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MicroRNA-383-5p regulates osteogenic differentiation of human periodontal ligament stem cells by targeting histone deacetylase 9.

Authors:
Lan Ma Di Wu

Arch Oral Biol 2021 May 25;129:105166. Epub 2021 May 25.

Department of Stomatology, Jingmen No.1 People's Hospital, China. Electronic address:

Objective: Human periodontal ligament stem cells (hPDLSCs) play an important role in regenerative engineering technology for periodontal therapy. The mechanism of microRNA (miR)-383-5p in osteogenic differentiation needs further exploration. This study aimed at investigating the potential role of miR-383-5p in the osteogenic differentiation of hPDLSCs. Read More

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Kinematics after cervical laminoplasty: risk factors for cervical kyphotic deformity after laminoplasty.

Spine J 2021 Jun 9. Epub 2021 Jun 9.

Department of Neurosurgery, Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea. Electronic address:

Background Context: Laminoplasty of the cervical spine is widely used as an effective surgical method to treat compressive myelopathy of the cervical spine; however, there is an adverse effect of kyphosis after surgery. The risk factors or predictors of kyphosis have not been sufficiently evaluated.

Purpose: To assess the risk factors for kyphosis following laminoplasty. Read More

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Notch pathway activation promotes the differentiation of beagle dog periodontal ligament stem cells to Schwann cells.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Dentistry, The Second Affiliated Hospital, Zhejiang University School of Medicine, China.

Background: Periodontal ligament stem cells (PDLSCs) have demonstrated the potential for differentiation into many cell types, though the molecular mechanism of their neural differentiation in particular remains largely unknown.

Objectives: The Notch signaling pathway plays a key role in regulating cell differentiation and development. In this article, we explore its potential role in the differentiation of PDLSCs to Schwann cells (SCs). Read More

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Inflammatory disease of the costotransverse joints: US evaluation in 15 symptomatic patients.

J Ultrasound 2021 Jun 12. Epub 2021 Jun 12.

Advanced Musculoskeletal Ultrasound, SIUMB School of Pisa, Pisa, Italy.

The costotransverse joints (CTJs) are small arthrodial joints which articulate with the costal tuberosity on the transverse process of the thoracic vertebrae. CTJs are composed of oval-shaped facets with a major axis, vertical at the upper vertebrae and almost horizontal at the lower vertebrae. This position explains the different movements of the ribs: the cranial ribs move on the sagittal plane and the caudal ribs on the transverse plane. Read More

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Serum cartilage oligomeric matrix protein is correlated with quantitative magnetic resonance imaging and arthroscopic cartilage findings in anterior cruciate ligament deficient knees without osteoarthritic changes.

Clin Rheumatol 2021 Jun 12. Epub 2021 Jun 12.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Introduction/objectives: To investigate the association between serum biomarker [cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3)] levels and clinical, magnetic resonance imaging (MRI), and arthroscopic findings in anterior cruciate ligament (ACL)-deficient knees without osteoarthritic changes on radiographs.

Method: Patients with ACL injury of Kellgren-Lawrence grade 0 or 1 were enrolled. Serum COMP and MMP-3 levels were measured preoperatively. Read More

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Safety and efficiency of modified sacrospinous ligament fixation for apical prolapse: Long-term studies and outcomes.

Int J Gynaecol Obstet 2021 Jun 12. Epub 2021 Jun 12.

Department of gynecological pelvic floor and oncology, Chongqing health center for women and children, Chongqing, China.

Objective: To explore the safety and efficiency of modified sacrospinous ligament fixation (MSSF) for apical prolapse.

Methods: It's a retrospective cohort study. Patients diagnosed with apical prolapse from 2014 to 2019 were recruited and divided into three groups, those are sacrospinous ligament fixation (SSF), MSSF and laparoscopic sacral hysteropexy (LSH). Read More

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Thermal sensitivity of Axolotl feeding behaviors.

Integr Comp Biol 2021 Jun 12. Epub 2021 Jun 12.

University of Massachusetts Lowell.

Musculoskeletal movement results from muscle contractions, recoil of elastic tendons, aponeuroses, and ligaments, or combinations thereof. Muscular and elastic contributions can vary both across behaviors and with changes in temperature. Skeletal muscles reach peak contraction speed at a temperature optimum with performance declining away from that optimum by approximately 50% per 10 °C, following the Q10 principle. Read More

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Agreement Between Clinical Examination and Magnetic Resonance Imaging in Acute Knee Trauma With Hemarthrosis.

Clin J Sport Med 2021 Jun 9. Epub 2021 Jun 9.

Department of Orthopaedics, NU-Hospital Group, Uddevalla/Trollhättan, Sweden; Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden; and Department of Orthopaedics, Helsingborg Hospital, Helsingborg, Sweden.

