210,187 results match your criteria limits range

Assessing Agreement between Frequency-Specific Chirp Auditory Steady-State Response and Pure Tone Audiometry in Adults by Intraclass Correlation Coefficient.

ORL J Otorhinolaryngol Relat Spec 2021 May 12:1-9. Epub 2021 May 12.

Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Introduction: Chirp auditory steady-state response (ASSR) can be used to assess frequency-specific hearing thresholds. However, its reliability has not been confirmed yet. The purpose of this proposed study is to analyze the agreement of thresholds measured by chirp-ASSR and pure tone audiometry (PTA) to investigate the value of chirp-ASSR in hearing threshold evaluation. Read More

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Changes in Physical Activity, Sleep, Mental Health, and Social Media Use During COVID-19 Lockdown Among Adolescent Girls: A Mixed-Methods Study.

J Phys Act Health 2021 May 11:1-9. Epub 2021 May 11.

Background: To suppress the transmission of coronavirus, many governments, including that of the island of Ireland, implemented a societal lockdown, which included school closures, limits on social gatherings, and time outdoors. This study aimed to evaluate changes in physical activity (PA), mental health, sleep, and social media use among adolescent girls during lockdown.

Methods: 281 female pupils (12-14 y) taking part in the ongoing Walking In Schools study on the island of Ireland self-reported PA, mental health, sleep, and social media use before (September-October 2019) and during lockdown (May-June 2020), via questionnaires. Read More

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Ultrasound deep beamforming using a multiconstrained hybrid generative adversarial network.

Med Image Anal 2021 Apr 28;71:102086. Epub 2021 Apr 28.

Fudan University, Department of Electronic Engineering, Shanghai 200433, China; Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Shanghai 200032, China. Electronic address:

Ultrasound beamforming is a principal factor in high-quality ultrasound imaging. The conventional delay-and-sum (DAS) beamformer generates images with high computational speed but low spatial resolution; thus, many adaptive beamforming methods have been introduced to improve image qualities. However, these adaptive beamforming methods suffer from high computational complexity, which limits their practical applications. Read More

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An innovative and simple all electrochemical approach to functionalize electrodes with a carbon nanotubes/polypyrrole molecularly imprinted nanocomposite and its application for sulfamethoxazole analysis.

J Colloid Interface Sci 2021 Apr 30;599:676-685. Epub 2021 Apr 30.

Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (Di.S.Te.B.A.), Università del Salento, via Monteroni, 73100 Lecce, Italy.

Sulfamethoxazole (SMX) is a commonly used antibiotic which accumulation can favor the development of antimicrobial resistance. Therefore, easy and cheap system to monitor the presence of SMX are needed for human health protection. Herein we present a straightforward all electrochemical approach to fabricate a sensor based on a nanocomposite molecularly imprinted polymer (nanoMIP) for the determination of SMX. Read More

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Formulation optimization, anesthetic activity, skin permeation, and transportation pathway of Alpinia galanga oil SNEDDS in zebrafish (Danio rerio).

Eur J Pharm Biopharm 2021 May 9. Epub 2021 May 9.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand; Research Center of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:

Alpinia galanga oil (AGO) has an anesthetic activity but its water insoluble property limits its clinical applications. The aim of the present study was to develop a self-nanoemulsifying drug delivery system of AGO (SNEDDS-AGO) to avoid the use of organic solvent and investigate AGO transportation pathway and anesthetic activity. Three optimized formulations from a contour plots of droplet size; SNEDDS-AGO-1, SNEDDS-AGO-2, and SNEDDS-AGO-3, composed of AGO, Miglyol 812, Cremophor RH 40, Capmul MCM EP, and ethanol at the ratios of 40:10:35:10:5, 40:20:15:20:5, and 60:10:15:10:5, respectively were selected as they possessed different droplet size of 62 ± 0. Read More

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Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis.

