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A case report of reconstruction of ocular and complete upper eyelid avulsion with severe facial soft tissue injuries using anterolateral thigh free flap.

Int J Surg Case Rep 2021 Apr 1;82:105856. Epub 2021 Apr 1.

Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.

Introduction And Importance: Ocular injury is second mostly caused by motor vehicle accident (MVA) and often leads to severe ocular injury even to visual loss and various aesthetic problems. The outcome is determined by the magnitude of the initial damage and treatment availability. Treating ocular and facial injury due to MVA is challenging given the scope of the damage and may result in various outcomes. Read More

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Quantifying the environmental impact of clustering strategies in waste management: A case study for plastic recycling from large household appliances.

Waste Manag 2021 Apr 7;126:497-507. Epub 2021 Apr 7.

KU Leuven, Departement of Mechanical Engineering, Celestijnenlaan 300A Box 2422, 3001 Leuven, Belgium; Flanders Make, Gaston Geenslaan 8, 3001 Heverlee, Belgium.

The complex composition of waste electrical and electronic equipment (WEEE) plastics represents a challenge during post-consumption plastic recycling. A single WEEE category, e.g. Read More

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Governance and groundwater modelling: Hints to boost the implementation of the EU Nitrate Directive. The Lombardy Plain case, N Italy.

Sci Total Environ 2021 Mar 27;782:146800. Epub 2021 Mar 27.

Department of Earth and Environmental Sciences, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.

The EU Nitrate Directive has been ruling for almost 30 years, nevertheless nitrate concentration in the Lombardy Plain did not decrease. Together with failures of management implementation, a possible cause for such field observations is that management actions were taken without adequately considering the actual hydrogeological dynamics. To consider this aspect, the paper presents a groundwater flow and transport numerical model of a specific area of the Lombardy Plain. Read More

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Achondroplasia from the viewpoint of orthodontics

Orv Hetil 2021 04 10;162(17):683-688. Epub 2021 Apr 10.

3 Heim Pál Országos Gyermekgyógyászati Intézet, Alvásdiagnosztikai és Terápiás Labor, Budapest.

Összefoglaló. Az achondroplasia kialakulásáért az FGFR3-gén mutációja tehető felelőssé, mely a porc növekedési lemezében található chondrocyták érésében okoz zavart. Az esetbemutatásban szereplő lánygyermeknél a születést követő első hónapban a klinikai, laboratóriumi és röntgenvizsgálatok alapján achondroplasia igazolódott. Read More

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Treatment for bleeding oesophageal varices in people with decompensated liver cirrhosis: a network meta-analysis.

Cochrane Database Syst Rev 2021 Apr 10;4:CD013155. Epub 2021 Apr 10.

Division of Surgery and Interventional Science, University College London, London, UK.

Background: Approximately 40% to 95% of people with liver cirrhosis have oesophageal varices. About 15% to 20% of oesophageal varices bleed within about one to three years after diagnosis. Several different treatments are available, including, among others, endoscopic sclerotherapy, variceal band ligation, somatostatin analogues, vasopressin analogues, and balloon tamponade. Read More

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Applying evidence-based methods to the development and use of adverse outcome pathways.

ALTEX 2021 Apr 8. Epub 2021 Apr 8.

Evidence-Based Toxicology Collaboration (EBTC) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

The workshop "Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests" was organized by the Evidence-based Toxicology Collaboration and hosted by the Grading of Recommendations Assessment, Development and Evaluation Working Group on June 12, 2019. The purpose of the workshop was to bring together international regulatory bodies, risk assessors, academic scientists, and industry to explore how systematic review methods and the adverse outcome pathway framework could be combined to develop and use mechanistic test methods for predicting the toxicity of chemical substances in an evidence-based manner. The meeting covered the history of biological frameworks, the way adverse outcome pathways are currently developed, the basic principles of systematic methodology, including systematic reviews and evidence maps, and assessment of certainty in models, and adverse outcome pathways in particular. Read More

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Ovarian vein thrombosis: a potential clinical consequence of ruptured ectopic pregnancy.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

College of Medicine, Florida State University, Sarasota, Florida, USA.

A healthy 32-year-old G3P3 woman with an unknown last menstrual period presented to the emergency department with intense abdominal pain and pain in the right chest that radiated down the right arm. Further workup showed that she had a ruptured ectopic pregnancy with significant haemoperitoneum. After successful laparoscopic evacuation of the ectopic pregnancy and haemoperitoneum, the patient subsequently developed a right ovarian vein thrombosis 4 weeks after the procedure. Read More

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PIEZO1 mutation: a rare aetiology for fetal ascites.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Maternal fetal Medicine, Trinity Health of New England, Hartford, Connecticut, USA.

