13,691 results match your criteria life preservation

Fertility-sparing uterine lesion resection in a woman with hemoperitoneum due to invasive mole: A rare case report.

Int J Surg Case Rep 2021 Jun 18;84:106117. Epub 2021 Jun 18.

Department of Radiology, Hamadan University of Medical Science, Hamadan, Iran. Electronic address:

Introduction: Gestational trophoblastic neoplasia comprises a unique group of human neoplastic diseases that derive from fetal trophoblastic tissues. The hydatidiform mole is the most common form of GTD, representing 80 % of cases. An invasive mole is a hydatidiform mole characterized by the enlarged hydropic villi invading into the myometrium, into vascular spaces, or into extrauterine sites. Read More

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Parenthood among men diagnosed with cancer in childhood and early adulthood: trends over time in a Danish national cohort.

Hum Reprod 2021 Jun 24. Epub 2021 Jun 24.

The Fertility Department, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Study Question: Is the rate of fatherhood among men diagnosed with cancer in childhood and early adulthood different from men without cancer, and, if so, have the differences changed over time?

Summary Answer: Men diagnosed with cancer have had significantly reduced rates of fatherhood compared with undiagnosed men; however, the rates of fatherhood among the cancer survivors have increased markedly over time.

What Is Known Already: The number of children and young adolescents who survive cancer has steadily increased over recent decades, with a current 5-year survival rate of approximately 80%. Consequently, life circumstances after cancer have gained increasing importance, including the desire among survivors to have children and a family. Read More

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Hyperkalemia: Major but still understudied complication among heart transplant recipients.

World J Transplant 2021 Jun;11(6):203-211

Department of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United States.

Hyperkalemia is a recognized and potentially life-threatening complication of heart transplantation. In the complex biosystem created by transplantation, recipients are susceptible to multiple mechanisms for hyperkalemia which are discussed in detail in this manuscript. Hyperkalemia in heart transplantation could occur pre-transplant, during the transplant period, or post-transplant. Read More

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Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant, "subfossil" koala lemur .

Proc Natl Acad Sci U S A 2021 Jun;118(26)

Department of Anthropology, Pennsylvania State University, University Park, PA 16802;

No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinction on the island. From morphological and isotopic analyses of skeletal "subfossil" remains we can reconstruct some of the biology and behavioral ecology of giant lemurs (primates; up to ∼160 kg) and other extraordinary Malagasy megafauna that survived into the past millennium. Yet, much about the evolutionary biology of these now-extinct species remains unknown, along with persistent phylogenetic uncertainty in some cases. Read More

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Host's guardian protein counters degenerative symbiont evolution.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, 305-8566 Tsukuba, Japan;

Microbial symbioses significantly contribute to diverse organisms, where long-lasting associations tend to result in symbiont genome erosion, uncultivability, extinction, and replacement. How such inherently deteriorating symbiosis can be harnessed to stable partnership is of general evolutionary interest. Here, we report the discovery of a host protein essential for sustaining symbiosis. Read More

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Multimorbidity in old age and its impact on life results.

Z Gerontol Geriatr 2021 Jun 23. Epub 2021 Jun 23.

Lehrstuhl für Rehabilitationswissenschaftliche Gerontologie, Humanwissenschaftliche Fakultät, Universität zu Köln, Cologne, Germany.

Background: High prevalence diseases, such as high blood pressure, dementia and depression in old age can lead to multimorbidity, which is often defined as the presence of more than one health condition in an individual. Multimorbidity has negative consequences on health-related quality of life and healthcare utilization. As many age-associated diseases are not curable, therapeutic goals like preservation of autonomy, functioning, and life satisfaction become more important in old age patients. Read More

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Pembrolizumab dramatically resolves choroidal metastatis from esophageal adenocarcinoma and restores vision: a case report.

Oxf Med Case Reports 2021 Jun 18;2021(6):omab047. Epub 2021 Jun 18.

Department of Ophthalmology, Loma Linda University School of Medicine, Loma Linda, CA, USA.

