159,182 results match your criteria life cycle


Menstrual distress in females of reproductive age: a literature review.

Int J Adolesc Med Health 2021 Jul 22. Epub 2021 Jul 22.

Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, India.

Menstrual-related issues have significant public-health ramifications. Women who are having menstruation troubles should get their mental health checked by healthcare specialists. In young women, a menstrual-related condition has serious health implications. Read More

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Platinum complexes inhibit HER-2 enriched and triple-negative breast cancer cells metabolism to suppress growth, stemness and migration by targeting PKM/LDHA and CCND1/BCL2/ATG3 signaling pathways.

Eur J Med Chem 2021 Jul 7;224:113689. Epub 2021 Jul 7.

Inner Mongolia University Research Center for Glycochemistry of Characteristic Medicinal Resources, School of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, PR China. Electronic address:

Triple-negative-breast cancer (TNBC) and HER-2 enriched positive aggressive types of breast cancer and are highly metastatic in nature. Anticancer agents those target TNBC and HER-2 enriched positive breast cancers are considered important in the field of breast cancer research. In search of the effective anticancer agents, we synthesized Pt(II) complexes to target these cancers. Read More

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Biomass as source for hydrochar and biochar production to recover phosphates from wastewater: A review on challenges, commercialization, and future perspectives.

Chemosphere 2021 Jul 15;286(Pt 1):131490. Epub 2021 Jul 15.

Department of Food, Agricultural and Biological Engineering, The Ohio State University, Wooster, OH, United States. Electronic address:

Excessive phosphate run-off with total phosphorus concentration greater than 20 μg P L triggers the growth of harmful algal species in waterbodies and potentially leads to eutrophication. This has severe negative implications on aquatic environment and impacts human health. The annual economic impact of harmful algal blooms is reported to be as high as $25 million for public health and commercial fishery sector, $29 million for recreation/tourism sector and $2 million for monitoring and management. Read More

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Stable transfection in protist Corallochytriumlimacisporum identifies novel cellular features among unicellular animals relatives.

Curr Biol 2021 Jul 14. Epub 2021 Jul 14.

Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Catalonia, Spain. Electronic address:

The evolutionary path from protists to multicellular animals remains a mystery. Recent work on the genomes of several unicellular relatives of animals has shaped our understanding of the genetic changes that may have occurred in this transition. However, the specific cellular modifications that took place to accommodate these changes remain unclear. Read More

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Model-guided development of an evolutionarily stable yeast chassis.

Mol Syst Biol 2021 Jul;17(7):e10253

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to rigorous experimental test. Here, we report the development of Saccharomyces cerevisiae chassis strains for dicarboxylic acid production using genome-scale metabolic modelling. Read More

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Investigating Endocrine Disrupting Properties of Chemicals in Fish and Amphibians: Opportunities to Apply the 3Rs.

Integr Environ Assess Manag 2021 Jul 22. Epub 2021 Jul 22.

Shell Health, Shell International B.V., Carel van Bylandtlaan 16, 2596 HR, The Hague, The Netherlands.

Many regulations are beginning to explicitly require investigation of a chemical's endocrine disrupting properties as a part of the safety assessment process, for substances already on or about to be placed on the market. Different jurisdictions are applying distinct approaches. However, all share a common theme requiring testing for endocrine activity and adverse effects, typically involving in vitro and in vivo assays on selected endocrine pathways. Read More

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Habitat use and nursery evaluation for the longnose stingray Hypanus guttatus (Bloch & Schneider, 1801) using vertebral microchemistry.

J Fish Biol 2021 Jul 22. Epub 2021 Jul 22.

Laboratório de Dinâmica de Populações Marinhas (DIMAR), Departamento de Pesca e Aquicultura, Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil.

Here, we use vertebral microchemistry to investigate the habitat use patterns of the longnose stingray Hypanus guttatus in the northern and northeastern regions of Brazil, and to evaluate the existence of potential nurseries of the species. Samples were collected in Maranhão, Rio Grande do Norte, and Pernambuco states between 2008 and 2019. Trace element concentrations of Ba:Ca, Mg:Ca, Mn:Ca, and Sr. Read More

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Forever young: stem cell and plant regeneration one century after Haberlandt 1921.

