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Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

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Rare case report of anorectal malformation and intestinal atresia.

Int J Surg Case Rep 2021 Apr 30;82:105945. Epub 2021 Apr 30.

Division of Pediatric Surgery, Department of Surgery, Loma Linda University Medical Center, United States of America. Electronic address:

Introduction: Intestinal malformations, such as intestinal atresia, malrotation, and anorectal malformation, are rare events, but concurrent intestinal atresia and anorectal malformation are rare in combination. These anomalies have similar in utero and perinatal symptoms, which can make the diagnosis of both defects prenatally challenging.

Presentation Of Case: We present a case of a male infant with a prenatal diagnosis of truncus arteriosus who on a 32-week routine prenatal ultrasound was suspected to have an intestinal malformation. Read More

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Firearm-Related Injuries: A Single Center Experience.

J Surg Res 2021 May 5;265:289-296. Epub 2021 May 5.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona. Electronic address:

Introduction: Firearm-related injuries (FRI) are an important public health crisis in the US. There is relatively less city level data examining the injury-related trends in Tucson, Arizona. Our study aims to examine FRI, in Southern Arizona's only Level I trauma center. Read More

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Leiomyosarcoma of the urinary bladder: A SEER database study and comparison to leiomyosarcomas of the uterus and extremities/trunk.

Ann Diagn Pathol 2021 Apr 22;53:151743. Epub 2021 Apr 22.

Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

No well-established staging system exists for bladder leiomyosarcoma (LMS), and the current staging system does not include tumor size, a thoroughly validated prognostic parameter for sarcomas. Uterine and extremity/trunk LMS are more common than those in the bladder and have well-established staging systems incorporating tumor size. We aim to improve the understanding of LMS of the urinary bladder by assessing cancer-specific survival (CSS) and comparing LMS at this unusual anatomic site to those arising at other sites using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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Validation of the Bath CRPS Body Perception Disturbance Scale.

J Pain 2021 May 5. Epub 2021 May 5.

Department of Psychology, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom; Centre for Pain Research, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom.

The Bath Complex Regional Pain Syndrome Body Perception Disturbance Scale ("B-CRPS-BPDS") measures alterations in body perception. We assessed its internal consistency, known group validity, construct validity, and associations with demographic and clinical characteristics. We also evaluated changes in, and baseline predictors of B-CRPS-BPDS scores at follow-up. Read More

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An increased posterior slope of the medial and lateral meniscus posterior horn is associated with anterior cruciate ligament injuries.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa; Department of Anatomy and Cellular Biology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.

Purpose: The purpose of this study was to measure slope of both the medial and lateral posterior horn of the meniscus, and its contribution to the overall resulting posterior tibial slope (bone and meniscus combined slope) in ACL-intact (ACLI) and ACL-deficient (ACLD) knees.

Methods: MR images of patients with intact menisci aged between 16-60 years were included. Posterior tibial bone slope (PTS) and meniscus slope (MS) were measured at 25%, 50%, and 75% from the medial and lateral borders of the tibial plateau. Read More

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Road accidents in children involving light electric vehicles cause more severe injuries than other similar vehicles.

Eur J Pediatr 2021 May 8. Epub 2021 May 8.

Pediatric Emergency Department, Meir Medical Center, Tchernichovsky 59 St., 4428164, Kfar Saba, Israel.

Road accidents in Israel were responsible for 23% of injuries in pediatric population between 2013 and 2017. In recent years, the massive entrance of e-bike and other light electric vehicles (called collectively LEV) into the roads is significantly changing the epidemiology of road accidents among children. The study aims to describe the causes, injury types, and other epidemiological characteristics of children injured in road accident and compare injuries of LEV to regular bicycles and other light non-electric vehicles (called collectively LNEV). Read More

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Preserved thenar muscles in non-ambulant Duchenne muscular dystrophy patients.

J Cachexia Sarcopenia Muscle 2021 May 8. Epub 2021 May 8.

Duchenne Center, Leiden, Netherlands.

Background: Clinical trials in Duchenne muscular dystrophy (DMD) focus primarily on ambulant patients. Results cannot be extrapolated to later disease stages due to a decline in targeted muscle tissue. In non-ambulant DMD patients, hand function is relatively preserved and crucial for daily-life activities. Read More

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Chronic hyperglycemia, hypercholesterolemia and metabolic syndrome are associated with risk of tendon injury.

