204,248 results match your criteria linear models

Detecting Injury Risk Factors with Algorithmic Models in Elite Women's Pathway Cricket.

Int J Sports Med 2021 Sep 24. Epub 2021 Sep 24.

Department for Health, University of Bath, Bath, United Kingdom of Great Britain and Northern Ireland.

This exploratory retrospective cohort analysis aimed to explore how algorithmic models may be able to identify important risk factors that may otherwise not have been apparent. Their association with injury was then assessed with more conventional data models. Participants were players registered on the England and Wales Cricket Board women's international development pathway (n=17) from April 2018 to August 2019 aged between 14-23 years (mean 18. Read More

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September 2021

Improving quality of PrEP counseling for adolescent girls and young women in Kenya with standardized patient actors: a dose-response analysis.

J Acquir Immune Defic Syndr 2021 Sep 23. Epub 2021 Sep 23.

Department of Global Health, University of Washington, Seattle, WA, USA Department of Epidemiology, University of Washington, Seattle, WA, USA Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya Policy Development & Evaluation Unit, Public Health Seattle/King County, Seattle, WA, USA Howard University, Washington, DC, USA Department of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA Department of Biostatistics, University of Washington, Seattle, WA, USA Department of Medicine, University of Washington, Seattle, WA, USA Department of Pediatrics, University of Washington, Seattle, WA, USA Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, WA, USA.

Background: Health care worker (HCW) training using standardized patient actors (SPs) is an evidence-based approach for improving patient-provider interactions. We evaluated whether SP training among HCWs in Western Kenya improved quality of PrEP counseling for adolescent girls and young women (AGYW).

Methods: We conducted a 2-day SP training intervention among HCWs providing PrEP counseling for AGYW. Read More

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September 2021

Peer Presence Increases Session Ratings of Perceived Exertion.

Int J Sports Physiol Perform 2021 Sep 24:1-5. Epub 2021 Sep 24.

Purpose: This study aimed to examine the effect of peer presence on session rating of perceived exertion (RPE) responses.

Method: Fourteen males, with mean (SD) age 22.4 (3. Read More

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September 2021

The diagnostic accuracy of MRI and nonenhanced CT for high-risk vertebral artery anatomy for subaxial anterior cervical spine surgery safety.

J Neurosurg Spine 2021 Sep 24:1-8. Epub 2021 Sep 24.

1Spine Care Institute, Hospital for Special Surgery, New York, New York.

Objective: Medial migration of the vertebral artery (VA) can be a risk factor for injury during anterior procedures. CT angiography (CTA) has been considered the gold standard for the evaluation of various areas of the arterial anatomy. MRI and nonenhanced CT are more commonly used as routine preoperative imaging studies, but it is unclear if these modalities can safely exclude the anomalous course of the VA. Read More

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September 2021

Modelling and optimization of high-pressure homogenization of not-from-concentrate juice: Achieving better juice quality using sustainable production.

Food Chem 2021 Sep 7;370:131058. Epub 2021 Sep 7.

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China.

The present work optimized high-pressure homogenization (HPH) parameters for not-from-concentrate combined peach and carrot juices, based on a two-step comprehensive model using factor analysis and analytic hierarchy process methods. Treating combined juice with pressures over 200 MPa retained more amounts of the bioactive compounds (carotenoids and polyphenols) than non-homogenization. Nutrition-oriented optimization, with higher judgement weight on nutritional properties, and sense-oriented optimization, with higher weight on sensory properties, were set up. Read More

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September 2021

Machine-learning insights into nitrate-reducing communities in a full-scale municipal wastewater treatment plant.

J Environ Manage 2021 Sep 21;300:113795. Epub 2021 Sep 21.

Department of Civil Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do, Republic of Korea. Electronic address:

This study carried out machine-learning (ML) modeling using activated sludge microbiome data to predict the operational characteristics of biological unit processes (i.e., anaerobic, anoxic, and aerobic) in a full-scale municipal wastewater treatment plant. Read More

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September 2021

County-level characteristics associated with incidence, late-stage incidence, and mortality from screenable cancers.

Cancer Epidemiol 2021 Sep 21;75:102033. Epub 2021 Sep 21.

Huntsman Cancer Institute, Salt Lake City, UT, USA; University of Utah, Salt Lake City, UT, USA.

Background: Cancer screening differs by rurality and racial residential segregation, but the relationship between these county-level characteristics is understudied. Understanding this relationship and its implications for cancer outcomes could inform interventions to decrease cancer disparities.

Methods: We linked county-level information from national data sources: 2008-2012 cancer incidence, late-stage incidence, and mortality rates (for breast, cervical, and colorectal cancer) from U. Read More

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September 2021

Process-oriented and personalized psychotherapeutic care for epilepsy: Interim results of a feasibility study.

