129,245 results match your criteria life work


Risk Intelligence as a Resource in Career Transition: The Role of College Satisfaction on the Visions about Future Jobs.

Eur J Investig Health Psychol Educ 2021 Sep 7;11(3):1030-1043. Epub 2021 Sep 7.

Faculty of Human and Social Sciences, Kore University, Cittadella Universitaria, 94100 Enna, Italy.

(1) Background: University transition is a critical step in career construction due to the uncertainty and unpredictability of socioeconomic conditions; these conditions compel people to manage a greater quantity of perceived risks associated with their career projects than in the past, and to face unexpected situations that could compromise their quality of life in educational and work contexts. After all, experiencing well-being during the university path can undoubtedly affect the visions of one's future work, especially when a transition period is nearby. The present study aimed to explore the role of subjective risk intelligence in expectations about future work, analyzing the potential mediational role of academic satisfaction in this relationship. Read More

View Article and Full-Text PDF
September 2021

A Closer Look at the Emotional Intelligence Construct: How Do Emotional Intelligence Facets Relate to Life Satisfaction in Students Involved in Bullying and Cyberbullying?

Eur J Investig Health Psychol Educ 2021 Jul 9;11(3):711-725. Epub 2021 Jul 9.

Department of Social Psychology, Social Work, Social Anthropology and East Asian Studies, University of Malaga, 29071 Malaga, Spain.

Adolescents' perception of their own emotional abilities has been related to psychological adjustment and well-being. However, there are still few studies focusing on specific emotional dimensions in relation to bullying and well-being in adolescence. This study analysed the relationship between emotional intelligence (EI) facets, satisfaction with life, bullying and cyberbullying in adolescents. Read More

View Article and Full-Text PDF

Relationship between Socio-Emotional Competencies and the Overlap of Bullying and Cyberbullying Behaviors in Primary School Students.

Eur J Investig Health Psychol Educ 2021 Jul 5;11(3):686-696. Epub 2021 Jul 5.

Department of Psychology, Faculty of Social Work, University of Castilla-La Mancha, Avda de los Alfares, 42, 16071 Cuenca, Spain.

Digital life forms part of daily reality for young people. For this reason, traditional bullying in school has been reproduced in the online environment, resulting in an overlap of off- and online bullying. Research on socio-emotional competencies and bullying is revealing interesting results among students in secondary schools. Read More

View Article and Full-Text PDF

The Effect of Ranibizumab Loading Treatment on Vision-Related Quality of Life in Diabetic Macular Edema.

Clin Pract 2021 Sep 14;11(3):659-670. Epub 2021 Sep 14.

Faculty of Medicine, Usak University, 64000 Usak, Turkey.

Aims: To investigate the changes in vision-related quality of life after a loading dose of three consecutive intravitreal ranibizumab (IVR) injections in patients with unilateral diabetic macular edema (DME).

Materials And Methods: Fifty-two eyes of 52 patients who received IVR injections in only one eye with DME were included in our study. The following characteristics of the patients were recorded: gender, education status, marital status, work status, presence of chronic disease. Read More

View Article and Full-Text PDF
September 2021

Time-programmed activation of dual polyprodrugs for synergistic cascade oxidation-chemotherapy.

Biomaterials 2021 Sep 20;278:121136. Epub 2021 Sep 20.

Institutes for Life Sciences, School of Medicine, South China University of Technology, Guangzhou, 510006, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, PR China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education and Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, PR China. Electronic address:

Combination therapy using multiple drugs with time-programmed administration is promising for enhanced cancer treatment. However, it is still challenging to achieve time-programmed drug release from a single nanocarrier. Here, dual polyprodrugs of hemicyanine dye (CyNH) and doxorubicin (DOX) are developed to achieve time-programmed prodrug activation for synergistic cascade oxidation therapy and chemotherapy. Read More

View Article and Full-Text PDF
September 2021

Environmental and energetic analysis of coupling a biogas combined cycle power plant with carbon capture, organic Rankine cycles and CO utilization processes.

