27,959 results match your criteria lifetime risk

Cardiovascular risk factors and major depressive disorder: a cross-sectional study in São Paulo, Brazil.

Sao Paulo Med J 2021 Jun 11. Epub 2021 Jun 11.

MD, PhD. Deputy Coordinator, Center for Clinical and Epidemiological Research, Hospital Universitário (HU), Universidade de Sao Paulo, Sao Paulo, SP, BR, and Full Professor, Department of Internal Medicine, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Background: Cardiovascular risk factors can mediate the association between depression and cardiovascular diseases.

Objective: To evaluate cardiovascular risk factors in adult individuals with and without histories of major depression in the metropolitan region of São Paulo, Brazil.

Design And Setting: Cross-sectional study in São Paulo (SP), Brazil. Read More

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[,,It overtook my body and soul": The experience of individuals receiving health-promoting service, of psychological trauma and health-related problems].

Laeknabladid 2021 Jul;107(7-8):337-344

University of Akureyri, Iceland.

Introduction: Accumulating evidence shows that those having experienced psychological trauma have increased risk of complex health problems. In primary health care health-promoting services are offered to individuals with complex health problems, based on an individualized approach. Trauma focused approach in healthcare help individuals increase quality of life after psychological trauma. Read More

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The role of national carbon pricing in phasing out China's coal power.

iScience 2021 Jun 27;24(6):102655. Epub 2021 May 27.

School of Economics and Management, North China Electric Power University, Beijing, 102206, China.

As the country with the world's largest coal power capacity, China is launching a national carbon market. How the carbon pricing may contribute to phasing out China's coal power is a great concern. We collect full-sample data set of China's 4540 operating coal plant units and develop a stochastic Monte-Carlo financial model to assess the financial sustainability of the plant operation. Read More

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Mitochondrial Disorders.

Dtsch Arztebl Int 2021 Oct 1(Forthcoming). Epub 2021 Oct 1.

Background: Mitochondrial disorders are among the most common heritable diseases, with an overall lifetime risk of approximately one in 1500. Nonetheless, their diagnosis is often missed because of their extreme phenotypic and genotypic heterogeneity.

Methods: This review is based on publications retrieved by a selective literature search on the clinical features, genetics, pathogenesis, diagnosis, and treatment of mitochondrial diseases. Read More

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October 2021

A national survey on depressive and anxiety disorders in Afghanistan: A highly traumatized population.

BMC Psychiatry 2021 Jun 22;21(1):314. Epub 2021 Jun 22.

Dept of Mental Health & Substance Abuse, Primary Health Care Directorate, Ministry of Public Health, Kabul, Afghanistan.

Background: This survey attempts to measure at a national level, exposures to major traumas and the prevalence of common mental health disorders in a low-income dangerous country, highly affected by conflicts: Afghanistan.

Methods: Trans-sectional probability survey in general population by multistage sampling in 8 provinces, represented nationwide: 4445 adults (4433 weighted),15 years or older, 81% participation rate. Face to face interviews used specific scales for measuring lifetime exposure (LEC 5 Life Events Checklist) and Post Traumatic Stress Disorder (PTSD Check List), a diagnostic standardized interview: Composite International Diagnostic Interview (Short Form) for. Read More

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Polycyclic aromatic hydrocarbons (PAHs) and their derivatives (oxygenated PAHs, azaarenes, and sulfur / oxygen-containing heterocyclic PAHs) in surface soils from a typical city, south China.

Chemosphere 2021 Jun 16;283:131190. Epub 2021 Jun 16.

Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China. Electronic address:

Polycyclic aromatic hydrocarbons derivatives (dPAHs) were reported to be more mutagenic than parent analogues, however, studies that involving dPAHs in environmental samples are still limited. Thirty-six polycyclic aromatic compounds (PACs; 17 parent PAHs, 1 alkyl-PAH, 6 oxygenated PAHs, 6 azaarenes, 3 sulfur-containing heterocyclic PAHs, and 3 oxygen-containing heterocyclic PAHs) were analyzed in n = 100 surface soil samples collected from a prefecture-level city (hereafter referred to as D city) in South China, in the year 2019. Total concentrations of 36 PACs ranged from 3. Read More

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Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.

PLoS One 2021 22;16(6):e0253005. Epub 2021 Jun 22.

Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida, United States of America.

Objectives: To estimate the seroprevalence of Chlamydia trachomatis (CT), herpes simplex type-2 (HSV2), hepatitis C (HCV), Epstein-Barr virus (EBV) and nine human papilloma virus (HPV) types, and investigated factors associated with the seropositivity among men from three countries (Brazil, Mexico and U.S).

Methods: Archived serum specimens collected at enrollment for n = 600 men were tested for antibodies against CT, HSV2, HCV, EBV, and 9-valent HPV vaccine types (6/11/16/18/31/33/45/52/58) using multiplex serologic assays. Read More

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Health Literacy for Children and Families.