Objective: Hemarthrosis after knee trauma often indicates serious joint injury. Few studies have evaluated agreement between clinical examination and findings from magnetic resonance imaging (MRI). We aimed to describe the agreement between acute clinical examination and subacute MRI findings after acute knee trauma with hemarthrosis and the importance of the subspecialty of the examiner. Read More

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Composite psychosocial risk based on the fear avoidance model in patients undergoing anterior cruciate ligament reconstruction: Cluster-based analysis.

Phys Ther Sport 2021 Jun 2;50:217-225. Epub 2021 Jun 2.

Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Musculoskeletal Research, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physical Medicine and Rehabilitation, Osher Center for Integrative Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Objectives: To examine associations between preoperative fear-avoidance model (FAM) risk subgroup status and patient expectation of surgical success with postoperative outcomes at 6 and 12 months after anterior cruciate ligament reconstruction (ACLR).

Design: Cohort study.

Setting: Academic medical center. Read More

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Partial Arthroscopic Trapeziectomy and Stabilisation by Ligamentoplasty: Outcomes in Patients Younger than 60 Years.

Orthop Traumatol Surg Res 2021 Jun 8:102983. Epub 2021 Jun 8.

Service de chirurgie orthopédique et traumatologique, centre hospitalier de Versailles, 78150 Le Chesnay, France.

Background: Thumb carpo-metacarpal joint (TCMJ) osteoarthritis is the fourth leading cause of referral to elective hand surgery. None of the available techniques has proved superior over the others. Some techniques carry unacceptable risks for younger patients, such as loss of strength and shortening of the thumb column after total trapeziectomy, or wear and loosening after total arthroplasty. Read More

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Gait Adaptations at 8 Years After Reconstruction of Unilateral Isolated and Combined Posterior Cruciate Ligament Injuries.

Am J Sports Med 2021 Jun 11:3635465211017147. Epub 2021 Jun 11.

Julius Wolff Institute, Berlin Institute of Health and Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: It remains unclear how posterior cruciate ligament (PCL) reconstruction influences long-term lower extremity joint biomechanics.

Purpose: To determine whether patients who underwent PCL reconstruction exhibited long-term alterations in lower limb gait mechanics.

Study Design: Controlled laboratory study. Read More

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An Anterior Cruciate Ligament In Vitro Rupture Model Based on Clinical Imaging[Formula: see text].

Am J Sports Med 2021 Jun 11:3635465211017145. Epub 2021 Jun 11.

Biomechanics Group, Mechanical Engineering Department, Imperial College London, London, UK.

Background: Biomechanical studies on anterior cruciate ligament (ACL) injuries and reconstructions are based on ACL transection instead of realistic injury trauma.

Purpose: To replicate an ACL injury in vitro and compare the laxity that occurs with that after an isolated ACL transection injury before and after ACL reconstruction.

Study Design: Controlled laboratory study. Read More

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Lateral Elbow Laxity Is Affected by the Integrity of the Radial Band of the Lateral Collateral Ligament Complex: A Cadaveric Model With Sequential Releases and Varus Stress Simulating Everyday Activities.

Am J Sports Med 2021 Jun 11:3635465211018208. Epub 2021 Jun 11.

UOC 1° Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milan, Italy.

Background: An elongation of the radial lateral collateral complex (R-LCL) can provoke symptomatic minor instability of the lateral elbow leading to lateral elbow pain. Biomechanical models investigating the effects of elongation and partial or complete lesions of the R-LCL on lateral elbow stability are lacking.

Purpose: To evaluate how partial and complete R-LCL release affects radiocapitellar joint stability in a setting of controlled varus load and progressive soft tissue release. Read More

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Thoracoscopic radical esophagectomy combined with left inferior pulmonary ligament lymphadenectomy for esophageal carcinoma via the right thoracic approach: A single-center retrospective study of 30 cases.

Medicine (Baltimore) 2021 Jun;100(23):e26302

Department of Cardiothoracic Surgery, The Affiliated Hospital of Putian University, Putian, Fujian.

Abstract: To evaluate the necessity, safety, and feasibility of left inferior pulmonary ligament lymphadenectomy during video-assisted thoracic surgery (VATS) radical esophagectomy via the right thoracic approach.Thirty patients (20 men, 10 women) with thoracic esophageal squamous cell carcinoma (ESCC) were recruited for this study. The patients' age ranged from 50 to 80 years, with an average age of 66. Read More

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Splenic Injury After a Colonoscopy: Threading the Scope Carefully in Heritable Connective Tissue Disorders.

Cureus 2021 Jun 4;13(6):e15444. Epub 2021 Jun 4.

Gastroenterology and Hepatology, Ascension Genesys Hospital, Grand Blanc, USA.