J Environ Manage 2021 Sep 22;300:113746. Epub 2021 Sep 22.

Chemical Engineering Department, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, 58060, Mexico.

Greenhouse gas emissions from power plants that use fossil fuels cause a serious impact to the environment, for this reason the use of renewable energy technologies is an important alternative as a way of combatting climate change. The production of power via biomass is considered as a carbon neutral energy resource, but it is well known that the non-fossil CO emitted from this type of processes can also be captured. In order to do so, in this work it is proposed a match between a Biogas combined cycle power plant and postcombustion carbon capture process, to capture the CO produced by the biogas combustion, and also it considered a match with an organic Rankine cycle that uses the wasted energy of the combustion gases. Read More

View Article and Full-Text PDF
September 2021

Metabolomics analysis of the 3D L-02 cell cultures revealing the key role of metabolism of amino acids in ameliorating hepatotoxicity of perfluorooctanoic acid.

Sci Total Environ 2021 Sep 20;806(Pt 1):150438. Epub 2021 Sep 20.

Southern Marine Science and Engineering Guangdong Laboratory, School of Marine Sciences, Sun Yat-Sen University, Zhuhai 519082, China. Electronic address:

To simulate the real cell status and morphology in the living systems is substantial for using cell models to address the detrimental effects of toxic contaminants. In this study, the comparative profiles of metabolites in three-dimensional (3D) human normal liver (L-02) cell spheroids with perfluorooctanoic acid (PFOA) treatment were analyzed using a metabolomic approach. The uniform 3D cell spheroids were well formed in 3 days (e. Read More

View Article and Full-Text PDF
September 2021

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.

Bioorg Med Chem 2021 Sep 17;48:116414. Epub 2021 Sep 17.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong, PR China. Electronic address:

The HIV-1 Capsid (CA) is considered as a promising target for the development of potent antiviral drugs, due to its multiple roles during the viral life cycle. Herein, we report the design, synthesis, and antiviral activity evaluation of series of novel phenylalanine derivatives as HIV-1 CA protein inhibitors. Among them, 4-methoxy-N-methylaniline substituted phenylalanine (II-13c) and indolin-5-amine substituted phenylalanine (V-25i) displayed exceptional anti-HIV-1 activity with the EC value of 5. Read More

View Article and Full-Text PDF
September 2021

Parenting styles and types: Breastfeeding attitudes in a large sample of mothers.

Midwifery 2021 Sep 14;103:103142. Epub 2021 Sep 14.

School of Psychology, University of Lincoln, Lincoln, United Kingdom.

Objective: The importance of breastfeeding for both maternal and infant health is well established. However, it remains the case that only a small percentage of infants are breastfed after the first six months of life. Maternal negative breastfeeding attitudes are associated with a reduced likelihood of breastfeeding an infant, but they are a malleable target for practitioner interventions. Read More

View Article and Full-Text PDF
September 2021

Crystal structure of histone chaperone Vps75 from Candida albicans.

Biochem Biophys Res Commun 2021 Sep 20;578:136-141. Epub 2021 Sep 20.

Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, Anhui, China; School of Life Sciences, Anhui University, Hefei, 230601, Anhui, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, 230601, Anhui, China. Electronic address:

Vps75 is a histone chaperone that interacts with the fungal-specific histone acetyltransferase Rtt109 and stimulates its acetylation activity on histone H3. Here we report the crystal structure of Vps75 of Candida albicans, one of the most common fungal pathogens. CaVps75 exists as a headphone-like dimer that forms a large negatively charged region on its concave side, showing the potential to bind positively charged regions of histones. Read More

View Article and Full-Text PDF
September 2021

EditPredict: Prediction of RNA editable sites with convolutional neural network.

Genomics 2021 Sep 22. Epub 2021 Sep 22.

