92,334 results match your criteria lifetime

Family Violence Exposure and Sexual Risk-Taking Among Latino Emerging Adults: The Role of Posttraumatic Stress Symptomology and Acculturative Stress.

J Fam Violence 2015 Nov 9;30(8):967-976. Epub 2015 Jun 9.

University of Arkansas, Fayetteville, AR 72701, USA.

This study proposes that posttraumatic stress symptomology and acculturative stress may further explain the relationship between family violence exposure and sexual risk-taking behaviors among Latino emerging adults (=1,100). A moderated mediation analysis indicated that lifetime rates of family violence exposure were positively associated with sexual risk-taking via posttraumatic stress symptomology, and this mediation significantly varied as a function of acculturative stress. Overall, the findings of the current study underscore a need for a better understanding of how family violence exposure puts Latino emerging adults at risk for aversive health outcomes and suggest the use of an ecological systemic framework that examines the interactions between family, individual, and cultural systems in relation to health risk-taking behaviors. Read More

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November 2015

Influences of COVID-19 pandemic lockdown on excess lifetime cancer risk value of natural radiation.

J Radioanal Nucl Chem 2021 Jul 27:1-8. Epub 2021 Jul 27.

Department of Physics, Faculty of Science, Al-Azhar University, Assiut, 71542 Egypt.

Abstract: This study focuses on the consequences of the COVID-19 pandemic on annual effective doses and excess lifetime cancer risk values due to ionizing radiation and radon which has been reported UNSCEAR 2000. The random data collection questionnaire method was applied to assess the indoor and outdoor occupancy factor for three age groups during the epidemic in Turkey. The results indicated age group C (Age > 65 y) has more influence from pandemic indoor and outdoor occupancy factor. Read More

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Positive attitudes to advance care planning - a Norwegian general population survey.

BMC Health Serv Res 2021 Aug 2;21(1):762. Epub 2021 Aug 2.

Centre for Medical Ethics, University of Oslo, Kirkeveien 166, Frederik Holsts hus, 0450, Oslo, Norway.

Background: Authorities recommend advance care planning and public acceptance of it is a prerequisite for widespread implementation. Therefore, we did the first study of the Norwegian public with an aim of getting knowledge on their attitudes to issues related to advance care planning.

Methods: An electronic survey to a nationally representative web panel of Norwegian adults. Read More

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Co-use of Tobacco Products and Cannabis among Veterans: A Preliminary Investigation of Prevalence and Associations with Mental Health Outcomes.

J Psychoactive Drugs 2021 Aug 1:1-8. Epub 2021 Aug 1.

Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

While tobacco product (such as combustible cigarettes and nicotine vaping products) and cannabis use rates remain high in the general United States (U.S.) population, veterans from the conflicts in Iraq and Afghanistan (i. Read More

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Sustainability in wood materials science: an opinion about current material development techniques and the end of lifetime perspectives.

Philos Trans A Math Phys Eng Sci 2021 Sep 2;379(2206):20200339. Epub 2021 Aug 2.

Swiss Wood Solutions AG, Überlandstrasse 129, 8600 Dübendorf, Switzerland.

Wood is considered the most important renewable resource for a future sustainable bioeconomy. It is traditionally used in the building sector, where it has gained importance in recent years as a sustainable alternative to steel and concrete. Additionally, it is the basis for the development of novel bio-based functional materials. Read More

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September 2021

Superoxide Ion and Singlet Oxygen Photogenerated by Metalloporphyrin-Based Metal-Organic Frameworks for Highly Efficient and Selective Photooxidation of a Sulfur Mustard Simulant.

ACS Appl Mater Interfaces 2021 Aug 1. Epub 2021 Aug 1.

College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou, Guangdong 510632, P. R. China.

