100,253 results match your criteria life events

Epidermal growth factor receptor and integrins meet redox signaling through P66shc and Rac1.

Cytokine 2021 Jun 19;146:155625. Epub 2021 Jun 19.

Department of Biotechnology, University of Kashmir, Srinagar, JK 190006, India. Electronic address:

This review examines the concerted role of Epidermal Growth Factor Receptor (EGFR) and integrins in regulating Reactive oxygen species (ROS) production through different signaling pathways. ROS as such are not always deleterious to the cells but they also act as signaling molecules, that regulates numerous indespensible physiological fuctions of life. Many adaptor proteins, particularly Shc and Grb2, are involved in mediating the downstream signaling pathways stimulated by EGFR and integrins. Read More

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Ruxolitinib for chronic steroid-refractory graft versus host disease: a single center experience.

Leuk Res 2021 Jun 11;109:106642. Epub 2021 Jun 11.

Haematology and Bone Marrow Transplant Unit, IRCSS San Raffaele Scientific Institute, Italy. Electronic address:

Background: Chronic Graft versus Host Disease (GvHD) is a serious complication of allogeneic hematopoietic stem cell transplant that severely impacts quality of life and long-term survival. About 50-to-60 % of patients treated with steroids require a further line of therapy due to lack of sustained response. Ruxolitinib, a JAK1/2 inhibitor, has recently been approved for the treatment of acute GvHD. Read More

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Elemental diet therapy for eosinophilic gastroenteritis and dietary habits.

Pediatr Int 2021 Jun 22. Epub 2021 Jun 22.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Backgrounds: Eosinophilic gastrointestinal disorders (EGID) are a group of conditions with increased eosinophilic infiltration in any part of the gastrointestinal tract. Although an allergic reaction to certain foods is considered the main cause of EGID, their detailed pathomechanism has not yet been elucidated, nor have proper management strategies been fully established. Moreover, some patients with intractable EGID are resistant to such therapies as an empirical elimination diet and corticosteroids. Read More

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Long-term efficacy and safety of risankizumab for the treatment of moderate-to-severe plaque psoriasis: interim analysis of the LIMMitless open-label extension trial beyond 3 years of follow-up.

Br J Dermatol 2021 Jun 22. Epub 2021 Jun 22.

Central Dermatology, Richmond Heights, MO, USA.

Background: Psoriasis is a chronic inflammatory skin disease requiring prolonged treatment. New biologic therapies require long-term evaluation to assess durability of their efficacy and safety profile over time.

Objectives: To evaluate long-term efficacy and safety of risankizumab (RZB) for the treatment of psoriasis. Read More

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Viromes in marine ecosystems reveal remarkable invertebrate RNA virus diversity.

Sci China Life Sci 2021 Jun 17. Epub 2021 Jun 17.

CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, 200031, China.

Little is known about ocean viromes and the ecological drivers of the evolution of aquatic RNA viruses. This study employed a meta-transcriptomic approach to characterize the viromes of 58 marine invertebrate species across three seas. This revealed the presence of 315 newly identified RNA viruses in nine viral families or orders (Durnavirales, Totiviridae, Bunyavirales, Hantaviridae, Picornavirales, Flaviviridae, Hepelivirales, Solemoviridae, and Tombusviridae), with most of them being sufficiently divergent to the already documented viruses. Read More

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Prognostic significance of liver stiffness assessed by fibrosis-4 index in patients with heart failure.

ESC Heart Fail 2021 Jun 22. Epub 2021 Jun 22.

Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Center for Metabolic Regulation of Healthy Aging (CMHA), Kumamoto University, Kumamoto, Japan.

Background: Heart failure (HF)-related congestive hepatopathy is a well-recognized problem in management of HF. The fibrosis-4 (FIB4) index calculated by [age × aspartate aminotransferase (IU/L)/platelet count (10 /L) × square root of alanine aminotransferase (IU/L)] is useful for evaluating liver stiffness. We aimed to investigate the impact of the FIB4 index on prognosis in patients with HF. Read More

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Quantitative mapping of human hair greying and reversal in relation to life stress.

Elife 2021 Jun 22;10. Epub 2021 Jun 22.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, United States.

Background: Hair greying is a hallmark of aging generally believed to be irreversible and linked to psychological stress.

Methods: Here, we develop an approach to profile hair pigmentation patterns (HPPs) along individual human hair shafts, producing quantifiable physical timescales of rapid greying transitions.