Comprehensive Cancer Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87109, USA. Electronic address:

RNA editing exerts critical impacts on numerous biological processes. While millions of RNA editings have been identified in humans, much more are expected to be discovered. In this work, we constructed Convolutional Neural Network (CNN) models to predict human RNA editing events in both Alu regions and non-Alu regions. Read More

View Article and Full-Text PDF
September 2021

Randomized double-blind trial comparing low dose and conventional dose of a modified traditional herbal formula Guizhi Fuling Wan in women with symptomatic uterine fibroids.

J Ethnopharmacol 2021 Sep 22:114676. Epub 2021 Sep 22.

Department of Chinese Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; Virginia University of Integrative Medicine, Fairfax, USA. Electronic address:

Ethnopharmacological Relevance: The herbal formula Guizhi Fuling Wan is one common remedy for treating uterine fibroids (UFs) and the relevant symptoms in Traditional Chinese Medicine (TCM). Previous systematic reviews showed that Guizhi Fuling Formula appeared to have additional benefit based on mifepristone treatment in reducing volume of fibroids.

Aim Of Study: To study the efficacy and safety of the conventional dose of a modified herbal formula Guizhi Fuling Wan in patients with symptomatic uterine fibroids in comparison with a sub-effective dose control. Read More

View Article and Full-Text PDF
September 2021

Inhibitors of protein kinases A and C impair the motility of oncospheres of the model tapeworm Hymenolepis microstoma.

Mol Biochem Parasitol 2021 Sep 22;246:111423. Epub 2021 Sep 22.

Sección Biología Celular, Facultad de Ciencias, Universidad de la República. Iguá 4225, CP11400, Montevideo, Uruguay. Electronic address:

The oncosphere larvae of tapeworms cyclically extend and retract their hooks during the penetration of the intestine of their intermediate hosts. The mechanisms regulating these movements are essentially unknown, in part due to the biohazardous nature of oncospheres from human pathogens. In this work, we standardized a method for the analysis of motility of hatched oncospheres (hexacanths) of the model tapeworm Hymenolepis microstoma. Read More

View Article and Full-Text PDF
September 2021

Two theories of action Edelman's Neuronal group selection and the poetics of Paul Valéry.

Authors:
Marcella Faria

Biosystems 2021 Sep 22:104549. Epub 2021 Sep 22.

Dactyl Foundation, 64 Grand Street, New York, NY, 10013, USA; STIAS, Stellenbosch Institute for Advanced Study, 10 Jean Marais Rd, Stellenbosch, SA, USA. Electronic address:

Motivated by two imperatives as they are framed in Code Biology - mechanism and actualization - we have turned to other attempts of modeling life at work. Here, we present two theories devoted to minds in action - one explains neuronal function, and the other dissects poetic crafting. Neuronal networks activation and poetic composition, respectively, are seen as the selection of specific connective patterns of either neurons or words, in action. Read More

View Article and Full-Text PDF
September 2021

Temperature, humidity and outdoor air quality indicators influence COVID-19 spread rate and mortality in major cities of Saudi Arabia.

Environ Res 2021 Sep 22:112071. Epub 2021 Sep 22.

Division of Biomedical and Life Sciences, Lancaster University, United Kingdom.

There is an increasing evidence that meteorological (temperature, humidity, dew) and air quality indicators (PM2.5, PM10, NO2, SO2, CO) are affecting the COVID-19 transmission rate and the number of deaths in many countries around the globe. However, there are contradictory results due to limited observations of these parameters and absence of conclusive evidence on such relationships in cold or hot arid tropical and subtropical desert climate of Gulf region. Read More

View Article and Full-Text PDF
September 2021

Antibiotics for lower respiratory tract infection in children presenting in primary care in England (ARTIC PC): a double-blind, randomised, placebo-controlled trial.

Lancet 2021 Sep 22. Epub 2021 Sep 22.

Primary Care Research Centre, Primary Care Population Sciences and Medical Education Unit, University of Southampton, Southampton, UK.

