Neurosci Biobehav Rev 2021 Jul 21. Epub 2021 Jul 21.
Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL, United States; Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, United States.
The National Institute of Mental Health Research Domain Criteria (RDoC) framework promotes the dimensional and transdiagnostic operationalization of psychopathology, but consideration of the neurodevelopmental foundations of mental health problems requires deeper examination. Irritability, the dispositional tendency to angry emotion that has both mood and behavioral elements, is dimensional, transdiagnostic, and observable early in life-a promising target for the identification of early neural indicators or risk factors for psychopathology. Here, we examine functional brain networks linked to irritability from preschool to adulthood and discuss how development and early experience may influence these neural substrates. Read More