54,366 results match your criteria life indicators

Low dietary phosphorus impairs keel bone health and quality in laying hens.

Br Poult Sci 2021 Jul 26. Epub 2021 Jul 26.

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, Heilongjiang, China.

1. Phosphorus (P) is a necessary nutrient for egg production and bone quality in poultry diets. To investigate the effects of low dietary available P (avP) on keel bone, 180 laying hens were fed either a control (C, 0. Read More

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In silico process characterization for biopharmaceutical development following the Quality by Design concept.

Biotechnol Prog 2021 Jul 26:e3196. Epub 2021 Jul 26.

Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe, Germany.

With the Quality by Design (QbD) initiative, regulatory authorities demand a consistent drug quality originating from a well-understood manufacturing process. This study demonstrates the application of a previously published mechanistic chromatography model to the in silico process characterization (PCS) of a monoclonal antibody polishing step. The proposed modeling workflow covered the main tasks of traditional PCS studies following the QbD principles, including criticality assessment of 11 process parameters and establishment of their proven acceptable ranges (PARs) of operation. Read More

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Multiple Cognitive and Behavioral Factors Link Association Between Brain Structure and Functional Impairment of Daily Instrumental Activities in Older Adults.

J Int Neuropsychol Soc 2021 Jul 26:1-14. Epub 2021 Jul 26.

Department of Psychiatry, Seoul Metropolitan Government-Seoul National University College Boramae Medical Center, Seoul, Republic of Korea.

Objective: Functional impairment in daily activity is a cornerstone in distinguishing the clinical progression of dementia. Multiple indicators based on neuroimaging and neuropsychological instruments are used to assess the levels of impairment and disease severity; however, it remains unclear how multivariate patterns of predictors uniquely predict the functional ability and how the relative importance of various predictors differs.

Method: In this study, 881 older adults with subjective cognitive complaints, mild cognitive impairment (MCI), and dementia with Alzheimer's type completed brain structural magnetic resonance imaging (MRI), neuropsychological assessment, and a survey of instrumental activities of daily living (IADL). Read More

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Using the Judgment Bias Task to Identify Behavioral Indicators of Affective State: Do Eye Wrinkles in Horses Reflect Mood?

Front Vet Sci 2021 8;8:676888. Epub 2021 Jul 8.

Division of Livestock Sciences, Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences, Vienna, Austria.

Identifying and validating behavioral indicators of mood are important for the assessment of animal welfare. Here, we investigated whether horses' eye wrinkle expression in a presumably neutral situation is a measure of mood as assessed in a cognitive judgment bias task (JBT). To this end, we scored pictures of the left and right eyes of 16 stallions for different aspects of eye wrinkle expression and tested the same individuals on a spatial JBT with active trial initiation. Read More

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High Expression Levels of CDK1 and CDC20 in Patients With Lung Squamous Cell Carcinoma are Associated With Worse Prognosis.

Front Mol Biosci 2021 7;8:653805. Epub 2021 Jul 7.

Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.

Progress related to the early detection and molecular targeted therapy of lung squamous cell carcinoma (LUSC) remains limited. The goal of our study was to identify key candidate indicators of LUSC. Three microarray datasets (GSE33532, GSE30219 and GSE19188) were applied to find differentially expressed genes (DEGs). Read More

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Assessment of ecological impairment of Arctic streams: Challenges and future directions.

Ecol Evol 2021 Jul 26;11(14):9715-9727. Epub 2021 Jun 26.

School for Resource and Environmental Studies Faculty of Management Dalhousie University Halifax Canada.

As increased growth and development put pressure on freshwater systems in Arctic environments, there is a need to maintain a meaningful and feasible framework for monitoring water quality. A useful tool for monitoring the ecological health of aquatic systems is by means of the analysis and inferences made from benthic invertebrates in a biomonitoring approach. Biomonitoring of rivers and streams within the Arctic has been under-represented in research efforts. Read More

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Effect of comprehensive care on the negative emotions and life quality in parturients with postpartum depression and gestational hypertension.

