7,260 results match your criteria life-threatening events


A new strategy for uncontrollable bleeding after treatment with rivaroxaban or apixaban.

Clin Adv Hematol Oncol 2019 Sep;17 Suppl 15(9):1-20

Massachusetts General Hospital, Boston, Massachusetts.

Anticoagulants are used in several settings to reduce the risk of thromboembolic events, but they can be associated with severe complications, such as potentially fatal bleeding. Two of the most widely used direct oral anticoagulants (DOACs), rivaroxaban and apixaban, are factor Xa inhibitors. If a patient receiving treatment with a factor Xa inhibitor presents with a major bleeding event, the physician must determine whether reversal of anticoagulation is needed. Read More

View Article and Full-Text PDF
September 2019

Inflammatory markers in autoimmunity induced by checkpoint inhibitors.

J Cancer Res Clin Oncol 2021 Apr 10. Epub 2021 Apr 10.

Department of Dermatology, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.

Purpose: Immune checkpoint inhibitors (ICI) are highly effective in several cancer entities, but also invoke a variety of immune-related adverse events (irAE). These are mostly reversible, but can be life-threatening or even fatal. Currently, the pathogenesis is not fully understood, but crucial for effective treatment. Read More

View Article and Full-Text PDF

COMPLEX CHEST WALL DEFORMITY CAUSING CARDIAC ARREST: A PECULIAR PEDIATRIC CASE.

Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):59-60. Epub 2021 Apr 8.

Department of Pediatric Surgery. Centro Hospitalar Universitário São João. Porto, Portugal.

Introduction: Congenital chest wall deformities are common in children, causing self and parental concern mainly due to cosmesis. These defects rarely cause severe symptoms in patients.

Case Report: 11-year-old girl with a complex chest wall deformity and severe scoliosis causing progressive neurological loss of function. Read More

View Article and Full-Text PDF

Real-World Observational Review of Andexanet Alfa Prescribing and Utilization Outcomes at a Community Teaching Hospital.

Crit Care Explor 2021 Apr 2;3(4):e0356. Epub 2021 Apr 2.

Ernest Mario School of Pharmacy-Rutgers University, Livingston, NJ.

Objectives: Andexanet alfa is the first approved antidote in the management of life-threatening bleeds in patients treated with Xa inhibitors. The ANNEXA-4 study was successful in reducing factor Xa levels during time of administration but lacked correlation to improved patient outcomes. Given its novel mechanism of action, U. Read More

View Article and Full-Text PDF

Pheochromocytoma Crisis in the Emergency Department.

Cureus 2021 Mar 3;13(3):e13683. Epub 2021 Mar 3.

Emergency Medicine, San Antonio Military Medical Center, San Antonio, USA.

Pheochromocytoma is a rare, often undiagnosed adrenal tumor that typically presents in early adulthood and is characterized by intermittent surges of catecholamines. While this "Great Mimic" may present with a variety of vague complaints such as headache, abdominal pain, or palpitations, it may also appear as a severely hypertensive patient with multi-organ failure and cardiopulmonary collapse known as pheochromocytoma crisis. Management of hypertensive emergency in these patients is unique, and the associated metabolic derangements, coagulopathy, thromboembolic events, and risk of adrenal capsule rupture add significant complexity, morbidity, and mortality to these cases. Read More

View Article and Full-Text PDF

Case report of recurring pneumonia due to unusual foreign body aspiration in the airway.

Medwave 2021 Mar 25;21(2):e8136. Epub 2021 Mar 25.

Hospital Regional Docente de Trujillo, Trujillo, Perú. ORCID: 0000-0001-5453-8998.

Foreign body aspiration is a rare but life-threatening event. Most accidental aspiration events occur in children. In adults, it can represent up to 25% of cases. Read More

View Article and Full-Text PDF

Clinical and genetic characteristics and course of congenital long QT syndrome in children: A nine-year single-center experience.

Anatol J Cardiol 2021 Apr;25(4):250-257

Department of Pediatric Cardiology, Istanbul Saglik Bilimleri University Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.