Epilepsy Behav 2021 Sep 21;124:108313. Epub 2021 Sep 21.

Institute of Synergetics and Psychotherapy Research, Paracelsus Medical University, Salzburg, Austria; University Hospital of Psychiatry, Psychotherapy and Psychosomatics, Paracelsus Medical University, Salzburg, Austria.

Background: There is great scientific and clinical interest in the effective integration of psychological treatments into comprehensive epilepsy care to optimize treatment outcomes and psychosocial functioning in people with epilepsy. Stepped care is a promising approach to accommodate personalized psychotherapeutic care in academic and regular outpatient settings. It aims at providing patients with the most adequate treatment duration, number of sessions, and treatment method while systematically monitoring their treatment processes. Read More

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September 2021

Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases.

Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.

Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND Institute for Molecular Medicine Finland, HiLIFE, Helsinki, FINLAND Department of Public Health, University of Helsinki, Helsinki, FINLAND, University of Helsinki Broad Institute of MIT & Harvard, Cambridge, MA Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND.

Introduction: Genetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRSs) and cardiometabolic diseases among the Finnish population.

Methods: PRSs for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genome-wide genotyping and extensive digital longitudinal health register data. Read More

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September 2021

On the Treatment of Optimization Problems with L1 Penalty Terms via Multiobjective Continuation.

IEEE Trans Pattern Anal Mach Intell 2021 Sep 24;PP. Epub 2021 Sep 24.

We present a novel algorithm that allows us to gain detailed insight into the effects of sparsity in linear and nonlinear optimization. Sparsity is of great importance in many scientific areas such as image and signal processing, medical imaging, compressed sensing, and machine learning, as it ensures robustness against noisy data and yields models that are easier to interpret due to the small number of relevant terms. It is common practice to enforce sparsity by adding the l1-norm as a penalty term. Read More

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September 2021

Wilson's Disease: An Analysis of Health Care Use and Cost Burden of Commercially Insured Adults in the United States.

Hepatol Commun 2021 Sep 2. Epub 2021 Sep 2.

Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

The economic and health care use burdens of Wilson's disease (WD) are unknown. In this study, we aimed to quantify this health care resource use and economic burden. We performed a retrospective case-control analysis of individuals in the Truven Health MarketScan Commercial Claims database (2007-2017). Read More

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September 2021

A Retrospective Study of Foot Biomechanics and Injury History in Varsity Football Athletes at the U.S. Naval Academy.

Mil Med 2021 Sep 24. Epub 2021 Sep 24.

The Center for Rehabilitation Sciences Research, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 , USA.

Introduction: The six-item Foot Posture Index (FPI-6) was previously developed as an assessment tool to measure the posture of the foot across multiple segments and planes. It was derived from a criterion-based observational assessment of six components of each foot during static standing. The association between abnormal foot posture and musculoskeletal injuries remains unclear and is in of need further exploration. Read More

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September 2021

Impact of different bilateral knee extension strengths on lower extremity performance.

Medicine (Baltimore) 2021 Sep;100(38):e27297

Faculty of Health Sciences, Tokyo Kasei University, Saitama, Japan.

Abstract: Despite the impact of leg muscle strength on lower extremity motor performance-including walking and sit-to-stand transfer-it remains difficult to predict the relationship between bilateral leg muscle strength and lower extremity performance. Therefore, this study was designed to predict lower extremity function through the differential modeling of logarithmic and linear regression, based on knee extension strength.The study included 121 individuals living in the same community. Read More

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September 2021

Parenting Stress, Child Weight-Related Behaviors, and Child Weight Status.

Child Obes 2021 Sep 24. Epub 2021 Sep 24.

Department of Health Behavior and Policy, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

There has been limited examination of the association between parenting stress and child weight-related behaviors. We aimed to determine whether parenting stress is associated with child weight-related behaviors, including physical activity, screen time, diet, sedentary time, and eating in the absence of hunger (EAH). Secondarily, we assessed association between parenting stress and child weight status. Read More

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September 2021

Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population.

Hepatol Commun 2021 Aug 28. Epub 2021 Aug 28.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Physiologic aging leads to attrition of telomeres and replicative senescence. An acceleration of this process has been hypothesized in the progression of chronic liver disease. We sought to examine the association of telomere length (TL) with liver disease and its impact on mortality risk. Read More

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Dietary Risks for Liver Mortality in NAFLD: Global Burden of Disease Data.

Hepatol Commun 2021 Jul 8. Epub 2021 Jul 8.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA.

Nonalcoholic fatty liver disease (NAFLD) is a common but complex chronic liver disease, driven by environmental and genetic factors. We assessed metabolic and dietary risk factor associations with NAFLD liver mortality using the Global Burden of Disease (GBD) 2017 data. NAFLD liver deaths were calculated (per 100,000) as age-standardized rates (ASRs) from 195 countries and territories (21 GBD regions; 7 GBD superregions). Read More

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Adipocytokines and Associations with Abnormal Body Composition in Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2021 Sep 24. Epub 2021 Sep 24.

