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Detecting and classifying neurotransmitter signals from ultra-high sensitivity PET data: the future of molecular brain imaging.

Phys Med Biol 2021 Jul 30. Epub 2021 Jul 30.

Biomedical Engineering, Yale University, New Haven, Connecticut, UNITED STATES.

Efforts to build the next generation of brain PET scanners are underway. It is expected that a new scanner (NS) will offer an order-of-magnitude improvement in sensitivity to counts compared to the current state-of-the-art, Siemens HRRT. Our goal was to explore the use of the anticipated increased sensitivity in combination with the linear-parametric neurotransmitter PET (lp-ntPET) model to improve detection and classification of transient dopamine (DA) signals. Read More

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An Accessible, 16-Week Neck Strength Training Program Improves Head Kinematics Following Chest Perturbation in Young Soccer Athletes.

J Sport Rehabil 2021 Jul 30:1-8. Epub 2021 Jul 30.

Context: Neck size and strength may be associated with head kinematics and concussion risks. However, there is a paucity of research examining neck strengthening and head kinematics in youths. In addition, neck training is likely lacking in youth sport due to a perceived inadequacy of equipment or time. Read More

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Label-free immunosensor for cardiac troponin I detection based on aggregation-induced electrochemiluminescence of a distyrylarylene derivative.

Biosens Bioelectron 2021 Jul 24;192:113532. Epub 2021 Jul 24.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, Jilin, 130022, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China. Electronic address:

Herein, the aggregation-induced electrochemiluminescence (AIECL) of a distyrylarylene derivative, 4,4'-bis(2,2-diphenylvinyl)-1,1'-biphenyl (DPVBi), was investigated for the first time. This luminophore exhibits significantly enhanced photoluminescence (PL) and electrochemiluminescence (ECL) emission with the increases of water content in organic/water mixtures. This high luminescence efficiency of DPVBi in aggregate state is due to the fact that the aggregates can reduce the energy loss by restricting the intramolecular motions. Read More

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Functional co-activation of the default mode network in APOE ε4-carriers: A replication study.

Neuroimage 2021 Jun 27;240:118304. Epub 2021 Jun 27.

Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom. Electronic address:

Structural and functional alterations of the brain in persons genetically at-risk for Alzheimer's disease (AD) are crucial in unravelling AD development. Filippini et al. found that the default mode network (DMN) is already affected in young APOE ε4-carriers, with increased co-activation of the DMN during rest and increased hippocampal task activation. Read More

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Simultaneous determination of dantrolene and paracetamol in human plasma by liquid chromatography tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 6;1179:122816. Epub 2021 Jul 6.

Modern University for Technology and Information, Cairo, Egypt. Electronic address:

A simple, sensitive, rapid and specific method based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the simultaneous quantification of dantrolene (DAN) and paracetamol (PAR) in real human plasma was developed and validated. The preparation of sample was achieved by liquid-liquid extraction with tertiary butyl methyl ether. The analysis was performed on a reversed-phase Ccolumn (1. Read More

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Multi-Site Evaluation of Immunoassays for Antipsychotic Drug Measurement in Clinical Samples.

J Appl Lab Med 2021 Jul 30. Epub 2021 Jul 30.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA.

Background: Atypical antipsychotic drugs are frequently used in the treatment of serious mental illness (SMI), specifically schizophrenia and bipolar disorder. Adherence to these prescribed drug regimens is a challenge to successful treatment with these drugs. For some of the more common drugs in this class, novel turbidimetric immunoassays have been developed for therapeutic drug monitoring (TDM) to aid in the management of patients prescribed these drugs. Read More

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Enhancing SERS detection on a biocompatible metallic substrate for diabetes diagnosing.