Objective: Long QT syndrome (LQTS) is an inherited primary arrhythmia syndrome associated with life-threatening ventricular arrhythmias and sudden death. This study aimed to report the clinical and genetic characteristics and outcomes of children diagnosed as having LQTS in a tertiary pediatric cardiology center in Turkey.

Methods: This was a retrospective review of pediatric patients diagnosed as having LQTS at our center from January 2011 to April 2020. Read More

View Article and Full-Text PDF

Causality assessment between reported fatal cerebral haemorrhage and suspected drugs: developing a new algorithm based on the analysis of the Japanese Adverse Event Report (JADER) database and literature review.

Authors:
Miki Ohta

Eur J Clin Pharmacol 2021 Apr 7. Epub 2021 Apr 7.

Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

Purpose: Cerebral haemorrhage is a life-threatening event with various causes including adverse drug reactions (ADRs). Several methods have been proposed for the causality assessment of ADRs, but none specific for cerebral haemorrhage. The purpose of this study was to develop an algorithm for causality assessment between drugs and fatal cerebral haemorrhage, based on the analysis of data from the Japanese Adverse Drug Event Report (JADER) database and literature review. Read More

View Article and Full-Text PDF

A Review of Cancer Immunotherapy Toxicity: Immune Checkpoint Inhibitors.

J Med Toxicol 2021 Apr 7. Epub 2021 Apr 7.

Cook County Health, Department of Emergency Medicine, Division of Medical Toxicology, 1950 W Polk Street, 7th Floor, Chicago, IL, 60612, USA.

Cancer immunotherapy, which leverages features of the immune system to target neoplastic cells, has revolutionized the treatment of cancer. The use of these therapies has rapidly expanded in the past two decades. Immune checkpoint inhibitors represent one drug class within immunotherapy with its first agent FDA-approved in 2011. Read More

View Article and Full-Text PDF

Euglycemic Diabetic Ketoacidosis and Sodium-Glucose Cotransporter-2 Inhibitors: A Focused Review of Pathophysiology, Risk Factors, and Triggers.

Cureus 2021 Mar 3;13(3):e13665. Epub 2021 Mar 3.

Department of Medicine, Ateneo de Manila School of Medicine and Public Health, Quezon City, PHL.

Diabetic ketoacidosis (DKA) is an acute and significant life-threatening complication of diabetes. The association of sodium-glucose cotransporter-2 inhibitors (SGLT2i) with euglycemic diabetic ketoacidosis (EDKA) has been well reported. This literature review was conducted to understand the mechanism of EDKA and identify the potential risk factors and precipitants for patients taking SGLT2i. Read More

View Article and Full-Text PDF

Impact of Coronary Artery Disease and Percutaneous Coronary Intervention on Transcatheter Aortic Valve Implantation.

J Interv Cardiol 2021 24;2021:6672400. Epub 2021 Mar 24.

Department of Cardiology, Rangueil University Hospital, Toulouse, France.

Introduction: The prevalence of coronary artery disease (CAD) detected in preoperative work-up for transcatheter aortic valve implantation (TAVI) is high. Instead, the management of a concomitant CAD remains unclear. We evaluate the impact of CAD and percutaneous coronary intervention (PCI) on TAVI procedures. Read More

View Article and Full-Text PDF

Evolution in the Presentation, Treatment, and Outcomes of Patients with Acute Mesenteric Ischemia.

Ann Vasc Surg 2021 Apr 3. Epub 2021 Apr 3.

Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, MA.

Objectives: Acute mesenteric ischemia (AMI) is a life-threatening condition associated with dismal outcomes. This study sought to evaluate the evolution of presentation, treatment, and outcomes of AMI over the past two decades.

Methods: AMI patients presenting at a single institution were reviewed (1993-2016). Read More

View Article and Full-Text PDF

The Effectiveness and Tolerability of Anti-Seizure Medication in Alcohol Withdrawal Syndrome: A Systematic Review, Meta-Analysis and GRADE of the evidence.

Addiction 2021 Apr 6. Epub 2021 Apr 6.

National Addiction Centre and the Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London and South London and the Maudsley NHS Foundation Trust.