Scand J Med Sci Sports 2021 May 8. Epub 2021 May 8.

Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Copenhagen University Hospital - Bispebjerg and Frederiksberg and Center for Healthy Aging, Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Tendon injury is a considerable problem affecting both physically active and sedentary people. The aim of this study was to examine the relationship between markers for metabolic disorders (hyperglycemia, hypercholesterolemia and metabolic syndrome) and the risk of developing tendon injuries requiring referral to a hospital. The Copenhagen City Heart Study is a prospective study of diabetic and nondiabetic individuals from the Danish general population with different physical activity levels. Read More

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Reference data for hop tests used in pediatric ACL injury rehabilitation: A cross-sectional study of healthy children.

Scand J Med Sci Sports 2021 May 8. Epub 2021 May 8.

Department of Midwifery, Occupational Therapy and Psychomotor Therapy, Faculty of Health, University College Copenhagen, Copenhagen, Denmark.

In rehabilitation, four single leg hop tests are frequently used for evaluation of ACL injured children. However, reference values on single leg hop performance and the corresponding limb symmetry indexes (LSIs) of healthy children younger than 15 years of age are lacking. Thus, the purpose was to describe hop performance and LSIs in healthy Danish children, and to quantify the proportion of participants passing LSI values of ≥85% as well as ≥90%. Read More

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Temporal control of muscle synergies is linked with alpha-band neural drive.

J Physiol 2021 May 7. Epub 2021 May 7.

Department of Computer Science, University of Southern California, Los Angeles, 90089, United States.

Key Points: It is theorized that the nervous system controls groups of muscles together as functional units, or 'synergies', resulting in correlated electromyographic (EMG) signals among muscles. However, such correlation does not necessarily imply group-level neural control. Oscillatory synchronization (coherence) among EMG signals implies neural coupling, but it is not clear how this relates to control of muscle synergies. Read More

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Mutation spectrum of hereditary myopathies in Turkish patients and novel variants.

Ann Hum Genet 2021 May 8. Epub 2021 May 8.

Department of Medical Genetics, University of Health Sciences, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey.

Hereditary myopathies are a heterogeneous disorder known to be associated with more than 100 genes. Although hereditary myopathy subgroups can be partially described with traditional methods such as muscle biopsy, next-generation sequencing (NGS) is essential to reveal the disease's underlying genetic etiology and molecular mechanisms. In this study, we performed clinical exome sequencing or whole-exome sequencing (CES/WES) in 20 unrelated Turkish patients. Read More

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Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period.

Sci Rep 2021 May 7;11(1):9765. Epub 2021 May 7.

INSERM U1037, Cancer Research Center in Toulouse (CRCT), Toulouse, France.

Soft tissue sarcoma represents about 1% of all adult cancers. Occurrence of multiple sarcomas in a same individual cannot be fortuitous. A 72-year-old patient had between 2007 and 2016 a glomangiopericytal tumor of the right forearm and a succession of sarcomas of the extremities: a leiomyosarcoma of the left buttock, a myxofibrosarcoma (MFS) of the right forearm, a MFS of the left scapula, a left latero-thoracic MFS and two undifferentiated sarcomas on the left forearm. Read More

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Medial malleolar osteotomy for intralesional curettage and bone grafting of primary aneurysmal bone cyst of the talus.

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Orthopaedics, AIIMS, Bhubaneswar, Orissa, India.

Access to the cystic lesion of the talar body without damage to the articular surface is difficult. This case report is about a 23-year-old man who had a symptomatic huge cystic lesion in the left-sided talus bone. Radiograph and CT scan showed an expansile lytic lesion within the talar body. Read More

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The development of a capacity-strengthening program to promote self-care practices among people with lymphatic filariasis-related lymphedema in the Upper West Region of Ghana.

Infect Dis Poverty 2021 May 7;10(1):64. Epub 2021 May 7.

AIM Initiative-American Leprosy Missions, Greenville, SC, USA.

Background: The Upper West region of Ghana is mostly made up of rural communities and is highly endemic for lymphatic filariasis (LF), with a significant burden of disability due to lymphedema and hydrocele. The aim of this paper is to describe an enhanced, evidence-based cascading training program for integrated lymphedema management in this region, and to present some initial outcomes.

Main Text: A baseline evaluation in the Upper West Region was carried out in 2019. Read More

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Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis.

Mol Brain 2021 May 7;14(1):76. Epub 2021 May 7.

Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060-8556, Japan.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disorder in which motor neurons within the brain and spinal cord degenerate. A single infusion of mesenchymal stem cells (MSCs) delays disease progression by protecting motor neurons and restoring the blood-spinal cord barrier in the SOD1G93A transgenic ALS rat model. However, the therapeutic effect of a single infusion of MSCs is transient and does not block disease progression. Read More

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Fracture characteristics by age, sex, and ambulatory status among individuals with cerebral palsy: a descriptive study.

Disabil Rehabil 2021 May 7:1-7. Epub 2021 May 7.

Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.

Purpose: To evaluate clinically relevant fracture characteristics by age, sex, and ambulatory status among individuals with cerebral palsy.

Methods: Fracture location, energy of fracture, and activities that lead to a fracture were assessed among a clinic-based sample of children (0-17 years;  = 57) and adults (18-70 years;  = 58) with cerebral palsy that sustained a fracture by sex and gross motor function classification system (GMFCS) I-III vs. IV/V. Read More

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Single dose perioperative intrathecal ketamine as an adjuvant to intrathecal bupivacaine: A systematic review and meta-analysis of adult human randomized controlled trials.

J Clin Anesth 2021 May 5;73:110331. Epub 2021 May 5.

Zucker School of Medicine at Hofstra/Northwell, Department of Anesthesiology, Northwell Health, New Hyde Park, NY, United States of America.

Study Objective: To identify whether adding intrathecal ketamine to intrathecal bupivacaine prolongs the time to first analgesic request in adult humans.

Design: A meta-analysis of randomized controlled trials in humans.

Setting: The majority of data was obtained in an operating room and postoperative recovery area. Read More

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Effect of trunk muscles fatigue on plantar pressure distribution in novice runners.

J Biomech 2021 Apr 28;122:110487. Epub 2021 Apr 28.

Department of Sports Biomechanics, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran. Electronic address:

During running, trunk muscles act to sufficiently contribute to the energy generation and transmission of the body parts. Improper function of trunk muscles affects running mechanics adversely and could result in altered lower limb energetics. The aim of this study was to examine the effects of trunk muscles fatigue on plantar pressure distribution in novice runners. Read More

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Treatment outcome of posttraumatic stress disorder: A white matter tract analysis.

J Anxiety Disord 2021 May 1;81:102412. Epub 2021 May 1.

University of Missouri-St. Louis, 1 University Blvd., St. Louis, MO 63121, United States. Electronic address:

Despite the development of empirically supported treatments for posttraumatic stress disorder (PTSD), many individuals remain symptomatic following therapy or dropout prematurely. Neuroimaging studies examining PTSD treatment outcome may offer valuable insights into possible mechanisms that may impact treatment efficacy. To date, few studies of PTSD have used neuroimaging to examine symptom change following completed treatment, and most have focused on gray matter. Read More

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A Systematic Review Of Primary Ankle Arthrodesis In The Treatment Of Pilon Fractures.

Foot (Edinb) 2021 Jan 21;47:101780. Epub 2021 Jan 21.

Division of foot, ankle and limb reconstruction surgery, Department of Trauma and Orthopaedics, The Queen Elizabeth University Hospital, Glasgow, United Kingdom.

Background: Pilon fractures are severe, intra-articular and comminuted fractures to the distal tibia. They are uncommon injuries and are often associated with fibular fractures. The optimal management of these fractures is widely debated. Read More

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January 2021

Fluorescence and thermal imaging of non-melanoma skin cancers before and during photodynamic therapy.

Photodiagnosis Photodyn Ther 2021 May 4:102327. Epub 2021 May 4.

Photobiology Unit, NHS Tayside, Ninewells Hospital and Medical School, Dundee, UK; The Scottish Photodynamic Therapy Centre, Dundee, UK; School of Medicine, University of Dundee, Dundee, UK.

Background: Photodynamic therapy (PDT) has been shown to be less effective on the extremities. Protoporphyrin-IX (PpIX) fluorescence and skin surface temperature are variables that have been implicated in the differences in efficacy with body site, but objective studies have not been undertaken.

Objectives: To further investigate observations from our previous study that temperature and fluorescence during pro-drug incubation are correlated, through a prospective objective investigation of the relationships between fluorescence and skin surface temperature before and during PDT and relationships with body site and efficacy. Read More

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Reconstruction by allograft-prosthetic composite reverse shoulder arthroplasty after proximal humerus tumor resection: clinical and radiographic assessment at a minimum 2 years' follow-up.

