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Non-alcoholic fatty liver disease - discussed under the light of Unani medicine.

J Complement Integr Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Moalajat (Medicine), National Institute of Unani Medicine (Under Ministry of AYUSH), Bangalore, India.

Non-alcoholic Fatty Liver Disease (NAFLD) is one of the diseases that have evolved lately into a major challenge for gastroenterologists. Although, the term NAFLD has not been familiar to the medical world since long, other conditions resembling the presentation of NAFLD have been there since primitive times. It is a reversible condition of the liver, wherein large vacuoles of triglyceride fat accumulates in liver cells via the process of steatosis, despite any evidence of excessive alcohol consumption. Read More

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September 2021

Effects of Light and Water Disturbance on the Growth of Microcystis aeruginosa and the Release of Algal Toxins.

Water Environ Res 2021 Sep 22. Epub 2021 Sep 22.

Beijing Yizhuang Water Company, Beijing, China.

Eutrophication of water constitutes a serious threat to global water quality. Light intensity and water disturbance are important factors affecting the growth of algae and the release of algal toxins. In this study, algal growth indicators, algal enzyme systems and algal toxin release in Microcystis aeruginosa under different light intensities and water disturbances were determined. Read More

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September 2021

Valid versus invalid radiation cancer risk assessment methods illustrated using Swiss population data.

J Radiol Prot 2021 Sep 22. Epub 2021 Sep 22.

University of Zurich Faculty of Science, Zurich, SWITZERLAND.

After the nuclear accident in Fukushima, the public interest in radiation related cancer-risk assessment increased. However, interpretations of results from epidemiological studies and comprehension of cancer risk assessment methods can be unclear and involve questions about correctness and validity of the approaches. To shed some light on this potential lack of clarity, valid versus invalid radiation cancer risk assessments methods are illustrated here using Swiss population data. Read More

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September 2021

Subvisible Particle Analysis of 17 Monoclonal Antibodies Approved in China Using Flow Imaging and Light Obscuration.

J Pharm Sci 2021 Sep 19. Epub 2021 Sep 19.

Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 31, Huatuo Road, Daxing District, Beijing, 102629, China. Electronic address:

In the study, subvisible particles in 205 samples from 17 commercial mAb drug products approved in China were analyzed using light obscuration (LO) and flow imaging microscopy (FIM) methods. For each method, a total 633 tests (runs) were performed. In the tests, samples in state of lyophilized powder or syringe package had significantly higher particle concentrations. Read More

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September 2021

Biomimetic crosslinking of collagen gels by energetic electrons: the role of L-lysine.

Acta Biomater 2021 Sep 19. Epub 2021 Sep 19.

Leibniz-Institut für Oberflächenmodifizierung e.V. (IOM), Permoserstr. 15, 04318 Leipzig, Germany; Division of Surface Physics, Department of Physics and Earth Sciences, University of Leipzig, Linnéstraße 5, 04103 Leipzig, Germany. Electronic address:

Energetic electrons have recently evolved as powerful tool for crosslinking bio-derived hydrogels without the need for adding potentially hazardous reagents. Application of this approach allows for synthesis of biomimetic collagen-derived networks of highly tunable properties and functionalization. Yet, the underlying reaction kinetics it still not sufficiently established at this point. Read More

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September 2021

Cellular bases of olfactory circuit assembly revealed by systematic time-lapse imaging.

Cell 2021 Sep 9. Epub 2021 Sep 9.

Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address:

Neural circuit assembly features simultaneous targeting of numerous neuronal processes from constituent neuron types, yet the dynamics is poorly understood. Here, we use the Drosophila olfactory circuit to investigate dynamic cellular processes by which olfactory receptor neurons (ORNs) target axons precisely to specific glomeruli in the ipsi- and contralateral antennal lobes. Time-lapse imaging of individual axons from 30 ORN types revealed a rich diversity in extension speed, innervation timing, and ipsilateral branch locations and identified that ipsilateral targeting occurs via stabilization of transient interstitial branches. Read More

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September 2021

Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain.