Background And Aims: Anti-seizure medications (ASMs) have been used historically as treatment options in alcohol withdrawal syndrome (AWS). In the past 10 years, there have been no large-scale meta-analyses comparing ASMs with placebo or the current AWS treatment standard, benzodiazepines. We aimed to evaluate the efficacy and tolerability of ASMs in AWS. Read More

View Article and Full-Text PDF

Adverse effects of COVID-19 mRNA-1273 vaccine: A randomized, cross-sectional study on healthcare workers with detailed self-reported symptoms.

J Med Virol 2021 Apr 6. Epub 2021 Apr 6.

Internal Medicine, Temple University Hospital, Philadelphia, USA.

Importance: There are concerns regarding the side effects of the new COVID-19 mRNA-1273 vaccine among healthcare workers (HCWs) in the United States OBJECTIVE: To investigate the side effects of the mRNA-1273 vaccine with detailed review of organ systems METHODS: A randomized, cross-sectional study using an independent online survey questionnaire with responses from HCWs RESULTS: Of all participants, 87.8% (1116/1271) provided complete responses. Of them, 38. Read More

View Article and Full-Text PDF

A Review of Cancer Immunotherapy Toxicity II: Adoptive Cellular Therapies, Kinase Inhibitors, Monoclonal Antibodies, and Oncolytic Viruses.

J Med Toxicol 2021 Apr 5. Epub 2021 Apr 5.

Department of Emergency Medicine, Division of Medical Toxicology, Cook County Health, 1950 W Polk Street, 7th Floor, Chicago, IL, 60612, USA.

Immunotherapy for cancer has undergone a rapid expansion in classes, agents, and indications. By utilizing aspects of the body's innate immune system, immunotherapy has improved life expectancy and quality of life for patients with several types of cancer. Adoptive cellular therapies, including chimeric antigen receptor T (CAR T) cell therapy, involve the genetic engineering of patient T cells to allow for targeting of neoplastic cells. Read More

View Article and Full-Text PDF

A Common 3'UTR Variant of the Gene Is Associated With Infant Life-Threatening and Sudden Death Events in the Italian Population.

Front Neurol 2021 19;12:642735. Epub 2021 Mar 19.

Laboratorio di Genetica e Genomica delle Malattie Rare, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Giannina Gaslini, Genoa, Italy.

Heterozygous mutations in the Paired like homeobox 2b () gene are causative of congenital central hypoventilation syndrome (CCHS), a rare monogenic disorder belonging to the family of neurocristopathies and due to a defective development of the autonomic nervous system. Most patients manifest sudden symptoms within 1 year of birth, mainly represented by central apnea and cyanosis episodes. The sudden appearance of hypoxic manifestations in CCHS and their occurrence during sleep resemble two other unexplained perinatal disorders, apparent life-threatening event (ALTE) and sudden and unexpected infant death (SUID), among which the vast majority is represented by sudden infant death syndrome (SIDS). Read More

View Article and Full-Text PDF

Cardiac adverse events associated with anti-PD-1 therapy in patients treated for advanced melanoma: relevance of dosing troponin T levels.

Eur J Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Department of Oncodermatology, Université de Nantes, CHU Nantes, CIC 1413, CRCINA, Nantes, France.

Background: Immune checkpoint inhibitors have improved the management of metastatic melanoma, however, we have witnessed an emergence of adverse cardiac events such as myocarditis.

Objectives: We first aimed to assess the prevalence of adverse cardiac events in patients treated with anti-PD-1 for metastatic melanoma. Our second objective was to determine the role of troponin monitoring in the diagnosis of these events. Read More

View Article and Full-Text PDF

A Normal Electrocardiogram Does Not Exclude Infra-Hisian Conduction Disease in Patients With Myotonic Dystrophy Type 1.

JACC Clin Electrophysiol 2021 Mar 25. Epub 2021 Mar 25.

Barts Heart Centre, St. Bartholomew's Hospital, London, United Kingdom. Electronic address:

Objectives: This study aimed to identify electrocardiographic (ECG) predictors of a prolonged His-ventricular (HV) interval in patients with type 1 myotonic dystrophy (DM1).

