41,080 results match your criteria linear mixed


A positron emission tomography study of the serotonin1B receptor effect of electroconvulsive therapy for severe major depressive episodes.

J Affect Disord 2021 Jul 17;294:645-651. Epub 2021 Jul 17.

Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Electroconvulsive therapy (ECT) is an effective treatment for depressive disorders, although its molecular mechanism of action is unknown. The serotonin 1B (5-HT) receptor is a potential target for treatment of depression and low 5-HT receptor binding in limbic regions has been reported in previous positron emission tomography (PET) studies of depression.

Methods: The objective of this longitudinal PET study was to examine the effect of ECT for depression on 5-HT receptor binding. Read More

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Infants Oscillatory Frequencies change during Free-Play.

Infant Behav Dev 2021 Jul 28;64:101612. Epub 2021 Jul 28.

Department of Psychology, Lancaster University, Bailrigg, UK; School of Psychology, The University of Waikato, New Zealand.

Social interactions are known to be an essential component of infant development. For this reason, exploring functional neural activity while infants are engaged in social interactions will enable a better understanding of the infant social brain. This in turn, will enable the beginning of disentangling the neural basis of social and non-social interactions as well as the influence that maternal engagement has on infant brain function. Read More

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Accelerated theta burst stimulation for the treatment of depression: A randomised controlled trial.

Brain Stimul 2021 Jul 28. Epub 2021 Jul 28.

Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Department of Psychiatry, Monash University, Camberwell, Victoria, Australia.

Introduction: Theta burst pattern repetitive transcranial magnetic stimulation (TBS) is increasingly applied to treat depression. TBS's brevity is well-suited to application in accelerated schedules. Sizeable trials of accelerated TBS are lacking; and optimal TBS parameters such as stimulation intensity are not established. Read More

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Impact of Daridorexant, a Dual Orexin Receptor Antagonist, on Cardiac Repolarization Following Bedtime Dosing: Results from a Thorough QT Study Using Concentration-QT Analysis.

Clin Drug Investig 2021 Jul 31. Epub 2021 Jul 31.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland.

Background And Objective: Daridorexant is a new dual orexin receptor antagonist currently in late-stage clinical development for the treatment of insomnia. This randomized, double-blind, placebo-controlled, four-period crossover study investigated the effect of daridorexant at a therapeutic and supratherapeutic dose on QT interval duration.

Methods: Thirty-six healthy subjects received single oral doses of daridorexant (50 mg; 200 mg), moxifloxacin (400 mg; open label), and placebo. Read More

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Changes in health-related quality of life for HCV-infected people who inject drugs on opioid agonist treatment following sustained virologic response.

Clin Infect Dis 2021 Jul 31. Epub 2021 Jul 31.

Clemson University School of Health Research, Clemson, SC, USA.

Background: Although efforts to treat hepatitis C virus (HCV) in people who inject drugs (PWID) yield high rates of sustained virologic response (SVR), the relationship between successful HCV treatment and health-related quality of life (HRQOL) among PWID is poorly understood. This study examined HRQOL changes throughout HCV treatment and post-treatment for PWID achieving SVR.

Methods: Participants included 141 PWID who achieved SVR following HCV treatment onsite at three opioid agonist treatment (OAT) clinics in Bronx, NY. Read More

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Evaluation of students' perceived clinical competence and learning needs following an online virtual simulation education programme with debriefing during the COVID-19 pandemic.

Nurs Open 2021 Jul 31. Epub 2021 Jul 31.

School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.

Aims And Objectives: This study aimed to evaluate the effect of a virtual simulation education programme with debriefing in undergraduate nursing students. Perceived clinical competence and learning needs of students in a simulation environment were also measured.

Background: Evidence showed virtual simulation education programmes provided better knowledge acquisition. Read More

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Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury: A CENTER-TBI Study.

Neurocrit Care 2021 Jul 30. Epub 2021 Jul 30.

Neurological Intensive Care Unit, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which is directly linked to body temperature, may influence brain physiology. Increased body and/or BT may cause secondary brain damage, with deleterious effects on intracranial pressure (ICP), cerebral perfusion pressure (CPP), and outcome. Read More

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Seasonal variation and predictors of intradialytic blood pressure decline: a retrospective cohort study.