Columbia University, New York, NY, USA.

Purpose: We determined associations between adipokines and abnormal body composition in patients with rheumatoid arthritis (RA).

Methods: Combining data from three RA cohorts, whole-body dual-energy absorptiometry measures of appendicular lean mass and fat mass indices were converted to age, sex, and race-specific Z-Scores. Lean mass relative to fat mass was determined based on prior methods. Read More

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September 2021

Anthropometric models to estimate fat mass at 3 days, 15 and 54 weeks.

Pediatr Obes 2021 Sep 24:e12855. Epub 2021 Sep 24.

Division of Endocrinology, Department of Medicine, New York Nutrition Obesity Research Center, Columbia University Irving Medical Center, New York, New York, USA.

Background: Currently available infant body composition measurement methods are impractical for routine clinical use. The study developed anthropometric equations (AEs) to estimate fat mass (FM, kg) during the first year using air displacement plethysmography (PEA POD® Infant Body Composition System) and Infant quantitative magnetic resonance (Infant-QMR) as criterion methods.

Methods: Multi-ethnic full-term infants (n = 191) were measured at 3 days, 15 and 54 weeks. Read More

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September 2021

Empagliflozin and uric acid metabolism in diabetes: a post-hoc analysis of the EMPA-REG OUTCOME trial.

Diabetes Obes Metab 2021 Sep 24. Epub 2021 Sep 24.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada.

Aims: Elevated uric acid (UA) levels are common in type 2 diabetes (T2D) and may lead to gouty arthritis. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) decrease UA levels and may reduce gout incidence. We aim to evaluate the effect of empagliflozin on UA levels, anti-gout medication and gout episodes in EMPA-REG OUTCOME (NCT01131676). Read More

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September 2021

Sleep duration, sleep problems and perceived stress are associated with hippocampal subfield volumes in later life: Findings from The Irish Longitudinal Study on Ageing (TILDA).

Sleep 2021 Sep 24. Epub 2021 Sep 24.

The Irish Longitudinal Study on Ageing, Trinity College Dublin, Ireland.

Study Objectives: This study examines the cross-sectional and two-year follow-up relationships between sleep and stress and total hippocampal volume and hippocampal subfield volumes among older adults.

Methods: 417 adults (aged 68.8±7. Read More

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September 2021

Health-Related Quality of Life and Its Contributors According to a Preference-Based Generic Instrument in Cirrhosis.

Hepatol Commun 2021 Sep 24. Epub 2021 Sep 24.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.

It is essential to determine contributors around impairment in health-related quality of life (HRQoL) in patients with cirrhosis aiming at improving health care and therapeutic strategy. Studies simultaneously incorporating disease severity based on biochemical parameters and other physical/psychological effects (i.e. Read More

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September 2021

Is organic chemistry really growing exponentially?

Angew Chem Int Ed Engl 2021 Sep 23. Epub 2021 Sep 23.

Ulsan National Institute of Science and Technology, Chemistry, IBS Center for Soft and Living Matter, Advanced Materials Research Bldg. (#103), Rm.313, 50, UNIST-gil, 44919, Ulsan, KOREA, REPUBLIC OF.

In terms of molecules and specific reaction examples reported in the literature, organic chemistry features an impressive, exponential growth. However, new reaction classes/types that fuel this growth are being discovered at a much slower and only linear (or even sublinear) rate. In effect, the proportion of newly discovered reaction types to all reactions being performed keeps decreasing, suggesting that synthetic chemistry becomes more reliant on reusing the well-known methods. Read More

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September 2021

Comparison of linear combination modeling strategies for edited magnetic resonance spectroscopy at 3 T.

NMR Biomed 2021 Sep 23:e4618. Epub 2021 Sep 23.

Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

J-difference-edited spectroscopy is a valuable approach for the in vivo detection of γ-aminobutyric-acid (GABA) with magnetic resonance spectroscopy (MRS). A recent expert consensus article recommends linear combination modeling (LCM) of edited MRS but does not give specific details regarding implementation. This study explores different modeling strategies to adapt LCM for GABA-edited MRS. Read More

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September 2021

Adolescents' symptoms of anxiety and depression before and during the Covid-19 outbreak - A prospective population-based study of teenagers in Norway.

Lancet Reg Health Eur 2021 Jun 28;5:100093. Epub 2021 Mar 28.

Department for Child and Adolescent Research, Norwegian Centre for Violence and Traumatic Stress Studies, Gullhaugveien 1-3, 0409 Oslo, Norway.

Background: Lockdown policies related to the Sars-Cov-2 pandemic has potential negative consequences for mental health in youths.