Background: Patients with DM1 have an increased risk of sudden cardiac death. The presence of His-Purkinje system disease/prolonged HV interval (≥70 ms) is associated with a higher risk of potentially life-threatening bradyarrhythmic events. Read More

View Article and Full-Text PDF

Prognosis of Primary Sclerosing Cholangitis According to Age of Onset.

J Hepatobiliary Pancreat Sci 2021 Apr 2. Epub 2021 Apr 2.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Liver failure and biliary tract cancer (BTC) are major life-threatening events in the clinical course of primary sclerosing cholangitis (PSC). Although these are competing events, they are typically evaluated as a composite prognostic endpoint. In Japan, the clinical characteristics and prognosis of PSC reportedly differ according to age of onset. Read More

View Article and Full-Text PDF

A Review of Biophysiological and Biochemical Indicators of Stress for Connected and Preventive Healthcare.

Diagnostics (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Smart Sensor Lab, Lambe Institute of Transitional Research, School of Medicine, National University of Ireland Galway (NUIG), H91 TK33 Galway, Ireland.

Stress is a known contributor to several life-threatening medical conditions and a risk factor for triggering acute cardiovascular events, as well as a root cause of several social problems. The burden of stress is increasing globally and, with that, is the interest in developing effective stress-monitoring solutions for preventive and connected health, particularly with the help of wearable sensing technologies. The recent development of miniaturized and flexible biosensors has enabled the development of connected wearable solutions to monitor stress and intervene in time to prevent the progression of stress-induced medical conditions. Read More

View Article and Full-Text PDF

Allergic Reactions to Current Available COVID-19 Vaccinations: Pathophysiology, Causality, and Therapeutic Considerations.

Vaccines (Basel) 2021 Mar 5;9(3). Epub 2021 Mar 5.

Department of Internal Medicine, Division of Cardiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.

Vaccines constitute the most effective medications in public health as they control and prevent the spread of infectious diseases and reduce mortality. Similar to other medications, allergic reactions can occur during vaccination. While most reactions are neither frequent nor serious, anaphylactic reactions are potentially life-threatening allergic reactions that are encountered rarely, but can cause serious complications. Read More

View Article and Full-Text PDF

Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices.

Int J Mol Sci 2021 Mar 24;22(7). Epub 2021 Mar 24.

Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia.

Medical devices are indispensable in the healthcare setting, ranging from diagnostic tools to therapeutic instruments, and even supporting equipment. However, these medical devices may be associated with life-threatening complications when exposed to blood. To date, medical device-related infections have been a major drawback causing high mortality. Read More

View Article and Full-Text PDF

The evolving role of preprints in the dissemination of COVID-19 research and their impact on the science communication landscape.

PLoS Biol 2021 Apr 2;19(4):e3000959. Epub 2021 Apr 2.

Hughes Hall College, University of Cambridge, Cambridge, United Kingdom.

The world continues to face a life-threatening viral pandemic. The virus underlying the Coronavirus Disease 2019 (COVID-19), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has caused over 98 million confirmed cases and 2.2 million deaths since January 2020. Read More

View Article and Full-Text PDF

Arrhythmic risk during pregnancy in patients with congenital heart disease.

Herzschrittmacherther Elektrophysiol 2021 Apr 1. Epub 2021 Apr 1.

Department of Congenital Heart Disease and Pediatric Cardiology, University Heart Center Freiburg-Bad Krozingen, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Arrhythmias play a significant role in the morbidity and mortality of patients with adult congenital heart disease (CHD). Pregnancy-associated physiological changes in hormonal status, hemodynamics, and myocardial structure further enhance arrhythmic risk in CHD patients, leading to increased adverse maternal and foetal events and making arrhythmias one of the most common complications during pregnancy. Nearly all CHD patients are affected by asymptomatic rhythm disturbances during the ante-, peri-, or post-partum periods, and almost one tenth of patients develop sustained, symptomatic arrhythmias requiring treatment. Read More

View Article and Full-Text PDF

Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare.

BMJ Open 2021 Mar 30;11(3):e043666. Epub 2021 Mar 30.