Results: Using this method, we show white/grey hairs that naturally regain pigmentation across sex, ethnicities, ages, and body regions, thereby quantitatively defining the reversibility of greying in humans. Read More

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Efficacy and Safety of Biosimilar and Originator Etanercept in Rheumatoid Arthritis Patients: Real-Life Data.

Isr Med Assoc J 2021 Jun;23(6):344-349

Rheumatology Unit, Internal Medicine Department, ASST Fatebenefratelli-Sacco, Milan State University School of Medicine, Milan, Italy.

Background: There is a lack of real-life clinical data for biosimilar etanercept, an anti-TNF blocking fusion protein. We describe the comparable efficacy and safety of originator and biosimilar etanercept in rheumatoid arthritis (RA) patients in a real-life clinical setting. Our data confirm that a biosimilar etanercept can be safely used as first-line treatment as well as in patients switched from a previous originator compound. Read More

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Incidence of Pneumocystis jirovecii pneumonia utilizing a polymerase chain reaction-based diagnosis in patients receiving bendamustine.

Cancer Med 2021 Jun 22. Epub 2021 Jun 22.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Background: Pneumocystis jirovecii pneumonia (PJP) is a life-threatening infection occurring in patients receiving bendamustine. The poorly defined incidence, particularly when utilizing polymerase chain reaction (PCR)-based diagnostic techniques, precipitates unclear prophylaxis recommendations. Our objective was to determine the cumulative incidence of PJP diagnosed by single copy target, non-nested PCR in patients receiving bendamustine. Read More

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L-carnitine supplementation for muscle weakness and fatigue in children with neurofibromatosis type 1: A Phase 2a clinical trial.

Am J Med Genet A 2021 Jun 21. Epub 2021 Jun 21.

Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Reduced muscle tone, muscle weakness, and physical fatigue can impact considerably on quality of life for children with neurofibromatosis type 1 (NF1). Human muscle biopsies and mouse models of NF1 deficiency in muscle show intramyocellular lipid accumulation, and preclinical data have indicated that L-carnitine supplementation can ameliorate this phenotype. The aim of this study is to examine whether daily L-carnitine supplementation is safe and feasible, and will improve muscle strength and reduce fatigue in children with NF1. Read More

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Sodium glucose-linked transport protein 2 inhibitors: An overview of genitourinary and perioperative implications.

Int J Urol 2021 Jun 22. Epub 2021 Jun 22.

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Sodium glucose-linked transport protein 2 inhibitors are relatively novel drugs, used for the treatment of type 2 diabetes mellitus. Their use since Pharmaceutical Benefits Scheme approval in Australia has increased drastically, possibly due to the low risk of hypoglycemic events and their advertised cardiovascular mortality benefits. However, as with any novel drug, adverse effects regarding their use require medical practitioner awareness for optimal patient outcomes. Read More

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Reductive dissolution of phosphorus associated with iron-oxides during saturation in agricultural soil profiles.

J Environ Qual 2021 Jun 22. Epub 2021 Jun 22.

Teagasc Crops, Environment and Land Use Programme, Johnstown Castle, Wexford, Ireland.

In soils with a fragipan or poor permeability, water may remain in a soil profile long enough to make it anaerobic and reductive. The reductive dissolution of iron (Fe) and manganese (Mn) oxides can release associated phosphorus (P). Therefore, the dissolved P would be vulnerable to subsurface flow, and could contaminate nearby streams. Read More

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Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients.

Sci Rep 2021 Jun 21;11(1):12929. Epub 2021 Jun 21.

Department of Neurology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

We investigated cardiovascular outcomes in ischemic stroke patients with newly diagnosed diabetes mellitus (DM) compared with those of patients with previously known DM and no DM using the glycosylated hemoglobin (HbA1c) criteria. The relationship between new DM diagnosis and cardiovascular risk remains unclear to date. We performed post hoc analysis using the data of participants from the Prevention of Cardiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage (PICASSO) trial. Read More

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The Effects of Oral Energy-Dense Supplements on Nutritional Status in Nondiabetic Maintenance Hemodialysis Patients.

Clin J Am Soc Nephrol 2021 Jun 21. Epub 2021 Jun 21.