Protoplasma 2021 Jul 22. Epub 2021 Jul 22.

Department of Biology, Stanford University, Stanford, CA, 94305, USA.

Plants are characterized by a post-embryonic mode of organ development, which results in a need for these photoautotrophic organisms to regenerate lost parts in the course of their life cycle. This capacity depends on the presence of "pluripotent stem cells," which are part of the meristems within the plant body. One hundred years ago, the botanist Gottlieb Haberlandt (1854-1945) published experiments showing wounding-induced callus formation, which led ultimately to plant regeneration in tissue culture and thence to the techniques of "plant biotechnology," with practical applications for mankind. Read More

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Functional and patient-reported changes in swallowing and voice after combined chemotherapy and radiotherapy for limited-stage small-cell lung cancer.

J Med Imaging Radiat Oncol 2021 Jul 21. Epub 2021 Jul 21.

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.

Introduction: The purpose of this study was to describe the nature and impact of dysphagia and dysphonia in patients with limited-stage small-cell lung cancer (SCLC) before and after chemoradiation.

Methods: A prospective cohort study was conducted on patients receiving chemoradiotherapy for limited-stage SCLC. Patients received either 40, 45 or 50 Gy, commencing the second cycle of chemotherapy. Read More

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Hypophosphatemia in critically ill pediatric patients receiving enteral and oral nutrition.

JPEN J Parenter Enteral Nutr 2021 Jul 21. Epub 2021 Jul 21.

State University of Campinas, Unicamp, Faculty of Medical Sciences, 126 Tessália Vieira de Camargo St., Barão Geraldo, Campinas, SP, Zip Code: 13083-887, Brazil.

Background: Hypophosphatemia (HP) is related to several comorbidities in pediatric intensive care units (PICUs). This study aimed to evaluate the incidence of HP in severely ill pediatric patients under oral and/or enteral nutrition. The secondary objectives were to investigate the association between HP and the inflammatory state, prolonged PICU length stay, severity, mortality, nutritional status, and protein, energy, calcium, vitamin D and phosphate intake METHODS: : A prospective, observational cohort study was conducted in a PICU of a quaternary hospital. Read More

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Comparative Transcriptome Analyses of the Developmental Stages of .

Front Vet Sci 2021 5;8:677045. Epub 2021 Jul 5.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, China.

Cerebral coenurosis, caused by the larvae of (, is a fatal central nervous system disease in sheep and other herbivores and occasionally humans. Comparative transcriptomic profiles of the developmental stages of the parasite remain unknown. In this study, RNA sequencing was used to determine the transcriptome profiles of different stages of the life cycle of , including Oncosphere, (Pro with Cyst), and Adult (Adu), as well as scolex-neck proglottids (Snp), immature-mature proglottids (Imp), and gravid proglottids (Grp) of the adult stage. Read More

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Aberrant Autophagy Impacts Growth and Multicellular Development in a Knockout Model of CLN5 Disease.

Front Cell Dev Biol 2021 5;9:657406. Epub 2021 Jul 5.

Department of Biology, Trent University, Peterborough, ON, Canada.

Mutations in cause a subtype of neuronal ceroid lipofuscinosis (NCL) called CLN5 disease. While the precise role of CLN5 in NCL pathogenesis is not known, recent work revealed that the protein has glycoside hydrolase activity. Previous work on the homolog of human CLN5, Cln5, revealed its secretion during the early stages of development and its role in regulating cell adhesion and cAMP-mediated chemotaxis. Read More

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Outlook of Cassava Brown Streak Disease Assessment: Perspectives of the Screening Methods of Breeders and Pathologists.

Front Plant Sci 2021 5;12:648436. Epub 2021 Jul 5.

Root Crops Program, National Crops Resources Research Institute (NaCRRI), Kampala, Uganda.

Cassava production and productivity in Eastern, Central, and Southern Africa are ravaged by cassava brown streak disease (CBSD), causing yield losses of up to 100% when susceptible varieties are grown. Efforts to develop CBSD-resistant clones are underway. However, the methods for screening CBSD resistance currently vary between breeders and pathologists, with the limited empirical data to support their choices. Read More

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Synergistic Activity of the HSP90 Inhibitor Ganetespib With Lapatinib Reverses Acquired Lapatinib Resistance in HER2-Positive Breast Cancer Cells.