Methods: Anxiety and depressive symptoms were assessed in 3 572 adolescents, age 13 to 16 using the Hopkins Symptom Checklist (HSCL-10), in a representative longitudinal survey of Norwegian youths between February 2019 (T1) and June 2020 (T2). Predictors for symptom change were analysed with linear mixed-effects models. Read More

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Association between Personal Activity Intelligence (PAI) and body weight in a population free from cardiovascular disease - The HUNT study.

Lancet Reg Health Eur 2021 Jun 21;5:100091. Epub 2021 Mar 21.

Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Postboks 8905, 7491 Trondheim, Norway.

Background: Personal Activity Intelligence (PAI) is a new metric for physical activity tracking, and is associated with reduced risk of all-cause and cardiovascular mortality. We prospectively investigated whether PAI is associated with lower body weight gain in a healthy population.

Methods: We included 85,243 participants (40,037 men and 45,206 women) who participated in at least one of three waves of the Trøndelag Health Study (HUNT1: 1984-86, HUNT2: 1995-97, and HUNT3: 2006-08). Read More

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Associations of Residential Greenness with Depression and Anxiety in Rural Chinese Adults.

Innovation (N Y) 2020 Nov 2;1(3):100054. Epub 2020 Nov 2.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.

Background: Depression and anxiety are top contributors to non-fatal health loss globally. Several studies have indicated the association between residential greenness and mental health.

Method: The participants (n = 27,366) were recruited from four counties in Henan Province, China during 2015-2017. Read More

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November 2020

Abnormalities in normal-appearing white matter from which multiple sclerosis lesions arise.

Brain Commun 2021 10;3(3):fcab176. Epub 2021 Aug 10.

Biogen Digital Health, Biogen, Cambridge, MA 02142, USA.

Normal-appearing white matter is far from normal in multiple sclerosis; little is known about the precise pathology or spatial pattern of this alteration and its relation to subsequent lesion formation. This study was undertaken to evaluate normal-appearing white matter abnormalities in brain areas where multiple sclerosis lesions subsequently form, and to investigate the spatial distribution of normal-appearing white matter abnormalities in persons with multiple sclerosis. Brain MRIs of pre-lesion normal-appearing white matter were analysed in participants with new T2 lesions, pooled from three clinical trials: SYNERGY (NCT01864148; = 85 with relapsing multiple sclerosis) was the test data set; ASCEND (NCT01416181; = 154 with secondary progressive multiple sclerosis) and ADVANCE (NCT00906399; = 261 with relapsing-remitting multiple sclerosis) were used as validation data sets. Read More

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Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes.

Front Cardiovasc Med 2021 7;8:606103. Epub 2021 Sep 7.

Department of Medicine, General Medicine and Hypertension Unit, University of Verona, Verona, Italy.

This study aimed to test the effect of multiple cardiovascular risk factors on subclinical indices of atherosclerosis in children and adolescents with type 1 diabetes (T1D). Carotid intima-media thickness (cIMT), carotid distensibility coefficient (cDC), and carotid-femoral pulse wave velocity (PWV) were measured in children and adolescents with T1D, in a follow-up at the outpatient clinics of Verona. Blood pressure (BP; both central and peripheral), metabolic and other cardiovascular risk factors were evaluated in multivariate linear regressions to assess the association with the measured indices of subclinical vascular damage. Read More

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September 2021

Plasma p-tau181 Level Predicts Neurodegeneration and Progression to Alzheimer's Dementia: A Longitudinal Study.

Front Neurol 2021 7;12:695696. Epub 2021 Sep 7.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Plasma-based biomarkers would be potential biomarkers for early diagnosis of Alzheimer's disease (AD) because they are more available and cost-effective than cerebrospinal fluid (CSF) or neuroimaging. Therefore, we aimed to evaluate whether phosphorylated tau181 (p-tau181) in plasma could be an accurate AD predictor. Participants from the ADNI database included 185 cognitively unimpaired subjects with negative Aβ (CU-), 66 subjects with pre-clinical AD (CU with positive Aβ), 164 subjects with mild cognitive impairment with negative Aβ (MCI-), 254 subjects with prodromal AD (MCI with positive Aβ), and 98 subjects with dementia. Read More

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September 2021

The Effects of Gene Variations of and on Patients with Propofol During Anesthesia Induction.

Pharmgenomics Pers Med 2021 17;14:1185-1192. Epub 2021 Sep 17.

Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.

Purpose: Propofol is one of the most commonly used intravenous sedatives in general anesthesia, while the individual variations of propofol are apparent. The objective of this study was to investigate the influence of genetic variations in GABAergic neurons and glutamatergic neurons on time to loss of consciousness (LOC) and the incidence of hypotension during anesthesia induction.

Patients And Methods: A total of 140 Chinese patients undergoing thyroid surgery or breast surgery were recruited. Read More

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September 2021