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Outcomes of modular endoprosthesis reconstruction versus cement spacer reconstruction following resection of proximal humeral tumors.

BMC Musculoskelet Disord 2022 May 21;23(1):484. Epub 2022 May 21.

Department of Orthopaedic Surgery, Menoufia University Faculty of Medicine, Shebin El-Kom, Menoufia, Egypt.

Background: There is no agreement about the best reconstructive option following resection of proximal humerus tumors. The purpose of this study was to compare the functional outcomes of endoprosthesis reconstruction versus nail cement spacer reconstruction after wide resection of proximal humeral tumors.

Methods: This retrospective comparative study included 58 patients with proximal humerus tumors who had undergone tumor resection and reconstruction with modular endoprosthesis (humeral hemiarthroplasties) or cement spacer. Read More

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Intra-articular opening wedge osteotomy for varus ankle arthritis with computer-assisted planning and patient-specific surgical guides: a retrospective case series.

BMC Musculoskelet Disord 2022 May 21;23(1):483. Epub 2022 May 21.

Tianjin Hospital, Tianjin, 300211, China.

Background: Computer-assisted preoperative planning, combined with PSI has become an effective technique for treating complex limb deformities. The purpose of this study was to evaluate the efficacy and safety of the novel technique in corrective osteotomy for intra-articular varus ankle deformities associated with osteoarthritis and ankle instability.

Methods: Nineteen patients with intra-articular varus ankle arthritis were reviewed between April 2017 and June 2019, including ten men and nine women with a mean age of 58. Read More

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Changes in Gastric Inhibitory Polypeptide (GIP) After Roux-en-Y Gastric Bypass in Obese Patients: a Meta-analysis.

Obes Surg 2022 May 21. Epub 2022 May 21.

Department of Gastrointestinal Surgery, The affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, 523320, China.

This meta-analysis aimed to evaluate changes in GIP after RYGB in obese patients. We searched PubMed, EMBASE, and CENTRAL for relevant studies from database inception through July 2021. Articles were eligible for inclusion if they reported pre-operative and post-operative fasting GIP levels. Read More

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Outcomes of 53 thoracic outlet syndrome cases with confirmed neurological deficit.

Orthop Traumatol Surg Res 2022 May 18:103329. Epub 2022 May 18.

Unité de chirurgie de la main et du membre supérieur, services d'orthopédie 1 et 2, CHRU de Tours, 37044 Tours, France. Electronic address:

Introduction: Neurogenic thoracic outlet syndromes (TOS) are dominated by the nonspecific forms. This study focuses only on the rarer true forms related to proximal nerve compression in the thoracic outlet, with the presence of motor (atrophy of the hand's intrinsic muscles) and/or sensory (hypoesthesia in the territory of the medial antebrachial cutaneous nerve) deficits. The objectives of this study were to define the clinical characteristics, anatomical causes and surgical results of this condition. Read More

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Knee Arthrodesis Using a Compression Clamp and a Single-Plane External Fixator to Treat Infection.

Orthop Traumatol Surg Res 2022 May 18:103330. Epub 2022 May 18.

Service de chirurgie orthopédique, hôpital Trousseau, CHRU de Tours, avenue de la République, Chambray-lès-Tours, 37044 Tours cedex 9, France; Faculté de Médecine, Université de Tours, France.

Background: In patients with knee infection, arthrodesis by external fixation is a limb-salvage procedure appropriate in highly selected patients. No hardware that might lead to infection is left in situ. However, the fusion rate is limited. Read More

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Trunk and lower extremity biomechanics during sit-to-stand after stroke: a systematic review.

Ann Phys Rehabil Med 2022 May 18:101676. Epub 2022 May 18.

Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium; Department of Physical and Rehabilitation Medicine, Ghent University Hospital, Ghent, Belgium. Electronic address:

Objectives: This systematic review aimed to pool available evidence of differences in trunk and lower extremity biomechanics during the different phases of a sit-to-stand (STS) task between persons with stroke and to healthy controls.

Methods: Four electronic databases (Medline, Web of Science, EMBASE, and Cochrane Library) were systematically searched up to, and including, December 2021. Studies were included if they investigated kinematic, kinetic and/or electromyographic outcome measures of adults with stroke during STS and compared results with healthy controls. Read More

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The Effects of Fluid Hydration Status on the Accuracy of Ultrasound Muscle Measurement in Hemodialysis Patients.

J Ren Nutr 2022 May 18. Epub 2022 May 18.

Department of Pain Management Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address:

Objective: This study aimed to explore the effects of fluid hydration status on ultrasound muscle measurement in hemodialysis (HD) patients.

Methods: Ultrasound muscle examination of the right rectus femoris and bioelectrical impedance analysis (BIA) measurement of the right lower limb were performed in HD patients at the periods of pre-dialysis and post-dialysis. The correlations between the changes of the corresponding ultrasound and BIA variables were analyzed. Read More

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Adaptations for bipedal walking: Musculoskeletal structure and three-dimensional joint mechanics of humans and bipedal chimpanzees (Pan troglodytes).

