA has been regarded as a universal building block for the construction of diverse materials for real-world applications. Through various approaches including ligation, polymerization, chemical crosslinking, and physical cross-linking, both pure and hybrid DNA gels have been developed as generic materials. Read More

View Article and Full-Text PDF
September 2021

Bacterial Contact-Dependent Inhibition Protein Binds near the Open Lateral Gate in BamA Prior to Toxin Translocation.

Biochemistry 2021 Sep 20. Epub 2021 Sep 20.

Department of Chemistry, The College of the Holy Cross, Worcester, Massachusetts 01610, United States.

Contact-dependent inhibition (CDI) is a mechanism of interbacterial competition in Gram-negative bacteria. The critical component of CDI systems is a large protein named CdiA; it forms a filament on the bacterial cell surface and contains a toxin domain at its C-terminal end. Upon binding to a receptor protein on the surface of a neighboring cell, CdiA delivers the toxin domain through the outer membrane of the neighboring bacterium. Read More

View Article and Full-Text PDF
September 2021

An Evaluation of Morphological Changes and Deformability of Suspended Red Blood Cells Prepared Using Whole Blood with Different Hemoglobin Levels of Tibetans.

Transfus Med Hemother 2021 Aug 18;48(4):210-219. Epub 2021 Mar 18.

Institute of Blood Transfusion, Peking Union Medical Collage, Chinese Academy of Medical Science, Chengdu, China.

Background: The hypoxic environment stimulates the human body to increase the levels of hemoglobin (HGB) and hematocrit and the number of red blood cells. Such enhancements have individual differences, leading to a wide range of HGB in Tibetans' whole blood (WB).

Study Design: WB of male Tibetans was divided into 3 groups according to different HGB (i. Read More

View Article and Full-Text PDF

Ultrasensitive electrochemical detection of CYFRA 21-1 via in-situ initiated ROP signal amplification strategy.

Anal Chim Acta 2021 Oct 27;1180:338889. Epub 2021 Jul 27.

Department of Endocrinology, The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, 450000, PR China. Electronic address:

The cytokeratin19 fragment (CYFRA 21-1) is an essential biomarker for non-small cell lung cancer (NSCLC). This work proposed a novel electrochemical immunosensor with a high selective and sensitive detection of CYFRA 21-1via the ring-opening polymerization (ROP) signal amplification strategy. Specifically, 3-mercaptopropionic (MPA) was employed as a cross-linking agent to immobilize cAb on the electrode surface for subsequent specific capture of CYFRA 21-1. Read More

View Article and Full-Text PDF
October 2021

Development of an environmental contextual factor item set relevant to global functioning and health in patients with axial Spondyloarthritis.

Rheumatology (Oxford) 2021 Sep 17. Epub 2021 Sep 17.

Rheumazentrum Ruhrgebiet, Herne Germany; and.

Objective: To describe the development of an Environmental contextual factors (EF) Item Set (EFIS) accompanying the disease specific Assessment of SpondyloArthritis international Society Health Index (ASAS HI).

Method: First, a candidate item pool was developed by linking items from existing questionnaires to 13 EF previously selected for the ICF/ASAS Core Set. Second, using data from two international surveys, which contained the EF item pool as well as the items from the ASAS HI, the number of EF-items was reduced based on the correlation between the item and the ASAS HI sum score combined with expert opinion. Read More

View Article and Full-Text PDF
September 2021

Contribution of enrofloxacin and Cu to the antibiotic resistance of bacterial community in a river biofilm.

Environ Pollut 2021 Sep 10;291:118156. Epub 2021 Sep 10.

Department of Environmental Science, Zhejiang University, Hangzhou, 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou, 310058, China. Electronic address:

Pollutants discharged from wastewater are the main cause of the spread of antibiotic resistance in river biofilms. There is controversy regarding the primary contribution of environmental selectors such as antibiotics and heavy metals to the development of antibiotic resistance in bacterial communities. Here, this study compared the effect of environmental safety concentration Cu and enrofloxacin (ENR) on the evolution of antibiotic resistance by examining phenotypic characteristics and genotypic profiles of bacterial communities in a river biofilm, and then distinguished the major determinants from a comprehensive perspective. Read More

View Article and Full-Text PDF
September 2021

Fine Particulate Matter (PM) and Chronic Kidney Disease.

Rev Environ Contam Toxicol 2021 Aug 26. Epub 2021 Aug 26.

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.

The impact of ambient particulate matter (PM) on public health has become a great global concern, which is especially prominent in developing countries. For health purposes, PM is typically defined by size, with the smaller particles having more health impacts. Particles with a diameter <2. Read More

View Article and Full-Text PDF

Platelet transfusion improves clot formation and platelet function in severely thrombocytopenic haematology patients.