Am J Transl Res 2021 15;13(6):7228-7234. Epub 2021 Jun 15.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu Province, China.

Objective: To investigate the efficacy of comprehensive care during the nursing process of parturients with gestational hypertension and postpartum depression.

Methods: This prospective study recruited 70 patients with gestational hypertension concurrent with postpartum depression, and the patients were randomly divided into a control group (35 patients received routine care) and an observation group (35 patients, treated by comprehensive care). Indicators including psychological condition, life quality, thyroid function, the incidence of eclampsia, and nursing satisfaction were recorded and compared before intervention (at the diagnosis of postpartum depression) and after intervention (three months after delivery) in the two groups. Read More

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The effects of CPET-guided cardiac rehabilitation on the cardiopulmonary function, the exercise endurance, and the NT-proBNP and hscTnT levels in CHF patients.

Am J Transl Res 2021 15;13(6):7104-7114. Epub 2021 Jun 15.

Cardiac Rehabilitation Center, Rizhao International Heart Hospital Rizhao, Shandong Province, China.

Objective: To explore the effects of cardiopulmonary exercise testing (CPET) on the cardiopulmonary function, the exercise endurance, and the NT-proBNP and hscTnT levels in chronic heart failure (CHF) patients.

Methods: Altogether 98 patients with CHF were randomly divided into a control group and a CPET group, with 49 cases in each group. The control group was administered routine treatment, and the CPET group was administered CPET cardiac rehabilitation training in addition to the routine treatment. Read More

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The influence of integrated healthcare on the nursing effect, negative emotions, and heart failure indicators in acute heart failure patients.

Am J Transl Res 2021 15;13(6):6694-6701. Epub 2021 Jun 15.

Intensive Care Unit 2, The Second Affiliated Hospital, Nantong University Nantong, Jiangsu Province, China.

Objective: To investigate the effect of integrated healthcare on the nursing of heart failure patients, as well as its influence on the negative emotions and the factors related to heart failure.

Methods: 150 patients with acute heart failure admitted to our hospital were randomly divided into two groups. The patients in the control group underwent routine care, and the patients in the research group were treated with integrated healthcare. Read More

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A nurse-led hierarchical management model for the out-of-hospital management of children with bronchial asthma: a prospective randomized controlled study.

Am J Transl Res 2021 15;13(6):6488-6497. Epub 2021 Jun 15.

Department of Internal Medicine, Huzhou Hospital of Traditional Chinese Medicine Affiliated Zhejiang University of Traditional Chinese Medicine Huzhou, Zhejiang Province, China.

Objective: To explore the effects of a nurse-led hierarchical management model for managing the out-of-hospital asthma control and quality of life in children with bronchial asthma.

Methods: A prospective randomized controlled study was designed. Children with bronchial asthma treated in our hospital were recruited as the study cohort and randomly divided into a test group (n=60) and a control group (n=60). Read More

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The effects of early enteral nutrition on the nutritional statuses, gastrointestinal functions, and inflammatory responses of gastrointestinal tumor patients.

Am J Transl Res 2021 15;13(6):6260-6269. Epub 2021 Jun 15.

Clinical Nutrition Division, Wujin Hospital Affiliated With Jiangsu University Changzhou 213017, Jiangsu Province, China.

Objective: This paper was designed to investigate the effects of early enteral nutrition (EEN) on the nutritional statuses, gastrointestinal functions, and inflammatory responses of gastrointestinal tumor patients.

Methods: A total of 194 gastrointestinal tumor patients treated in our hospital from May 2017 to February 2019 were recruited as the study cohort. Among them, 101 patients were administered enteral nutrition (the study group), and 93 patients were administered parenteral nutrition (the control group). Read More

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Global Family Change: Persistent Diversity with Development.

Popul Dev Rev 2019 Mar 19;45(1):133-168. Epub 2018 Dec 19.