Opt Lett 2021 Aug;46(15):3801-3804

A method to realize surface-enhanced Raman spectroscopy (SERS) at a titanium alloy substrate for glucose detection has been experimentally demonstrated. A silver-coated laser-induced periodic surface structure (LIPSS) was prepared via femtosecond laser micro-processing. The low detection limit of glucose is 10/ and, a good linear relationship between the glucose concentration and Raman intensity is found in the range between 1×10 and 1×10/. Read More

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Flexible Pressure Sensors Based on the Controlled Buckling of Doped Semiconducting Polymer Nanopillars.

ACS Appl Mater Interfaces 2021 Jul 30. Epub 2021 Jul 30.

Leibniz-Institut für Polymerforschung Dresden e.V. (IPF), Hohe Str. 6, Dresden 01069, Germany.

Mechanically flexible and electrically conductive nanostructures are highly desired for flexible piezoresistive pressure sensors toward health monitoring or robotic skin applications. The popular approach for these sensors is to combine flexible but insulating polymers as a micro- or nanostructural functional medium and conductive materials covering the polymer surface, which could give rise to many practical issues, for example, durability, compatibility, and complicated processing steps. We herein report a piezoresistive pressure sensor with a functional component of nanopillars of a doped semiconducting polymer, operating at low bias voltage with a sensing mechanism based on controlled buckling. Read More

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Relationship between obesity index and cardiovascular risk in primary care patients on Crete, Greece: a data driven sub-analysis.

Ann Ig 2021 Aug 3. Epub 2021 Aug 3.

Clinic of Social and Family Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.

Background: The present sub-analysis aimed to examine the relationship between obesity index and cardiovascular risk among primary care attendees.

Study Design: Stratified random sampling was previously used to recruit general practitioners, practicing on Crete island, Greece, whose patients were then enrolled.

Methods: Initial sample included 815 primary care attendees (55. Read More

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Trends in stress among pregnant and postpartum women during the COVID-19 pandemic.

JMIR Ment Health 2021 Jul 2. Epub 2021 Jul 2.

Behavioral and Community Health Sciences, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, US.

Background: Stress is associated with adverse birth and postpartum health outcomes. Few studies have longitudinally explored racial differences in maternal stress in a birthing population in the United States (US) during the ongoing COVID-19 pandemic.

Objective: This study aimed to: (1) assess changes in reported stress before, during, and after initial emergency declarations (e. Read More

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Transformation of Multicolour Flow Cytometry data with OTflow prevents misleading multivariate analysis (MVA) results and incorrect immunological conclusions.

Cytometry A 2021 Jul 29. Epub 2021 Jul 29.

TI-COAST, Amsterdam, The Netherlands.

Introduction: The rapid evolution of the flow cytometry field, currently allowing the measurement of 30-50 parameters per cell, has led to a marked increase in deep multivariate information. Manual gating is insufficient to extract all this information. Therefore, multivariate analysis (MVA) methods have been developed to extract information and efficiently analyse the high-density multicolour flow cytometry (MFC) data. Read More

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Total water intake by kilogram of body weight: Analysis of the Australian 2011 to 2013 National Nutrition and Physical Activity Survey.

Nutr Diet 2021 Jul 29. Epub 2021 Jul 29.

Department of Rural Health, University of Newcastle, Tamworth, New South Wales, Australia.

Aim: Water is critical for human survival, yet water intake equations may not reflect contemporary populations. This research aims to determine the total water intake of a representative Australian population, per kilogram of body weight (mL/kg) and stratified by age and sex.

Methods: A secondary analysis of the 2011 to 2013 National Nutrition and Physical Activity Survey (n = 10 146) was conducted. Read More

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Head Circumference within the Normal Range and Neurodevelopmental Outcomes in Preterm Infants.

Am J Perinatol 2021 Jul 29. Epub 2021 Jul 29.

Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama.

Objective:  We sought to determine if variation in head circumference (HC) within the range of normal (5th-10th and 90th-95th percentile) is associated with poor neurodevelopmental outcomes (NDO), which defined as mild or moderate delay by Bayley II psychometrics (BSID-II).