Br J Haematol 2021 Sep 16. Epub 2021 Sep 16.

Department of Medicine Huddinge, Center for Haematology and Regenerative Medicine (HERM), Karolinska Institutet, Stockholm, Sweden.

Prophylactic platelet (PLT) transfusion is a common practice in severely thrombocytopenic patients that reduces mortality, but responses to platelet transfusions are variable and difficult to predict in individual patients. In this prospective study, we evaluated the outcome of PLT transfusions in 40 patients with haematological malignancies, linking corrected count increment (CCI) to clot formation and agonist-induced platelet activation after transfusion. The CCI was highly variable between patients and 34% showed no response (1-h CCI < 7,5). Read More

View Article and Full-Text PDF
September 2021

A dual signal-amplified electrochemiluminescence immunosensor based on core-shell [email protected] nanosphere for procalcitonin detection.

Mikrochim Acta 2021 Sep 16;188(10):344. Epub 2021 Sep 16.

Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People's Republic of China.

A dual signal-amplified sandwich electrochemiluminescence (ECL) immunosensor was fabricated for trace detection of procalcitonin (PCT). [email protected] composed of sea urchin-like [email protected] nanoparticles coated on CeO hollow nanospheres was immobilized on electrode surface to electrochemically catalyze HO to produce a large number of superoxide anion (O). The immunosensor was prepared by linking the capture antibody on immobilized [email protected] with heptapeptide (HWRGWVC), which could maintain the activity of the antibody. Read More

View Article and Full-Text PDF
September 2021

Association of Ambient Fine Particulate Matter (PM) with Elevated Fecal Hemoglobin Concentration and Colorectal Carcinogenesis: A Population-Based Retrospective Cohort Study.

Cancer Control 2021 Jan-Dec;28:10732748211041232

Innovation and Policy Center for Population Health and Sustainable Environment, College of Public Health, 33561National Taiwan University, Taipei, Taiwan.

The roles of ambient fine particulate matter (PM) in the prevention of colorectal cancer (CRC) have been scarcely highlighted as there is short of empirical evidence regarding the influences of PM on multistep carcinogenic processes of CRC. A retrospective cohort design with multistate outcomes was envisaged by linking monthly average PM concentrations at 22 city/county level with large-scale cohorts of cancer-screened population to study the influences of PM on short-term inflammatory process and multistep carcinogenic processes of CRC. Our study included a nationwide CRC screening cohort of 4,628,995 aged 50-69 years who attended first screen between 2004 and 2009 and continued periodical screens until 2016. Read More

View Article and Full-Text PDF
September 2021

Reactivity of chloroacetamides toward sulfide + black carbon: Insights from structural analogues and dynamic NMR spectroscopy.

Sci Total Environ 2021 Sep 3;803:150064. Epub 2021 Sep 3.

Department of Civil and Environmental Engineering, Villanova University, Villanova, PA 19085, USA. Electronic address:

Chloroacetamides are commonly used in herbicide formulations, and their occurrence has been reported in soils and groundwater. However, how their chemical structures affect transformation kinetics and pathways in the presence of environmental reagents such as hydrogen sulfide species and black carbon has not been investigated. In this work, we assessed the impact of increasing Cl substituents on reaction kinetics and pathways of six chloroacetamides. Read More

View Article and Full-Text PDF
September 2021

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.

J Am Chem Soc 2021 Sep 14;143(37):15073-15083. Epub 2021 Sep 14.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Proteolysis targeting chimeras (PROTACs) represent a new class of promising therapeutic modalities. PROTACs hijack E3 ligases and the ubiquitin-proteasome system (UPS), leading to selective degradation of the target proteins. However, only a very limited number of E3 ligases have been leveraged to generate effective PROTACs. Read More

View Article and Full-Text PDF
September 2021

Design and characterization of small-diameter tissue-engineered blood vessels constructed by electrospun polyurethane-core and gelatin-shell coaxial fiber.

Bioengineered 2021 Dec;12(1):5769-5788

School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, China.

Substitution or bypass is the most effective treatment for vascular occlusive diseases.The demand for artificial blood vessels has seen an unprecedented rise due to the limited supply of autologous blood vessels. Tissue engineering is the best approach to provide artificial blood vessels. Read More

View Article and Full-Text PDF
December 2021

Prokaryotic viruses impact functional microorganisms in nutrient removal and carbon cycle in wastewater treatment plants.

Nat Commun 2021 Sep 13;12(1):5398. Epub 2021 Sep 13.

Environmental Microbiome Engineering and Biotechnology Laboratory, Center for Environmental Engineering Research, Department of Civil Engineering, The University of Hong Kong, Hong Kong, China.