Br J Clin Pharmacol 2021 Jun 21. Epub 2021 Jun 21.

Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

The relationship between reading ability and health, known as health literacy, broadly reflects the skills and competencies required to operate within the healthcare environment. It is only recently that we have seen attempts to conceptualize health literacy in the context of medication use by using terms such as medication literacy. Health literacy changes over one's lifetime and is dependent on factors such as numeracy, education, income, gender, and country. Read More

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Shift in Living Kidney Donor Demographics Over the Past 50 Years in a German Transplant Center.

Ann Transplant 2021 Jun 22;26:e929693. Epub 2021 Jun 22.

Department of Nephrology, Ruprecht Karls University, Heidelberg, Germany.

BACKGROUND Living kidney donors may face health risks after donation. Age, sex, body mass index, comorbidities, and relationship to the recipient have an impact on lifetime living kidney donor risk. In view of a changing landscape in renal transplantation with increasing organ shortages, the selection criteria for potential donors may have changed over time. Read More

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Comparison of original and modified Q risk 2 risk score with Framingham risk score - An Indian perspective.

Indian Heart J 2021 May-Jun;73(3):353-358. Epub 2021 Jan 19.

Department of Cardiology, NRS Medical College, Kolkata, India. Electronic address:

Objective: No study among Indian population has proposed modification of existing cardiovascular disease (CVD) risk scores or novel risk scores as risk estimation using conventional risk calculators can't be generalized because of epidemiological differences.

Material And Methods: A single center observational study was performed at a tertiary care center among participants having no evidence of CVD. Prevalence of various cardiac risk factors were analysed and 10-year risk was estimated using Framingham risk score (FRS), Q risk 2 score calculator (QRISK2) and Modified Q risk 2 (mQRISK2) which included smokeless tobacco consumption. Read More

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January 2021

Occupational exposure to polycyclic aromatic hydrocarbons and risk of prostate cancer.

Environ Health 2021 Jun 21;20(1):71. Epub 2021 Jun 21.

Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Université du Québec, 531 Boulevard des Prairies, Laval, Québec, H7V 1B7, Canada.

Background: Several industries entailing exposure to polycyclic aromatic hydrocarbons (PAHs) are known or suspected carcinogens. A handful of studies have assessed the role of PAHs exposure in prostate cancer risk, but none has examined tumor aggressiveness or the influence of screening practices and detection issues. We aimed to examine the association between lifetime occupational exposure to PAHs and prostate cancer risk. Read More

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Potential Cost-Effectiveness of Risk-Based Pancreatic Cancer Screening in Patients With New-Onset Diabetes.

J Natl Compr Canc Netw 2021 Jun 21:1-9. Epub 2021 Jun 21.

1CHOICE Institute, Department of Pharmacy, University of Washington, Seattle, Washington.

Background: There are no established methods for pancreatic cancer (PAC) screening, but the NCI and the Pancreatic Cancer Action Network (PanCAN) are investigating risk-based screening strategies in patients with new-onset diabetes (NOD), a group with elevated PAC risk. Preliminary estimates of the cost-effectiveness of these strategies can provide insights about potential value and inform supplemental data collection. Using data from the Enriching New-Onset Diabetes for Pancreatic Cancer (END-PAC) risk model validation study, we assessed the potential value of CT screening for PAC in those determined to be at elevated risk, as is being done in a planned PanCAN Early Detection Initiative trial. Read More

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Childhood adversity links to self-reported mood, anxiety, and stress-related disorders.

Alan R King

J Affect Disord 2021 Jun 6;292:623-632. Epub 2021 Jun 6.

University of North Dakota, Psychology Department, Stop 8380, Grand Forks, ND 58202-8380, United States. Electronic address:

Background: Child abuse has been identified within the DSM-5 as a putative etiologic risk for over two dozen psychiatric disorders.

Methods: This study examined associations between self-reported diagnostic histories of six Mood, Anxiety and Stress-Related Disorders and childhood adversities measured using dichotomous ACE (Adverse Childhood Experiences) counts and dimensional indices of child abuse.

Results: Adversity odds ratio were all significant (p < . Read More

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Discrimination, High-Effort Coping, and Cardiovascular Risk Profiles in the Jackson Heart Study: a Latent Profile Analysis.

J Racial Ethn Health Disparities 2021 Jun 21. Epub 2021 Jun 21.

Department of Medicine, University of Mississippi Medical Center, Jackson, 39216, MS, USA.

African Americans exhibit heightened risk of cardiovascular disease (CVD) necessitating further examination of biological pathways contributing to CVD incidence. An integrated specificity model suggests discrimination elicits psychophysiological responses that contribute to allostatic load (AL) but may differ by level of perceived discrimination and coping style. Differing psychophysiological risk responses may contribute to varying CVD risk patterns overtime. Read More

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Metagenomics to Identify Pathogens in Diabetic Foot Ulcers and the Potential Impact for Clinical Care.