Stem Cell Reports 2021 May;16(5):1317-1330

Gladstone Institutes, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

Lineage tracing is a powerful tool in developmental biology to interrogate the evolution of tissue formation, but the dense, three-dimensional nature of tissue limits the assembly of individual cell trajectories into complete reconstructions of development. Human induced pluripotent stem cells (hiPSCs) can recapitulate aspects of developmental processes, providing an in vitro platform to assess the dynamic collective behaviors directing tissue morphogenesis. Here, we trained an ensemble of neural networks to track individual hiPSCs in time-lapse microscopy, generating longitudinal measures of cell and cellular neighborhood properties on timescales from minutes to days. Read More

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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.

Immunity 2021 May 5. Epub 2021 May 5.

Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Electronic address:

Blockade of the inhibitory receptor TIM-3 shows efficacy in cancer immunotherapy clinical trials. TIM-3 inhibits production of the chemokine CXCL9 by XCR1 classical dendritic cells (cDC1), thereby limiting antitumor immunity in mammary carcinomas. We found that increased CXCL9 expression by splenic cDC1s upon TIM-3 blockade required type I interferons and extracellular DNA. Read More

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DNA-based microparticle tension sensors (µTS) for measuring cell mechanics in non-planar geometries and for high-throughput quantification.

Angew Chem Int Ed Engl 2021 May 12. Epub 2021 May 12.

Emory University, Chemistry, 1515 Dickey Dr., 30322, Atlanta, UNITED STATES.

Mechanotransduction, the interplay between physical and chemical signaling, plays vital roles in many biological processes ranging from cell differentiation to metastasis. The state-of-the-art techniques to quantify cell forces employ deformable polymer films or molecular probes tethered to glass substrates. These types of flat substrates limit applications in investigating mechanotransduction on non-planar geometries where physiological activities such as phagocytosis and immunological synapse formation mostly occur. Read More

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Celebrating 60 Years of Accomplishments of the Armed Forces Radiobiology Research Institute1.

Radiat Res 2021 May 12. Epub 2021 May 12.

Scientific Research Department.

Chartered by the U.S. Congress in 1961, the Armed Forces Radiobiology Research Institute (AFRRI) is a Joint Department of Defense (DoD) entity with the mission of carrying out the Medical Radiological Defense Research Program in support of our military forces around the globe. Read More

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Improving the Gastrointestinal Stability of Linaclotide.

J Med Chem 2021 May 12. Epub 2021 May 12.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

High susceptibility to proteolytic degradation in the gastrointestinal tract limits the therapeutic application of peptide drugs in gastrointestinal disorders. Linaclotide is an orally administered peptide drug for the treatment of irritable bowel syndrome with constipation (IBS-C) and abdominal pain. Linaclotide is however degraded in the intestinal environment within 1 h, and improvements in gastrointestinal stability might enhance its therapeutic application. Read More

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Sampling Efficiency Improvement to an Electrospray Ionization Mass Spectrometer and Its Implications for Liquid Chromatography Based Inlet Systems in the Nanoliter to Milliliter per Minute Flow Range.

J Am Soc Mass Spectrom 2021 May 12. Epub 2021 May 12.

SCIEX, 71 Four Valley Drive, Concord, Ontario L4K 4 V8, Canada.

This paper describes electrospray sampling efficiency measurements obtained on a triple quadrupole mass spectrometer equipped with a large atmosphere to vacuum sampling aperture and modified ion optics designed to confine the ions traveling in the intense expanding gas beam and prevent scattering losses in the entrance optics of the mass analyzer. Sampling efficiency, defined as the ratio of the number of ions captured in the first vacuum stage of the entrance optics to the number of analyte molecules entering the ion source, is a measure of sensitivity that takes into account both ionization efficiency at atmospheric pressure, the efficiency of transporting the ions from atmosphere to vacuum, and the efficiency of confining them in the subsequent gas expansion before mass analysis. Sampling efficiency measurements were conducted under high-performance liquid chromatography sample introduction conditions using columns and flow rates spanning the nanoflow (300 nL/min), microflow (3-60 μL/min), and milliflow (100-500 μL/min) ranges. Read More

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CRISPR Enzyme Kinetics for Molecular Diagnostics.