Esophageal adenocarcinoma historically is an aggressive cancer with poor long-term survival. Ocular metastasis secondary to gastrointestinal malignancy is rare. In managing patients with ocular metastasis, quality of life (specifically vision preservation) is one of the most important factors patients and providers consider when deciding on a treatment regimen. Read More

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Recent updates and current issues of sentinel node navigation surgery for early gastric cancer.

Chin J Cancer Res 2021 Apr;33(2):142-149

Center for Gastric Cancer, Research Institute & Hospital, National Cancer Center, Goyang-si 410-769, Republic of Korea.

With the increase in the incidence of early gastric cancer (EGC), several endoscopic and laparoscopic approaches, such as endoscopic submucosal dissection and function-preserving gastrectomy, have been accepted as standard treatments. Sentinel node navigation surgery (SNNS) is an ideal surgical option for preservation of most parts of the stomach and consequent maintenance of normal gastric function to improve quality of life in patients with EGC. Although many previous studies and clinical trials have demonstrated the safety and feasibility of the sentinel node concept in gastric cancer, the clinical application of SNNS is debatable. Read More

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Quantitative mapping of human hair greying and reversal in relation to life stress.

Elife 2021 Jun 22;10. Epub 2021 Jun 22.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, United States.

Background: Hair greying is a hallmark of aging generally believed to be irreversible and linked to psychological stress.

Methods: Here, we develop an approach to profile hair pigmentation patterns (HPPs) along individual human hair shafts, producing quantifiable physical timescales of rapid greying transitions.

Results: Using this method, we show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans. Read More

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Phenolic Preservative Removal from Commercial Insulin Formulations Reduces Tissue Inflammation while Maintaining Euglycemia.

ACS Pharmacol Transl Sci 2021 Jun 26;4(3):1161-1174. Epub 2021 Apr 26.

Department of Biomedical Engineering, Integrative Biosciences Center, Wayne State University, Detroit, Michigan 48202,United States.

: Exogenous insulin therapy requires stabilization of the insulin molecule, which is achieved through the use of excipients (e.g., phenolic preservatives (PP)) that provide protein stability, sterility and prolong insulin shelf life. Read More

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Conservative (non-radical) surgery for stage IB1 cervical cancer.

Best Pract Res Clin Obstet Gynaecol 2021 May 24. Epub 2021 May 24.

Consultant Gynaecological Oncologist, Queen Elizabeth Hospital, Gateshead, NE9 6SX, UK. Electronic address:

There has been lively debate in recent years following the publication of various retrospective case series and small cohort studies that suggest certain women presenting with International Federation of Gynecology and Obstetrics (FIGO) stage IB1 cervical cancer (pre-2018 revised classification) may be treated by non-radical surgery, either simple hysterectomy or cone biopsy, where fertility preservation is required. A strictly defined histological criterion is necessary for selecting such cases, incorporating tumour dimensions including estimated tumour volume, lympho-vascular space invasion and pelvic lymph node status. Meta-analyses of these studies show that the oncological outcomes are comparable to the excellent results achieved by radical hysterectomy and radical trachelectomy. Read More

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Inhibition of Aspergillus flavus growth and aflatoxins production on peanuts over α-FeO nanorods under sunlight irradiation.

Int J Food Microbiol 2021 Jun 15;353:109296. Epub 2021 Jun 15.

Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China; National Reference Laboratory for Agricultural Testing P.R.China, Key Laboratory of Detection for Mycotoxins, Laboratory of Quality & Safety Risk Assessment for Oilseed Products (Wuhan), Quality Inspection & Test Center for Oilseed Products, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Wuhan 430062, China.

Peanut is an important resource of edible oil and digestible protein in daily life, which is rich in the nutriments and antioxidants such as vitamins, minerals and polyphenols. However, peanut is susceptible to the contamination of Aspergillus flavus (A. flavus), which can produce highly carcinogenic toxins that brings serious threats to human health and food safety. Read More

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Recent developments of natural antimicrobials and antioxidants on fish and fishery food products.