The exploration of highly efficient materials for the degradation of chemical warfare agents has been a longstanding task for preventing human exposure. Herein, we report a series of metal-organic frameworks (MOFs) M-TCPP-La based on metallo-tetra(4-carboxyphenyl)porphyrin and La, which were applied to selectively oxidize 2-chloroethyl ethyl sulfide (CEES, a sulfur mustard simulant) as heterogeneous photocatalysts. After irradiation from a commercial blue light-emitting diode (LED), both superoxide ion and singlet oxygen were generated by M-TCPP-La and involved in selective oxidization of CEES to 2-chloroethyl ethyl sulfoxide (CEESO). Read More

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Cost-Utility Analysis of Fixed-Dose Combination of Indacaterol Acetate Glycopyrronium Bromide and Mometasone Furoate as a Maintenance Treatment in Adult Patients with Asthma Not Adequately Controlled with a Maintenance Combination of a Long-Acting Beta-Agonist and a High Dose of an Inhaled Corticosteroid Who Experienced One or More Asthma Exacerbations in the Previous Year.

Clin Drug Investig 2021 Jul 31. Epub 2021 Jul 31.

AdRes Health Economics and Outcome Research, Via Alfieri 17, 10121, Turin, Italy.

Background And Objective: In asthma, symptom control is a primary goal that is not consistently met with available treatment options. The first commercially available fixed-dose combination in a single inhaler of a long-acting beta-agonist (indacaterol, IND), an inhaled corticosteroid (mometasone furoate, MF) and a long-acting muscarinic antagonist (glycopyrronium, GLY) has shown promising clinical results in phase III trials. The aim of the present study is to evaluate the cost-utility of IND/GLY/MF fixed-dose combination relative to a combination of salmeterol/fluticasone and tiotropium or salmeterol/fluticasone or IND/MF in adult patients with asthma, from the Italian Health Service (NHS) perspective. Read More

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Automated detection of substance use information from electronic health records for a pediatric population.

J Am Med Inform Assoc 2021 Aug 1. Epub 2021 Aug 1.

Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Objective: Substance use screening in adolescence is unstandardized and often documented in clinical notes, rather than in structured electronic health records (EHRs). The objective of this study was to integrate logic rules with state-of-the-art natural language processing (NLP) and machine learning technologies to detect substance use information from both structured and unstructured EHR data.

Materials And Methods: Pediatric patients (10-20 years of age) with any encounter between July 1, 2012, and October 31, 2017, were included (n = 3890 patients; 19 478 encounters). Read More

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Mobilization and health risk assessment of fertilizer induced uranium in coastal groundwater.

Environ Res 2021 Jul 29:111791. Epub 2021 Jul 29.

Health Physics Division, BARC, Mumbai, India.

Uranium (U) in groundwater is hazardous to human health, especially if it is present in drinking water. The semiarid regions of southern India chiefly depend on groundwater for drinking purposes. In this regard, a comprehensive sampling strategy was adopted to collect groundwater representing different lithologies of the region. Read More

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Redox chemistry of lens crystallins: A system of cysteines.

Exp Eye Res 2021 Jul 29:108707. Epub 2021 Jul 29.

Department of Chemistry, Centro de Investigación y de Estudios Avanzados (Cinvestav), Mexico City, Mexico.

The nuclear region of the lens is metabolically quiescent, but it is far from inert chemically. Without cellular renewal and with decades of environmental exposures, the lens proteome, lipidome, and metabolome change. The lens crystallins have evolved exquisite mechanisms for resisting, slowing, adapting to, and perhaps even harnessing the effects of these cumulative chemical modifications to minimize the amount of light-scattering aggregation in the lens over a lifetime. Read More

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The first European consensus on principles of management for achondroplasia.

Orphanet J Rare Dis 2021 07 31;16(1):333. Epub 2021 Jul 31.

Central German Competence Network for Rare Diseases (MKSE), Dept of Pediatrics, University Hospital, Otto-von-Guericke University, Magdeburg, Germany.

Achondroplasia is the most common type of skeletal dysplasia, caused by a recurrent pathogenic variant in the fibroblast growth factor receptor 3 (FGFR3). The management of achondroplasia is multifaceted, requiring the involvement of multiple specialties across the life course. There are significant unmet needs associated with achondroplasia and substantial differences in different countries with regard to delivery of care. Read More

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Concentrations and health risks of heavy metals in five major marketed marine bivalves from three coastal cities in Guangxi, China.