Cell Rep 2021 Sep;36(12):109721

Neuroscience Institute, Washington Road, Princeton University, Princeton, NJ 08544, USA. Electronic address:

Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by using transsynaptic tracing viruses and a whole-brain analysis pipeline. With retrograde tracing, we find that most descending paths originate from the somatomotor cortex. Read More

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September 2021

InO:H-Based Hole-Transport-Layer-Free Tin/Lead Perovskite Solar Cells for Efficient Four-Terminal All-Perovskite Tandem Solar Cells.

ACS Appl Mater Interfaces 2021 Sep 22. Epub 2021 Sep 22.

Light Technology Institute (LTI), Karlsruhe Institute of Technology, Engesserstrasse 13, 76131 Karlsruhe, Germany.

Narrow-band gap (NBG) Sn-Pb perovskites with band gaps of ∼1.2 eV, which correspond to a broad photon absorption range up to ∼1033 nm, are highly promising candidates for bottom solar cells in all-perovskite tandem photovoltaics. To exploit their potential, avoiding optical losses in the top layer stacks of the tandem configuration is essential. Read More

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September 2021

Modular Photocatalytic Synthesis of α-Trialkyl-α-Tertiary Amines.

J Am Chem Soc 2021 Sep 22. Epub 2021 Sep 22.

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

Molecules displaying an α-trialkyl-α-tertiary amine motif provide access to an important and versatile area of biologically relevant chemical space but are challenging to access through existing synthetic methods. Here, we report an operationally straightforward, multicomponent protocol for the synthesis of a range of functionally and structurally diverse α-trialkyl-α-tertiary amines, which makes use of three readily available components: dialkyl ketones, benzylamines, and alkenes. The strategy relies on the of use visible-light-mediated photocatalysis with readily available Ir(III) complexes to bring about single-electron reduction of an all-alkyl ketimine species to an α-amino radical intermediate; the α-amino radical undergoes Giese-type addition with a variety of alkenes to forge the α-trialkyl-α-tertiary amine center. Read More

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September 2021

Second near-infrared (NIR-II) imaging: a novel diagnostic technique for brain diseases.

Rev Neurosci 2021 Sep 22. Epub 2021 Sep 22.

State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu611137, China.

Imaging in the second near-infrared II (NIR-II) window, a kind of biomedical imaging technology with characteristics of high sensitivity, high resolution, and real-time imaging, is commonly used in the diagnosis of brain diseases. Compared with the conventional visible light (400-750 nm) and NIR-I (750-900 nm) imaging, the NIR-II has a longer wavelength of 1000-1700 nm. Notably, the superiorities of NIR-II can minimize the light scattering and autofluorescence of biological tissue with the depth of brain tissue penetration up to 7. Read More

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September 2021

Shedding Light on Incidence and Burden of Physeal Injuries in Youth Elite Football Academy: A 4-Season Prospective Study.

Scand J Med Sci Sports 2021 Sep 22. Epub 2021 Sep 22.

Edge Hill University, Department of Sport and Physical Activity, Ormskirk, UK.

Introduction: Physeal injuries have been overlooked in epidemiological research in youth sports. Our prospective study investigated the incidence, severity, and burden of physeal injuries in a youth elite football academy.

Methods: 551 youth male football players from Under-9 to Under-19 were included and observed over four consecutive seasons. Read More

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September 2021

Computational discovery of PtS/GaSe van der Waals heterostructure for solar energy applications.

Phys Chem Chem Phys 2021 Sep 22;23(36):20163-20173. Epub 2021 Sep 22.

School of Materials Science and Engineering, and Center for Integrated Computational Materials Science, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, P. R. China.