Compr Rev Food Sci Food Saf 2021 Jun 19. Epub 2021 Jun 19.

Department of Seafood Processing Technology, Faculty of Fisheries, Cukurova University, Adana, Turkey, 01330, Turkey.

Fish and fishery products (FFP) are highly perishable due to their high nutritional value and moisture content. The spoilage is mainly caused by microorganisms and chemical reactions, especially lipid oxidation, leading to losses in quality and market value. Microbiological and lipid deteriorations of fishery-derived products directly lower their nutritive value and pose the risk of toxicity for human health. Read More

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Homeostasis effects of fermented Maillard reaction products by Lactobacillus gasseri 4 M13 in dextran sulfate sodium-induced colitis mice.

J Sci Food Agric 2021 Jun 18. Epub 2021 Jun 18.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, 1, 5-ga, Anam-dong, Sungbuk-gu, Seoul, 02841, Republic of Korea.

Background: The incidence of inflammatory bowel disease (IBD) continues to increase worldwide. Multiple factors, including diet, loss of the intestinal barrier function, and imbalance of the immune system can cause IBD. A balanced diet is important for maintaining a healthy bowel and preventing IBD from occurring. Read More

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Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss.

Front Cell Neurosci 2021 1;15:658662. Epub 2021 Jun 1.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Noise exposure is the most important external factor causing acquired hearing loss in humans, and it is strongly associated with the production of reactive oxygen species (ROS) in the cochlea. Several studies reported that the administration of various compounds with antioxidant effects can treat oxidative stress-induced hearing loss. However, traditional systemic drug administration to the human inner ear is problematic and has not been successful in a clinical setting. Read More

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Mapping and Crosswalk of the Oxford Hip Score and Different Versions of the Hip Disability and Osteoarthritis Outcome Score.

Clin Orthop Relat Res 2021 Jul;479(7):1534-1544

Orthopedics Department, Lille University Hospital Lille, Hôpital Salengro, Lille, France.

Background: Patient-reported outcome measures such as the Oxford-12 Hip Score and Hip Disability and Osteoarthritis Outcome Score (HOOS) are used in daily orthopaedic practice to evaluate patients. Because different studies use different scores, it would be important to build conversion tables between scores (crosswalk) to compare the results of one study with those of another study. Various mapping methods can be used to develop crosswalk tables that convert Oxford-12 scores to the HOOS (and its derivatives, including the HOOS physical function short form, HOOS joint replacement, and HOOS-12) and vice versa. Read More

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Pulse-dose-rate interstitial brachytherapy in anal squamous cell carcinoma: clinical outcomes and patients' health quality perception.

J Contemp Brachytherapy 2021 Jun 18;13(3):263-272. Epub 2021 May 18.

Brachytherapy Unit, Radiation Oncology Department, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.

Purpose: To examine clinical outcomes and quality of life of patients with anal squamous cell carcinoma treated with interstitial pulsed-dose-rate brachytherapy (PDR-BT) with a boost to residual tumor after external radiotherapy.

Material And Methods: Medical records of patients receiving a brachytherapy boost after radiotherapy for anal squamous cell carcinoma in our Institute between 2008 and 2019 were retrospectively reviewed. After receiving pelvic irradiation ± concurrent chemotherapy, patients received PDR-BT boost to residual tumor, in order to deliver a minimal total dose of 60 Gy. Read More

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Evaluating the long-term effect of space radiation on the reproductive normality of mammalian sperm preserved on the International Space Station.

Sci Adv 2021 Jun 11;7(24). Epub 2021 Jun 11.

Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi 400-8510, Japan.

Space radiation may cause DNA damage to cells and concern for the inheritance of mutations in offspring after deep space exploration. However, there is no way to study the long-term effects of space radiation using biological materials. Here, we developed a method to evaluate the biological effect of space radiation and examined the reproductive potential of mouse freeze-dried spermatozoa stored on the International Space Station (ISS) for the longest period in biological research. Read More

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Archaea: A Gold Mine for Topoisomerase Diversity.