Curr Diab Rep 2021 Jun 21;21(8):26. Epub 2021 Jun 21.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Purpose Of Review: Diabetes mellitus may affect every third adult American by 2050, and about one-third will develop a diabetic foot ulcer (DFU) during their lifetime. The current standard of care results in healing of less than 50% of all DFUs. Many individuals with DFU develop limb-threatening infection which place them at risk for additional morbidity and mortality. Read More

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Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash.

Rheumatology (Oxford) 2021 Jun 21. Epub 2021 Jun 21.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Objectives: Myositis-specific autoantibodies (MSAs) define distinct clinical subsets of idiopathic inflammatory myopathies (IIMs). The anti-nuclear matrix protein 2 (NXP2) antibody, a MSA detected in juvenile/adult IIMs, has been reported to be associated with a high risk of subcutaneous calcinosis, subcutaneous oedema, and internal malignancies. The study aimed to clarify the clinical features of anti-NXP2 antibody-positive IIMs in detail. Read More

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Effect of human body position on gamma radiation dose rate from granite stones.

J Environ Health Sci Eng 2021 Jun 26;19(1):933-939. Epub 2021 Apr 26.

Faculty of Engineering, University of Kyrenia, TRNC, via Mersin 10, Kyrenia, Turkey.

The use of granite stones as building materials in homes or offices can result in the residents' long-term whole-body exposure to gamma radiation. Although the whole-body annual dose has been investigated in the literature, it is obvious that different human organs receive different equivalent dose due to different position respect to the walls and floor covered by granite stones. In this paper, the effect of distance from the walls and floor of a room on the equivalent dose is investigated by using MCNPX code. Read More

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Assessment of incremental lifetime cancer risks of ambient air PM-bound PAHs in oil-rich cities of Iran.

J Environ Health Sci Eng 2021 Jun 12;19(1):319-330. Epub 2021 Jan 12.

Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This study investigates the concentrations of PM-bound PAHs and their seasonal variations in three cities of Ahvaz, Abadan, and Asaluyeh in Iran. The mean concentrations of PM in two warm and cold seasons in Ahvaz were higher and in Abadan and Assaluyeh were lower than the national standard of Iran and the guidelines of the World Health Organization. The Σ16 PAHs concentration in ambient air PM during the cold season in Ahvaz, Abadan and Asaluyeh was 244. Read More

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Benzene emissions from gas station clusters: a new framework for estimating lifetime cancer risk.

J Environ Health Sci Eng 2021 Jun 7;19(1):273-283. Epub 2021 Jan 7.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W 168th St., New York, NY 10032 USA.

Purpose: During gas station operation, unburned fuel can be released to the environment through distribution, delivery, and storage. Due to the toxicity of fuel compounds, setback distances have been implemented to protect the general population. However, these distances treat gasoline sales volume as a categorical variable and only account for the presence of a single gas station and not clusters, which frequently occur. Read More

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Threshold Analysis of the Cost-effectiveness of Endoscopic Ultrasound in Patients at High Risk for Pancreatic Ductal Adenocarcinoma.

Pancreas 2021 Jun 19. Epub 2021 Jun 19.

From the Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA Division of Digestive and Liver Diseases, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY Division of Gastroenterology, St Luke's University Health Network, Allentown, PA Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA Division of Gastroenterology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: Data from the International Cancer of the Pancreas Screening Consortium studies have demonstrated that screening for pancreatic ductal adenocarcinoma can be effective and that surveillance improves survival in high-risk individuals. Endoscopic ultrasound (EUS) and cross-sectional imaging are both used, although there is some suggestion that EUS is superior. Demonstration of the cost-effectiveness of screening is important to implement screening in high-risk groups. Read More

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Exposure to anesthesia is not associated with development of α-synucleinopathies: A nested case-control study.

Parkinsonism Relat Disord 2021 Jun 8;88:76-81. Epub 2021 Jun 8.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address:

Introduction: Preclinical studies suggest that inhalational anesthetics may induce neuropathology changes in the nigrostriatal system, leading to development of α-synucleinopathies. We explored the role of general anesthesia in the development of Parkinson disease (PD) and other α-synucleinopathies.

Methods: All α-synucleinopathy cases in Olmsted County, Minnesota, from January 1991, to December 2010, were identified from diagnostic codes, and then reviewed for type and index date of diagnosis. Read More

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Current Resources for Evidence-Based Practice, July 2021.

Marit L Bovbjerg

J Obstet Gynecol Neonatal Nurs 2021 Jun 17. Epub 2021 Jun 17.