Ecotoxicol Environ Saf 2021 Jul 28;223:112562. Epub 2021 Jul 28.

Department of Cell Biology, School of Life Sciences, and School of Medicine, Guangxi University, Nanning 530004, China. Electronic address:

Seafood consumption provides essential elements to humans while also posing risks to human health. A total of 2610 individuals of five edible marine bivalve species (Ruditapes philippinarum, Paphia undulata, Meretrix meretrix, Sinonovacula constricta and Meretrix lyrata) were randomly sampled from six farmer markets in three cities (Beihai, Qinzhou and Fangchenggang) in the southernmost coastal region of China. The concentrations of heavy metals (Cu, Pb, Zn, Cd, Cr, Hg and As) were determined by inductively coupled plasma mass spectrometry (ICP-MS). Read More

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A semi-Markov model comparing the lifetime cost-effectiveness of mesh prophylaxis to prevent parastomal hernia in patients undergoing end colostomy creation for rectal cancer.

Colorectal Dis 2021 Jul 31. Epub 2021 Jul 31.

The CIPHER study group investigators.

Aim: Parastomal hernia (PSH) is a common problem following colostomy. Using prophylactic mesh during end colostomy creation may reduce PSH incidence, but concerns exist regarding the optimal type of mesh, potential long-term complications, and cost-effectiveness of its use. We evaluated the cost-effectiveness of mesh prophylaxis to prevent PSH in patients undergoing end colostomy for rectal cancer. Read More

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A Cross-Sectional Study of Retired Great British Olympians (Berlin 1936-Sochi 2014): Olympic Career Injuries, Joint Health in Later Life, and Reasons for Retirement from Olympic Sport.

Sports Med Open 2021 Jul 31;7(1):54. Epub 2021 Jul 31.

Institute for Sport, PE and Health Sciences Moray House School of Education and Sport, University of Edinburgh, Edinburgh, UK.

Background: The relationship between Olympic career sport injury and the long-term musculoskeletal health of the elite athlete remains unclear. This study describes the lifetime prevalence of medical attention injuries that occurred during training and/or competition as part of the athlete's Olympic career, reasons for retirement from Olympic sport, and the point prevalence of pain and osteoarthritis (OA) among retired Great Britain's (GB) Olympians.

Methods: This cross-sectional study involved distributing a questionnaire to retired GB Olympians who had competed at 36 Olympic Games between Berlin 1936 and Sochi 2014. Read More

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Pre-existing thyroiditis ameliorates papillary thyroid cancer: insights from a new mouse model.

Endocrinology 2021 Jul 31. Epub 2021 Jul 31.

Division of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Ross Research Building-Room 656, 720 Rutland Avenue, Baltimore, MD, 21205, USA.

Papillary Thyroid Cancer (PTC) often co-occurs with Hashimoto's thyroiditis, an association that has long been reported in clinical studies yet remains controversial. Some studies, in fact, have suggested a protective effect of thyroiditis while others have not. We generated a mouse model where PTC and thyroiditis develop in a predictable manner, combining the oncogenic drive of the BRAF v600E mutation (inducible by tamoxifen) to the thyroiditis susceptibility of the NOD. Read More

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Myosin's powerstroke occurs prior to the release of phosphate from the active site.

Cytoskeleton (Hoboken) 2021 Jul 30. Epub 2021 Jul 30.

Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts.

Myosins are a family of motor proteins responsible for various forms of cellular motility, including muscle contraction and vesicular transport. The most fundamental aspect of myosin is its ability to transduce the chemical energy from the hydrolysis of ATP into mechanical work, in the form of force and/or motion. A key unanswered question of the transduction process is the timing of the force-generating powerstroke relative to the release of phosphate (P ) from the active site. Read More

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Nanoparticles for In Vivo Lifetime Multiplexed Imaging.

Methods Mol Biol 2021 ;2350:239-251

ARC Centre of Excellence for Nanoscale Biophotonics, RMIT University, Melbourne, Australia.