M Liang, National Clinical Research Center of Kidney Diseases, Guangzhou, China

Fat-based energy-dense nutritional supplements may offer benefits over protein or carbohydrate dense supplements for patients receiving dialysis because of the adverse metabolic consequences of the latter. We conducted a randomized controlled trial to assess the effects of the short-term use of a fat-based nutritional supplement on various measures of nutritional status in patients receiving maintenance hemodialysis who have low dietary energy intake. We enrolled nondiabetic patients receiving hemodialysis for more than 3 months and had inadequate dietary energy intake (<30kcal/kg/d). Read More

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Etiology of Autoimmune Islet Disease: Timing Is Everything.

Åke Lernmark

Diabetes 2021 Jun 21. Epub 2021 Jun 21.

Department of Clinical Sciences, Lund University Clinical Research Centre, Skåne University Hospital, Malmö, Sweden

Life is about timing.-Carl LewisThe understanding of autoimmune type 1 diabetes is increasing, and examining etiology separate from pathogenesis has become crucial. The components to explain type 1 diabetes development have been known for some time. Read More

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[How do patients manage their urostomy in everyday life? A questionnaire survey].

Prog Urol 2021 Jun 18. Epub 2021 Jun 18.

Service de chirurgie urologique et andrologique, CHU de Limoges, 2 avenue Martin-Luther-King, 87000 Limoges, France.

Introduction: The complications of stoma and peristomal are encountered by nearly 80% of patients within two years of surgery. The objective of this study was to evaluate the practical modalities of daily management of stoma and possible skin complications in a series of patients with non-continent urinary stoma.

Methods: Monocentric study by questionnaires including all patients with non-continent urinary stoma between 2007 and 2019 in a French university center. Read More

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Effects of weight loss medications on mortality and cardiovascular events: A systematic review of randomized controlled trials in adults with overweight and obesity.

Nutr Metab Cardiovasc Dis 2021 May 28. Epub 2021 May 28.

Center for Outcomes Research and Clinical Epidemiology - CORESEARCH, Pescara, Italy. Electronic address:

Aims: Adults affected by obesity are at higher risk of premature mortality. Medications can help to lose weight and to maintain weight loss. Aim of this meta-analysis was to assess whether anti-obesity medications affect all-cause mortality, mortality due to cardiovascular events, cardiovascular risk factors and body weight. Read More

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Predicting 30-day mortality after ST elevation myocardial infarction: Machine learning- based random forest and its external validation using two independent nationwide datasets.

J Cardiol 2021 Jun 18. Epub 2021 Jun 18.

The Mina and Everard Goodman Faculty of Life Sciences. Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Various prognostic models for mortality prediction following ST-segment elevation myocardial infarction (STEMI) have been developed over the past two decades. Our group has previously demonstrated that machine learning (ML)-based models can outperform known risk scores for 30-day mortality post-STEMI. The study aimed to redevelop an ML-based random forest prediction model for 30-day mortality post-STEMI and externally validate it on a large cohort. Read More

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Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs.

BMC Vet Res 2021 Jun 21;17(1):220. Epub 2021 Jun 21.

Department of Internal Medicine, École Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, Maisons-Alfort, France.

Background: 5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties. To reduce systemic toxicity of 5-fluorouracil during chemotherapy, 5- fluorocytosine can be used as a targeted anticancer agent. Read More

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Triple versus LAMA/LABA combination therapy for patients with COPD: a systematic review and meta-analysis.

Respir Res 2021 Jun 22;22(1):183. Epub 2021 Jun 22.

Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: Recently, the addition of inhaled corticosteroid (ICS) to long-acting muscarinic antagonist (LAMA) and long-acting beta-agonist (LABA) combination therapy has been recommended for patients with COPD who have severe symptoms and a history of exacerbations because it reduces the exacerbations. In addition, a reducing effect on mortality has been shown by this treatment. However, the evidence is mainly based on one large randomized controlled trial IMPACT study, and it remains unclear whether the ICS add-on treatment is beneficial or not. Read More

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Benefit of measuring vedolizumab concentrations in inflammatory bowel disease patients in a real-world setting.

Scand J Gastroenterol 2021 Jun 21:1-8. Epub 2021 Jun 21.

Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Objectives: We set out to determine the reasons for serum vedolizumab (VDZ) trough concentration (TC) measurements in inflammatory bowel disease (IBD) patients and to evaluate treatment modifications after therapeutic drug measurement (TDM). We also evaluated the effect of increased dosing on patients' response to VDZ therapy.

Methods: We performed a retrospective cohort study of IBD patients who received VDZ therapy at Helsinki University Hospital and whose VDZ levels were measured between June 2014 and December 2018. Read More

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Neural Substrates of Vulnerability to Anxiety in Response to Stressful Life Events: A COVID-19 Study.