Front Microbiol 2021 25;12:661411. Epub 2021 May 25.

Département de biologie, Institut de Biologie de l'Ecole Normale Supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, France.

The control of DNA topology is a prerequisite for all the DNA transactions such as DNA replication, repair, recombination, and transcription. This global control is carried out by essential enzymes, named DNA-topoisomerases, that are mandatory for the genome stability. Since many decades, the Archaea provide a significant panel of new types of topoisomerases such as the reverse gyrase, the type IIB or the type IC. Read More

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Global profiling of RNA-binding protein target sites by LACE-seq.

Nat Cell Biol 2021 Jun 9;23(6):664-675. Epub 2021 Jun 9.

Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

RNA-binding proteins (RBPs) have essential functions during germline and early embryo development. However, current methods are unable to identify the in vivo targets of a RBP in these low-abundance cells. Here, by coupling RBP-mediated reverse transcription termination with linear amplification of complementary DNA ends and sequencing, we present the LACE-seq method for identifying RBP-regulated RNA networks at or near the single-oocyte level. Read More

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Engaging a polylactide copolymer in oral tissue regeneration: first validation of Suprathel for guided epithelial and osseous healing.

J Med Life 2021 Mar-Apr;14(2):181-197

Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

The present study investigated the capacity of Suprathel (a copolymer membrane, so far validated for skin regeneration) to also regenerate oral tissue - mucosa and bone, by comparing this biomaterial, in a split-mouth rabbit model, to Mucoderm, a xenogeneic collagen matrix certified for keratinized oral mucosa healing. The clinical reason behind this experimental animal model was to determine whether the benefits of this advanced skin regeneration product (Suprathel) could be conveyed for future evaluation in clinical trials of oral tissue regeneration in humans. The outcomes of this study validated the use of Suprathel, a terpolymer of polylactide with trimethylene carbonate and ε-caprolactone, for stimulation of oral epithelium and alveolar bone regeneration in rabbits. Read More

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Comparison of short-stem versus conventional stem for hip arthroplasty in patients younger than 60 years: 7-14 years follow-up.

Eur J Orthop Surg Traumatol 2021 Jun 7. Epub 2021 Jun 7.

Hip Unit, Department of Orthopaedics, Centro Hospitalar E Universitário Do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal.

Purpose: Short-stem prostheses in hip arthroplasty have emerged as an alternative to conventional stems, especially in younger patients. The purpose of this study was to compare functional and radiological results of a short metaphyseal fitting cementless stem versus a conventional stem implant, in patients younger than 60 years.

Methods: All patients operated from January 2006 to April 2013 were included, obtaining a minimum follow-up of 7 years. Read More

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Patients' and Providers' Needs and Preferences When Considering Fertility Preservation Before Cancer Treatment: Decision-Making Needs Assessment.

JMIR Form Res 2021 Jun 7;5(6):e25083. Epub 2021 Jun 7.

Department of Gynecological Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Background: As cancer treatments continue to improve, it is increasingly important that women of reproductive age have an opportunity to decide whether they want to undergo fertility preservation treatments to try to protect their ability to have a child after cancer. Clinical practice guidelines recommend that providers offer fertility counseling to all young women with cancer; however, as few as 12% of women recall discussing fertility preservation. The long-term goal of this program is to develop an interactive web-based patient decision aid to improve awareness, access, knowledge, and decision making for all young women with cancer. Read More

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Combined Effect of the Essential Oil and Collagen Film on the Quality of Pacific Mackerel () Fillet During Cold Storage.

Foodborne Pathog Dis 2021 Jun 4. Epub 2021 Jun 4.

Department of Food Science and Pharmaceutics, Zhejiang Ocean University, Zhoushan, China.

