29,876 results match your criteria limb ischemia

Lies, damned lies, and statistics, but bleeding and acute limb ischemia are facts!

Catheter Cardiovasc Interv 2021 May;97(6):1139-1140

Penn State Heart and Vascular Institute, Hershey Medical Center, Hershey, Pennsylvania, USA.

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Short and long-term outcome after common femoral artery hybrid procedure in patients with intermittent claudication and chronic limb threatening ischemia.

Vasa 2021 May 11:1-9. Epub 2021 May 11.

Department of Vascular Surgery, Barmherzige Brüder Hospital Regensburg, Germany.

This study aimed to evaluate the differences between the outcomes of patients with intermittent claudication (IC) and chronic limb threatening ischemia (CLTI) who underwent a hybrid procedure comprising common femoral artery endarterectomy and endovascular therapy. This was a retrospective single-center study of all patients with peripheral arterial occlusive disease (PAD) who underwent the hybrid procedure between March 2007 and August 2018. The primary endpoint was primary patency after 7 years. Read More

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Thalamic versus midbrain tremor; two distinct types of Holmes' Tremor: a review of 17 cases.

J Neurol 2021 May 11. Epub 2021 May 11.

Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.

Introduction: Holmes Tremor (HT) is a unique and debilitating movement disorder. It usually results from lesions of the midbrain and its connection but can also result from posterior thalamic injury. Clinical examination can help lesion localization between these two areas. Read More

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Usefulness of ultrasound-guided tibio-pedal access in patients with critical limb ischemia.

Cir Esp 2021 May 7. Epub 2021 May 7.

Servicio de angiología y cirugía vascular, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Llobregat, España.

Introduction: Retrograde access performed guided by fluoroscopy or ultrasound. We aimed to analyze the usefulness of ultrasound in retrograde access in patients with critical limb ischemia.

Methods: Observational analytical study. Read More

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Human bone marrow-derived, pooled, allogeneic mesenchymal stromal cells manufactured from multiple donors at different times show comparable biological functions in vitro, and in vivo to repair limb ischemia.

Stem Cell Res Ther 2021 May 10;12(1):279. Epub 2021 May 10.

Stempeutics Research Pvt Ltd, 3rd Floor, Manipal Hospitals Whitefield Pvt. Ltd., #143, EPIP Industrial Area, K R Puram Hobli, Bengaluru, India.

Background: We have previously demonstrated that a pooled population of bone marrow-derived, allogeneic mesenchymal stromal cells (BMMSC), Stempeucel®-1, produced under good manufacturing practices (GMP) conditions, showed clinical efficacy and safety in patients suffering from critical limb ischemia (CLI) due to Buerger's disease. While Stempeucel®-1 is currently used for CLI and other clinical indications, we wanted to ensure that the product's continuity is addressed by developing and characterizing a second generation of pooled product (Stempeucel®-1A), manufactured identically from second BM aspirates of the same three donors after a 2-year interval.

Methods: The two versions of Stempeucel® were manufactured and subjected to gene and protein expression analysis. Read More

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COVID-19 and arterial thrombosis: Report of 2 cases.

Radiol Case Rep 2021 Jul 29;16(7):1603-1607. Epub 2021 Apr 29.

Department of Hematology & Oncology Saint Joseph's University Medical Center Paterson, New Jersey, U.S.A.

The SARS-CoV-2 infection has been predominately associated with lung disease. However, emerging evidence has associated the COVID-19 infection with a hypercoagulable state. This hypercoagulable state can occur despite the use of anticoagulants and antiplatelets. Read More

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Adrenergic Receptor Stimulation Promotes Reperfusion in Ischemic Limbs in a Murine Diabetic Model.

Front Pharmacol 2021 22;12:666334. Epub 2021 Apr 22.

University of Sydney, Faculty of Medicine and Health, Sydney, NSW, Australia.