Study Design:  This is a secondary analysis of a randomized controlled trial assessing the benefits of magnesium for the prevention of cerebral palsy. Fetuses with a normal HC at birth defined as within 5th to 95th percentile were included. Read More

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CT-based thermometry with virtual monoenergetic images by dual-energy of fat, muscle and bone using FBP, iterative and deep learning-based reconstruction.

Eur Radiol 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology, Jena University Hospital - Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany.

Objectives: The aim of this study was to evaluate the sensitivity of CT-based thermometry for clinical applications regarding a three-component tissue phantom of fat, muscle and bone. Virtual monoenergetic images (VMI) by dual-energy measurements and conventional polychromatic 120-kVp images with modern reconstruction algorithms adaptive statistical iterative reconstruction-Volume (ASIR-V) and deep learning image reconstruction (DLIR) were compared.

Methods: A temperature-regulating water circuit system was developed for the systematic evaluation of the correlation between temperature and Hounsfield units (HU). Read More

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"Switch-on" fluorescence sensing platform based on porphyrin metal-organic frameworks for rapid and specific detection of zinc ion.

Anal Bioanal Chem 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, Liaoning, China.

Zinc ion (Zn) is a necessary transition metal ion in the human body and plays a vital role in biological systems. Therefore, it is meaningful for rapid, sensitive, and specific detection of Zn. Herein, a "switch-on" fluorescence sensing platform for the detection of Zn was successfully established. Read More

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Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic Study of Tebipenem Pivoxil Granules After Single Escalating Oral Dose in Healthy Chinese Volunteers.

Front Pharmacol 2021 13;12:696165. Epub 2021 Jul 13.

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China.

Tebipenem pivoxil (TBPM-PI), an oral carbapenem antibiotic, has shown special advantages in pediatric infections and was in urgent need in China. Although pharmacokinetics, urinary excretion, and metabolite information of its active form tebipenem (TBPM) has been reported, ethnic differences may exist among the Chinese and Japanese population. By now, no systematic pharmacokinetics, urinary excretion, metabolites, or safety information has been revealed to the Chinese population. Read More

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Synthesis of Spirocyclic Piperidines by Radical Hydroarylation.

Synlett 2021 19;32(2):211-214. Epub 2020 Nov 19.

Department of Chemistry, Emory University, Atlanta, GA 30322, USA.

Reported here are conditions for the construction of spirocyclic piperidines from linear aryl halide precursors. These conditions employ a strongly reducing organic photoredox catalyst in combination with a trialkylamine reductant to achieve formation of aryl radical species. Regioselective cyclization followed by hydrogen-atom transfer affords a range of complex spiropiperidines. Read More

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November 2020

Dietary sodium and cardiovascular morbidity/mortality: a brief commentary on the 'J-shape hypothesis'.

J Hypertens 2021 Jul 28. Epub 2021 Jul 28.

Cardiovascular Prevention & Research Unit, Clinic & Laboratory of Pathophysiology, Department of Medicine, National and Kapodistrian University of Athens Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens Hellenic Foundation for Cardiovascular Health and Nutrition, Athens Department of Food Science and Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, Athens, Greece.

The last decade, a growing number of evidence support J-shape or inverse - instead of positive linear -- associations between dietary sodium intake and cardiovascular morbidity/mortality. A careful evaluation of these studies leads to the following observations: less accurate methods for dietary sodium assessment are usually used; most studies included high-risk participants, enhancing the possibility of a 'reverse causality' phenomenon. However, these limitations do not explain all the findings. Read More

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Nature of dynamic gradients, glass formation, and collective effects in ultrathin freestanding films.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Department of Chemical, Biological and Materials Engineering, University of South Florida, Tampa, FL 33620;

Molecular, polymeric, colloidal, and other classes of liquids can exhibit very large, spatially heterogeneous alterations of their dynamics and glass transition temperature when confined to nanoscale domains. Considerable progress has been made in understanding the related problem of near-interface relaxation and diffusion in thick films. However, the origin of "nanoconfinement effects" on the glassy dynamics of thin films, where gradients from different interfaces interact and genuine collective finite size effects may emerge, remains a longstanding open question. Read More

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Relationship between burnout and mistreatment: Who plays a role?