Background: Antibiotic resistance is a global public health threat. Antibiotics are very commonly prescribed for children presenting with uncomplicated lower respiratory tract infections (LRTIs), but there is little evidence from randomised controlled trials of the effectiveness of antibiotics, both overall or among key clinical subgroups. In ARTIC PC, we assessed whether amoxicillin reduces the duration of moderately bad symptoms in children presenting with uncomplicated (non-pneumonic) LRTI in primary care, overall and in key clinical subgroups. Read More

View Article and Full-Text PDF
September 2021

Estimated effect of increased diagnosis, treatment, and control of diabetes and its associated cardiovascular risk factors among low-income and middle-income countries: a microsimulation model.

Lancet Glob Health 2021 Sep 22. Epub 2021 Sep 22.

Institute for Applied Health Research, University of Birmingham, Birmingham, UK; Centre for Global Surgery, Department of Global Health, Stellenbosch University, Cape Town, South Africa; Medical Research Council-Wits University Rural Public Health and Health Transitions Research Unit, Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

Background: Given the increasing prevalence of diabetes in low-income and middle-income countries (LMICs), we aimed to estimate the health and cost implications of achieving different targets for diagnosis, treatment, and control of diabetes and its associated cardiovascular risk factors among LMICs.

Methods: We constructed a microsimulation model to estimate disability-adjusted life-years (DALYs) lost and health-care costs of diagnosis, treatment, and control of blood pressure, dyslipidaemia, and glycaemia among people with diabetes in LMICs. We used individual participant data-specifically from the subset of people who were defined as having any type of diabetes by WHO standards-from nationally representative, cross-sectional surveys (2006-18) spanning 15 world regions to estimate the baseline 10-year risk of atherosclerotic cardiovascular disease (defined as fatal and non-fatal myocardial infarction and stroke), heart failure (ejection fraction of <40%, with New York Heart Association class III or IV functional limitations), end-stage renal disease (defined as an estimated glomerular filtration rate <15 mL/min per 1·73 m or needing dialysis or transplant), retinopathy with severe vision loss (<20/200 visual acuity as measured by the Snellen chart), and neuropathy with pressure sensation loss (assessed by the Semmes-Weinstein 5·07/10 g monofilament exam). Read More

View Article and Full-Text PDF
September 2021

Identifying the content for an item bank and computerized adaptive testing system to measure the impact of age-related macular degeneration on health-related quality of life.

Qual Life Res 2021 Sep 25. Epub 2021 Sep 25.

Singapore Eye Research Institute, Singapore National Eye Centre, The Academia, 20 College Road, Level 6, Singapore, 169856, Singapore.

Purpose: We are developing an age-related macular degeneration (AMD) health-related quality of life (HRQoL) item bank, applicable to Western and Asian populations. We report primarily on content generation and refinement, but also compare the HRQoL issues reported in our study with Western studies and current AMD-HRQoL questionnaires.

Methods: In this cross-sectional, qualitative study of AMD patients attending the Singapore National Eye Centre (May-December 2019), items/domains were generated from: (1) AMD-specific questionnaires; (2) published articles; (3) focus groups/semi-structured interviews with AMD patients (n = 27); and (4) written feedback from retinal experts. Read More

View Article and Full-Text PDF
September 2021

Pioneering, prodigious and perspicacious: Grunya Efimovna Sukhareva's life and contribution to conceptualising autism and schizophrenia.

Eur Child Adolesc Psychiatry 2021 Sep 25. Epub 2021 Sep 25.

Faculty of Education, University of Cambridge, 184 Hills Road, Cambridge, CB2 8PQ, UK.

Grunya Efimovna Sukhareva's seminal role in being the first to publish a clinical description of autistic traits in 1925, before both Kanner and Asperger, has been revealed relatively recently. Nevertheless, Sukhareva's work is little known and largely unrecognised beyond Russia. Amidst calls for greater recognition of her pivotal contribution in the genesis of autism conceptualisation and categorisation, this article provides a biographical and historical background. Read More

View Article and Full-Text PDF
September 2021

SmCo5 with a reconstructed oxyhydroxide surface for spin selective water oxidation under elevated temperature.

Angew Chem Int Ed Engl 2021 Sep 24. Epub 2021 Sep 24.