Peripheral arterial disease (PAD) is a major burden, resulting in limb claudication, repeated surgical interventions and amputation. There is an unmet need for improved medical management of PAD that improves quality of life, maintains activities of daily life and reduces complications. Nitric oxide (NO)/redox balance is a key regulator of angiogenesis. Read More

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Endovascular treatment of hemodialysis-induced lower limb artery ischemia: retrospective analysis from a single center.

Ann Palliat Med 2021 Apr;10(4):4661-4669

Department of Nephrology, Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Wuxi, China.

Background: Critical limb artery ischemia is one of common complications after hemodialysis, with endovascular therapy (EVT) having become its first-line treatment. There is no relevant study investigating the relationship between EVT and the prognosis of hemodialysis patients with critical lower limb ischemia, the most common site of vascular dysfunction.

Methods: This was a retrospective, nonrandomized, single-center study. Read More

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Designing and utilizing 3D-printed skin incision guides during the first Dutch bilateral hand-arm transplantation.

J Plast Reconstr Aesthet Surg 2021 Apr 18. Epub 2021 Apr 18.

Department of Plastic Surgery, Radboudumc, Nijmegen, the Netherlands.

Objective: To preoperatively plan skin incision in the case of the first Dutch bilateral hand-arm transplantation.

Background: A bilateral hand-arm transplantation has been performed for the first time in the Netherlands in 2019. In the context of preparation for this surgical procedure, the optimal patient-specific skin flap was determined. Read More

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Acute upper limb ischemia as a complication of tunneled hemodialysis catheter placement via the right internal jugular vein.

Ahmet Can Topcu

J Vasc Access 2021 May 7:11297298211015041. Epub 2021 May 7.

Department of Cardiovascular Surgery, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey.

Arterial injury during internal jugular vein cannulation can cause devastating complications such as stroke, hematoma, hemothorax, pseudoaneurysm, AV fistula, or even death. Acute upper limb ischemia caused by inadvertent arterial puncture during internal jugular vein cannulation has been rarely reported. The present report describes the case of a patient who experienced right upper limb ischemia caused by subclavian artery thrombosis developed during attempted placement of a tunneled hemodialysis catheter via the right internal jugular vein. Read More

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Xenotransplantation of neonatal porcine bone marrow-derived mesenchymal stem cells improves murine hind limb ischemia through lymphangiogenesis and angiogenesis.

Xenotransplantation 2021 May 6:e12693. Epub 2021 May 6.

Department of Regenerative Medicine & Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Background: The clinical utility of stem cell therapy for peripheral artery disease has not been fully discussed, and one obstacle is limited donor supplies. In this study, we attempted to rescue mouse ischemic hind limb by xenotransplantation of neonatal porcine bone marrow-derived mesenchymal stem cells (npBM-MSCs).

Methods: Neonatal porcine bone marrow-derived mesenchymal stem cells were transplanted to ischemic hind limbs of male C57BL/6J mice (npBM-MSCs group). Read More

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Recombinant fusion protein by lysozyme and antibacterial peptide enhances ischemic wound healing via angiogenesis and reduction of inflammation in diabetic mice.

PeerJ 2021 16;9:e11256. Epub 2021 Apr 16.

Department of Pathophysiology, School of Basic Medicine, Wannan Medical College, Wuhu, Anhui, China.

Background & Aims: Lysozyme and antibacterial peptides have been reported to broad-spectrum antibacterial activity and can further improve wound healing. The aim of this study was to assess the effectiveness of a recombinant fusion protein created by combining lysozyme and an antibacterial peptide in forming new vessels and wound healing in an ischemic hind limb.

Methods: An ischemic hind limb model was established by isolation and ligation of the femoral artery in diabetic mice. Read More

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Simultaneous acute myocardial infarction, stroke and critical limb ischaemia: an unusual presentation requiring multidisciplinary approach.

BMJ Case Rep 2021 May 6;14(5). Epub 2021 May 6.