Front Pharmacol 2021 5;12:651516. Epub 2021 Jul 5.

School of Pharmacy, Fujian Medical University, Fuzhou, China.

Lapatinib is an FDA-approved EGFR and HER2 tyrosine kinase inhibitor for the treatment of HER2-positive breast cancer patients. However, its therapeutic efficacy is limited by primary or acquired resistance. In the present study, we established breast cancers cells with acquired lapatinib resistance and investigated the antitumor activity of the second-generation HSP90 inhibitor ganetespib in association with lapatinib in lapatinib-sensitive and -resistant cells. Read More

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Real time remote symptom monitoring during chemotherapy for cancer: European multicentre randomised controlled trial (eSMART).

BMJ 2021 07 21;374:n1647. Epub 2021 Jul 21.

Population Health and Genomics, Medical School, University of Dundee, Dundee, UK.

Objective: To evaluate effects of remote monitoring of adjuvant chemotherapy related side effects via the Advanced Symptom Management System (ASyMS) on symptom burden, quality of life, supportive care needs, anxiety, self-efficacy, and work limitations.

Design: Multicentre, repeated measures, parallel group, evaluator masked, stratified randomised controlled trial.

Setting: Twelve cancer centres in Austria, Greece, Norway, Republic of Ireland, and UK. Read More

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Effects of Heme Electronic Structure and Local Heme Environment on Catalytic Activity of a Peroxidase-Mimicking Heme-DNAzyme.

Inorg Chem 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, University of Tsukuba, Tsukuba 305-8571, Japan.

The catalytic cycle of a peroxidase-mimicking heme-DNAzyme involves an iron(IV)oxo porphyrin π-cation radical intermediate known as compound formed through heterolytic O-O bond cleavage of an Fe-bound hydroperoxo ligand (Fe-OOH) in compound , like that of a heme enzyme such as horseradish peroxidase (HRP). Peroxidase assaying of complexes composed of chemically modified hemes possessing various electron densities of the heme iron atom (ρ) and parallel-stranded tetrameric G-quadruplex DNAs of oligonucleotides d(TTAGGG), d(TTAGGGT), and d(TTAGGGA) was performed to elucidate the effects of the heme electronic structure and local heme environment on the catalytic activity of the heme-DNAzyme. The study revealed that the DNAzyme activity is enhanced through an increase in the ρ and general base catalysis of the adenine base adjacent to the heme, which are reminiscent of the "push" and "pull" mechanisms in the catalytic cycle of HRP, respectively, and that the activity of the heme-DNAzyme can be independently controlled through the heme electronic structure and local heme environment. Read More

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Unbalanced status and multidimensional influences of municipal solid waste management in Africa.

Chemosphere 2021 Oct 15;281:130884. Epub 2021 May 15.

Department of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.

The overall status of MSW management in Africa is evaluated systematically, in sight of life cycle indicators such as MSW generation daily per capita, collection and treatment methods. The relations of life cycle indictors with driving factors, including economic level, geographical location, urbanization and solid waste legislation process, are discussed. The results present that the major indicators had obvious regional differences, which can divide Africa into three levels: North Africa and South Africa > West Africa and Central Africa > East Africa. Read More

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October 2021

Poultry litter stabilization by two-stage composting-vermicomposting process: Environmental, energetic and economic performance.

Chemosphere 2021 Oct 15;281:130872. Epub 2021 May 15.

Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL-CONICET), Güemes N(◦) 3450, Santa Fe, S3000GLN, Argentina; Facultad de Ingeniería y Ciencias Hídricas, Universidad Nacional del Litoral, Ruta Nacional N° 168 Km 472.4, 3000, Santa Fe, Argentina.

Poultry litter (PL) is a heterogeneous mixture that contains bedding materials, antibiotics, dead skin, feed scraps, water, feathers and the resulting microbiota from poultry production cycle. Although its treatment does not receive attention, it is an important organic resource generated in the north-east region of Santa Fe Province since animal primary production is one of the main economic activities there and in the whole country. The objective of this work was to analyse the economic and energy aspects and the environmental impact of two scenarios corresponding to treat two different mixtures of organic wastes: Eucalyptus sp. Read More

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October 2021

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress.