We present a case of isolated fetal ascites diagnosed at 20 weeks' gestation. No aetiology was identified on extensive prenatal workup, including prenatal microarray. The patient terminated the pregnancy at 23 weeks' gestation. Read More

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Successful transition from insulin to sulfonylurea, on second attempt, in a 24-year-old female with neonatal diabetes secondary to KCNJ11 gene mutation.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.

Neonatal diabetes (NDM) is defined as diabetes that occurs in the first 6 months of life, the majority of cases are due to sporadic mutations. ATP-sensitive potassium channels located in the beta cells of the pancreas play a major role in insulin secretion and blood glucose homeostasis. Mutations that alter the function of these channels may lead to NDM. Read More

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Perioperative management of cranial diabetes insipidus in a patient requiring a tracheostomy.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Department of Otolaryngology and Head and Neck Surgery, Guy's and Saint Thomas' NHS Foundation Trust, London, UK.

Cranial diabetes insipidus (DI), which can cause life-threatening dehydration, is treated with desmopressin, often intranasally. This is challenging in patients whose nasal airflow is altered, such as those requiring tracheostomy. We report the case of a patient, taking intranasal desmopressin for cranial DI, who underwent partial glossectomy, free-flap reconstruction and tracheostomy. Read More

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Traumatic Spinal Injury: Preliminary Results of Respiratory Function, Voice and Quality of Life.

J Voice 2021 Apr 6. Epub 2021 Apr 6.

Adjunct Professor, Speech Therapy Course, Ceilândia Campus of the University of Brasilia; Department where the study was conducted: Ceilândia Campus of the University of Brasilia, Federal District, Brazil, Center for Voice Studies - CEV.

Objectives: Assess respiratory muscle strength, voice and the quality of life of patients with traumatic cervical and thoracic spinal cord injury.

Methods: Preliminary analytical case control study of 28 adult men, aged between 18 and 65 years, divided into two groups: a research group consisting of 14 patients with cervical and thoracic spinal cord injury, and control group (CG) with 14 noninjured individuals. The subjects had their maximum inspiratory and expiratory pressures measured, underwent voice handicap index-10 assessment, had their voices recorded for auditory perception analysis, using the voice deviation and GRBASI scales, and for acoustic analysis, based on extraction of the parameters selected and completed a quality-of-life questionnaire (WHOQOL-bref protocol). Read More

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[Rehabilitation in Tay-Sachs disease: A case report].

Rehabilitacion (Madr) 2021 Apr 6. Epub 2021 Apr 6.

Servicio de Medicina Física y Rehabilitación, Hospital Clínico San Carlos, Madrid, España.

Tay-Sachs disease, or GM2 gangliosidosis, is a congenital and neurodegenerative disease caused by the absence or deficiency of the essential enzyme B-hexosaminidase. The timing of the development of neurological manifestations and their severity depend on the mutation, time since disease onset and the patient's characteristics. The disease impairs quality of life and increases mortality. Read More

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Uterine pseudoaneurysm on the basis of deep infiltrating endometriosis during pregnancy-a case report.

BMC Pregnancy Childbirth 2021 Apr 9;21(1):282. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, University Hospital of Basel, Basel, Switzerland.

Background: Pseudoaneurysm of the uterine artery (UPA) is a rare cause of potentially life-threatening hemorrhage during pregnancy and puerperium. It is an uncommon condition that mainly occurs after traumatic injury to a vessel following pelvic surgical intervention, but also has been reported based on underlying endometriosis. There is an increased risk of developing UPA during pregnancy. Read More

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Life expectancy in adulthood is falling for those without a BA degree, but as educational gaps have widened, racial gaps have narrowed.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

School of Public and International Affairs, Princeton University, Princeton, NJ 08544.

A 4-y college degree is increasingly the key to good jobs and, ultimately, to good lives in an ever-more meritocratic and unequal society. The bachelor's degree (BA) is increasingly dividing Americans; the one-third with a BA or more live longer and more prosperous lives, while the two-thirds without face rising mortality and declining prospects. We construct a time series, from 1990 to 2018, of a summary of each year's mortality rates and expected years lived from 25 to 75 at the fixed mortality rates of that year. Read More

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Acute gastrointestinal bleeding: results from the prospective German electronic registry of nearly 11 000 endoscopies (ALGK GI-bleeding registry).

Z Gastroenterol 2021 Apr 9. Epub 2021 Apr 9.

ALGK (Arbeitsgemeinschaft Leitende Gastroenterologische Krankenhausärzte; Working Group of Leading German Gastroenterologists in Hospitals).

Background And Study Aims:  Gastrointestinal bleeding is frequently observed in the German population. However, recent epidemiological data are not available. This study aimed to elucidate gastrointestinal bleeds under real-life conditions in 3 German hospitals. Read More

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Influence of reduction quality on functional outcome and quality of life in the surgical treatment of tibial plateau fractures: a retrospective cohort study.