Foundation Programme, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK

We report the case of a 57-year-old man who presented overnight to a district general hospital as a primary percutaneous coronary intervention alert for an inferior ST elevation myocardial infarction. On presentation to cardiac catheterisation lab, he had ongoing chest pain but began to complain of left-sided limb weakness and pain in his right leg. He was found to have dense hemiparesis on examination with an National Institute of Health Stroke Scale of 8 and an absent right femoral pulse. Read More

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Remote Ischemic Conditioning and Stroke Recovery.

Neurorehabil Neural Repair 2021 May 6:15459683211011224. Epub 2021 May 6.

University of Ottawa, ON, Canada.

Remote ischemic conditioning (RIC) is a noninvasive procedure whereby several periods of ischemia are induced in a limb. Although there is growing interest in using RIC to improve stroke recovery, preclinical RIC research has focused exclusively on neuroprotection, using male animals and the intraluminal suture stroke model, and delivered RIC at times not relevant to either brain repair or behavioral recovery. In alignment with the Stroke Recovery and Rehabilitation Roundtable, we address these shortcomings. Read More

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Efficacy and one-year outcomes of Luminor® paclitaxel-coated drug-eluting balloon in the treatment of popliteal artery atherosclerosis lesions.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

University of Palermo - Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), Palermo, Italy; Vascular Surgery Unit, AOUP "P. Giaccone", Palermo, Italy.

Purpose: Reporting outcomes with a new generation paclitaxel eluting balloon (Luminor®; iVascular, Vascular, S.L.U. Read More

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Aspiration Thrombectomy with the Indigo System for Acute Lower Limb Ischemia: preliminary experience and analysis of parameters affecting the outcome.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Department of Surgical and Medical Sciences and Translational Medicine, "Sapienza" - University of Rome, Italy. Radiology and Interventional Radiology Unit, Sant'Andrea University Hospital.

Purpose: The purpose of our study is to assess the short-term technical success and the safety of the Indigo System in a series of patients undergoing vacuum-assisted catheter direct thrombus aspiration (IS-CDTA) for acute lower limb ischemia (ALLI) and to evaluate which parameters may affect the outcome.

Materials And Methods: All procedures using the IS-CDTA for ALLI, performed in a single-centre Interventional Radiology Unit from February 2016 to March 2020, were retrospectively analysed. Technical success was defined as the achievement of nearly-complete or complete revascularization (TIPI grade 2/3) and considered as a good outcome. Read More

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Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, EPE, Praceta Professor Mota Pinto, 3000-075 Coimbra, Portugal. Electronic address:

Introduction: Charlson Comorbidity Index (CCI) is commonly used in outcome studies to adjust for patient comorbid conditions but has not been specifically validated for use in acute embolic lower limb ischaemia (AELLI).

Objectives: The aim of this study was to access whether a high CCI score unadjusted (CCIu) and adjusted (CCIa) by age relates to major amputation and mortality after a first episode of AELLI.

Methods: The last 100 patients presenting with the first event of AELLI submitted to embolectomy at our Vascular Surgery Department were retrospectively evaluated. Read More

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Associations of clinical frailty with severity of limb threat and outcomes in chronic limb-threatening ischaemia.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Department of Cardiovascular Sciences, University of Leicester, UK; Leicester Vascular Institute, University Hospitals of Leicester NHS Trust, UK; National Institute for Health Research Leicester Biomedical Research Centre - The Glenfield Hospital, Leicester, UK.

Objective: Investigate the relationship of frailty and severity of chronic limb-threatening ischaemia (CLTI), and their comparative associations with one-year outcomes, in patients presenting to a vascular limb salvage (VaLS) clinic.

Methods: This retrospective cohort study utilised data collected from a prospectively maintained VaLS clinic database. Patients aged ≥50 presenting to the VaLS clinic with CLTI between February 2018 and April 2019 were included. Read More

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Anxiety and depression scores in patients subjected to arterial revascularization for critical limb ischemia.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Hospital Israelita Albert Einstein, Avenida Albert Einstein, 627, bloco A1, sala 422, Morumbi. ZIP: 05652-900. São Paulo, SP Brazil.