EMBO Mol Med 2021 Jul 20:e13901. Epub 2021 Jul 20.

Department of Infectious Diseases, Italian Institute of Health, Rome, Italy.

HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a determinant of susceptibility to HIV-1 infection, but its role in the development and maintenance of HIV-1 latency has not been elucidated. By combining transcriptomic, proteomic, and metabolomic analyses, we here show that transition to latent HIV-1 infection downregulates glycolysis, while viral reactivation by conventional stimuli reverts this effect. Read More

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SPOT: a web-tool enabling swift profiling of transcriptomes.

Bioinformatics 2021 Jul 21. Epub 2021 Jul 21.

Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Im Neuenheimer Feld 344, Heidelberg, 69120, Germany.

: The increasing number of single cell and bulk RNAseq datasets describing complex gene expression profiles in different organisms, organs or cell types calls for an intuitive tool allowing rapid comparative analysis. Here we present Swift Profiling Of Transcriptomes (SPOT) as a web tool that allows not only differential expression analysis but also fast ranking of genes fitting transcription profiles of interest. Based on a heuristic approach the spot algorithm ranks the genes according to their proximity to the user-defined gene expression profile of interest. Read More

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Anti-Fouling Magnetic Beads Combined with Signal Amplification Strategies for Ultra-Sensitive and Selective Electrochemiluminescence Detection of MicroRNAs in Complex Biological Media.

Anal Chem 2021 Jul 21. Epub 2021 Jul 21.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Ministry of Education; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.

Herein, an electrochemiluminescence (ECL) microRNA biosensor based on anti-fouling magnetic beads (MBs) and two signal amplification strategies was developed. The newly designed anti-fouling dendritic peptide was wrapped on the surfaces of MBs to make them resistant to nonspecific adsorption of biomolecules in complex biological samples so as to realize accurate and selective target recognition. One of the amplification strategies was achieved through nucleic acid cycle amplification based on the DNAzyme on the surfaces of MBs. Read More

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Multi-Functional Metal Phosphides as Superior Host Materials for Advanced Lithium-Sulfur Batteries.

Chemistry 2021 Jul 19. Epub 2021 Jul 19.

Gannan Normal University, School of Physics and Electronics, CHINA.

For the past few years, a new generation of energy storage system with large theoretical specific capacity is urgently needed because of the rapid development of the society. Lithium-sulfur (Li-S) batteries are regarded as one of the most promising candidates of novel battery systems, when resurged at the end of the 21st century. Li-S batteries have attracted more and more attention, attributed to their notably high theoretical energy density of 2600 W h kg -1 which almost quintuple larger than that of commercial lithium-ion batteries (LIBs). Read More

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Self-Assembling Films of Covalent Organic Frameworks Enable Long-Term, Efficient Cycling of Zinc-Ion Batteries.

Adv Mater 2021 Jul 19:e2101726. Epub 2021 Jul 19.

Center for Soft and Living Matter, Institute for Basic Science, UNIST-gil 50, Ulsan, 44919, South Korea.

Despite their safety, nontoxicity, and cost-effectiveness, zinc aqueous batteries still suffer from limited rechargeability and poor cycle life, largely due to spontaneous surface corrosion and formation of large Zn dendrites by irregular and uneven plating and stripping. In this work, these untoward effects are minimized by covering Zn electrodes with ultrathin layers of covalent organic frameworks, COFs. These nanoporous and mechanically flexible films form by self-assembly-via the straightforward and scalable dip-coating technique-and permit efficient mass and charge transport while suppressing surface corrosion and growth of large Zn dendrites. Read More

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ASPEN definitions in pediatric intestinal failure.

JPEN J Parenter Enteral Nutr 2021 Jul 21. Epub 2021 Jul 21.

Group for Improvement of Intestinal Function and Treatment, Department of Surgery, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

Pediatric intestinal failure (PIF) is a relatively rare disease entity which requires focused interdisciplinary care and specialized nutrition management. There has long been a lack of consensus in the definition of key terms related to PIF due to its rarity and plethora of small studies rather than large trials. As such, the American Society for Parenteral and Enteral Nutrition (ASPEN) Pediatric Intestinal Failure Section, composed of clinicians from a variety of disciplines caring for children with intestinal failure, is uniquely poised to provide insight into this definition void. Read More

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Single-cell analyses reveal the differentiation shifts of Schwann cells in neonatal rat sciatic nerves.