Hypertens Res 2021 Jul 30. Epub 2021 Jul 30.

Division of Endocrinology, Metabolism and Nephrology Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

The risk factors for intradialytic systolic blood pressure decline remain poorly understood. We aimed to identify clinical and laboratory predictors of the intradialytic systolic blood pressure decline, considering its seasonal variation. In a retrospective cohort of 47,219 hemodialysis sessions of 307 patients undergoing hemodialysis over one year in three dialysis clinics, the seasonal variation and the predictors of intradialytic systolic blood pressure decline (predialysis systolic blood pressure--nadir intradialytic systolic blood pressure) were assessed using cosinor analysis and linear mixed models adjusted for baseline or monthly hemodialysis-related variables, respectively. Read More

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A non-linear ensemble model-based surgical risk calculator for mixed data from multiple surgical fields.

BMC Med Inform Decis Mak 2021 Jul 30;21(Suppl 2):88. Epub 2021 Jul 30.

Department of Tumor Gynecology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, 350014, China.

Background: The misestimation of surgical risk is a serious threat to the lives of patients when implementing surgical risk calculator. Improving the accuracy of postoperative risk prediction has received much attention and many methods have been proposed to cope with this problem in the past decades. However, those linear approaches are inable to capture the non-linear interactions between risk factors, which have been proved to play an important role in the complex physiology of the human body, and thus may attenuate the performance of surgical risk calculators. Read More

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Managing rumination and worry: A pilot study of an internet intervention targeting repetitive negative thinking in Australian adults.

J Affect Disord 2021 Jul 23;294:483-490. Epub 2021 Jul 23.

Black Dog Institute, The University of New South Wales, Sydney, NSW, 2052, Australia.

Background: Rumination and worry, both forms of repetitive negative thinking (RNT), have been implicated in the onset, maintenance, severity, and relapse risk of depression and anxiety disorders. Despite promising initial findings for internet-delivered interventions targeting both rumination and worry simultaneously, no studies have investigated treatment effects in an adult population or when delivered in a brief, unguided format. We developed a 3-lesson unguided online treatment program targeting both rumination and worry and evaluated the adherence and effectiveness in Australian adults using an open pilot trial. Read More

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Simulation-based education and the effect of multiple simulation sessions - A randomised controlled study.

Nurse Educ Today 2021 Jul 16;106:105059. Epub 2021 Jul 16.

Department of Anaesthesia & Intensive Care, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway. Electronic address:

Background: Simulation-based education may improve clinical decision-making skills and supplement clinical placement of nursing students to prepare them for real healthcare settings. Exposing students to several simulation sessions could maximise learning, but longitudinal randomised studies are lacking regarding the effects of simulation-based education.

Objective: In this randomised study, we followed a class of nursing students to assess the effect of multiple simulations on the students' self-reported clinical decision-making skills and self-confidence. Read More

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Carbon neutrality targets, optimal environmental management strategies & the role of financial development: New evidence incorporating non-linear effects and different income levels.

J Environ Manage 2021 Jul 27;297:113352. Epub 2021 Jul 27.

Huddersfield Business School, University of Huddersfield, UK.

Financial development has been found to have mixed effects on CO2 emissions. One reason appears to be the relationship is not linear, as is assumed in most earlier studies. This paper re-examines the relationship between financial development and CO2 emissions based on a panel data of 61 countries categorised as high- and middle-income economies, from 1990 to 2018. Read More

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Association of transportation noise with sleep during the first year of life: A longitudinal study.

Environ Res 2021 Jul 27:111776. Epub 2021 Jul 27.

Division of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, University of Zurich, Zurich, Switzerland; University Children's Hospital Basel (UKBB), Basel, Switzerland. Electronic address:

Study Objectives: During infancy, adequate sleep is crucial for physical and neurocognitive development. In adults and children, night-time noise exposure is associated with sleep disturbances. However, whether and to what extent infants' sleep is affected, is unknown. Read More

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Variation in Hospital Performance Measures from the Turkey Ministry of Health.