Anal Chem 2021 May 12. Epub 2021 May 12.

Department of Mechanical Engineering, Stanford University, Stanford, California 94305, United States.

CRISPR-diagnostic assays have gained significant interest in the last few years. This interest has grown rapidly during the current COVID-19 pandemic, where CRISPR-diagnostics have been frontline contenders for rapid testing solutions. This surge in CRISPR-diagnostic research prompts the following question: what exactly are the achievable limits of detection and associated assay times enabled by the kinetics of enzymes such as Cas12 and Cas13? To explore this question, we here present a model based on Michaelis-Menten enzyme kinetics theory applied to CRISPR enzymes. Read More

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Hydrogen Gas Sensors Using Palladium Nanogaps on an Elastomeric Substrate.

Adv Mater 2021 May 12:e2005929. Epub 2021 May 12.

Department of Materials Science and Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-gu, Seoul, 03722, Republic of Korea.

With the recent reillumination of the hydrogen economy around the world, the demand for H sensors is expected to increase rapidly. Due to safety issues caused by the highly flammable and explosive character of hydrogen gas (H ), it is imperative to develop the sensors that can quickly and sensitively detect H leaks. For the development of H sensors, Pd-based materials have been extensively used due to the high affinity of Pd metal for H . Read More

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Transparency of racial participation reporting in randomized controlled trials of minimally invasive surgical techniques.

Surg Endosc 2021 May 12. Epub 2021 May 12.

Department of Urologic Surgery, Vanderbilt University Medical Center, A1302 Medical Center North, Nashville, TN, 37232-2765, USA.

Background: Enrolment of racial/ethnic minorities in randomized controlled trials (RCTs) has historically been poor, despite efforts at improving access to RCTs. Under-representation of racial/ethnic minorities limits the external validity and generalizability of trials. Our objective was to determine to what extent are published RCTs of minimally invasive surgical techniques reporting the racial composition of their study cohorts and to describe the racial composition of patients enrolled in these trials, where data were available. Read More

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High variability and lack of standardization in the evaluation of return to sport after ACL reconstruction: a systematic review.

Knee Surg Sports Traumatol Arthrosc 2021 May 12. Epub 2021 May 12.

Sports Medicine Institute, Hospital for Special Surgery, New York, NY, USA.

Purpose: Return to sport (RTS) after ACL reconstruction (ACLR) has been recognized as an important outcome, which is associated with success of the surgery. This study aimed to assess the methods used to determine return to sport after ACLR in the published literature, report on variability of methods and evaluate their strength in establishing accurate RTS data.

Methods: Electronic databases (PubMed, Cochrane Library and Embase) were searched via a defined search strategy with no limits, to identify relevant studies from January 2008 to December 2020 for inclusion in the review. Read More

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Expanding the Limits of Liver Transplantation for Hepatocellular Carcinoma: Is There a Limit?

Clin Liver Dis 2021 Feb 17;25(1):19-33. Epub 2020 Oct 17.

Division of Gastroenterology, University of California, San Francisco, 513 Parnassus Avenue, S-357, San Francisco, CA 94143, USA. Electronic address:

Liver transplantation is a treatment option for hepatocellular carcinoma within Milan criteria. With careful selection practices, patients with larger tumors can do well with successful downstaging followed by liver transplantation and should not be excluded based on tumor size or number alone. When considering expanded criteria for hepatocellular carcinoma, however, survival outcomes after liver transplantation should be comparable with patients without hepatocellular carcinoma. Read More

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February 2021

Correlated structure of neuronal firing in macaque visual cortex limits information for binocular depth discrimination.

J Neurophysiol 2021 May 12. Epub 2021 May 12.

Physiology, Anatomy & Genetics, University of Oxford, United Kingdomgrid.4991.5.