Population Studies Center and Department of Sociology, University of Pennsylvania. Address: 332 McNeil Building, 3718 Locust Walk, Philadelphia, PA, 19104 USA.

This article provides a broad empirical overview of the relationship between family change and socioeconomic development drawing on 30-plus years of Demographic and Health Surveys data from 3.5 million respondents across 84 low- and middle-income countries (LMICs). We conduct two sets of analyses. Read More

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Regulatory Resources and Emotional States in Overcoming Difficulties of Self-organization During Lockdown.

Psychol Stud (Mysore) 2021 Jul 18:1-11. Epub 2021 Jul 18.

Psychological Institute of the Russian Academy of Education, Moscow, Russia.

The research aimed to study the characteristics of the joint influence of conscious self-regulation and emotional states on life self-organization during a lockdown and identify the factors that contribute to overcoming emerging difficulties. It was conducted online, using the block site builder Tilda Publishing (tilda.ws) and a Google Forms survey administration application. Read More

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Health effects from heat waves in France: an economic evaluation.

Eur J Health Econ 2021 Jul 25. Epub 2021 Jul 25.

Santé publique France (SpF), 12, rue du Val d'Osne, 94415, Saint-Maurice Cedex, France.

Background: Scarcity of data on the health impacts and associated economic costs of heat waves may limit the will to invest in adaptation measures. We assessed the economic impact associated with mortality, morbidity, and loss of well-being during heat waves in France between 2015 and 2019.

Methods: Health indicators monitored by the French national heat wave plan were used to estimate excess visits to emergency rooms and outpatient clinics and hospitalizations for heat-related causes. Read More

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Linking irritability and functional brain networks: a transdiagnostic case for expanding consideration of development and environment in RDoC.

Neurosci Biobehav Rev 2021 Jul 21. Epub 2021 Jul 21.

Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL, United States; Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, United States.

The National Institute of Mental Health Research Domain Criteria (RDoC) framework promotes the dimensional and transdiagnostic operationalization of psychopathology, but consideration of the neurodevelopmental foundations of mental health problems requires deeper examination. Irritability, the dispositional tendency to angry emotion that has both mood and behavioral elements, is dimensional, transdiagnostic, and observable early in life-a promising target for the identification of early neural indicators or risk factors for psychopathology. Here, we examine functional brain networks linked to irritability from preschool to adulthood and discuss how development and early experience may influence these neural substrates. Read More

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Nursing diagnosis neonatal hyperbilirubinemia: A survival analysis.

Int J Nurs Knowl 2021 Jul 24. Epub 2021 Jul 24.

Department of Nursing, Federal University of Ceará, Fortaleza, Brazil.

Purpose: To analyze the short-term survival of the nursing diagnosis of neonatal hyperbilirubinemia in hospitalized neonates within the first 24 h of life and over a maximum of 7 days.

Methods: A prospective open cohort study with a longitudinal design was developed with 120 newborns during the first 24 h of life. The survival rate after a nursing diagnosis of neonatal hyperbilirubinemia was analyzed for 7 days. Read More

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Life Cycle Assessment of Sustainable Asphalt Pavement Solutions Involving Recycled Aggregates and Polymers.

Materials (Basel) 2021 Jul 11;14(14). Epub 2021 Jul 11.

Department of Civil, Construction and Environmental Engineering, University of Naples Federico II, Via Claudio 21, 80125 Naples, Italy.

The pursuit of sustainability in the field of road asphalt pavements calls for effective decision-making strategies, referring to both the technical and environmental sustainability of the solutions. This study aims to compare the life cycle impacts of several pavement solution alternatives involving, in the binder and base layers, some eco-designed, hot- and cold-produced asphalt mixtures made up of recycled aggregates in substitution for natural filler and commercial recycled polymer pellets for dry mixture modification. The first step focused on the technical and environmental compatibility assessment of the construction and demolition waste (CDW), jet grouting waste (JGW), fly ash (FA), and reclaimed asphalt pavement (RAP). Read More

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Mental Health and Psychological Wellbeing during the COVID-19 Lockdown: A Longitudinal Study in the Balearic Islands (Spain).

