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Research agenda setting with children with juvenile idiopathic arthritis: lessons learned.

Child Care Health Dev 2021 Aug 4. Epub 2021 Aug 4.

Department of Ethics, Law and Humanities, Amsterdam UMC (Location VUmc), Amsterdam, the Netherlands.

Background: Several health research agendas have successfully been developed with adults but rarely with children. Children are still seldom recognized as possessing credible knowledge about their own body and life. The objective is to understand the research priorities of Dutch children with juvenile idiopathic arthritis (JIA), within a nationwide research agenda-setting exercise for JIA with patients, parents and clinicians, as well as researching how children can be involved. Read More

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Supported Independence: The Role of Supervision to Help Trainees Manage Uncertainty.

Acad Med 2021 Aug 3. Epub 2021 Aug 3.

J.S. Ilgen is associate professor, Department of Emergency Medicine, University of Washington, Seattle, Washington, and PhD candidate, School of Health Professions Education (SHE), Maastricht University, Maastricht, The Netherlands; ORCID: http://orcid.org/0000-0003-4590-6570. A.B.H. de Bruin is professor, School of Health Professions Education, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands; ORCID: http://orcid.org/0000-0001-5178-0287. P.W. Teunissen is professor, School of Health Professions Education, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands, and maternal fetal medicine specialist, Department of Obstetrics & Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands; ORCID: http://orcid.org/0000-0002-0930-0048. J. Sherbino is professor, Division of Emergency Medicine, Department of Medicine, and assistant dean, McMaster Education Research, Innovation and Theory (MERIT) program, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada; ORCID: http://orcid.org/0000-0003-0344-8057. G. Regehr is professor, Department of Surgery and Centre for Health Education Scholarship, University of British Columbia, Vancouver, British Columbia, Canada. ORCID: http://orcid.org/0000-0002-3144-331X.

Purpose: Safe and effective supervised practice requires a negotiated partnership between trainees and their supervisors. Substantial work has explored how supervisors make judgments about trainees' readiness to safely engage in critical professional activities, yet less is known about how trainees leverage the support of supervisors when they perceive themselves to be at the limits of their abilities. The purpose of this study is to explore how trainees use supervisory support to navigate experiences of clinical uncertainty. Read More

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What Is an Innovation Article? A Systematic Overview of Innovation in Health Professions Education Journals.

Acad Med 2021 Aug 3. Epub 2021 Aug 3.

J.M. Colbert-Getz is associate professor and assistant dean of education quality improvement, University of Utah School of Medicine, Salt Lake City, Utah. S.B. Bierer is associate professor and director of assessment and evaluation, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. A. Berry is executive director of faculty life, University of Central Florida College of Medicine, Orlando, Florida. E. Bradley is associate professor of medical education and director of curriculum evaluation, University of Virginia School of Medicine, Charlottesville, Virginia. H. Han is associate professor, Department of Medical Education, Southern Illinois University School of Medicine, Springfield, Illinois. C. Mooney is assistant professor of medicine and director of assessment, University of Rochester School of Medicine and Dentistry, Rochester, New York. K. Szauter is assistant dean of educational affairs, University of Texas Medical Branch, Galveston, Texas. C.R. Teal is assistant dean of assessment and evaluation, Office of Medical Education, University of Kansas School of Medicine, Kansas City, Kansas. J. Youm is assistant dean of education compliance and quality, University of California, Irvine School of Medicine, Irvine, California. B.C. O'Brien is professor, Department of Medicine, and education scientist, Center for Faculty Educators, University of California, San Francisco, San Francisco, California.

Purpose: Innovation articles have their own submission category and guidelines in health professions education (HPE) journals, which suggests innovation might be a unique genre of scholarship. Yet, the requirements for innovation submissions vary among journals, suggesting ambiguity about the core content of this type of scholarship. To reduce this ambiguity, the researchers conducted a systematic overview to identify key features of innovation articles and evaluate their consistency in use across journals. Read More

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The Role of Perfluorinated Compound Pollution in the Development of Acute and Chronic Kidney Disease.

Contrib Nephrol 2021 Aug 4;199:1-12. Epub 2021 Aug 4.

International Renal Research Institute of Vicenza (IRRIV), San Bortolo Hospital, Vicenza, Italy.

Clinical Background: Poly- and perfluorinated compound (PFCS) pollution has been found to be the driver of different diseases, including glucose intolerance, hyperlipidemia, thyroid diseases, gestational diabetes mellitus and hypertension, testicular and genitourinary cancer, as well as impaired kidney function. This review focuses on the renal effects of PFCS, intending to clarify their occurrence and pathogenetic mechanisms. Epidemiology: Between October 31st, 2017, and March 31st, 2020, most frequently analyzed PFCS were perfluorooctane sulfonate, perfluorooctanoic acid, sodium perfluoro-1-hexanesulfonate, perfluoro-n-nonanoic acid, and perfluoro-n-decanoic acid. Read More

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Cost-Effectiveness Analysis of Durvalumab Plus Chemotherapy in the First-Line Treatment of Extensive-Stage Small Cell Lung Cancer.

J Natl Compr Canc Netw 2021 Aug 4. Epub 2021 Aug 4.

1Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan.

Background: In the CASPIAN trial, durvalumab + chemotherapy demonstrated significant improvements in overall survival compared with chemotherapy alone in patients with extensive-stage small cell lung cancer (SCLC). We aimed to assess the cost-effectiveness of durvalumab in patients with extensive-stage SCLC from the US healthcare system perspective.