Am J Surg 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, University of Alabama Birmingham, Birmingham, AL, USA.

Introduction: Surgery residents have high burnout rates and mistreatment occurs during training. We hypothesized that residents who reported mistreatment would be more likely to experience burnout.

Methods: A multi-institutional observational study asked residents to complete the Maslach Burnout Inventory and to rate how often they experienced mistreatment. Read More

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LC-MS/MS method for the quantification of the anti-cancer agent infigratinib: Application for estimation of metabolic stability in human liver microsomes.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 2;1179:122806. Epub 2021 Jul 2.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Infigratinib (INF) is a novel small molecule, administered orally, which acts as a human fibroblast growth factor receptors (FGFRs) inhibitor. FGFRs are a family of receptor tyrosine kinases (RTK) reported to be upregulated in various tumor cell types. In 1 December 2020, BridgeBio Pharma Inc. Read More

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Dummy molecularly imprinted membranes based on an eco-friendly synthesis approach for recognition and extraction of enrofloxacin and ciprofloxacin in egg samples.

J Chromatogr A 2021 Jul 14;1653:462411. Epub 2021 Jul 14.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning, 110016, PR China. Electronic address:

In this work, novel dummy molecularly imprinted membranes (MIMs) were fabricated using the nylon-66 (NY-66) membranes as the subtracts based on an eco-friendly "sandwich" technology with less consumption of organic reagents at mild conditions for recognition and extraction of enrofloxacin (ENR) and ciprofloxacin (CIP) in egg samples. The prepared MIMs were characterized by SEM, ATR-FTIR and TGA, showing the successful construction of uniform and porous polymers on the surface of membranes. A series of adsorption affinity tests were investigated, indicating the prepared materials had specific recognition capacity and excellent stability as novel sorbents. Read More

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Novel label-free fluorescence aptasensor for chloramphenicol detection based on a DNA four-arm junction-assisted signal amplification strategy.

Food Chem 2021 Jul 21;366:130648. Epub 2021 Jul 21.

Key Laboratory of Animal Resistance Biology of Shandong Province, Institute of Biomedical Sciences, Key Laboratory of Food Nutrition and Safety of Shandong Normal University, College of Life Science, Shandong Normal University, Jinan 250014, PR China. Electronic address:

A novel label-free fluorescence aptasensor was established for chloramphenicol (CAP) detection by DNA four-arm junction-assisted target recycling and SYBR Green I dye-aided fluorescence-signal amplification. The CAP aptamer was hybridized to its complementary strand (primer) to form a double-stranded primer/aptamer complex. In the presence of CAP, aptamers can specifically bind with CAP to dissociate primers, which can trigger the self-assembly of four hairpins to continuously generate DNA four-arm junctions. Read More

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Tuning CO sensing properties of HPTS along with newly synthesized coordination polymers (CPs).

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 21;263:120224. Epub 2021 Jul 21.

Dokuz Eylül University, Faculty of Sciences, Department of Chemistry, Izmir, Turkey.

Coordination polymers (CPs), new functional hybrid materials, have received important attention due to their structural features and many different applications such as gas storage, catalysis, energy storage, small molecule adsorption, luminescence, and chemical sensors. In this study, two newly synthesized metal-organic frameworks (MOFs); [Mn(µ-dmg)-(µ-dmg)(µ-bipy)] (CP1) and [Mn(µ-dmg)(µ-dmg)(µ-dpeten)] (CP2); were used for sensing of gaseous carbon dioxide with a spectrofluorometric method with a dye, 8-hydroxypyrene-1, 3, 6-trisulfonic acid (HPTS) as matrix additive material for the first time. The ion-pair form of the HPTS was used in the polymethyl methacrylate matrix as a thin film form. Read More

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Normal Left Ventricular Systolic and Diastolic Strain Rate Values in Children Derived from Two-Dimensional Speckle-Tracking Echocardiography.