Service de Dermatologie, Assistance Publique-Hôpitaux de Paris Hôpital Saint-Louis, Paris, France

Introduction: Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening disease characterised by recurrent flares of widespread neutrophilic aseptic skin pustular eruption. Despite the availability of approved biologics for GPP in Japan, Taiwan and Thailand, associated evidence is largely based on uncontrolled studies in which acute flares were not directly assessed. Therefore, there is a high unmet need to investigate new rapid-acting effective treatments that resolve symptoms associated with acute GPP flares. Read More

View Article and Full-Text PDF

Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors.

Clin Oncol Case Rep 2020 Nov 17;3(5). Epub 2020 Sep 17.

Section of Medical Oncology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

Checkpoint inhibitor immunotherapy has significantly advanced treatment of a growing number of advanced malignancies. A consequences of immune system activation that leads to tumor cell destruction by checkpoint inhibitor therapy is the development of immune-related adverse events, some of which can be life threatening. There are limited data on the use of checkpoint inhibitor therapy in patients with preexisting autoimmunity owing to concerns that underlying autoimmune disease may be exacerbated by checkpoint inhibitor treatment. Read More

View Article and Full-Text PDF
November 2020

Gadolinium-based Contrast Agents for Cardiac MRI: Use of Linear and Macrocyclic Agents with Associated Safety Profile from 154 779 European Patients.

Radiol Cardiothorac Imaging 2020 Oct 29;2(5):e200102. Epub 2020 Oct 29.

Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Robert-Koch-Strasse 40, 37075 Goettingen, Germany (J.U., O.A.B., J.L.); Section of Interventional Radiology, Yale School of Medicine, New Haven, Conn (J.U.); Department of Radiology, Antwerp University Hospital, Antwerp, Belgium (R.S.); Department of Radiology, Holy Heart Hospital, Lier, Belgium (R.S.); Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy (M.F.); Department of Radiology, Center for Medical Imaging, University Medical Center Groningen, Groningen, the Netherlands (R.V.); Radiology Department, University Hospital Basel, Basel, Switzerland (J.B.); German Cardiovascular Research Center (DZHK), Partner site Goettingen, Germany (J.L.); and Department of Diagnostic and Interventional Radiology, University of Leipzig-Heart Centre, Leipzig, Germany (M.G.).

Purpose: To assess current use and acute safety profiles of gadolinium-based contrast agents (GBCAs) in cardiac MRI given recent suspensions of GBCA approval.

Materials And Methods: Patients were retrospectively included from the multinational multicenter European Society of Cardiovascular Radiology (ESCR) MR/CT Registry collected between January 2013 and October 2019. GBCA-associated acute adverse events (AAEs) were classified as mild (self-limiting), moderate (pronounced AAE requiring medical management), and severe (life threatening). Read More

View Article and Full-Text PDF
October 2020

Acute on Chronic Theophylline Toxicity in an Elderly Patient.

Cureus 2021 Feb 22;13(2):e13484. Epub 2021 Feb 22.

Cardiology, Orlando Veterans Affairs (VA) Medical Center, Orlando, USA.

Theophylline toxicity has become rare in the 21st century, as the drug has fallen out of favor due to serious life-threatening adverse events, narrow therapeutic window and readily available therapeutic alternatives. The wide array of clinical symptoms related to theophylline toxicity makes this diagnosis challenging for the treating physician. We report a case of an elderly gentleman who presented with respiratory failure and seizures due to severe theophylline toxicity. Read More

View Article and Full-Text PDF
February 2021

A Case of Cytokine Release Syndrome Induced by Immune-checkpoint Inhibitor Therapy for Non-small-cell Lung Cancer.

Intern Med 2021 Mar 29. Epub 2021 Mar 29.

Department of Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan.

Immune-related adverse events, including autoimmune toxicity, may develop as a consequence of immune-checkpoint inhibitor (ICI) cancer therapy. Cytokine release syndrome (CRS) is a severe and life-threatening cytokine-associated toxicity that can develop after adoptive T-cell therapy. We herein report a rare case of severe CRS after ICI therapy for advanced non-small-cell lung cancer. Read More

View Article and Full-Text PDF