Lifetime multiplexed imaging refers to the simultaneous labeling of different structures with fluorescent probes that present identical photoluminescence spectra and distinct fluorescence lifetimes. This technique allows extracting quantitative information from multichannel in vivo fluorescence imaging. In vivo lifetime multiplexed imaging requires fluorophores with excitation and emission bands in the near-infrared (NIR) and tunable fluorescence lifetimes, plus an imaging system capable of time-resolved image acquisition and analysis. Read More

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January 2021

Fourier Multiplexed Fluorescence Lifetime Imaging.

Leilei Peng

Methods Mol Biol 2021 ;2350:157-172

Wyant College of Optical Science, University of Arizona, Tucson, AZ, USA.

Fluorescence lifetime imaging microscopy (FLIM) is a widely used functional imaging method in bioscience. Fourier multiplexed FLIM (FmFLIM), a frequency-domain lifetime measurement method, explores the principle of Fourier (frequency) multiplexing to achieve parallel lifetime detection on multiple fluorescence labels. Combining FmFLIM with a confocal scanning microscope allows multiplexed 3D lifetime imaging of cells and tissues. Read More

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January 2021

Weighted Lindley frailty model: estimation and application to lung cancer data.

Lifetime Data Anal 2021 Jul 30. Epub 2021 Jul 30.

Institute of Mathematical and Computer Sciences, University of São Paulo, São Paulo, São Carlos, 13566-590, Brazil.

In this paper, we propose a novel frailty model for modeling unobserved heterogeneity present in survival data. Our model is derived by using a weighted Lindley distribution as the frailty distribution. The respective frailty distribution has a simple Laplace transform function which is useful to obtain marginal survival and hazard functions. Read More

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Spectral Behavior and Photophysical Parameters of Dihydrophenanthro[9,10-e][1,2,4]Triazine Derivative Dyes in Sol-Gel and Methyl Methacrylate Polymer Matrices.

J Fluoresc 2021 Jul 30. Epub 2021 Jul 30.

Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.

This paper deals with the optical and photophysical properties of dihydrophenanthro[9,10-e][1,2,4]triazine fluorescent dyes doped in Silicate based sol-gel and homo-poly methyl methacrylate (PMMA). Solid hosts were found to effect on the optical and photophysical parameters such as molar absorptivity, cross sections of singlet-singlet electronic absorption and emission spectra, excited state lifetime, quantum yield of fluorescence. The dipole moment of electronic transition, the length of attenuation and oscillator strength of electronic transition from S → S have been calculated. Read More

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Responses to pictorial versus text-only cigarillo warnings among a nationally representative sample of US young adults.

Tob Control 2021 Jul 30. Epub 2021 Jul 30.

Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Background: The US Food and Drug Administration requires six text-only warnings for cigar products, including cigarillos. Research has demonstrated the superiority of pictorial over text-only cigarette warnings, yet the relative effectiveness of pictorial warnings for cigarillos has not been examined. We examined the impact of pictorial cigarillo warnings compared with text-only warnings. Read More

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Collaboration to Improve Neuroprotection and Neuropromotion in the NICU: Team Education and Family Engagement.

Neonatal Netw 2021 Jul;40(4):212-223

The number of babies born extremely low birth weight surviving to be discharged home after experiencing the NICU continues to improve. Unfortunately, early sensory development for these babies occurs in an environment vastly different from the intended in-utero environment and places them at high risk of long-term neurodevelopmental and neurocognitive challenges. Our goal in the NICU must transition from simply discharge home to supporting the neurosensory development necessary for a thriving lifetime. Read More

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Differences in Lifetime Earning Potential Between Pediatric and Adult Physicians.

Pediatrics 2021 Aug;148(2)

Departments of Pediatrics and Emergency Medicine, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.

Objectives: Compare lifetime earning potential between academic pediatric and adult medicine generalists and subspecialists. Evaluate the effect of decreasing the length of training for pediatric subspecialties whose length of training is longer than that for the adult medicine counterpart.

Methods: Using compensation and debt data from national physician surveys for 2019-2020, we estimated and compared the lifetime earning potential for academic pediatric and adult physicians. Read More

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The Names of Things: The 2018 Bernard Sachs Lecture.

William B Dobyns

Pediatr Neurol 2021 Jun 30. Epub 2021 Jun 30.