Int J Qual Health Care 2021 Jul 30. Epub 2021 Jul 30.

Precision Vaccines Program, Department of Pediatrics, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.

Background: The Turkish healthcare system has seen broad population-based improvements in expanded health insurance coverage and access to healthcare services. Hospital performance in this national system is understudied. We aimed to identify trends in hospital performance over time following implementation of the Health Transformation Program and describe how regional outcomes correlate with regional vital statistics. Read More

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Effectiveness of drug safety measures for reducing the incidence of adverse drug reactions: Post-hoc analysis of data from all-case surveillance of iguratimod using generalized estimating equations.

PLoS One 2021 30;16(7):e0253513. Epub 2021 Jul 30.

Clinical Planning and Development Department, Medical HQ, Eisai Co., Ltd., Tokyo, Japan.

A post-marketing study was performed on all patients who had started treatment with iguratimod, a conventional synthetic disease-modifying antirheumatic drug approved in Japan. During the study period, various safety measures were implemented to reduce risks. We investigated the frequency of adverse drug reactions before and after implementation of each safety measure to examine the preventive effect of these measures. Read More

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Outcomes of Care Among Patients With Gout in Europe: A Cross-sectional Survey.

J Rheumatol 2021 Jun 15. Epub 2021 Jun 15.

The data collection for this study was funded by Grünenthal GmbH. R. te Kampe, MSc, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, and Department of Rheumatology, VieCuri Medical Center, Venlo, the Netherlands; T.L. Jansen, MD, PhD, M. Janssen, MD, PhD, Department of Rheumatology, VieCuri Medical Center, Venlo, the Netherlands; C. van Durme, MD, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands, and Centre Hospitalier Chrétien, Liège, Belgium; G. Petersen, PhD, Grünenthal GmbH, Aachen, Germany; A. Boonen, Professor, MD, PhD, Department of Internal Medicine, Maastricht University Medical Center, and Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands. GP is a full-time employee in the department of Governmental Affairs & Patient Centricity at Grünenthal GmbH. Address correspondence to R. te Kampe, Department of Rheumatology, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands. Email: Accepted for publication May 28, 2021.

Objective: To assess health- and patient-centered outcomes in gout across Europe, and explore patient-, care-, and country-level characteristics associated with these outcomes.

Methods: Patients with self-reported physician-diagnosed gout from 14 European countries completed an online survey. Multivariable mixed-effect logistic and linear regressions were computed for health outcomes (gout flare recurrence) and patient-centered outcomes (patient satisfaction with current medication, and unaddressed goals), accounting for clustering within countries. Read More

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Acute responses of airway oxidative stress, inflammation, and hemodynamic markers to ambient PM and their trace metal contents among healthy adolescences: A panel study in highly polluted versus low polluted regions.

Environ Pollut 2021 Jul 16;288:117797. Epub 2021 Jul 16.

Health Office, Education Department of East Azerbaijan, Tabriz, Iran.

Particulate air pollutants are known contributors to global cardiorespiratory mortality through several pathways. We examined the effects of varied exposure to PM and trace metals on biological markers of airway inflammation, oxidative stress, and hemodynamic function of young individuals living in two different exposure settings. We enrolled and followed a panel of 97 healthy nonsmoking participants aged 15-18 years living in a highly polluted metropolitan city of Tabriz (TBZ) and a much less polluted semi-urban town of Hadishahr (HDS). Read More

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Face mask-wear did not affect large-scale patterns in escape and alertness of urban and rural birds during the COVID-19 pandemic.

Sci Total Environ 2021 Jun 24;793:148672. Epub 2021 Jun 24.

Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Praha 6, Czech Republic; Department of Zoology, Poznań University of Life Sciences, Wojska Polskiego 71C, 60-625 Poznań, Poland.