Lianne Schmaal

Am J Psychiatry 2021 06;178(6):477-479

Orygen, Parkville, Australia; and the Centre for Youth Mental Health, University of Melbourne, Australia.

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Precision medicine in Fabry disease.

Nephrol Dial Transplant 2021 Jun;36(Supplement_2):14-23

Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, Interdisciplinary Fabry Center Münster, University Hospital Münster, Münster, Germany.

Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (GLA) gene, leading to a deficiency in α-galactosidase A. The lysosomal accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3) and its deacylated form, globotriaosylsphingosine (lyso-Gb3), results in progressive renal failure, cardiomyopathy associated with cardiac arrhythmia and recurrent cerebrovascular events, significantly limiting life expectancy in affected patients. In male patients, a definitive diagnosis of FD involves demonstrating a GLA deficiency in leucocytes. Read More

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Variation in self-identified most stressful life event by outcome of previous pregnancy in a population-based sample interviewed 6-36 months following delivery.

Soc Sci Med 2021 Jun 16;282:114138. Epub 2021 Jun 16.

Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA, 30322, United States.

The majority of health research uses a deductive approach to measure stressful life events, despite evidence that perception of what is stressful varies. The goal of this project was to 1) describe the distribution of self-identified most stressful life events in a cohort of women who experienced a perinatal loss (stillbirth or neonatal death) or live birth in the previous three years and 2) test how childhood adversity influences participant selection of their most stressful life event. We used data from 987 women (282 with stillbirth, 657 without loss, and 48 with a neonatal death in the first 28 days) in the Stillbirth Collaborative Research Network - OASIS (Outcomes after Study Index Stillbirth) follow-up study, a population-based sample set in five U. Read More

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Black-White racial health disparities in inflammation and physical health: Cumulative stress, social isolation, and health behaviors.

Psychoneuroendocrinology 2021 May 8;131:105251. Epub 2021 May 8.

Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

Black Americans have vastly increased odds and earlier onsets of stress- and age-related disease compared to White Americans. However, what contributes to these racial health disparities remains poorly understood. Using a sample of 1577 older adults (32. Read More

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Spatiotemporally flexible subnetworks reveal the quasi-cyclic nature of integration and segregation in the human brain.

Neuroimage 2021 Jun 18:118287. Epub 2021 Jun 18.

Department of Women's and Children's health, Karolinska Institutet, Sweden.

Though the organization of functional brain networks is modular at its core, modularity does not capture the full range of dynamic interactions between individual brain areas nor at the level of subnetworks. In this paper we present a hierarchical model that represents both flexible and modular aspects of intrinsic brain organization across time by constructing spatiotemporally flexible subnetworks. We also demonstrate that segregation and integration are complementary and simultaneous events. Read More

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Late-onset adverse events under anti-PD1 therapy in melanoma patients: an observational study from MELBASE, a nationwide prospective cohort.

J Am Acad Dermatol 2021 Jun 18. Epub 2021 Jun 18.

CHU and UMR 1098, Besançon;. Electronic address:

The purpose was to evaluate late-onset AEs in melanoma patients treated with anti-PD1 administered at least 2 years in a real-life setting. Patients were screened from MelBase (NCT02828202), a French multicentric biobank dedicated to the prospective follow-up of unresectable stage III or IV melanoma. 119 patients who received anti-PD1 during at least 2 years from January 2013 to November 2019 were included. Read More

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ZAP70 activation is an early event of T cell immunity that involved in the anti-bacterial adaptive immune response of Nile tilapia.

Dev Comp Immunol 2021 Jun 18:104177. Epub 2021 Jun 18.

State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, Shanghai 200241, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address:

ZAP70 is essential for initiating the early events of T-cell antigen receptor (TCR) signaling cascade to ensure proper T cell activation and function. However, whether this molecule takes part in the T cell immune response of early vertebrates remains unclear. In the present study, using a teleost model Nile tilapia (Oreochromis niloticus), we investigated the potential involvement of ZAP70 in the T cell activation and adaptive immunity of fish species. Read More

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Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial.


Lancet Respir Med 2021 Jun 18. Epub 2021 Jun 18.

Background: Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuous positive airway pressure (CPAP) administered immediately after major abdominal surgery could prevent postoperative morbidity.

Methods: PRISM was an open-label, randomised, phase 3 trial done at 70 hospitals across six countries. Read More

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