J Hum Evol 2022 May 17;168:103195. Epub 2022 May 17.

School of Kinesiology, University of Michigan, Ann Arbor, MI 48109-2013, USA.

Humans are unique among apes and other primates in the musculoskeletal design of their lower back, pelvis, and lower limbs. Here, we describe the three-dimensional ground reaction forces and lower/hindlimb joint mechanics of human and bipedal chimpanzees walking over a full stride and test whether: 1) the estimated limb joint work and power during the stance phase, especially the single-support period, is lower in humans than bipedal chimpanzees, 2) the limb joint work and power required for limb swing is lower in humans than in bipedal chimpanzees, and 3) the estimated total mechanical power during walking, accounting for the storage of passive elastic strain energy in humans, is lower in humans than in bipedal chimpanzees. Humans and bipedal chimpanzees were compared at matched dimensionless and dimensional velocities. Read More

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Potential of Continuous Local Antibiotic Perfusion Therapy for Fracture-Related Infections.

Infect Dis Ther 2022 May 21. Epub 2022 May 21.

Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.

Introduction: Fracture-related infections (FRIs) are challenging for orthopedic surgeons, as conventional surgical treatment and systemic antimicrobial therapy cannot completely control local infections. Continuous local antibiotic perfusion (CLAP) is a novel and innovative therapy for bone and soft-tissue infections, and is expected to eradicate biofilms by maintaining a sustained high concentration of antimicrobial agents at the infected site. If CLAP therapy can eradicate infection even in cases with implants while preserving the implants, it would be an ideal and effective treatment for local refractory infections. Read More

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Floating aortic arch thrombus involving the left common carotid artery complicated with ischemic stroke associated with cocaine use.

Neurol Sci 2022 May 21. Epub 2022 May 21.

Stroke Unit, Centre Hospitalier Sud-Francilien, Corbeil-Essonnes, France.

Background: Floating aortic thrombi (FLOAT) are rare, with very few cases attributed to cocaine use. We report a new case of FLOAT involving the left common carotid artery due to cocaine use, for the first time, complicated with acute ischemic stroke.

Methods: We present in detail our case report, and then, a literature search in PubMed and Scopus was performed up to March 20, 2022, to review the reported cases of aortic thrombus associated with cocaine use. Read More

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All-terrain vehicle (ATV)-related injuries among different age groups: insights from a 9-year observational study.

Eur J Trauma Emerg Surg 2022 May 21. Epub 2022 May 21.

Trauma Surgery Section, Hamad Medical Corporation & Weill Cornell Medical College, Hamad General Hospital (HGH), PO Box 3050, Doha, Qatar.

Purpose: To describe the epidemiology, patterns, seasonality and outcome of all-terrain vehicle-related injuries (ATVRIs) among different age groups in Qatar.

Methods: A retrospective analysis of all patients hospitalized with ATVRI from 2010 to 2018 was conducted. Data were analyzed by age, gender, seasonality, and Injury severity Score  (ISS). Read More

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Remote ischaemic preconditioning - translating cardiovascular benefits to humans.

J Physiol 2022 May 21. Epub 2022 May 21.

Department of Kinesiology, California State University Bakersfield, Bakersfield, CA, USA.

Remote ischaemic preconditioning (RIPC), induced by intermittent periods of limb ischaemia and reperfusion, confers cardiac and vascular protection from subsequent ischaemia-reperfusion (IR) injury. Early animal studies reliably demonstrate that RIPC attenuated infarct size and preserved cardiac tissue. However, translating these adaptations to clinical practice in humans has been challenging. Read More

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Improved arthroscopic high-strength suture fixation for the treatment of posterior cruciate ligament avulsion fracture.

J Orthop Surg (Hong Kong) 2022 May-Aug;30(2):10225536221101701

Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.

To investigate the curative effects of improved non-absorbable high-strength fixation under arthroscopy on posterior cruciate ligament (PCL) avulsion fracture. A retrospective analysis was performed on 16 cases of PCL avulsion fracture in 15 patients who underwent high-strength suture fixation under arthroscopy from December 2017 to November 2019. According to the Meyers-McKeever classification, there were 2 cases of type II and 14 cases of type III. Read More

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The impact of subclinical neck pain on goal-directed upper limb movement in the horizontal plane.

Exp Brain Res 2022 May 20. Epub 2022 May 20.

Faculty of Health Sciences, Ontario Tech University, 2000 Simcoe Street North, Oshawa, ON, L1G 0C5, Canada.

Subclinical neck pain (SCNP) refers to recurrent neck pain and/or stiffness for which individuals have not yet sought treatment. Prior studies have shown that individuals with SCNP have altered cerebellar processing that exhibits an altered body schema. The cerebellum also plays a vital role in upper limb reaching movements through refining internal models and integrating sensorimotor information. Read More

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The effect of intermittent pneumatic compression on deep-vein thrombosis and ventilation-free days in critically ill patients with heart failure.

Sci Rep 2022 May 20;12(1):8519. Epub 2022 May 20.

Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.

There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in critically ill patients with HF. Read More

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Lack of muscle stem cell proliferation and myocellular hypertrophy in sIBM patients following blood-flow restricted resistance training.