Actions taken against the COVID-19 pandemic have dramatically affected many aspects of human activity, giving us a unique opportunity to study how wildlife responds to the human-induced rapid environmental changes. The wearing of face masks, widely adopted to prevent pathogen transmission, represents a novel element in many parts of the world where wearing a face mask was rare before the COVID-19 outbreak. During September 2020-March 2021, we conducted large-scale multi-species field experiments to evaluate whether face mask-use in public places elicits a behavioural response in birds by comparing their escape and alert responses when approached by a researcher with or without a face mask in four European countries (Czech Republic, Finland, Hungary, and Poland) and Israel. Read More

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Trends and Variation in the Use of Observation Stays at Children's Hospitals.

J Hosp Med 2021 Jul 21. Epub 2021 Jul 21.

Surgical Outcomes Quality Improvement Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Background: Observation status could improve efficiency of healthcare resource use but also might shift financial burdens to patients and hospitals. Although the use of observation stays has increased for adult patient populations, the trends are unknown among hospitalized children.

Objective: The goal of this study was to describe recent trends in observation stays for pediatric populations at children's hospitals. Read More

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Predicting Depressive Symptom Severity Through Individuals' Nearby Bluetooth Device Count Data Collected by Mobile Phones: Preliminary Longitudinal Study.

JMIR Mhealth Uhealth 2021 Jul 30;9(7):e29840. Epub 2021 Jul 30.

Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Background: Research in mental health has found associations between depression and individuals' behaviors and statuses, such as social connections and interactions, working status, mobility, and social isolation and loneliness. These behaviors and statuses can be approximated by the nearby Bluetooth device count (NBDC) detected by Bluetooth sensors in mobile phones.

Objective: This study aimed to explore the value of the NBDC data in predicting depressive symptom severity as measured via the 8-item Patient Health Questionnaire (PHQ-8). Read More

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A Mobile Peer Intervention for Preventing Mental Health and Substance Use Problems in Adolescents: Protocol for a Randomized Controlled Trial (The Mind Your Mate Study).

JMIR Res Protoc 2021 Jul 30;10(7):e26796. Epub 2021 Jul 30.

The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, Australia.

Background: Anxiety, mood, and substance use disorders have significant social and economic impacts, which are largely attributable to their early age of onset and chronic disabling course. Therefore, it is critical to intervene early to prevent chronic and debilitating trajectories.

Objective: This paper describes the study protocol of a CONSORT (Consolidated Standards of Reporting Trials)-compliant randomized controlled trial for evaluating the effectiveness of the Mind your Mate program, a mobile health (mHealth) peer intervention that aims to prevent mental health (focusing on anxiety and depression) and substance use problems in adolescents. Read More

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Trends in stress among pregnant and postpartum women during the COVID-19 pandemic.

JMIR Ment Health 2021 Jul 2. Epub 2021 Jul 2.

Behavioral and Community Health Sciences, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, US.

Background: Stress is associated with adverse birth and postpartum health outcomes. Few studies have longitudinally explored racial differences in maternal stress in a birthing population in the United States (US) during the ongoing COVID-19 pandemic.

Objective: This study aimed to: (1) assess changes in reported stress before, during, and after initial emergency declarations (e. Read More

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Efficacy of sonic vs manual toothbrushing after professional mechanical plaque removal: a 6-months randomized clinical trial.

Int J Dent Hyg 2021 Jul 30. Epub 2021 Jul 30.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Aim: The aim of this study was to compare the efficacy of two brushing methods (manual VS sonic) in terms of plaque control after a session of Professional Mechanical Plaque Removal (PMPR).

Methods: Subjects with gingivitis underwent a session of PMPR and were randomly assigned to sonic (SB) or manual brushing (MB). Oral hygiene instructions were provided at Baseline (BL), 2 (T0a), 4 (T0b) and 6 weeks (T1), and 6 months (T2). Read More

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A systems engineering framework for the optimization of food supply chains under circular economy considerations.

Sci Total Environ 2021 Jun 29;794:148726. Epub 2021 Jun 29.

Texas A&M Energy Institute, Texas A&M University, 1617 Research Pkwy, College Station, TX 77843, United States. Electronic address:

The current linear "take-make-waste-extractive" model leads to the depletion of natural resources and environmental degradation. Circular Economy (CE) aims to address these impacts by building supply chains that are restorative, regenerative, and environmentally benign. This can be achieved through the re-utilization of products and materials, the extensive usage of renewable energy sources, and ultimately by closing any open material loops. Read More

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Effect of hydroxychloroquine on the cardiac ventricular repolarization - a randomized clinical trial.