Nanyang Technological University, School of Materials Science and Engineering, 50 Nanyang Ave., Blk N4.1-02-27, 639798, Singapore, SINGAPORE.

The efficiency of electrolytic hydrogen production is limited by the slow reaction kinetics of oxygen evolution reaction (OER). Surface reconstructed ferromagnetic (FM) catalysts with spin pinning effect at the FM/oxyhydroxide interface could enhance the spin-dependent OER kinetics. However, in real-life applications electrolyzers are operated under elevated temperature, which may disrupt the spin orientations of FM catalysts and limit their performance. Read More

View Article and Full-Text PDF
September 2021

Comparison of 12 and 24-hours shift impacts on ICU nursing care, efficiency, safety, and work-life quality.

Int Nurs Rev 2021 Sep 25. Epub 2021 Sep 25.

Visiting Professor, Editor in Chief, International Nursing Review, Faculty of Nursing Chiang Mai, Chiang Mai University, Bangkok, Thailand.

Background: Nursing care quality is a central concern of health policy, and nurses' shift schedules affect the quality of care and their work-life status internationally. A lack of reliable information on the differences between 24- and 12-h shifts on care quality, nursing care quality, patient safety, and adverse and missed events warranted investigation in Cambodia.

Aim: We aimed to examine the impacts of 12-h shifts compared with 24-h shifts. Read More

View Article and Full-Text PDF
September 2021

Are infectious reproductive pathogens of large ruminants a threat to improving food security? An investigation from Cambodia.

Trop Anim Health Prod 2021 Sep 24;53(5):480. Epub 2021 Sep 24.

The University of Sydney, Sydney School of Veterinary Science, 425 Werombi Road, Camden, NSW, 2570, Australia.

In Cambodia, information on common pathogens causing reproductive losses in cattle and buffalo are lacking, despite there being a need to address livestock health to enhance food security. We analysed stored buffalo (n = 29) and cattle (n = 471) serum samples collected in 2016 using commercially available enzyme-linked immunosorbent assay kits. Antibodies to Neospora caninum, bovine viral diarrhoea virus (BVDV), Leptospira interrogans serovar Hardjo and Brucella abortus were detected in buffalo samples at 79. Read More

View Article and Full-Text PDF
September 2021

Structural changes in the gut microbiota community of the black-necked crane (Grus nigricollis) in the wintering period.

Arch Microbiol 2021 Sep 24. Epub 2021 Sep 24.

College of Life Science, Sichuan Agricultural University, No. 46, Xinkang Road, Yucheng District, Ya'an, 625014, Sichuan, People's Republic of China.

During overwintering of black-necked cranes (Grus nigricollis), the composition and function of the gut microbiota changes are of considerable interest for understanding its environmental adaption mechanism. In this study, we characterized the structure of the gut microbiota from the black-necked crane in the Dashanbao wintering area, and compared the early-winter (November) microbiota to the late-winter (March of the next year) microbiota. The results showed that the gut microbiota diversity of black-necked crane in the early-overwintering stage was higher than that in the late-overwintering stage, but it did not reach a significant level. Read More

View Article and Full-Text PDF
September 2021

Accumbofrontal tract integrity is related to early life adversity and feedback learning.

Neuropsychopharmacology 2021 Sep 24. Epub 2021 Sep 24.

University of Wisconsin-Madison, Madison, WI, USA.

Abuse, neglect, exposure to violence, and other forms of early life adversity (ELA) are incredibly common and significantly impact physical and mental development. While important progress has been made in understanding the impacts of ELA on behavior and the brain, the preponderance of past work has primarily centered on threat processing and vigilance while ignoring other potentially critical neurobehavioral processes, such as reward-responsiveness and learning. To advance our understanding of potential mechanisms linking ELA and poor mental health, we center in on structural connectivity of the corticostriatal circuit, specifically accumbofrontal white matter tracts. Read More

View Article and Full-Text PDF
September 2021

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.