Objectives: This study aims to examine the changes in anxiety and depression scores in 138 patients with critical limb ischemia (rest pain or gangrene) who had no previous psychiatric history, at 30 days and 6 months after surgical revascularization.

Methods: Patients were submitted to a questionnaire-based evaluation using the Beck Anxiety and Depression Inventories before surgery (no more than three days before surgery) ("Pre-Op"), 30 days after surgical revascularization ("Early PO") and at least 6 months after surgical revascularization ("Late PO"). The cut-off scores for depression were (1) < 10, no depression or minimal depression; (2) 10‒18, mild to moderate depression; (3) 19‒29, moderate to severe depression; and (4) 30‒63, severe depression. Read More

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Vascular permeability of skeletal muscle microvessels in rat arterial ligation model: in vivo analysis using two-photon laser scanning microscopy.

Am J Physiol Regul Integr Comp Physiol 2021 May 5. Epub 2021 May 5.

Department of Engineering Science, University of Electro-Communications, Chofu, Tokyo, Japangrid.266298.1.

Peripheral artery disease (PAD) in the lower limb compromises oxygen supply due to arterial occlusion. Ischemic skeletal muscle is accompanied by capillary structural deformation. Therefore, using novel microscopy techniques, we tested the hypothesis that endothelial cell swelling temporally and quantitatively corresponds to enhanced microvascular permeability. Read More

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Activating transcription factor 4 regulates angiogenesis under lipid overload via methionine adenosyltransferase 2A-mediated endothelial epigenetic alteration.

FASEB J 2021 Jun;35(6):e21612

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, P.R. China.

Lipid overload is intimately connected with the change of endothelial epigenetic status which impacts cellular signaling activities and endothelial function. Activating transcription factor 4 (ATF4) is involved in the regulation of lipid metabolism and meanwhile an epigenetic modifier. However, the role of ATF4 in the angiogenesis under lipid overload is not well understood. Read More

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"Ranger BTK" a Prospective Single-Centre Cohort Study on a New Drug-Coated Balloon for Below the Knee Lesions in Patients with Critical Limb Ischemia.

Cardiovasc Intervent Radiol 2021 May 4. Epub 2021 May 4.

Université de Paris, INSERM U970, 75015, Paris, France.

Purpose: Restenosis remains a limitation of endovascular angioplasty with a patency of 30% in BTK at 12 months. Several studies on drug-coated balloons have not demonstrated any improvements in terms of patency and target lesions revascularization in BTK lesions. This prospective single-centre cohort study evaluates the safety and efficacy of a new generation low-dose drug-coated balloon (DCB) with a reduced crystalline structure to treat below the knee (BTK) lesions in patients with critical limb ischemia (CLI). Read More

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Acute Limb Ischemia as the Initial Severe Presentation in COVID-19.

Cureus 2021 Mar 31;13(3):e14226. Epub 2021 Mar 31.

Cardiology, St. Joseph's University Medical Center, Paterson, USA.

Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by an overwhelming inflammatory response in a subset of patients, resulting in respiratory compromise, multiorgan failure, and death. A common complication seen in patients hospitalized with COVID-19 infections is the development of venous and arterial thromboemboli. This occurs especially in patients who suffer from severe respiratory or systemic manifestations on the COVID-19 spectrum of disease. Read More

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Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.

Basic Res Cardiol 2021 May 3;116(1):32. Epub 2021 May 3.

Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.

Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments: remote ischaemic conditioning (RIC), involving cycles of ischaemia/reperfusion applied to a peripheral organ or tissue, or by systemic administration of glucagon-like-peptide-1 (GLP-1) receptor (GLP-1R) agonists. The mechanisms underlying RIC- and GLP-1-induced neuroprotection are not completely understood. Read More

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Arterial Thrombotic Sequalae After Covid-19: Mind The Gap.

Ann Vasc Surg 2021 Apr 30. Epub 2021 Apr 30.

Unit of Vascular and Endovascular Surgery, General Surgery Department, University Hospital of Udine, Udine, Italy.