2D van der Waals (vdW) heterostructures as potential materials for solar energy-related applications have been brought to the forefront for researchers. Here, by employing first-principles calculations, we proposed that the PtS/GaSe vdW heterostructure is a distinguished candidate for photocatalytic water splitting and solar cells. It is shown that the PtS/GaSe heterostructure exhibits high thermal stability with an indirect band gap of 1. Read More

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September 2021

Epidemiology of Irritable Bowel Syndrome in Albania.

J Gastrointestin Liver Dis 2021 Sep 21;30(3):334-338. Epub 2021 Sep 21.

2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.

Background And Aims: Irritable bowel syndrome (IBS) is a chronic condition, with a relatively high prevalence and represents a burden for the healthcare budgets. Knowing the prevalence of IBS is important for scientific and practical estimation of its impact. The recent Rome IV global study has shed light on the prevalence of IBS in many countries, but reports are lacking from other countries. Read More

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September 2021

What's the relative humidity in tropical caves?

PLoS One 2021 22;16(9):e0250396. Epub 2021 Sep 22.

Department of Environmental Science, American University, Washington, DC, United States of America.

Relative humidity (RH) was measured at hourly intervals for approximately one year in two caves at seven stations near Playa del Carmen in Quintana Roo, Mexico. Sistema Muévelo Rico is a 1.1 km long cave with 12 entrances and almost no dark zone. Read More

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September 2021

Rewinding the molecular clock in the genus Carabus (Coleoptera: Carabidae) in light of fossil evidence and the Gondwana split: A reanalysis.

PLoS One 2021 22;16(9):e0256679. Epub 2021 Sep 22.

Institute of Biosciences, General and Systematic Zoology, University of Rostock, Rostock, Germany.

Molecular clocks have become powerful tools given increasing sequencing and fossil resources. However, calibration analyses outcomes depend on the choice of priors. Here, we revisited the seminal dating study published by Andújar and coworkers of the genus Carabus proposing that prior choices need re-evaluation. Read More

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September 2021

Technical Refinement in Three-Dimensional Nipple-Areola Complex Tattooing of the Reconstructed Breast.

Plast Reconstr Surg 2021 Oct;148(4):737-746

From the Institute for Plastic Surgery, Southern Illinois University School of Medicine; and Newage Tattoo.

Summary: Three-dimensional nipple-areola complex tattooing has previously been described as an alternative to surgical reconstruction using local flaps and grafts. This technique offers patients an option that can achieve aesthetically pleasing results without a donor site, changes in projection over time, or additional scarring. Plastic surgeons may be limited in their ability to create a realistic-appearing nipple-areola complex because of limited experience with basic tattooing techniques and unfamiliarity with the artistic principles of light and shadow required to create depth on a two-dimensional surface. Read More

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October 2021

Self-perceived Burden: A Critical Evolutionary Concept Analysis.

J Hosp Palliat Nurs 2021 Sep 20. Epub 2021 Sep 20.

Sharon E. Bigger, PhD, RN, CHPN, is assistant professor of nursing, East Tennessee State University, Johnson City. Timothea Vo, BS, RN, CTN-B, is PhD student, University of Connecticut, Storrs.

The purpose of this article is to critically analyze the concept of self-perceived burden. The Rodgers Evolutionary Model is augmented with concept critique, a dialogic process grounded in critical hermeneutics. Self-perceived burden is a relatively mature concept with psychological, relational, and dimensional attributes that are shaped by culture and sociopolitical structures. Read More

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September 2021

The State of Mind of Healthcare Professionals in the Light of the COVID-19: Insights from Text Analysis of Twitter's Online Discourses.

J Med Internet Res 2021 Jul 23. Epub 2021 Jul 23.

Department of Nursing, Ben-Gurion University of the Negev, Beer Sheva, IL.

Background: The COVID-19 pandemic has affected populations worldwide, with extreme health, economic, social, and political implications. Healthcare professionals (HCPs) are at the core of pandemic response and are among the most crucial factors in maintaining coping capacities. Yet, they are also vulnerable to mental health effects, managing a long-lasting emergency under lack of resources and complicated personal concerns. Read More

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Circadian regulation of vertebrate cone photoreceptor function.