Nat Commun 2021 Sep 24;12(1):5631. Epub 2021 Sep 24.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.

Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor dramatically increase lifespan and immunity, but generally impair motility, growth, and reproduction. Whether these pleiotropic effects can be dissociated at a specific step in insulin/IGF-1 signaling pathway remains unknown. Read More

View Article and Full-Text PDF
September 2021

The Effects of Social Location and Situational Factors on Young Women's Disclosure of Intimate Partner Violence Across Relationships.

Violence Vict 2021 Sep 24. Epub 2021 Sep 24.

Department of Social Work, University of Wisconsin-Whitewater, Whitewater, WI.

The goal of the study was to examine disclosure of physical and sexual intimate partner violence (IPV) victimization across abusive relationships within a sociodemographically diverse sample of young women. We recruited 283 participants, ages 18 to 24, from a university, a 2-year college, and community sites serving low-income young women, and assessed physical and sexual IPV victimization, and related disclosure, across each of their abusive relationships (415 total). We used multilevel modeling to examine the effects of social location and situational factors on the odds of any disclosure of abuse during first relationships and across relationships. Read More

View Article and Full-Text PDF
September 2021

Pulmonary rehabilitation for idiopathic pleuroparenchymal fibroelastosis: A retrospective study on its efficacy, feasibility, and safety.

Respir Investig 2021 Sep 21. Epub 2021 Sep 21.

Department of Respiratory Medicine and Allergy, Tosei General Hospital, 160 Nishioiwake-cho, Seto, Aichi, 489-8642, Japan. Electronic address:

Background: The beneficial effects of pulmonary rehabilitation (PR) for patients with idiopathic pleuroparenchymal fibroelastosis (IPPFE) remain unknown. This study aimed to examine the efficacy, feasibility, and safety of PR for IPPFE.

Methods: We retrospectively investigated 25 patients with IPPFE referred for PR between April 2007 and March 2017. Read More

View Article and Full-Text PDF
September 2021

Fatigue self-management education in persons with disease-related fatigue: A comprehensive review of the effectiveness on fatigue and quality of life.

Patient Educ Couns 2021 Sep 14. Epub 2021 Sep 14.

Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, Manno, Landquart, Switzerland.

Objectives: To systematically synthesize the effectiveness of fatigue self-management education (SME) on fatigue and quality of life (QoL) in persons with disease-related fatigue, and to describe the intervention characteristics.

Methods: We systematically reviewed the literature on SMEs in people with disease-related fatigue. We included randomized controlled trials (RCT), which aimed to improve self-management skills for fatigue in daily life. Read More

View Article and Full-Text PDF
September 2021

Pre-vaccination vulnerability and suspected adverse events following HPV vaccination. A case-control study nested in the Danish national birth cohort.

Vaccine 2021 Sep 21. Epub 2021 Sep 21.

Research Unit for Epidemiology, Department of Public Health, Aarhus University, Denmark. Electronic address:

Previous studies have indicated that girls experiencing suspected adverse events (AE) following HPV vaccination were more vulnerable prior to vaccination. However, no study has previously investigated differences in vulnerability using prospectively collected self-reported measures of vulnerability. The objective of this study therefore was to describe the distribution of biological and psychosocial indicators of vulnerability in girls referred to a hospital setting due to suspected adverse events and compare it with a sample of non-referred HPV vaccinated girls. Read More

View Article and Full-Text PDF
September 2021

Barriers and facilitators of type 1 diabetes self-care in adolescents and young adults.

J Pediatr Nurs 2021 Sep 21. Epub 2021 Sep 21.

Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, Monza, Italy. Electronic address:

Purpose: This study explores the disease experience of adolescents and young adults with T1DM focusing on the barriers and facilitators that characterise their disease self-care. Self-care requires complex decision making and cooperation between patients, their families, the healthcare team, and the social support system. Personal and social factors affect self-care, and specific challenges impact adolescents and young adults, putting them at a higher risk of poor glycaemic control and more severe complications. Read More

View Article and Full-Text PDF
September 2021