Investigations have shown that infection from the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is responsible also for initiating severe inflammatory responses that can lead macrovascular and microvascular thrombosis. Several studies have already described acute limb ischemia and peripheral arterial disease in critically ill patients with Coronavirus disease 2019 (Covid-19), as well as coronary artery disease and ischemic stroke as a manifestation usually associated with respiratory distress. However, what still remains unclear is how long inflammation and thrombotic derangements can last after recovery from the symptoms of Covid-19. Read More

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A Systematic Review and Meta-Analysis of Endovascular Angiosomal Revascularization in the Setting of Collateral Vessels.

J Vasc Surg 2021 Apr 30. Epub 2021 Apr 30.

Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital; Washington, District of Columbia. Electronic address:

Objectives: Endovascular procedures for targeted treatment of lower extremity wounds can be subdivided as direct (DR), indirect (IR), and indirect revascularization via collateral flow (IRc). While previous systematic reviews assert superiority of DR when compared to IR, the role of collateral vessels in clinical outcomes remains to be defined. This systematic review and meta-analysis aims to define the utility of DR, IR, and IRc in treatment of lower extremity wounds with respect to 1) wound healing, 2) major amputation 3) reintervention and 4) all-cause mortality. Read More

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Early evaluation of the infrainguinal revascularization strategy selection tool of the Global Vascular Guidelines for chronic limb-threatening ischemia patients.

J Vasc Surg 2021 Apr 30. Epub 2021 Apr 30.

Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.

Objective: The Global Vascular Guidelines (GVG) propose a novel Global Anatomic Staging System (GLASS) with the Wound, Ischemia, and foot Infection (WIfI) classification system as a clinical decision-making tool for interventions in chronic limb-threatening ischemia (CLTI). We assessed the validity of clinical staging and the relationship between the treatments recommended by the GVG and the outcomes of the actual procedures.

Methods: This retrospective single-center observational study included 117 CLTI patients undergoing infrainguinal revascularization in our hospital between 2015 and 2019. Read More

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Management Strategy for Lower Extremity Malperfusion Due to Acute Aortic Dissection.

J Vasc Surg 2021 Apr 30. Epub 2021 Apr 30.

Division of Vascular Surgery and Endovascular Therapy, Keck Medical Center of USC, Los Angeles, CA. Electronic address:

Objective: Aortic dissection can result in devastating cerebral, visceral, renal, spinal, and extremity ischemia. We describe the management and outcomes of patients presenting with aortic dissection and lower extremity malperfusion.

Methods: A single-center institutional aortic database was queried for patients with aortic dissection and lower extremity malperfusion (LEM) from 2011-2019. Read More

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Safety of Silk-elastin Sponges in Patients with Chronic Skin Ulcers: A Phase I/II, Single-center, Open-label, Single-arm Clinical Trial.

Plast Reconstr Surg Glob Open 2021 Apr 28;9(4):e3556. Epub 2021 Apr 28.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Although traditional wound dressings such as collagen scaffolds promote granulation tissue formation, the efficacy of these dressings in chronic wounds is limited because of high susceptibility to bacterial growth. Biomaterials that can be applied to chronic wounds should have an anti-bacterial function. We previously reported that administering a silk-elastin solution that forms moisturizing hydrogels to wound surfaces of diabetic mice reduced bacterial growth and promoted granulation tissue formation compared with control or carboxymethyl cellulose hydrogels. Read More

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Balloon-Assisted Coils Embolization for Ophthalmic Segment Aneurysms of the Internal Carotid Artery.

Front Neurol 2021 15;12:658661. Epub 2021 Apr 15.

Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

To explore the role of balloon-assisted coils technique for ophthalmic segment aneurysms (OSAS). Clinical data of 30 patients with OSAS were reviewed between December 2017 and December 2018. OSAS were defined as arising from the internal carotid artery (ICA), reaching from the distal dural ring to the origin of the posterior communicating artery. Read More

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