Essential oils (EOs) and collagen have received recent attention in the seafood industry due to their abilities of antibacterial and seafood preservation individually. However, to the authors' best knowledge, very few publications address the issue of the combined effect of EOs and collagen on seafood preservation. Pacific mackerel is one of the most economically valuable fish species in China and easy to deteriorate during storage. Read More

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[Brain Functional Networks and Awake Craniotomy for Gliomas].

No Shinkei Geka 2021 May;49(3):556-567

Department of Neurosurgery, Kanazawa University.

The sophisticated functional networks of the human brain are integral to life, controlling domains such as language understanding and production and social cognition, which are important for inter-personal communication. Glioma, a primary brain tumor, infiltrates into the brain tissue, forcing the normal brain to reorganize the neural networks(brain plasticity)to resist the invasion. Awake craniotomy for gliomas enables reliable intraoperative identification and preservation of not only the innate normal brain functional areas but also the brain functional networks that have adapted and changed in response to the tumor-invasive environment. Read More

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[Glioma Surgery and Surgical Supporting Technology].

Kuniaki Saito

No Shinkei Geka 2021 May;49(3):536-548

Department of Neurosurgery, Kyorin University Faculty of Medicine.

Maximum safe resection is the principal goal of glioma surgery to improve patient prognosis, and various skills and techniques are available to achieve this. First, detailed preoperative image assessment of the tumor, arteries, veins, and white matter is helpful in developing the surgical plan. Second, surgical supporting technology, such as a navigation system, electrophysiological monitoring, awake craniotomy, and fluorescence-guided surgery, are vital for glioma surgery. Read More

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Hydrogen gas as a central on-off functional switch of reversible metabolic arrest - New perspectives for biotechnological applications.

J Biotechnol 2021 Jul 4;335:9-18. Epub 2021 Jun 4.

Department of Biology, University of Crete, Voutes University Campus, GR-70013, Heraklion, Crete, Greece. Electronic address:

Metabolism is the sum of all chemical reactions that sustain life. There is an ongoing effort to control metabolic rate, which correlates with the maximum lifespan potential and constitutes one of the oldest scientific questions. Herein, we report on the complete reversible arrest of cellular metabolism and cell growth in a series of organisms, from microalgae to yeast upon exposure to a 100 % hydrogen atmosphere. Read More

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Keys to discern the Phoenician, Punic and Roman mining in a typical coastal environment through the multivariate study of trace element distribution.

Sci Total Environ 2021 May 26;790:147986. Epub 2021 May 26.

University of Natural Resources and Applied Life Sciences, Peter Johan Str. 82, 1190 Viena, Austria. Electronic address:

Trace element concentrations in the Cartagena Bay coastal record reveal a contribution of natural processes. However, the influence of anthropogenic factors predominates in the last three millennia, particularly aerosol deposition linked to mining and industrial activities in the area. The coastal record of Cartagena can be considered a preserved environment, suitable to search for regional human activity fingerprinting, specifically that related to the deposition of heavy metals such as Pb and Cu. Read More

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Fluorescence angiography-assisted debridement of critically perfused glabrous skin in degloving foot injuries: Two case reports.

Medicine (Baltimore) 2021 Jun;100(22):e26235

Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Rationale: Degloving foot injuries are challenging to treat and associated with life-long sequelae for patients. An appropriate debridement of ischemic soft tissues with maximal preservation of glabrous skin is key during the reconstruction of these injuries. Indocyanine green (ICG) fluorescence angiography is an established technique for the intraoperative evaluation of tissue perfusion. Read More

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Lenvatinib versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma: patient-reported outcomes from a randomised, open-label, non-inferiority, phase 3 trial.

Lancet Gastroenterol Hepatol 2021 Jun 1. Epub 2021 Jun 1.

FSBSI N N Blokhin Russian Cancer Research Center, Moscow, Russia.

Background: Hepatocellular carcinoma is the third-leading cause of cancer-related death worldwide. Preservation of health-related quality of life (HRQOL) during treatment is an important therapeutic goal. The aim of this study was to evaluate the effect of treatment with lenvatinib versus sorafenib on HRQOL. Read More

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