J Cell Physiol 2021 Jul 20. Epub 2021 Jul 20.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu, China.

Schwann cells provide essential physical and chemical support for neurons and play critical roles in the peripheral nervous system. To acquire an enhanced understanding of the genetic characteristics of Schwann cells, we analyzed single-cell transcriptional profiling of Schwann cells in neonatal rat sciatic nerves, ordered the pseudotemporal states of Schwann cells, and determined the magnitude of RNA velocity vectors as well as cell cycle stages of Schwann cell subtypes. We discovered the cellular heterogeneity of Schwann cells in neonatal rat sciatic nerves, revealed the dynamic changes of Schwann cell subtypes, and pointed out the differentiation trajectory from Timp3- and Col5a3-expressing Schwann cell subtype 3 to other Schwann cell subtypes. Read More

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In vitro cellular and proteome assays identify Wnt pathway and CDKN2A-regulated senescence affected in mesenchymal stem cells from mice after a chronic LD gamma irradiation in utero.

Radiat Environ Biophys 2021 Jul 21. Epub 2021 Jul 21.

Institute of Radiation Biology, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health GmbH (HMGU), Ingolstaedter Landstraße 1, 85764, Neuherberg, Germany.

Reliable data on the effects of chronic prenatal exposure to low dose (LD) of ionizing radiation in humans are missing. There are concerns about adverse long-term effects that may persist throughout postnatal life of the offspring. Due to their slow cell cycle kinetics and life-long residence time in the organism, mesenchymal stem cells (MSCs) are more susceptible to low level genotoxic stress caused by extrinsic multiple LD events. Read More

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Juniperus communis extract induces cell cycle arrest and apoptosis of colorectal adenocarcinoma in vitro and in vivo.

Braz J Med Biol Res 2021 16;54(10):e10891. Epub 2021 Jul 16.

Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Republic of China, Taiwan.

Juniperus communis (JCo) is a well-known traditional Chinese medicinal plant that has been used to treat wounds, fever, swelling, and rheumatism. However, the mechanism underlying the anticancer effect of JCo extract on colorectal cancer (CRC) has not yet been elucidated. This study investigated the anticancer effects of JCo extract in vitro and in vivo as well as the precise molecular mechanisms. Read More

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sp. (ATCC 50594) Life Cycle: Myzocytosis and Possible Links to the Origin of Intracellular Parasitism.

Trop Med Infect Dis 2021 Jul 11;6(3). Epub 2021 Jul 11.

Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA.

species are free living bi-flagellated protists that prey on algae and bodonids in a process known as myzocytosis. species are phylogenetically related to Apicomplexa. We investigated the life cycle of sp. Read More

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A systematic review on efficacy, safety, and treatment-durability of low-dose rituximab for the treatment of Pemphigus: special focus on COVID-19 pandemic concerns.

Immunopharmacol Immunotoxicol 2021 Jul 21:1-12. Epub 2021 Jul 21.

Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran.

Background: Rituximab is a FDA-approved monoclonal antibody for adults with moderate to severe potentially life-threatening pemphigus vulgaris. Recent studies have focused on assessments of efficacy and safety of low-dose rituximab (<2 gram in each cycle).

Method: Databases were searched from 2010 to 2020 (last update: 1 June 2020). Read More

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EV71 2A Protease inhibits P-body formation to promote viral RNA synthesis.

J Virol 2021 Jul 21:JVI0092221. Epub 2021 Jul 21.

State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, LuoJia Hill, Wuhan, 430072, China.

Several viruses were proved to inhibit the formation of RNA processing bodies (P-bodies); however, knowledge regarding whether enterovirus blocks P-body formation remains unclear, and the detailed molecular mechanisms and functions of picornavirus regulation of P-bodies are limited. Here we show the crucial role of 2A protease in inhibiting P-bodies to promote viral replication during enterovirus 71 infection. Moreover, we found that the activity of 2A protease is essential to inhibit P-body formation, which was proved by the result that infection of EV71-2A, the 2A protease activity-inactivated recombinant virus, failed to block the formation of P-bodies. Read More

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