An extensive review of new resources to support the provision of evidence-based care for women and infants. The current column includes a discussion of how fetal monitoring may lead to overuse of birth-related interventions, commentaries on reviews focused on bedsharing, and women's lifetime estrogen exposure and risk of cardiovascular mortality. Read More

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Hypertension in Women Across the Lifespan.

Curr Atheroscler Rep 2021 Jun 19;23(8):43. Epub 2021 Jun 19.

Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, 622 West 168th Street, PH 3-342, New York, NY, 10032, USA.

Purpose Of Review: We will highlight the biological processes across a women's lifespan from young adulthood through menopause and beyond that impact blood pressure and summarize women's representation in hypertension clinical trials.

Recent Findings: Throughout their lifetime, women potentially undergo several unique sex-specific changes that may impact their risk of developing hypertension. Blood pressure diagnostic criteria for pregnant women remains 140/90 mmHg and has not been updated for concordance with the 2017 ACC/AHA guideline due to a lack of data. Read More

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Levels of polycyclic aromatic hydrocarbons in edible and fried vegetable oil: a health risk assessment study.

Environ Sci Pollut Res Int 2021 Jun 19. Epub 2021 Jun 19.

School of Food & Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, 526061, China.

Polycyclic aromatic hydrocarbons (PAHs) are environmental chemicals that are formed due to incomplete combustion of the organic matters, or during heat treatment of the food. The objectives of the present study were first to estimate levels of the 15-priority PAHs in the edible vegetable oil (corn oil, sunflower oil, olive oil, and canola oil) collected from Egypt. Furthermore, the effect of heat treatment on the formation of PAHs in the canola oil was further examined. Read More

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The Boston Assessment of Traumatic Brain Injury-Lifetime Semistructured Interview for Assessment of TBI and Subconcussive Injury Among Female Survivors of Intimate Partner Violence: Evidence of Research Utility and Validity.

J Head Trauma Rehabil 2021 Jun 15. Epub 2021 Jun 15.

Translational Research Center for TBI and Stress Disorders and Geriatric Research, Education and Clinical Center (Drs Fortier Kim, and Fonda and Mss Beck and Currao), and Women's Health Sciences Division, National Center for PTSD (Drs Iverson and Galovski), VA Boston Healthcare System, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (Dr Fortier); Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts (Drs Iverson, Fonda, and Galovski); and College of Nursing, University of Missouri Saint Louis (Dr Werner).

Objective: To adapt the Boston Assessment of TBI-Lifetime (BAT-L) interview specifically for female survivors of intimate partner violence (IPV), validate the adapted BAT-L/IPV, and report the prevalence of head injury.

Setting: The BAT-L is the first validated instrument to diagnose traumatic brain injuries (TBIs) throughout the life span for post-9/11 veterans. The BAT-L/IPV was adapted to target diagnostic issues belonging exclusively to IPV while maintaining its life span approach. Read More

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The real-world cost-effectiveness of bariatric surgery for the treatment of severe obesity: a cost-utility analysis.

CMAJ Open 2021 Apr-Jun;9(2):E673-E679. Epub 2021 Jun 18.

Departments of Surgery (Lester, Birch) and Medicine (Padwal, Sharma, So, Ye, Klarenbach), University of Alberta, Edmonton, Alta.

Background: Severe obesity is associated with adverse health outcomes and increased risk of death. This study evaluates the real-world cost-utility of therapy for severe obesity, from the publicly funded health care system and societal perspectives.

Methods: We conducted a cost-utility analysis using primary data from a prospective observational cohort of adults living with severe obesity (BMI ≥ 35 kg/m and a major medical comorbidity or BMI ≥ 40 kg/m) who were enrolled in a regional obesity program over 2 years. Read More

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JCL Roundtable: Global Think Tank on Lipoprotein(a).

J Clin Lipidol 2021 May-Jun;15(3):387-393

Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA. Electronic address:

Lipoprotein(a) operates in causal pathways to promote atherosclerosis, arterial thrombosis, and aortic stenosis. It has been associated with rare cases of nonatherosclerotic arterial thrombotic stroke at any age. Inherited variation of lipoprotein(a) levels substantially increases cardiovascular risk in 20% of people worldwide. Read More

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Return on investment of self-measured blood pressure is associated with its use in preventing false diagnoses, not monitoring hypertension.

PLoS One 2021 18;16(6):e0252701. Epub 2021 Jun 18.

Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, United States of America.

Previous research indicates that patient self-measured blood pressure (SMBP) is a cost-effective strategy for improving hypertension (HTN) diagnosis and control. However, it is unknown which specific uses of SMBP produce the most value. Our goal is to estimate, from an insurance perspective, the return-on-investment (ROI) and net present value associated with coverage of SMBP devices when used (a) only to diagnose HTN, (b) only to select and titrate medication, (c) only to monitor HTN treatment, or (d) as a bundle with all three uses combined. Read More

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