Br J Clin Pharmacol 2021 Jul 30. Epub 2021 Jul 30.

Centre for Human Drug Research, Leiden, The Netherlands.

Introduction: Hydroxychloroquine has been suggested as possible treatment for Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2). Studies reported an increased risk of QTcF-prolongation after treatment with hydroxychloroquine. The aim of this study was to analyze the concentration-dependent effects of hydroxychloroquine on the ventricular repolarization, including QTcF-duration and T-wave morphology. Read More

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County-level phenomapping to identify disparities in cardiovascular outcomes: An unsupervised clustering analysis: Short title: Unsupervised clustering of counties and risk of cardiovascular mortality.

Am J Prev Cardiol 2020 Dec 20;4:100118. Epub 2020 Nov 20.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Introduction: Significant heterogeneity in cardiovascular disease (CVD) risk and healthcare resource allocation has been demonstrated in the United States, but optimal methods to capture heterogeneity in county-level characteristics that contribute to CVD mortality differences are unclear. We evaluated the feasibility of unsupervised machine learning (ML)-based phenomapping in identifying subgroups of county-level social and demographic risk factors with differential CVD outcomes.

Methods: We performed a cross-sectional study using county-level data from 2008 to 2018 from the Centers for Disease Control (CDC) WONDER platform and the 2020 Robert Wood Johnson County Health Rankings program. Read More

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December 2020

Population Pharmacokinetics of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia.

Front Pharmacol 2021 13;12:701452. Epub 2021 Jul 13.

Department of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.

High-dose methotrexate (HD-MTX) is widely used in pediatric acute lymphoblastic leukemia (ALL) treatment regimens. In this study, we aimed to develop a population pharmacokinetic (PK) model of HD-MTX in Chinese pediatric patients with ALL for designing personalized dosage regimens. In total, 4,517 MTX serum concentration data for 311 pediatric patients with ALL, aged 0. Read More

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Stochastic Functional Estimates in Longitudinal Models with Interval-Censored Anchoring Events.

Scand Stat Theory Appl 2020 Sep 23;47(3):638-661. Epub 2019 Oct 23.

Department of Biostatistics, Indianan University, Indianapolis, USA.

Timelines of longitudinal studies are often anchored by specific events. In the absence of fully observed the anchoring event times, the study timeline becomes undefined, and the traditional longitudinal analysis loses its temporal reference. In this paper, we considered an analytical situation where the anchoring events are interval-censored. Read More

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September 2020

Accuracy of OCT-derived net corneal astigmatism measurement.

J Cataract Refract Surg 2021 Jul 27. Epub 2021 Jul 27.

Casey Eye Institute and Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.

Purpose: To assess the repeatability and accuracy of corneal astigmatism measurement with a spectral-domain optical coherence tomography (OCT) system (Avanti, Optovue) and compare them with Scheimpflug imaging (Pentacam HR, Oculus) and swept-source optical biometry (IOLMaster 700, Carl Zeiss Mediatec AG).

Setting: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.

Design: Prospective cross-sectional observational study. Read More

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Impact of Atrial Fibrillation Case Volume in the Emergency Department on Early and Late Outcomes of Patients With New Atrial Fibrillation.

Ann Emerg Med 2021 Aug;78(2):242-252

Alberta SPOR Support Unit Data Platform, University of Alberta, Edmonton, Canada; Division of General Internal Medicine, University of Alberta, Edmonton, Canada.

Study Objective: To define the association between atrial fibrillation case volume in the emergency department and death or all-cause hospitalization at 30 days and 1 year in patients with new atrial fibrillation. Secondary objectives examined repeat ED visits and the management of atrial fibrillation within 90 days.

Methods: We identified all adults presenting to an ED in Alberta, Canada, with a new primary diagnosis of atrial fibrillation/flutter between 2009 and 2015 using International Classification of Diseases, 10th Revision code I48. Read More

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