Variability in cortical neural activity potentially limits sensory discriminations. Theoretical work shows that information required to discriminate two similar stimuli is limited by the correlation structure of cortical variability. We investigated these information-limiting correlations by recording simultaneously from visual cortical areas V1 and V4 in macaque monkeys, performing a binocular, stereo-depth discrimination task. Read More

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Tardigrade Survival Limits in High-Speed Impacts-Implications for Panspermia and Collection of Samples from Plumes Emitted by Ice Worlds.

Astrobiology 2021 May 11. Epub 2021 May 11.

Centre for Astrophysics and Planetary Science, School of Physical Sciences, University of Kent, Canterbury, UK.

The ability of tardigrades to survive impact shocks in the kilometer per second and gigapascal range was investigated. When rocks impact planetary surfaces, the impact speeds and shock pressures are in the kilometer per second and gigapascal range. This investigation tested whether tardigrades can survive in impacts typical of those that occur naturally in the Solar System. Read More

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Limits and Convergence properties of the Sequentially Markovian Coalescent.

Mol Ecol Resour 2021 May 12. Epub 2021 May 12.

Department of Life Science Systems, Technical University of Munich.

Several methods based on the SequentiallyMarkovian Coalescent (SMC) make use of full genome sequence data from samples to infer population demographic history including past changes in population size, admixture, migration events and population structure. More recently, the original theoretical framework has been extended to allow the simultaneous estimation of population size changes along with other life-history traits such as selfing or seed banking. The latter developments enhance the applicability of SMC methods to non-model species. Read More

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Validation of an endoscopic flavectomy training model.

Rev Col Bras Cir 2021 7;48:e202027910. Epub 2021 May 7.

- Universidade Federal do Paraná (UFPR), Departamento de Cirurgia - Ortopedia e Traumatologia - Curitiba - PR - Brasil.

Objective: to validate a lumbar spine endoscopic flavectomy simulator using the construct method and to assess the acceptability of the simulator in medical education.

Methods: thirty medical students and ten video-assisted surgery experienced orthopedists performed an endoscopic flavectomy procedure in the simulator. Time, look-downs, lost instruments, respect for the stipulated edge of the ligamentum flavum, regularity of the incision, GOALS checklist (Global Operative Assessment of Laparoscopic Skills), and responses to the Likert Scale adapted for this study were analyzed. Read More

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Effect of the silkworm pupa protein-glucose conjugate on the thermal stability and antioxidant activity of anthocyanins.

Food Funct 2021 May;12(9):4132-4141

School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212018, China. and Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, Jiangsu 212018, China.

Anthocyanin (cyanidin-3-O-glucose) is a natural water-soluble pigment with a robust antioxidant capacity. However, its poor stability and bioavailability limits its application as a functional food ingredient. This study explored the ability of the silkworm pupa protein-glucose (Spp-Glu) conjugate, developed under wet-heating conditions, to improve the thermal stability and antioxidant activity of cyanidin-3-O-glucose (C3G) at pH 3. Read More

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The edge of reason: reporting and inference near the detection limit.

Anal Methods 2020 Jan;12(3):401-403

Although the general concept of a detection limit as a lower practical operating limit for an analytical method is widely understood, the precise interpretation of results near the IUPAC limit of detection is rarely as well understood or implemented. It is important to distinguish between statements about the analytical result, which is known, and inferences about the true value, which are not known. It is also crucial to understand that there are at least two quite different limits involved and that the limit most commonly referred to as the 'limit of detection' is, surprisingly, not intended as the criterion for detection of an analyte. Read More

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January 2020

Photon management to reduce energy loss in perovskite solar cells.

Chem Soc Rev 2021 May 12. Epub 2021 May 12.

State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, People's Republic of China.

Despite the rapid development of perovskite solar cells (PSCs) over the past few years, the conversion of solar energy into electricity is not efficient enough or cost-competitive yet. The principal energy loss in the conversion of solar energy to electricity fundamentally originates from the non-absorption of low-energy photons ascribed to Shockley-Queisser limits and thermalization losses of high-energy photons. Enhancing the light-harvesting efficiency of the perovskite photoactive layer by developing efficient photo management strategies with functional materials and arrays remains a long-standing challenge. Read More

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Why do we need the uncertainty factor?

