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Central sympathetic nerve activation in subarachnoid hemorrhage.

J Neurochem 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Kurume University School of Medicine 67, Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Subarachnoid hemorrhage (SAH) is a life-threatening condition, and although its two main complications-cerebral vasospasm (CVS)/delayed cerebral ischemia (DCI) and early brain injury (EBI)-have been widely studied, prognosis has not improved over time. The sympathetic nerve (SN) system is important for regulating cardiovascular function and is closely associated with cerebral vessels and the regulation of cerebral blood flow and cerebrovascular function; thus, excessive SN activation leads to a rapid breakdown of homeostasis in the brain. In the hyperacute phase, patients with SAH can experience possibly lethal conditions that are thought to be associated with SN activation (catecholamine surge)-related arrhythmia, neurogenic pulmonary edema, and irreversible injury to the hypothalamus and brainstem. Read More

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September 2021

Non-IFNγ Whole Blood Cytokine Responses to Mycobacterium tuberculosis Antigens in HIV-exposed Infants.

Pediatr Infect Dis J 2021 Oct;40(10):922-929

Department of Medicine, University of Washington, Seattle, Washington.

Background: HIV-exposed uninfected (HEU) infants have increased risk of tuberculosis (TB). Testing for Mycobacterium tuberculosis (Mtb) infection is limited by reduced Quantiferon (QFT) sensitivity in infants and tuberculin skin test (TST) cross-reactivity with Bacillus Calmette-Guérin vaccine. Our objective is to assess if non-IFNγ cytokine responses to Mtb-specific antigens have improved sensitivity in detecting Mtb infection in HEU infants compared with QFT. Read More

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October 2021

Sustainable application of Cassia obovata-based chrysophanic acid as potential source of yellow natural colorant for textile dyeing.

Environ Sci Pollut Res Int 2021 Sep 15. Epub 2021 Sep 15.

Applied Chemistry Research Centre, PCSIR Laboratories Complex, Ferozepur Road, Lahore, Pakistan.

In the current pandemic scenario, sustainable green products particularly antiviral, antioxidant, and antibacterial in nature are gaining worldwide fame in almost every walk of life. Cassia obovata (C. obovata) has been valorized as a source of yellow natural dye for nylon dyeing. Read More

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September 2021

Implementation of a cloud-based electronic patient-reported outcome (ePRO) platform in patients with advanced cancer.

J Patient Rep Outcomes 2021 Sep 15;5(1):91. Epub 2021 Sep 15.

Stanford Cancer Institute, Stanford, USA.

Background: Patient reported outcomes (PROs) have been associated with improved symptom management and quality of life in patients with cancer. However, the implementation of PROs in an academic clinical practice has not been thoroughly described. Here we report on the execution, feasibility and healthcare utilization outcomes of an electronic PRO (ePRO) application for cancer patients at an academic medical center. Read More

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September 2021

STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity.

Plant Cell 2021 Sep 15. Epub 2021 Sep 15.

State Key Laboratory of Plant Physiology and Biochemistry, College of Natural Resources and Environmental Science, Zhejiang University, Hangzhou, 310058, China.

Protons (H+) in acidic soils arrest plant growth. However, the mechanisms by which plants optimize their biological processes to diminish the unfavorable effects of H+ stress remain largely unclear. Here, we showed that in the roots of Arabidopsis thaliana, the C2H2-type transcription factor STOP1 in the nucleus was enriched by low pH in a nitrate-independent manner, with the spatial expression pattern of NITRATE TRANSPORTER 1. Read More

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September 2021

Identification of Species by Combining Molecular and Morphological Data Using Convolutional Neural Networks.

Syst Biol 2021 Sep 15. Epub 2021 Sep 15.

College of Life Sciences, Capital Normal University, Beijing 100048, People's Republic of China.