Elife 2021 Sep 22;10. Epub 2021 Sep 22.

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

Eukaryotes generally display a circadian rhythm as an adaption to the reoccurring day/night cycle. This is particularly true for visual physiology that is directly affected by changing light conditions. Here we investigate the influence of the circadian rhythm on the expression and function of visual transduction cascade regulators in diurnal zebrafish and nocturnal mice. Read More

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September 2021

Photo-Activated Carbon Dots for Inactivation of Foodborne Pathogens and .

Appl Environ Microbiol 2021 Sep 22:AEM0104221. Epub 2021 Sep 22.

Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise (BRITE), North Carolina Central University, Durham, NC 27707, USA.

Foodborne pathogens have long been recognized as major challenges for the food industry and repeatedly implicated in food product recalls and outbreaks of foodborne diseases. This study demonstrated the application of a recently discovered class of visible-light activated carbon-based nanoparticles, namely carbon dots (CDots), for photodynamic inactivation of foodborne pathogens. The results demonstrated that CDots were highly effective in the photo-inactivation of in suspensions and on stainless steel surfaces. Read More

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September 2021

Photothermal Circular Dichroism of Single Nanoparticles Rejecting Linear Dichroism by Dual Modulation.

ACS Nano 2021 Sep 22. Epub 2021 Sep 22.

Huygens-Kamerlingh Onnes Laboratory, Leiden University, Leiden, 2300 Rapenburg, Netherlands.

Circular dichroism (CD) is the property of chiral nanoobjects to absorb circularly polarized light of either handedness to different extents. Photothermal microscopy enables the detection of CD signals with high sensitivity and provides a direct absorptive response of the samples under study. To achieve CD measurements at the single-particle level, one must reduce such artifacts as leakage of linear dichroism (LD) and residual intensity modulation. Read More

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September 2021

Thermally Activated Delayed Fluorescence Amorphous Molecular Materials for High-Performance Organic Light-Emitting Diodes.

ACS Appl Mater Interfaces 2021 Sep 22. Epub 2021 Sep 22.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

Small-molecule thermally activated delayed fluorescence (TADF) materials have been extensively developed to actualize efficient organic LEDs (OLEDs). However, organic small molecules generally compromise thin film quality and stability due to the tendency of crystallization, aggregation, and phase separation, which hence degrade the efficiency and long-term stability of the OLEDs. Here, for the first time, we exploit the unique molecular configuration of the bimesitylene scaffold to design two highly efficient TADF amorphous molecular materials with excellent thermal and morphological stabilities. Read More

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September 2021

Atomically Dispersed s-Block Magnesium Sites for Electroreduction of CO2 to CO.

Angew Chem Int Ed Engl 2021 Sep 22. Epub 2021 Sep 22.

Central South University, 932 Lushan Nan road, Changsha, CHINA.

Atomically dispersed transition metal sites have been extensively studied for CO 2 electroredution reaction (CO 2 RR) to CO due to their robust CO 2 activation ability. However, the strong hybridization between directionally localized d orbits and CO vastly limits CO desorption and thus the activities of atomically d ispersed transition metal sites. In contrast, s-block metal sites possess nondirectional ly delocalized 3s orbits and hence weak CO adsorption ability, providing a promising way to solve the suffered CO desorption issue. Read More

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September 2021

Lewis Acid-Promoted Oxidative Addition at a [Ni0(diphosphine)2] Complex: The Critical Role of a Secondary Coordination Sphere.

Chemistry 2021 Sep 22. Epub 2021 Sep 22.

University of Windsor, Chemistry and Biochemistry, 401 Sunset Ave, N9B3P4, Windsor, CANADA.

Oxidative addition represents a critical elementary step in myriad catalytic transformations. Here, the importance of thoughtful ligand design cannot be overstated. In this work, we report the intermolecular activation of iodobenzene (PhI) at a coordinatively saturated 18-electron [Ni0(diphosphine)2] complex bearing a Lewis acidic secondary coordination sphere. Read More

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September 2021

Serum Neurofilament Light: a Potential Diagnostic and Prognostic Biomarker in Obstetric Posterior Reversible Encephalopathy Syndrome.