As one of the largest biotechnological applications, activated sludge (AS) systems in wastewater treatment plants (WWTPs) harbor enormous viruses, with 10-1,000-fold higher concentrations than in natural environments. However, the compositional variation and host-connections of AS viruses remain poorly explored. Here, we report a catalogue of ~50,000 prokaryotic viruses from six WWTPs, increasing the number of described viral species of AS by 23-fold, and showing the very high viral diversity which is largely unknown (98. Read More

View Article and Full-Text PDF
September 2021

Integration of community-based testing data into national HIV surveillance in Poland, Serbia and Slovakia within the framework of INTEGRATE project.

BMC Infect Dis 2021 Sep 13;21(Suppl 2):800. Epub 2021 Sep 13.

Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Health Department, Generalitat de Catalunya, Badalona, Spain.

Background: Community-based voluntary counselling and testing contributes to early HIV diagnoses among key populations. Testing data from such decentralized services is however often not standardized nor linked to national surveillance systems. This study aimed to support the integration of community testing data into respective national surveillance and monitoring and evaluation systems for those infections. Read More

View Article and Full-Text PDF
September 2021

Extracellular matrix remodeling is associated with the survival of cardiomyocytes in the subendocardial region of the ischemic myocardium.

Exp Biol Med (Maywood) 2021 Sep 13:15353702211042020. Epub 2021 Sep 13.

Regenerative Medicine Research Center, Sichuan University West China Hospital, Chengdu, Sichuan 610041, China.

A significant amount of cardiomyocytes in subendocardial region survive from ischemic insults. In order to understand the mechanism by which these cardiomyocytes survive, the present study was undertaken to examine changes in these surviving cardiomyocytes and their extracellular matrix. Male C57BL/6 mice aged 8-12 weeks old were subjected to a permanent left anterior descending coronary artery ligation to induce ischemic injury. Read More

View Article and Full-Text PDF
September 2021

Cultural diversity approaches in schools and adolescents' willingness to support refugee youth.

Br J Educ Psychol 2021 Sep 13:e12458. Epub 2021 Sep 13.

University of Potsdam, Germany.

Background: Culturally diverse schools contribute to adolescents' intergroup relations. Complex and inclusive social identities are mechanisms that can explain the link between structural school cultural diversity (i.e. Read More

View Article and Full-Text PDF
September 2021

The use of health facility data to assess the effects of armed conflicts on maternal and child health: experience from the Kivu, DR Congo.

BMC Health Serv Res 2021 Sep 13;21(Suppl 1):195. Epub 2021 Sep 13.

Centre for Global Public Health, Department of Community Health Sciences, Rady Faculty of Health Sciences University of Manitoba, Winnipeg, Manitoba, Canada.

Background: In conflict-affected settings, data on reproductive, maternal, newborn and child health (RMNCH) are often lacking for priority setting and timely decision-making. We aimed to describe the levels and trends in RMNCH indicators within Kivu provinces between 2015 and 2018, by linking conflict data with health facility (HF) data from the District Health Information System 2 (DHIS2).

Methods: We used data from the DHIS2 for the period 2015-2018, the 2014 Demographic and Health Survey, the 2018 Multiple Indicators Cluster Survey and the Uppsala Conflict Data Program. Read More

View Article and Full-Text PDF
September 2021

Systemic comorbidities of rosacea: practice gaps among dermatologists.

Arch Dermatol Res 2021 Sep 12. Epub 2021 Sep 12.

Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

Rosacea is a chronic inflammatory skin condition that is associated with multiple systemic comorbidities, with the strongest evidence linking rosacea to hypertension, dyslipidemia, inflammatory bowel disease, and anxiety and depression. To assess dermatologists' awareness of and screening practices for rosacea comorbidities, we developed a survey that was distributed to attendings and residents across four academic dermatology departments in Massachusetts. A total of 73 dermatologists with varying experience participated in the study. Read More

View Article and Full-Text PDF
September 2021

Facile In Situ Chemical Cross-Linking Gel Polymer Electrolyte, which Confines the Shuttle Effect with High Ionic Conductivity and Li-Ion Transference Number for Quasi-Solid-State Lithium-Sulfur Battery.

ACS Appl Mater Interfaces 2021 Sep 10;13(37):44497-44508. Epub 2021 Sep 10.

School of Chemical Engineering, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu 610065, P. R. China.

As a secondary Li-ion battery with high energy density, lithium-sulfur (Li-S) batteries possess high potential development prospects. One of the important ingredients to improve the safety and energy density in Li-S batteries is the solid-state electrolyte. However, the poor ionic conductivity largely limits its application for the commercial market. Read More

View Article and Full-Text PDF
September 2021