Integrative taxonomy is central to modern taxonomy and systematic biology, including behaviour, niche preference, distribution, morphological analysis and DNA barcoding. However, decades of use demonstrate that these methods can face challenges when used in isolation, for instance, potential misidentifications due to phenotypic plasticity for morphological methods, and incorrect identifications because of introgression, incomplete lineage sorting and horizontal gene transfer for DNA barcoding. Although researchers have advocated the use of integrative taxonomy, few detailed algorithms have been proposed. Read More

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September 2021

Modelling the central nervous system: tissue engineering of the cellular microenvironment.

Emerg Top Life Sci 2021 Sep 15. Epub 2021 Sep 15.

College of Health and Life Sciences, School of Biosciences, Aston University, Birmingham, U.K.

With the increasing prevalence of neurodegenerative diseases, improved models of the central nervous system (CNS) will improve our understanding of neurophysiology and pathogenesis, whilst enabling exploration of novel therapeutics. Studies of brain physiology have largely been carried out using in vivo models, ex vivo brain slices or primary cell culture from rodents. Whilst these models have provided great insight into complex interactions between brain cell types, key differences remain between human and rodent brains, such as degree of cortical complexity. Read More

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September 2021

Pilot study: specific immunotherapy in patients with Papular urticaria by Cimex lectularius.

Eur Ann Allergy Clin Immunol 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Immunology and Allergy, Hospital General De México (Dr Eduardo Liceaga), Ciudad De Mexico, Mexico.

Summary: Papular urticaria is a chronic allergic reaction induced by insect bites. In México the most common causative arthropods reported are bed bugs, fleas and mosquitoes. Approximately 70% of people who are bitten by experience hypersensitive reactions, papular urticaria, extensive erythema, urticaria, and even anaphylaxis has been reported, Pruritus is the major complaint, impairing quality of life and sleep. Read More

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September 2021

Child growth faltering dynamics in food insecure districts in rural Ethiopia.

Matern Child Nutr 2021 Sep 15:e13262. Epub 2021 Sep 15.

Center for Food Science and Nutrition. College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Child undernutrition disproportionally affects children in low- and middle-income countries. In Ethiopia, both wasting and stunting are serious public health concerns, with high human and economic costs. Understanding the dynamics in ponderal and linear growth faltering is critical to inform the design of innovative interventions that can prevent both wasting and stunting in poor and complex settings. Read More

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September 2021

Patient-Reported Outcomes with Selpercatinib Among Patients with RET Fusion-Positive Non-small Cell Lung Cancer in the Phase 1/2 LIBRETTO-001 Trial.

Oncologist 2021 Sep 15. Epub 2021 Sep 15.

University of California at San Francisco, USA.

Background: LIBRETTO-001 is an ongoing, global, open-label, phase 1/2 study of selpercatinib in patients with advanced or metastatic solid tumors. We report interim patient-reported outcomes in patients with RET fusion-positive non-small-cell lung cancer (NSCLC).

Patients And Methods: Patients completed the EORTC QLQ-C30 version 3. Read More

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September 2021

Roux-en-Y versus Billroth-I reconstruction after distal gastrectomy for gastric cancer.

Cochrane Database Syst Rev 2021 Sep 15;9:CD012998. Epub 2021 Sep 15.

Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan.

Background: Gastric cancer is the fifth most common cancer diagnosed worldwide. Due to improved early detection rates of gastric cancer and technological advances in treatments, a significant improvement in survival rates has been achieved in people with cancer undergoing gastrectomy. Subsequently, there has been increasing emphasis on postgastrectomy syndrome (e. Read More

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September 2021

Effect of nickel salts on the production of biochar derived from alkali lignin: properties and applications.

Bioresour Technol 2021 Sep 9;341:125876. Epub 2021 Sep 9.

Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China. Electronic address:

The massive generation of alkali lignin, has aroused the attention of all walks of life, and an eco-friendly utilization approach needs to be exploited. Herein, a simple pretreatment method with nickel salts was developed for the valorisation of alkali lignin through slow pyrolysis. The pretreatment of nickel salts improved the foaming or swelling behaviors of alkali lignin upon heating, and the specific surface area and total pore size of biochars increased about thirteenfold and eighteenfold, respectively. Read More

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September 2021

Metabolism perturbation Causedby the overexpression of carbon monoxide dehydrogenase/Acetyl-CoA synthase gene complex accelerated gas to acetate conversion rate ofEubacterium limosumKIST612.

Bioresour Technol 2021 Sep 4;341:125879. Epub 2021 Sep 4.

School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. Electronic address:

Microbial conversion of carbon monoxide (CO) to acetate is a promising upcycling strategy for carbon sequestration. Herein, we demonstrate that CO conversion and acetate production rates of Eubacterium limosum KIST612 strain can be improved by in silico prediction and in vivo assessment. The mimicked CO metabolic model of KIST612 predicted that overexpressing the CO dehydrogenase (CODH) increases CO conversion and acetate production rates. Read More

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September 2021

Improved Pb(II) removal in aqueous solution by [email protected] and [email protected] biochar composites: Efficiencies and mechanisms.

Chemosphere 2021 Aug 31;287(Pt 1):132087. Epub 2021 Aug 31.

School of Life Science, School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, Zhejiang, 312000, PR China. Electronic address:

Novel biochars, namely nano iron [email protected] walnut shell biochar ([email protected]), [email protected] and [email protected], were prepared by WNS loaded with nano FeS and starch (or chitosan). Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration. The materials were characterized by SEM, EDS, FTIR and XRD, and the preparation was successful. Read More

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[Comparison of unicompartmental knee arthroplasty and total knee arthroplasty in the treatment of severe medial compartment osteoarthritis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1125-1132

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Objective: To compare the effectiveness of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) in the treatment of severe medial compartment osteoarthritis (OA).

Methods: A clinical data of 69 patients (69 knees), who underwent joint replacement due to severe medial compartment OA between February 2015 and September 2018 and met the selection criteria, was retrospectively analyzed. Among them, 38 cases were treated with UKA (UKA group) and 31 cases with TKA (TKA group). Read More

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September 2021

Comparison of effectiveness between modified transvaginal mesh surgery and vaginal pessary treatment in patients with symptomatic pelvic organ prolapse.

Low Urin Tract Symptoms 2021 Sep 14. Epub 2021 Sep 14.

Department of Urology, Kyorin University School of Medicine, Tokyo, Japan.

Objectives: This study aimed to compare the efficacy of modified transvaginal mesh (TVM) surgery and vaginal pessary in patients with symptomatic pelvic organ prolapse (POP).

Methods: We retrospectively analyzed 130 patients with symptomatic POP treated with either modified TVM (n = 62) or vaginal pessary (n = 68). To evaluate the prolapse, lower urinary tract, bowel, and sexual symptoms and prolapse-related quality of life (QOL) were assessed using the prolapse QOL questionnaire. Read More

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September 2021

Depressive symptoms interfere with the improvement in exercise capacity by cardiac rehabilitation after left ventricular assist device implantation.

Artif Organs 2021 Sep 14. Epub 2021 Sep 14.

Faculty of Rehabilitation, Shijonawate Gakuen University, 5-11-10 Houjou Daito, Osaka, 574-0011, Japan.

Background: Although depressive symptoms are associated with an increased risk of readmission after left ventricular assist device (LVAD) implantation, it is unclear whether they affect the efficacy of exercise-based cardiac rehabilitation (EBCR). This study aimed to investigate the effect of depressive symptoms on EBCR efficacy.

Methods: We analyzed 48 patients who participated in EBCR after LVAD implantation (mean age 45±12 years; 60% male). Read More

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September 2021

Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies.

Neurosci Bull 2021 Sep 14. Epub 2021 Sep 14.

Key Laboratory of Brain Functional Genomics of Shanghai and the Ministry of Education, Institute of Brain Functional Genomics, School of Life Science and the Collaborative Innovation Center for Brain Science, East China Normal University, Shanghai, 200062, China.