Neuromuscul Disord 2022 Apr 26. Epub 2022 Apr 26.

Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Rheumatology, Odense University Hospital, Odense, Denmark.

Sporadic inclusion body myositis (sIBM) is characterised by skeletal muscle inflammation, progressive muscle loss and weakness, which is largely refractory to immunosuppressive treatment. Low-load blood-flow restricted (BFR) training has been shown to evoke gains in myofibre cross sectional area (mCSA) in healthy adults. This could partially be due to the activation and integration of muscle satellite cells (SC) resulting in myonuclei addition. Read More

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Palliative Care Consultation is Associated with Decreased Rates of In-Hospital Mortality Among Patients Undergoing Major Amputation.

Ann Vasc Surg 2022 May 17. Epub 2022 May 17.

University of Maryland School of Medicine; Division of Vascular Surgery, Department of Surgery, University of Maryland Medical Center.

Objective: Despite advancements in medical care and surgical techniques, major amputation continues to be associated with risks for morbidity and mortality. Palliative care programs may help alleviate symptoms and align patients' goals and the care they receive with their treatment plan. Access to specialty Palliative medicine among vascular surgery patients is limited . Read More

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Predictors of amputation-free survival after endovascular intervention for chronic limb-threatening ischemia in the modern era.

Ann Vasc Surg 2022 May 17. Epub 2022 May 17.

Department of Surgery, Advocate Lutheran General Hospital, Park Ridge, IL.

Objective: Chronic limb-threatening (CLTI) is associated with 25% limb loss and 25% mortality at 1-year. Its lethality increases to 45% in patients subjected to a major amputation. Percutaneous peripheral intervention (PPI) constitutes an attractive and less morbid treatment option for patients with CLTI. Read More

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Noninvasive Capsulotomy for Refractory Depression by Frameless Stereotactic Radiosurgery.

Int J Radiat Oncol Biol Phys 2022 May 17. Epub 2022 May 17.

Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN.

Purpose: Effective treatment options for refractory depression are needed. Recent advancements permit both precise ablative radiation and functional neurologic connectome analysis using standard MRI. We combined these innovations to perform stereotactic radiosurgical capsulotomy for the treatment of medically refractory major depressive disorder and study connectome response using a novel tractography-based approach. Read More

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A comprehensive Triple Repeat Primed PCR (TR-PCR) and a Long-Range PCR (LR-PCR) agarose-based assay for improved genotyping of GAA repeats in Friedreich's Ataxia.

J Mol Diagn 2022 May 17. Epub 2022 May 17.

ARUP Institute for Clinical and Experimental Pathology, University of Utah, Salt Lake City, Utah; Department of Pathology, University of Utah, Salt Lake City, Utah.

Friedreich's ataxia (FRDA) is a rare autosomal recessive, neuro-muscular degenerative disease caused by an expansion of a trinucleotide (GAA) repeat in intron 1 of the FXN gene. It is common in the Caucasian population, characterized by progressive gait and limb ataxia, lack of tendon reflexes in the legs, loss of position sense, and hypertrophic cardiomyopathy. Detection and genotyping of the trinucleotide repeat length is important for the diagnosis and prognosis of the disease. Read More

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Dermoid Cyst of the Left Upper Limb: A Common Case in a Rare Site.

Am J Med Sci 2022 May 17. Epub 2022 May 17.

Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.. Electronic address:

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The development, internal construct and uni-dimensionality of the Tetraplegia Upper Limb Activities Questionnaire, TUAQ. Part 1.

Arch Phys Med Rehabil 2022 May 17. Epub 2022 May 17.

Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch, New Zealand.

Objective: This study aims to develop a patient reported outcome measure that focuses on relevant daily activities relying on upper extremity for individuals with tetraplegia.

Design: Cross-sectional study.

Setting: SCI units in two countries. Read More

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Reproducibility, construct validity and responsiveness of the Tetraplegia Upper Limb Activities Questionnaire, TUAQ. Part 2.: Psychometric testing of TUAQ.

Arch Phys Med Rehabil 2022 May 17. Epub 2022 May 17.

Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch, New Zealand.

Objective: To test reliability, construct validity and responsiveness of the Tetraplegic Upper limb Activity Questionnaire (TUAQ), a patient report outcome measure that assesses perceived performance and satisfaction with ten standardized activities.

Design: Outcome measure psychometric evaluation.

Setting: Spinal cord injury units in two countries. Read More

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When left is right: The effects of paw preference training on behaviour in mice.

Behav Brain Res 2022 May 17:113929. Epub 2022 May 17.

Department of Behavioural Biology, University of Münster, Badestr. 13, 48149 Münster, Germany; DFG Research Training Group EvoPAD, University of Münster, Hüfferstr. 1a, 48149 Münster, Germany. Electronic address:

Spontaneous limb preferences exist in numerous species. To investigate the underlying mechanisms of these preferences, different methods, such as training, have been developed to shift preferences artificially. However, studies that systematically examine the effects of shifting preferences on behaviour and physiology are largely missing. Read More

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