Division of Genetics and Metabolism, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota. Electronic address:

In 2018, I was honored to receive the Bernard Sachs Award for a lifetime of work expanding knowledge of diverse neurodevelopmental disorders. Summarizing work over more than 30 years is difficult but is an opportunity to chronicle the dramatic changes in the medical and scientific world that have transformed the field of Child Neurology over this time, as reflected in my own work. Here I have chosen to highlight five broad themes of my research beginning with my interest in descriptive terms that drive wider understanding and my choice for the title of this review. Read More

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Narrative arcs and shaping influences in long-term medication adherence.

Soc Sci Med 2021 Jul 24;285:114264. Epub 2021 Jul 24.

Department of Marketing, University of Tennessee, 321 Stokely Management Center, 916 Volunteer Boulevard, Knoxville, TN, 37996-0530, USA. Electronic address:

Long-term adherence to medications is not well understood and poses a significant challenge for many chronically ill persons. Past research provides insights on adherence in short durations such as a day or several weeks, even though chronically ill patients are required to take medications for periods as long as a lifetime. To fill this important knowledge gap, we study the temporal unfolding of prolonged medication-taking experiences among thirty adults, mostly African American, with chronic hypertension in the U. Read More

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Assessment of toxicity and potential health risk from persistent pesticides and heavy metals along the Delhi stretch of river Yamuna.

Environ Res 2021 Jul 27:111780. Epub 2021 Jul 27.

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.

The present study aims at the assessment of environmental quality of the most polluted stretch of river Yamuna along the megacity of Delhi. The study was conducted in order to examine toxicity and health hazards associated with persistent pollutants present in the fluvial ecosystem. Eighty four sediment and 56 vegetable samples from same locations were collected from the Delhi segment of river Yamuna flood plain in order to examine 20 organochlorine pesticides (OCPs) and 9 heavy metals (Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn). Read More

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NPAHs and OPAHs in the atmosphere of two central European cities: Seasonality, urban-to-background gradients, cancer risks and gas-to-particle partitioning.

Sci Total Environ 2021 Jun 25;793:148528. Epub 2021 Jun 25.

RECETOX Centre, Masaryk University, Czech Republic.

Derivatives of polycyclic aromatic hydrocarbons (PAHs) such as nitrated- and oxygenated-PAHs (NPAHs and OPAHs) could be even more toxic and harmful for the environment and humans than PAHs. We assessed the spatial and seasonal variations of NPAHs and OPAHs atmospheric levels, their cancer risks and their gas-to-particle partitioning. To this end, about 250 samples of fine particulate matter (PM) and 50 gaseous samples were collected in 2017 in central Europe in the cities of Brno and Ljubljana (two traffic and two urban background sites) as well as one rural site. Read More

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In Situ Membrane Biotinylation Enables the Direct Labeling and Accurate Kinetic Analysis of Small Extracellular Vesicles in Circulation.

Anal Chem 2021 Jul 30. Epub 2021 Jul 30.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

Circulating small extracellular vesicles (sEVs) are naturally occurring nanosized membrane vesicles that convey bioactive molecules between cells. Conventionally, to evaluate their behaviors in vivo, circulating sEVs have to be isolated from the bloodstream, then labeled with imaging materials in vitro, and finally injected back into the circulation of animals for subsequent detection. The tedious isolation-labeling-reinfusion procedures might have an undesirable influence on the natural properties of circulating sEVs, thereby changing their behaviors and the detected kinetics in vivo. Read More

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A General and Predictive Understanding of Thermal Transport from 1D- and 2D-Confined Nanostructures: Theory and Experiment.

ACS Nano 2021 Jul 30. Epub 2021 Jul 30.

Physics Department, Universitat Autònoma de Barcelona, Bellaterra, Catalonia 08193, Spain.

Heat management is crucial in the design of nanoscale devices as the operating temperature determines their efficiency and lifetime. Past experimental and theoretical works exploring nanoscale heat transport in semiconductors addressed known deviations from Fourier's law modeling by including parameters, such as a size-dependent thermal conductivity. However, recent experiments have qualitatively shown behavior that cannot be modeled in this way. Read More

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