Colonoscopies have reduced colorectal cancer (CRC) burden in the United States, and their utility has expanded to include various diagnostic and therapeutic indications. Complications are seen in up to 1% and increase with age and polypectomy. As colonoscopies become widespread, specific populations seem to be at a much higher risk; notably patients with heritable connective tissue disorders (HCTD). Read More

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Coronary Artery Fistula Aneurysm: Pathological Analysis After Surgery.

Cureus 2021 May 8;13(5):e14903. Epub 2021 May 8.

Cardiology, Kawasaki Municipal Ida Hospital, Kawasaki, JPN.

An asymptomatic 75-year-old woman was identified with a 40-mm-sized, round-shaped lesion beside the pulmonary artery on computed tomography (CT). Coronary angiography showed a coronary artery fistula (CAF) with an aneurysm branching from the left anterior descending artery toward the pulmonary artery. The CAF aneurysm (CAFA) was resected and coronary artery bypass graft surgery using the left internal thoracic artery was performed successfully. Read More

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Knee Extensor Mechanism Strength and Its Relationship to Patellofemoral Kinematics in Individuals With Arthrofibrosis Within 6 Months After Anterior Cruciate Ligament Reconstruction.

J Sport Rehabil 2021 Jun 10:1-6. Epub 2021 Jun 10.

Context: Performance in strength and assessment of patellar tracking is important for patients with arthrofibrosis after anterior cruciate ligament (ACL) reconstruction.

Objective: The study was to examine the difference of patellofemoral kinematics between the affected and the contralateral limb and to evaluate the relationship between knee extensor strength and patellofemoral kinematics in patients with arthrofibrosis after ACL reconstruction.

Design: Cohort study (diagnosis); level of evidence, 3. Read More

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Differences in fatigability of vastus medialis muscle between patients with limb symmetry index of <90% and ≥90% after chronic anterior cruciate ligament reconstruction.

Knee 2021 Jun 7;31:39-45. Epub 2021 Jun 7.

Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama City, Wakayama 641-8509, Japan. Electronic address:

Background: A limb symmetry index (LSI) of ≥90% for the quadriceps is recommended for return to sports activity after anterior cruciate ligament reconstruction (ACLR). However, there is no information on differences in muscle fatigability between patients with LSI of <90% and ≥90%. The aim of this study was to assess the difference in quadriceps muscle fatigability on the involved side between post-ACLR patients with LSI of <90% and ≥90%. Read More

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Evaluation of the Intact Anterior Talofibular and Calcaneofibular Ligaments, Injuries, and Repairs With and Without Augmentation: A Biomechanical Robotic Study.

Am J Sports Med 2021 Jun 10:3635465211018645. Epub 2021 Jun 10.

The Steadman Clinic, Vail, Colorado, USA.

Background: Acute ankle sprains are common injuries. The anterior talofibular (ATFL) and calcaneofibular ligaments (CFL) are the most injured lateral structures. However, controversy exists on the optimal surgical treatment when the injury is both acute and severe or becomes chronic and unstable. Read More

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The outcomes of quadriceps tendon autograft for anterior cruciate ligament reconstruction in adolescent athletes: a retrospective case series.

Eur J Orthop Surg Traumatol 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedics, Penn State Health Milton S. Hershey Medical Center, 500 University Dr., 414 Hallmark South, Hershey, PA, 17033, USA.

Background: Multiple graft options exist for anterior cruciate ligament (ACL) reconstruction in an adolescent athlete. Patellar tendon harvest can lead to anterior knee pain, while hamstring tendon harvest can affect knee flexion strength and alter mechanics. Allograft is less desirable in pediatric patients due to the higher failure rate and slight risk of disease transmission. Read More

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[A new retractor to protect the popliteal vessels in open wedge high tibial osteotomy].

Oper Orthop Traumatol 2021 Jun 10. Epub 2021 Jun 10.

Gelenkchirurgie Orthopädie Hannover, Bertastr. 10, 30159, Hannover, Deutschland.

Objective: Establish a safe technique for high tibia osteotomy.

Indications: Varus deformity of proximal tibia, high tibia osteotomy indicated.

Contraindications: Correct placement of retractor not possible. Read More

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Outcomes of Joint Preservation Surgery in Valgus Ankle Arthritis Without Deltoid Ligament Insufficiency.

Foot Ankle Int 2021 Jun 10:10711007211016001. Epub 2021 Jun 10.

Seoul Foot and Ankle Center, Dubalo Orthopaedic Clinic, Seochogu, Seoul, Republic of Korea.

Background: To date, information about the role of proximal alignment correction in treating nontraumatic valgus ankle arthritis is limited. This study aimed to report outcomes of realignment surgery, including supramalleolar correction in valgus arthritic ankles without evidence of deltoid ligament insufficiency.

Methods: Thirteen patients (13 ankles) who underwent joint preservation surgery for valgus ankle arthritis without evidence of deltoid ligament insufficiency were reviewed. Read More

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Expansion of Spinal Canal with Lift-Open Laminoplasty: A New Method for Compression Cervical Myelopathy.