J Clin Med 2021 Jul 20;10(14). Epub 2021 Jul 20.

Primary Care Research Unit of Mallorca, Balearic Health Service, 07002 Palma, Balearic Islands, Spain.

Confining the entire population to a lockdown after the outbreak of SARS-CoV-2 was an unprecedented measure designed to protect the health of those living in Spain. The objective of the present study is to assess the evolution of mental health and psychological wellbeing during lockdown. To do this, we carried out a longitudinal study, via an online survey over the eight weeks of lockdown (weekly assessments). Read More

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Relevant Factors in Adolescent Well-Being: Family and Parental Relationships.

Int J Environ Res Public Health 2021 Jul 19;18(14). Epub 2021 Jul 19.

Faculty of Education, Pontifical University of Salamanca, 37007 Salamanca, Spain.

Health-related quality of life, teachers' opinion of academic performance and self-perceived health are indicators of well-being in the adolescent stage. Some variables, such as those related to the quality of family and parental relationships, may influence these indicators and thus condition well-being during this stage of life and beyond. In this research, the aforementioned variables are analyzed jointly. Read More

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Subjective Well-Being and Parenthood in Chile.

Int J Environ Res Public Health 2021 Jul 11;18(14). Epub 2021 Jul 11.

Department of Psychology, Universidad de Concepción, Concepcion 4070386, Chile.

Being a parent plays an important role in people's life trajectory and identity. Though the general cultural perception is that having children is a source of subjective well-being, there is evidence that, at least in some societies, the subjective well-being of those who are parents is worse, in some aspects, than that of those who are not. This gap has been the object of interest and controversy. Read More

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Do Cardiovascular Diseases Significantly Influence Healthy Aging?

Int J Environ Res Public Health 2021 Jul 6;18(14). Epub 2021 Jul 6.

Department of Economics, "Dunărea de Jos" University of Galati, 800201 Galați, Romania.

Population development is reflected by sustainable development indicators, among them are the indicators describing longevity and healthy aging. Longevity is reflected by life expectancy, and healthy aging is reflected by healthy life expectancy; high values of these indicators reflect good conditions of living for people. Life expectancy and healthy life expectancy analyses are of big interest among academics, policymakers, medical researchers, and others in order to direct the flow of funds in the most effective way possible to the population groups in most need. Read More

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Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues.

Int J Mol Sci 2021 Jul 16;22(14). Epub 2021 Jul 16.

Department of Life Sciences, Texas A&M University, Corpus Christi, TX 78412, USA.

Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. Read More

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Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Center of Medical Innovation and Translational Research, Department of Medical Data Science, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, Japan.

The recent advances in deciphering the human genome allow us to understand and evaluate the mechanisms of human genome age-associated transformations, which are largely unclear. Genome sequencing techniques assure comprehensive mapping of human genetics; however, understanding of gene functional interactions, specifically of time/age-dependent modifications, remain challenging. The age of the genome is defined by the sum of individual (inherited) and acquired genomic traits, based on internal and external factors that impact ontogenesis from the moment of egg fertilization and embryonic development. Read More

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The Paternal Transition Entails Neuroanatomic Adaptations that are Associated with the Father's Brain Response to his Infant Cues.

Cereb Cortex Commun 2020 4;1(1):tgaa082. Epub 2020 Nov 4.

Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain.

The transition into fatherhood is a life-changing event that requires substantial psychological adaptations. In families that include a father figure, sensitive paternal behavior has been shown to positively impact the infant's development. Yet, studies exploring the neuroanatomic adaptations of men in their transition into fatherhood are scarce. Read More

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November 2020

Patient-reported outcomes, sociodemographic and clinical factors are associated with 1-year mortality in patients with ischemic heart disease-findings from the DenHeart cohort study.