Mol Neurobiol 2021 Sep 22. Epub 2021 Sep 22.

Department of Obstetrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical Center for Critical Pregnant Women, No. 63, Duobao Road, Guangzhou, 510150, Guangdong, China.

Obstetric posterior reversible encephalopathy syndrome (PRES), caused by preeclampsia (PE) or eclampsia, is a clinical imaging syndrome and a critical maternal complication, with vasogenic edema in white matter as a typical imaging characteristic. Serum neurofilament light (NFL) is a marker of neuroaxonal injury. Therefore, we performed this study to explore the diagnostic and prognostic role of NFL in obstetric PRES. Read More

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September 2021

Preparation and properties of floral CaO/ZnO composite from Achatina fulica snail shell.

Environ Sci Pollut Res Int 2021 Sep 22. Epub 2021 Sep 22.

College of Resources and Environment, Jilin Agricultural University, Changchun, 130118, People's Republic of China.

In this study, CaO prepared by calcination treatment from abandoned Achatina fulica shell was used as a raw material, and the floral CaO/ZnO photocatalytic composite material was prepared through co-precipitation method. SEM study showed ZnO with spindle-like petals in the range of 500-1000 nm grown on the surface of CaO carrier. The mapping image shows that the base component of the floral structure is mainly CaO, which is because CaO is not only in the reaction as a carrier, but also creates an alkaline environment in the methanol system, which is advantageous for co-precipitation. Read More

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September 2021

Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity.

J Biol Inorg Chem 2021 Sep 22. Epub 2021 Sep 22.

Department of Chemistry, Gauhati University, Guwahati, 781014, Assam, India.

Co(II) complexes having a ferrocene-based curcuminoid (Fc-curH) ligand viz. [Co(L)(Fc-cur)]ClO (1, 2), where L is phenanthroline base, namely, 1,10-phenanthroline (phen in 1) and dipyrido[3,2-a:2',3'-c]phenazine (dppz in 2) have been synthesized, characterized and evaluated as photochemotherapeutic agents in vitro. The corresponding Co(II) complexes of the naturally occurring polyphenol curcumin (curH), namely, [Co(L)(cur)]ClO (3, 4), where L is phen (in 3) and dppz (in 4) were synthesized and their photo-induced anticancer activities compared with their ferrocene containing counterparts 1 and 2. Read More

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September 2021

Seeing the light: surgical circadian rhythm.

Br J Surg 2021 Sep 22. Epub 2021 Sep 22.

Discipline of Surgery, Queen Elizabeth Hospital, University of Adelaide, Adelaide, South Australia, Australia.

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September 2021

Dual spindles assemble in bovine zygotes despite the presence of paternal centrosomes.

J Cell Biol 2021 Nov 22;220(11). Epub 2021 Sep 22.

Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

The first mitosis of the mammalian embryo must partition the parental genomes contained in two pronuclei. In rodent zygotes, sperm centrosomes are degraded, and instead, acentriolar microtubule organizing centers and microtubule self-organization guide the assembly of two separate spindles around the genomes. In nonrodent mammals, including human or bovine, centrosomes are inherited from the sperm and have been widely assumed to be active. Read More

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November 2021

Caffeine intake reduces sedentary time and increases physical activity predisposition in obese police officers.

Braz J Med Biol Res 2021 20;54(11):e11556. Epub 2021 Sep 20.

Grupo de Pesquisa em Performance Humano, Universidade Tecnológica Federal do Paraná, Curitiba, PR, Brasil.

Sedentary time is associated with increased obesity in police officers. Caffeine intake may reduce sedentary time but it has not been extensively investigated. In the present study, the effect of caffeine ingestion on sedentary time was investigated in obese police officers. Read More

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September 2021