J Am Soc Echocardiogr 2021 Jul 26. Epub 2021 Jul 26.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Background: Strain rate (SR) parameters derived from two-dimensional speckle-tracking echocardiography (2DSTE) have prognostic value in children with heart disease. Routine use is hindered by a lack of normative data. Our aim was to determine reference values and Z-scores for left ventricular systolic and diastolic SR in a large cohort of healthy children. Read More

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DNA Structure-Stabilized Liquid-Liquid Self-Assembled Ordered Au Nanoparticle Interface for Sensitive Detection of MiRNA 155.

Anal Chem 2021 Jul 29. Epub 2021 Jul 29.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University) Ministry of Education; College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.

Au nanoparticles (Au NPs) can be self-assembled in a bottom-up orderly manner at the oil-water interface, which is widely used as SERS platforms, but the stability of the Au NP interface needs to be improved due to shaking or shifting and the Brownian motion. The DNA structure with unique sequence specificity, excellent programmability, and flexible end-group modification capability owns good potential to precisely control the plasmonic structure's distance. In this study, a large area of the SERS substrate is obtained from the DNA structure-stabilized self-assembled ordered Au NPs on the cyclohexane-water interface. Read More

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Sources and Fate of the Anti-Androgenic Fluorescent Dye 4-Methyl-7-Diethylaminocoumarin in Small River Systems.

Environ Toxicol Chem 2021 Jul 29. Epub 2021 Jul 29.

UFZ - Helmholtz Centre for Environmental Research, 04318, Leipzig, Germany.

Recently, the potent antiandrogen 4-methyl-7-diethylaminocoumarin (C47), and its potential transformation products 4-methyl-7-ethylaminocoumarin (C47T1) and 4-methyl-7-aminocoumarin (C47T2) were identified as novel environmental contaminants. We assessed for the first time the sources, distribution and fate of these compounds in aquatic systems using the Holtemme river (Saxony-Anhalt, Germany), which is a hotspot for these contaminants. To this end, wastewater treatment plant influent and effluent samples, surface water samples over three years and the longitudinal profiles in water, sediment and gammarids were analyzed. Read More

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Knowledge, attitude and practices of community pharmacists regarding COVID-19: A paper-based survey in Vietnam.

PLoS One 2021 29;16(7):e0255420. Epub 2021 Jul 29.

Center for Population Health Sciences, Hanoi University of Public Health, Hanoi City, Vietnam.

Objective: To survey the knowledge, attitude, and practices of Vietnamese pharmacists regarding the COVID-19 pandemic.

Method: This cross-sectional, paper-based study was conducted from June to August 2020. A validated questionnaire (Cronbach's alpha = 0. Read More

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Relationship of particle density and organic content in sieve fractions of road-deposited sediments from varying traffic sites based on a novel data set.

Sci Total Environ 2021 Jul 1;794:148812. Epub 2021 Jul 1.

Fachgebiet Siedlungswasserwirtschaft und Hydromechanik (Institute of Urban Water Management and Hydromechanics), Frankfurt University of Applied Sciences, Nibelungenplatz 1, 60318 Frankfurt am Main, Germany. Electronic address:

Pollutants (e.g. heavy metals) are to a large extent bound to particles in runoff from traffic areas. Read More

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Horseradish peroxidase-catalyzed formation of polydopamine for ultra-sensitive magnetic relaxation sensing of aflatoxin B.

J Hazard Mater 2021 Jun 12;419:126403. Epub 2021 Jun 12.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China. Electronic address:

Aflatoxin B as one of the most toxic mycotoxins poses a major health risk to humans and animals. Highly sensitive detection methods of aflatoxin B are urgently required because of its low abundance in biological samples. In this work, we developed a magnetic relaxation sensing strategy using enzyme-catalyzed formation of polydopamine for signal amplification. Read More

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