Orthop Traumatol Surg Res 2021 May 4:102957. Epub 2021 May 4.

Service d'Orthopedie-Traumatologie, Centre Hospitalier Universitaire de Toulouse-Purpan, Toulouse, France.

Introduction: Reverse shoulder arthroplasty (RSA) is an option to conserve limb function after resection of proximal humerus malignancy. An allograft-composite RSA is an alternative to a tumor prosthesis, and can restore proximal humeral bone stock. The aim of the present study was to assess medium-term radiographic and clinical results for such composite implants. Read More

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Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy.

Am J Hum Genet 2021 May;108(5):857-873

GeneDx, Gaithersburg, MD 20877, USA.

The ALF transcription factor paralogs, AFF1, AFF2, AFF3, and AFF4, are components of the transcriptional super elongation complex that regulates expression of genes involved in neurogenesis and development. We describe an autosomal dominant disorder associated with de novo missense variants in the degron of AFF3, a nine amino acid sequence important for its binding to ubiquitin ligase, or with de novo deletions of this region. The sixteen affected individuals we identified, along with two previously reported individuals, present with a recognizable pattern of anomalies, which we named KINSSHIP syndrome (KI for horseshoe kidney, NS for Nievergelt/Savarirayan type of mesomelic dysplasia, S for seizures, H for hypertrichosis, I for intellectual disability, and P for pulmonary involvement), partially overlapping the AFF4-associated CHOPS syndrome. Read More

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Lower-limb medical and rehabilitation exoskeletons: A review of the current designs.

IEEE Rev Biomed Eng 2021 May 7;PP. Epub 2021 May 7.

Medical and rehabilitation exoskeletons are being increasingly considered by therapists when choosing a treatment for individuals affected by lower limb impairments. Although all such exoskeletons seem to provide similar features and performance, there are, in practice, significant differences among them in terms of maximum walking speed, maximum torque, weight, autonomy, interaction with the user, or even the way to use it. In this review, the state of the art of the main commercial exoskeletons is described, while analyzing their properties, advantages, and disadvantages. Read More

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Clinical Efficacy of Minimally Invasive Elastic Stable Intramedullary Nailing for Limb Long Bone Fractures in Children.

Orthop Surg 2021 May 7. Epub 2021 May 7.

Department of Orthopaedics, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Objective: The aim of the present paper was to investigate the clinical efficacy of minimally invasive elastic stable intramedullary nailing (ESIN) for long bone fractures in children.

Methods: A total of 350 children with limb fractures from June 2012 to June 2018 were recruited and randomized into two groups: an ESIN group (n = 175) treated with elastic stable intramedullary nailing, and an MPIF group (n = 175), treated with metal plate internal fixation. Both groups received the same physical examination and routine medication. Read More

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Associations Between Periosteal Reaction of Proximal Tibial and Medial Compartment Knee Osteoarthritis.

Orthop Surg 2021 May 7. Epub 2021 May 7.

School of Medicine, Nankai University, Tianjin, China.

Objective: To evaluate and analyze the potential relationship between periosteal reaction and medial compartment knee osteoarthritis (KOA), and to assess the independent risk factors for the development of periosteal reaction associated with medial compartment KOA.

Methods: This is a retrospective comparative study. From January 2019 to December 2019 at the Third Hospital of Hebei Medical University, a total of 363 patients (726 knees) with medial compartment KOA were enrolled in this study according to our inclusion and exclusion criteria, including 91 males and 272 females, with an mean age of 57. Read More

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A phase 1b/2a, open-label, multiple ascending dose trial of domagrozumab in FKRP limb-girdle muscular dystrophy.

Muscle Nerve 2021 May 7. Epub 2021 May 7.

Center for Genetic Muscle Disorders, Kennedy Krieger Institute, Baltimore, MD.

Introduction: We report the results of a phase 1b/2a, open-label, multiple ascending dose trial of domagrozumab, a myostatin inhibitor, in patients with FKRP-associated limb-girdle muscular dystrophy.

Methods: Nineteen patients were enrolled and assigned to one of three dosing arms (5 mg/kg, 20mg/kg, or 40mg/kg every 4 weeks). Following 32 weeks of treatment, participants receiving the lowest dose were switched to the highest dose (40mg/kg) for an additional 32 weeks. Read More

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