Orthop Traumatol Surg Res 2021 Apr 6:102922. Epub 2021 Apr 6.

MINTOS - Medical Imaging and Navigation in Trauma and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Heidelberg University Hospital, Ludwig-Guttmann-Str. 13, 67071 Ludwigshafen, Germany. Electronic address:

Background: Despite a substantial improvement in the operative treatment of tibial plateau fractures, the surgical procedure remains controversial and is generally challenging, as patients may develop postoperative arthritis and functional impairment of the knee joint.

Hypothesis: In the surgical treatment of tibial plateau fractures the intraoperative reposition quality has the greatest influence on the postoperative outcome, whereby misalignments of >/= 2 mm lead to a worse result.

Patients And Methods: 41 patients with tibial plateau fractures were postoperatively examined. Read More

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Hyperbaric oxygen management of recurrent cellulitis in poikiloderma with neutropenia.

Am J Med Genet A 2021 Apr 9. Epub 2021 Apr 9.

Department of Internal Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA.

Poikiloderma with neutropenia (PN), is a rare autosomal recessive condition with many associated complications and manifestations. Here we present a patient with confirmed PN who is of one-quarter Chucktaw or Cherokee heritage with no known descent from the Navajo tribe. The patient's condition was complicated by chronic bilateral lower limb cellulitis and associated osteomyelitis which was unresponsive to extensive antibiotic regimens. Read More

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Approaches to understanding COVID-19 and its neurological associations.

Ann Neurol 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurology, Center for Global Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

There is an accumulating volume of research into neurological manifestations of COVID-19. However, inconsistent study designs, inadequate controls, poorly-validated tests, and differing settings, interventions, and cultural norms weaken study quality, comparability, and thus the understanding of the spectrum, burden and pathophysiology of these complications. Therefore, a global COVID-19 Neuro Research Coalition, together with the WHO, has reviewed reports of COVID-19 neurological complications and harmonised clinical measures for future research. Read More

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Use of 1064nm Nd:YAG Laser Biostimulation for Immediate Reversal of a Long-Standing Paresthesia of the Superior Labial Branch of the Infraorbital Nerve Following a Root Coverage Procedure: A Case Report.

Authors:
Alan M Timko

Clin Adv Periodontics 2021 Apr 9. Epub 2021 Apr 9.

Diplomate of the American Board of Periodontology, Private Practice, 9401 McKnight Rd., Suite 301-A, Pittsburgh, PA, 15237.

Introduction: Paresthesia is a common cause of dental malpractice litigation. Symptoms range from minimal to severely affecting the quality of life. Effective treatments of post-traumatic paresthesias are scarce. Read More

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Harming one to benefit another: The paradox of autonomy and consent in maternity care.

Authors:
Elselijn Kingma

Bioethics 2021 Apr 9. Epub 2021 Apr 9.

Department of Philosophy, King's College London, London, United Kingdom of Great Britain and Northern Ireland.

This paper critically analyses 'the paradox of autonomy and consent in maternity care'. It argues that maternity care has certain features that increase the need for explicit attention to, and respect for, both autonomy and rigorous informed consent processes. And, moreover, that the resulting need is considerably greater than in almost all other areas of medicine. Read More

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A case of black esophagus with duodenal involvement.

Clin J Gastroenterol 2021 Apr 9. Epub 2021 Apr 9.

Department of Emergency Medicine, Nagayama Hospital, 1-1-10 Okubohigashi, Kumatori, Osaka, 590-0406, Japan.

Black esophagus is a rare condition referred from acute necrosis of the esophagus, with characteristic endoscopic finings of circumferential black appearance of the mucosa. Black esophagus is associated with systemic dysfunction, such as massive bleeding, or severe dehydration. Although the duodenal mucosa is also susceptible to ischemia, reports of black esophagus with duodenal involvement, such as bleeding or perforation, are limited. Read More

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Lifelong Impact of Severe Atopic Dermatitis on Quality of Life: A Case Report.

Dermatol Ther (Heidelb) 2021 Apr 9. Epub 2021 Apr 9.

Department of Dermatology, Wake Forest School of Medicine, Center for Dermatology Research, Winston-Salem, NC, USA.

Severe, uncontrolled atopic dermatitis (AD) persisting from childhood to adulthood can have enduring quality of life (QoL) impacts on daily functioning, academics, career, family and social life, and mental health. In addition, AD has an impact on direct and indirect healthcare resource utilization. Several studies have attempted to quantify the quality of life and direct/indirect economic burden of AD. Read More

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GnRH agonist-associated pituitary apoplexy: a case series and review of the literature.

Pituitary 2021 Apr 9. Epub 2021 Apr 9.

Neuroendocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 100 Blossom Street, Cox140, Boston, MA, 02114, USA.

Purpose: To examine the clinical presentation and longitudinal outcome of Pituitary Apoplexy (PA) after gonadotropin-releasing hormone agonist (GnRHa) in a series of patients and compare to prior reports.

Methods: A retrospective chart review was performed on seven patients receiving GnRHa who developed PA. Prior reported cases were analyzed. Read More

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Development and evaluation of air pollution-linked quality of life (AP-QOL) questionnaire: insight from two different cohorts.

Environ Sci Pollut Res Int 2021 Apr 9. Epub 2021 Apr 9.

Department of Civil Engineering, Indian Institute of Technology Delhi, New Delhi, 110016, India.

In this study, the air pollution-related quality of life (AP-QOL) questionnaire was carried out in two geographically and economically different groups including New Delhi (Megacity) and Hamirpur, Himachal Pradesh (town), and APE scores were linked with respiratory and cardiovascular illness. The APE-Score was developed by AP-QOL questionnaire responses using Delphi technique and further analyzed using principal component analysis (PCA). For reliability of APE-Score and AP-QOL questionnaire, α-Cronbach's test and basic statistics were performed. Read More

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Novel life cycle stages of Colpodella sp. (Apicomplexa) identified using Sam-Yellowe's trichrome stains and confocal and electron microscopy.

Int Microbiol 2021 Apr 9. Epub 2021 Apr 9.

Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA.

Colpodella spp. are free-living flagellates closely related to the apicomplexans. Human infections by Colpodella sp. Read More

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How political philosophies can help to discuss and differentiate theories in community ecology.

Authors:
Annette Voigt

Hist Philos Life Sci 2021 Apr 9;43(2):54. Epub 2021 Apr 9.

Group of Open Space Development, Department of Architecture, Urban and Landscape Planning, University of Kassel, Kassel, Germany.

This paper uses structural analogies to competing political philosophies of human society as a heuristic tool to differentiate between ecological theories and to bring out new aspects of apparently well-known classics of ecological scholarship. These two different areas of knowledge have in common that their objects are 'societies', i.e. Read More

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Cost-effectiveness analysis of colorectal cancer screening in a low incidence country: The case of Saudi Arabia.

Saudi J Gastroenterol 2021 Apr 7. Epub 2021 Apr 7.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Colorectal cancer (CRC) screening is cost-effective in many Western countries, and many have successfully implemented CRC screening programs. For countries with a lower CRC incidence, like Saudi Arabia, the value of CRC screening is less evident and requires careful weighing of harms, benefits, and costs.

Methods: We used the MISCAN-Colon microsimulation model to simulate a male and female cohort with life expectancy and CRC risk as observed in Saudi Arabia. Read More

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Born in the Purple: An Exceptional Case of Cutis Marmorata Telangiectatica Congenita.

Acta Dermatovenerol Croat 2020 Dec;28(4):247-248

Department of Dermatology, University General Hospital of Patras, Rion, Greece, Greece;

A full-term, 2-day-old female neonate with a congenital non-tender reticular patch that did not disappear with local warming was referred to our department for consultation. The family history as well as the antenatal course and delivery were unremarkable. On examination, we evidenced a fixed, marbled, bluish to deep purple lesion with a fishnet appearance extending over the right side of her body, face, and scalp. Read More

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December 2020

Plexiform Neurofibroma Without Neurofibromatosis Type 1.

Acta Dermatovenerol Croat 2020 Dec;28(7):245-246

Professor Uwe Wollina, MD, Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Friedrichtstrasse 41, 01067 Dresden, Germany;

Dear Editor, Plexiform neurofibroma (PNF) is a particular subtype of benign nerve sheath tumors with a reticular growth pattern not respecting tissue borders and involving several nerve branches or fascicles. It is most commonly reported in patients with neurofibromatosis type-1 (NF-1) and represents in up to 30% of NF-1 patients (1,2). Other possible associations include schwannomatosis, multiple cutaneous schwannomas syndrome, and rarely neurofibromatosis type-2 (NF-2) (3). Read More

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December 2020

Voltage-Modulated Structure Stress for Enhanced Electrochemcial Performances: The Case of μ-Sn in Sodium-Ion Batteries.

Nano Lett 2021 Apr 9. Epub 2021 Apr 9.

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.

Alloy-type anodes in alkaline ion batteries have to face the challenges of huge volume change and giant structure strain/stress upon cycling. Here, reducing the structure stress for advanced performances by voltage regulation is demonstrated by using microsized Sn (μ-Sn) for sodium ion batteries as a model. Density functional theory and finite element analysis indicate that Sn/NaSn is the crucial phase transition highly responsible for inducing surface cracks, particle aggregations, and cell failures. Read More

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