Anal Methods 2019 Apr;11(15):2105-2107

The uncertainty factor is a new way to express measurement uncertainty. It is especially applicable when the uncertainty is large (e.g. Read More

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Lupus-like membranous nephropathy. Is it lupus? Report of 5 cases in a reference hospital in Mexico.

Lupus 2021 May 12:9612033211013584. Epub 2021 May 12.

Hospital Central "Dr. Ignacio Morones Prieto" and Faculty of Medicine, Universidad Autónoma de San Luis Potosí, S.L.P., México.

Lupus nephritis requires antinuclear antibodies as classification criteria. There is a group of patients with nephrotic syndrome and conclusive histopathological findings for lupus nephritis, without classification criteria for systemic lupus erythematosus (SLE) or extrarenal manifestations. These groups of patients have been described as "lupus-like" nephritis or "renal-limited lupus nephritis". Read More

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Worldwide aflatoxin contamination of agricultural products and foods: From occurrence to control.

Compr Rev Food Sci Food Saf 2021 May;20(3):2332-2381

Oil Crops Research Institute, Chinese Academy of Agricultural Science (CAAS), Xudong, Wuhan, Hubei, 430062, China.

Aflatoxins represent a global public health and economic concern as they are responsible for significant adverse health and economic issues affecting consumers and farmers worldwide. Produced by fungal species from the Aspergillus genus, aflatoxins are a toxic, mutagenic, and carcinogenic group of fungal metabolites that routinely contaminate food and agricultural products. Climate and diet are essential factors in the aflatoxin contamination of food and subsequent human exposure process. Read More

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Remote hand: Hand-centered peripersonal space transfers to a disconnected hand avatar.

Atten Percept Psychophys 2021 May 11. Epub 2021 May 11.

Department of Psychology, The University of Tokyo, Tokyo, Japan.

The space surrounding our body is called peripersonal space (PPS). It has been reported that visuo-tactile facilitation occurs more strongly within PPS than outside PPS. Furthermore, previous research has revealed several methods by which PPS can be extended. Read More

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Critical Tools in Tableting Research: Using Compaction Simulator and Quality by Design (QbD) to Evaluate Lubricants' Effect in Direct Compressible Formulation.

AAPS PharmSciTech 2021 May 11;22(4):151. Epub 2021 May 11.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Altinbas University, Istanbul, Turkey.

As commonly known, the product development stage is quite complex, requires intensive knowledge, and is time-consuming. The selection of the excipients with the proper functionality and their corresponding levels is critical to drug product performance. The objective of this study was to apply quality by design (QbD) principles for formulation development and to define the desired product quality profile (QTPP) and critical quality attributes (CQA) of a product. Read More

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Extracting automata from neural networks using active learning.

PeerJ Comput Sci 2021 19;7:e436. Epub 2021 Apr 19.

School of Computing, Engineering and Digital Technologies, Teesside University, Middlesbrough, United Kingdom.

Deep learning is one of the most advanced forms of machine learning. Most modern deep learning models are based on an artificial neural network, and benchmarking studies reveal that neural networks have produced results comparable to and in some cases superior to human experts. However, the generated neural networks are typically regarded as incomprehensible black-box models, which not only limits their applications, but also hinders testing and verifying. Read More

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Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection.

Adv Sci (Weinh) 2021 05 3;8(9):2004555. Epub 2021 Mar 3.

Key Laboratory of Neurological Function and Health School of Basic Medical Sciences Guangzhou Medical University Guangzhou 511436 China.

Parkinson's disease (PD) is characterized by the progressive deterioration of dopamine (DA) neurons, and therapeutic endeavors are aimed at preventing DA loss. However, lack of effective brain delivery approaches limits this strategy. In this study, a "Trojan horse" system is used for substantia nigra-targeted delivery of a blood brain barrier-penetrating peptide (RVG29) conjugated to the surface of nanoparticles loaded with the natural autophagy inducer 4,4'-dimethoxychalcone (DMC) (designated as RVG-nDMC). Read More

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