A large number of putative risk genes for autism spectrum disorder (ASD) have been reported. The functions of most of these susceptibility genes in developing brains remain unknown, and causal relationships between their variation and autism traits have not been established. The aim of this study was to predict putative risk genes at the whole-genome level based on the analysis of gene co-expression with a group of high-confidence ASD risk genes (hcASDs). Read More

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September 2021

Does Climate Variability Impact COVID-19 Outbreak? An Enhanced Semantics-Driven Theory-Guided Model.

SN Comput Sci 2021 9;2(6):452. Epub 2021 Sep 9.

Department of Computer Science and Engineering, Indian Institute of Technology (IIT), Kharagpur, India.

COVID-19, a life-threatening infection by novel coronavirus, has broken out as a pandemic since December 2019. Eventually, with the aim of helping the World Health Organization and other health regulators to combat COVID-19, significant research effort has been exerted during last several months to analyze how the various factors, especially the climatic aspects, impact on the spread of this infection. However, due to insufficient test and lack of data transparency, these research findings, at times, are found to be inconsistent as well as conflicting. Read More

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September 2021

Inspiratory muscle training in children and adolescents living with neuromuscular diseases: A pre-experimental study.

S Afr J Physiother 2021 31;77(1):1577. Epub 2021 Aug 31.

Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Rondebosch, South Africa.

Background: Children with neuromuscular diseases (NMD) are at risk of morbidity and mortality because of progressive respiratory muscle weakness and ineffective cough. Inspiratory muscle training (IMT) aims to preserve or improve respiratory muscle strength, thereby reducing morbidity and improving health-related quality of life (HRQoL).

Objectives: To describe the safety and feasibility of a 6-week IMT programme using an electronic threshold device (Powerbreathe®). Read More

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Whole genome sequencing of two human rhinovirus A types (A101 and A15) detected in Kenya, 2016-2018.

Wellcome Open Res 2021 8;6:178. Epub 2021 Jul 8.

Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.

Virus genome sequencing is increasingly utilized in epidemiological surveillance. Genomic data allows comprehensive evaluation of underlying viral diversity and epidemiology to inform control. For human rhinovirus (HRV), genomic amplification and sequencing is challenging due to numerous types, high genetic diversity and inadequate reference sequences. Read More

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Studying at university in later life slows cognitive decline: A long-term prospective study.

Alzheimers Dement (N Y) 2021 8;7(1):e12207. Epub 2021 Sep 8.

Wicking Dementia Research & Education Centre College of Health and Medicine University of Tasmania Hobart Tasmania Australia.

Introduction: Declining cognition in later life is associated with loss of independence and quality of life. This decline in cognition may potentially be reduced or reversed through engaging in cognitively stimulating activities. This study examined the potential for university attendance in later life to enhance cognitive function in older adults. Read More

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September 2021

Fracture Nonunions and Delayed Unions Treated With Low-Intensity Pulsed Ultrasound Therapy: A Clinical Series.

Cureus 2021 Aug 10;13(8):e17067. Epub 2021 Aug 10.

Dermatology, James Cook University Hospital, Middlesbrough, GBR.

The incidence of nonunion of fractures has been steadily rising owing to improved life expectancy following severe injuries along with rising cases of polytrauma. Once a nonunion is established, the chances of spontaneous healing are deemed to be quite low. Fracture nonunion continues to be a challenge in clinical practice with nonunions having a considerable impact on patient's quality of life causing both functional and psychosocial disability. Read More

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Hypocalcemia in a Patient With Metastatic Prostate Cancer From Denosumab Treatment.

Cureus 2021 Aug 10;13(8):e17046. Epub 2021 Aug 10.

Hematology / Oncology, Bassett Medical Center, Cooperstown, USA.