Authors:
Huan Wang Lei Zhang

Orthop Surg 2021 Jun 10. Epub 2021 Jun 10.

Spinal Surgery Unit, Shengjing Hospital of China Medical University, Shenyang, China.

Objective: This study is to introduce lift-open laminoplasty and verify the increase of the spinal canal area following this surgical technique according to the preoperative anatomical measurement.

Methods: There are 82 patients (43 male and 39 female) analyzed in our study from January 2019 to December 2020. The average age was 63. Read More

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Four-Dimensional CT Analysis of Dorsal Intercalated Segment Instability in patients with Suspected Scapholunate Instability.

J Wrist Surg 2021 Jun 22;10(3):234-240. Epub 2021 Jan 22.

Guilloz Imaging Department, Central Hospital, Nancy University Hospital, Nancy, France.

 In this study we sought to evaluate the contribution of dynamic four-dimensional computed tomography (4DCT) relative to the standard imaging work-up for the identification of the dorsal intercalated segment instability (DISI) in patients with suspected chronic scapholunate instability (SLI).  Forty patients (22 men, 18 women; mean age 46.5 ± 13. Read More

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Palmar Musculature: Does It Affect the Development of Carpal Tunnel Syndrome? A Pilot Study.

J Wrist Surg 2021 Jun 3;10(3):196-200. Epub 2021 Jan 3.

Departments of Orthopaedic Surgery and Radiology, School of Medicine, New York University, New York.

 The etiology of carpal tunnel syndrome (CTS) is multifactorial. Static mechanical characteristics of CTS have been described, but dynamic (muscular) parameters remain obscure. We believe that musculature overlying the transverse carpal ligament may have an effect on carpal tunnel pressure and may explain the prevalence of CTS in manual workers. Read More

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Evaluation of variations of the glenoid attachment of the inferior glenohumeral ligament by magnetic resonance arthrography.

Radiol Bras 2021 May-Jun;54(3):148-154

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP), Ribeirão Preto, SP, Brazil.

Objective: To evaluate the anatomical variations of the attachment of the inferior glenohumeral ligament (IGHL) to the anterior glenoid rim.

Materials And Methods: This was a retrospective review of 93 magnetic resonance arthrography examinations of the shoulder. Two radiologists, who were blinded to the patient data and were working independently, read the examinations. Read More

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Formation of three-dimensional bicontinuous structures via molten salt dealloying studied in real-time by in situ synchrotron X-ray nano-tomography.

Nat Commun 2021 Jun 9;12(1):3441. Epub 2021 Jun 9.

Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, NY, USA.

Three-dimensional bicontinuous porous materials formed by dealloying contribute significantly to various applications including catalysis, sensor development and energy storage. This work studies a method of molten salt dealloying via real-time in situ synchrotron three-dimensional X-ray nano-tomography. Quantification of morphological parameters determined that long-range diffusion is the rate-determining step for the dealloying process. Read More

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Torsion of the wandering spleen as an abdominal emergency: a case report.

BMC Surg 2021 Jun 9;21(1):289. Epub 2021 Jun 9.

Department of General Surgery, Amiri Medical Complex, Qargha Road, Afshar, Kabul, Afghanistan.

Background: Wandering spleen is a rare clinical entity with a less than 0.2% reporting incidence rate. In this case, the spleen is present abnormally in the abdominal or pelvic cavity instead of its normal anatomical location. Read More

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Clinical outcomes of arthroscopic and navigation-assisted two tunnel technique for coracoclavicular ligament augmentation of acute acromioclavicular joint dislocations.

BMC Musculoskelet Disord 2021 Jun 9;22(1):528. Epub 2021 Jun 9.

Division of Arthroscopy, Joint Surgery and Sport Injuries, Department of Orthopedics, Trauma, and Plastic Surgery, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.

Background: The purpose of this study was to present a navigated image-free augmentation technique for the acromioclavicular joint (ACJ) and coracoclavicular (CC) ligaments and to report the clinical and radiological outcomes.

Methods: From 2013 to 2018, 35 eligible patients were treated with our navigated image-free ACJ- and CC-augmentation technique. The average follow-up was 3 years. Read More

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Computational Breast Anatomy Simulation Using Multi-scale Perlin Noise.

IEEE Trans Med Imaging 2021 Jun 9;PP. Epub 2021 Jun 9.

Virtual clinical trials (VCTs) of medical imaging require realistic models of human anatomy. For VCTs in breast imaging, a multi-scale Perlin noise method is proposed to simulate anatomical structures of breast tissue in the context of an ongoing breast phantom development effort. Four Perlin noise distributions were used to replace voxels representing the tissue compartments and Cooper's ligaments in the breast phantoms. Read More

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