Qual Life Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Purpose: In patients with ischemic heart disease, the objectives were (1) to explore associations between patient-reported outcomes, sociodemographic, and clinical factors at discharge and 1-year all-cause mortality and (2) to investigate the discriminant predictive performance of the applied patient-reported outcome instruments on 1-year all-cause mortality.

Methods: Data from the Danish national DenHeart cohort study were used. Eligible patients (n = 13,476) were invited to complete a questionnaire-package, of which 7167 (53%) responded. Read More

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The Diagnostic Value of Coagulation Indicators and Inflammatory Markers in Distinguishing Between Strangulated and Simple Intestinal Obstruction.

Surg Laparosc Endosc Percutan Tech 2021 Jul 21. Epub 2021 Jul 21.

Prenatal Diagnosis Center Departments of Emergency Radiological Clinical Laboratory, Boai Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan, Guangdong, China.

Background: Intestinal obstruction with strangulation can be life-threating, and it is critical to make an accurate and timely diagnosis for emergency surgery.

Objective: This was aimed to investigate the value of coagulation indicators and inflammatory markers in distinguishing between strangulated and simple intestinal obstruction.

Materials And Methods: Fifty-four patients with intestinal obstruction were retrospectively studied. Read More

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Daily experiences of subjective age discordance and well-being.

Psychol Aging 2021 Jul 22. Epub 2021 Jul 22.

Institute of Psychogerontology.

Subjective age discordance (SAD) captures the difference between how old one feels and how old one would ideally like to be. We investigated the presence, strength, and fluctuation of this discordance in daily life as well as its relationship to various indicators of physical and psychological well-being with an 8-day diary study. Participants were 116 older and 107 younger adults who completed daily measures of felt age, ideal age, positive and negative affect, physical symptoms, and stressors. Read More

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Multi-State Analysis of the Impact of Childhood Starvation on the Healthy Life Expectancy of the Elderly in China.

Front Public Health 2021 5;9:690645. Epub 2021 Jul 5.

Department of Health Management, Harbin Medical University, Harbin, China.

Child malnutrition is not only common in developing countries but also an important issue faced by developed countries. This study aimed to explore the influence and degree of childhood starvation on the health of the elderly, which provides a reference for formulating health-related policies under the concept of full lifecycle health. Based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2008, 2011, and 2014, this study took a total of 13,185 elderly people aged 65-99 years as the target population. Read More

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Observation on the Clinical Effect of Apatinib Combined with Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer.

Pak J Med Sci 2021 Jul-Aug;37(4):1036-1041

Hong-zhen Zhang, Department of Oncology, Hebei General Hospital, Shijiazhuang, 050051, Hebei, China.

Objectives: To evaluate the clinical effect of apatinib combined with chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC).

Methods: Eighty patients with advanced NSCLC treated in Hebei General Hospital from January 2017 to July 2020 were randomly divided into two groups: the experimental group and the control group, each with 40 cases. Patients in the control group were treated with conventional paclitaxel combined with cisplatin chemotherapy, while patients in the experimental group were treated with apatinib mesylate tablets based on the treatment of the control group. Read More

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December 2020

Neonatal mortality prediction with routinely collected data: a machine learning approach.

BMC Pediatr 2021 Jul 21;21(1):322. Epub 2021 Jul 21.

Department of Epidemiology, School of Public Health, University of São Paulo, 715 Av Dr Arnaldo, Sao Paulo, SP, 01246-904, Brazil.

Background: Recent decreases in neonatal mortality have been slower than expected for most countries. This study aims to predict the risk of neonatal mortality using only data routinely available from birth records in the largest city of the Americas.

Methods: A probabilistic linkage of every birth record occurring in the municipality of São Paulo, Brazil, between 2012 e 2017 was performed with the death records from 2012 to 2018 (1,202,843 births and 447,687 deaths), and a total of 7282 neonatal deaths were identified (a neonatal mortality rate of 6. Read More

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