Denosumab is a humanized monoclonal antibody that binds RANKL to inhibit osteoclast activity. It is indicated for the prevention of skeletal-related events (SRE) in patients with solid tumors who have bone metastasis and in patients with multiple myeloma. Hypocalcemia is one of the known side effects of denosumab, which can be prevented with calcium supplementation. Read More

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Association of Weight Loss With Improved Sexual Function in Females.

Cureus 2021 Aug 3;13(8):e16849. Epub 2021 Aug 3.

Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK.

Introduction The prevalence of obesity in developing countries, including Pakistan, has increased several fold in recent times. Obesity appears to negatively affect sexual functioning, hence affecting the quality of life. Its impact on sexual function is understudied. Read More

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Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer.

Theranostics 2021 26;11(18):9054-9088. Epub 2021 Aug 26.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, South Africa.

In recent years tremendous effort has been invested in the field of cancer diagnosis and treatment with an overall goal of improving cancer management, therapeutic outcome, patient survival, and quality of life. Photodynamic Therapy (PDT), which works on the principle of light-induced activation of photosensitizers (PS) leading to Reactive Oxygen Species (ROS) mediated cancer cell killing has received increased attention as a promising alternative to overcome several limitations of conventional cancer therapies. Compared to conventional therapies, PDT offers the advantages of selectivity, minimal invasiveness, localized treatment, and spatio-temporal control which minimizes the overall therapeutic side effects and can be repeated as needed without interfering with other treatments and inducing treatment resistance. Read More

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An "eat me" combinatory nano-formulation for systemic immunotherapy of solid tumors.

Theranostics 2021 11;11(18):8738-8754. Epub 2021 Aug 11.

Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.

Tumor immunogenic cell death (ICD), induced by certain chemotherapeutic drugs such as doxorubicin (Dox), is a form of apoptosis potentiating a protective immune response. One of the hallmarks of ICD is the translocation of calreticulin to the cell surface acting as an 'eat me' signal. This manuscript describes the development of a stable nucleic acid-lipid particles (SNALPs) formulation for the simultaneous delivery of ICD inducing drug (Dox) with small interfering RNA (siRNA) knocking down CD47 (siCD47), the dominant 'don't eat me' marker, for synergistic enhancement of ICD. Read More

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Smart magnetic resonance imaging-based theranostics for cancer.

Theranostics 2021 7;11(18):8706-8737. Epub 2021 Aug 7.

Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, UK, SE1 7EH.

Smart theranostics are dynamic platforms that integrate multiple functions, including at least imaging, therapy, and responsiveness, in a single agent. This review showcases a variety of responsive theranostic agents developed specifically for magnetic resonance imaging (MRI), due to the privileged position this non-invasive, non-ionising imaging modality continues to hold within the clinical imaging field. Different MRI smart theranostic designs have been devised in the search for more efficient cancer therapy, and improved diagnostic efficiency, through the increase of the local concentration of therapeutic effectors and MRI signal intensity in pathological tissues. Read More

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A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases.

NPJ Breast Cancer 2021 Sep 14;7(1):121. Epub 2021 Sep 14.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Breast cancer is the most commonly diagnosed cancer in women worldwide. Approximately one-tenth of all patients with advanced breast cancer develop brain metastases resulting in an overall survival rate of fewer than 2 years. The challenges lie in developing new approaches to treat, monitor, and prevent breast cancer brain metastasis (BCBM). Read More

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September 2021

Genetic basis and adaptation trajectory of soybean from its temperate origin to tropics.

Nat Commun 2021 Sep 14;12(1):5445. Epub 2021 Sep 14.

Innovative Center of Molecular Genetics and Evolution, School of Life Sciences, Guangzhou University, Guangzhou, China.

Soybean (Glycine max) serves as a major source of protein and edible oils worldwide. The genetic and genomic bases of the adaptation of soybean to tropical regions remain largely unclear. Here, we identify the novel locus Time of Flowering 16 (Tof16), which confers delay flowering and improve yield at low latitudes and determines that it harbors the soybean homolog of LATE ELONGATED HYPOCOTYL (LHY). Read More

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September 2021