Patients And Methods: A comprehensive Markov model was adapted to evaluate cost and effectiveness of durvalumab combination versus platinum/etoposide alone in the first-line therapy of extensive-stage SCLC based on data from the CASPIAN study. Read More

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Three-Day Remote Monitoring of Gait Among Young and Older Adults Using Participants' Personal Smartphones.

J Aging Phys Act 2021 Aug 4:1-8. Epub 2021 Aug 4.

Conventional one-time gait analyses do not evaluate walking across more than a few steps, cannot monitor changes longitudinally, and do not reflect performance in real-life environments. To successfully quantify age-related gait decrement, technology that can continuously monitor gait is vital. This study examined the feasibility and validity for participant smartphones to remotely assess gait. Read More

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Psychological Effects of Whole-Body Vibration Training in Frail Older Adults: An Open, Randomized Control Trial.

J Aging Phys Act 2021 Aug 4:1-11. Epub 2021 Aug 4.

The aim of this study was to identify the psychological effects of whole-body vibration (WBV) exercise in frail older adults. About 117 male and female volunteers (82.5 ± 7. Read More

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LC-MS-based identification and antioxidant evaluation of small molecules from the cinnamon oil extraction waste.

Food Chem 2021 Jul 12;366:130576. Epub 2021 Jul 12.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangdong Pharmaceutical University, Guangzhou 510006, China; Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:

Cinnamon oil is obtained by steam distillation from cinnamon leaves and is usually considered highly cost-effective compared to bark oil, however, which results in tons of waste cinnamon leaves (WCL) discarded annually. By using MS/MS molecular networking (MN) assisted profiling, six main chemical diversities including flavonols and flavones, phenolic acids, lactones, terpenoids, phenylpropanoids and flavanols were rapid revealed from WCL aqueous extract. 101 compounds were tentatively identified by assigning their MS/MS fragments within typical pathways under ESI-MS/MS dissociation. Read More

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Non-life-threatening ailments and rational patience when expected treatment outcomes are continuously improving.

J Health Econ 2021 Jul 16;79:102495. Epub 2021 Jul 16.

Department of Economics, University of Central Florida, P.O. Box 161400, Orlando, FL 32816-1400, USA. Electronic address:

The time at which a rational patient chooses to undergo an elective medical procedure for a non-life-threatening ailment is contemplated. The resulting model is purposely uncomplicated but general, and accounts for several basic factors that might affect such a decision. One such factor is that a patient cannot know with certainty the degree to which the medical procedure will be successful. Read More

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Separation of vigabatrin enantiomers using mixed-mode chromatography and its application to determine the vigabatrin enantiomer levels in rat plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 27;1179:122866. Epub 2021 Jul 27.

Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-shi, Chiba 274-8510, Japan. Electronic address:

Mixed-mode chromatography-comprising a mixed phase with reversed and ionic phases, enabling hydrophobic and ion-exchange interactions simultaneously-was applied to identify vigabatrin enantiomers by HPLC with pre-column fluorescence derivatization with 2,5-dioxopyrrolidin-1-yl (4-(((2-nitrophenyl)sulfonyl)oxy)-6-(3-oxomorpholino)quinoline-2-carbonyl)prolinate (Ns-MOK-(S)-Pro-OSu). The MOK-(S)-Pro-vigabatrin enantiomers were efficiently separated within 12 min (total analysis time per sample: 28 min, including washing and equilibrium time for the column). The mobile phase was HO/CHOH/10 mM ammonium formate (pH 2. Read More

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Sociodemographic and work-related predictors of chronic lower back pain in the United States: the 2018 National Health Interview Survey data.

Public Health 2021 Aug 1;198:30-34. Epub 2021 Aug 1.

School of Public Health, Texas A&M University, College Station, TX, USA.

Objective: The aim of this study is to explore the current characteristics of people with chronic lower back (CLB) pain, and the sociodemographic and work-related predictors of this pain.

Study Design: The study design used in the study is a cross-sectional study.

Method: The 2018 National Health Interview Survey data were used. Read More

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Sex-specific association of exposure to bedroom light at night with general and abdominal adiposity in young adults.

Ecotoxicol Environ Saf 2021 Aug 1;223:112561. Epub 2021 Aug 1.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Experimental animal studies and limited epidemiologic evidence among elder population suggest that exposure to light at night (LAN) may be obesogenic. Nevertheless, little is known about the possible impact of bedroom LAN exposure on subsequent adiposity and the distribution pattern of the accumulated fat, especially in younger population. Here, we estimated longitudinal associations of objectively assessed bedroom LAN exposure with general and abdominal adiposity among young adults. Read More

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The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling.

Cell Rep 2021 Aug;36(5):109466

Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. Electronic address:

The evolutionarily conserved Nrf2-Keap1 pathway is a key antioxidant response pathway that protects cells/organisms against detrimental effects of oxidative stress. Impaired Nrf2 function is associated with cancer and neurodegenerative diseases in humans. However, the function of the Nrf2-Keap1 pathway in the developing nervous systems has not been established. Read More

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Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow.

Cell Rep 2021 Aug;36(5):109480

The School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Recent multi-omics studies show different immune tumor microenvironment (TME) compositions in glioblastoma (GBM). However, temporal comprehensive knowledge of the TME from initiation of the disease remains sparse. We use Cre recombinase (Cre)-inducible lentiviral murine GBM models to compare the cellular evolution of the immune TME in tumors initiated from different oncogenic drivers. Read More

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Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage.

Cell Rep 2021 Aug;36(5):109484

Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

We lack a holistic understanding of the genetic programs orchestrating embryonic colon morphogenesis and governing damage response in the adult. A window into these programs is the transcriptomes of the epithelial and mesenchymal cell populations in the colon. Performing unbiased single-cell transcriptomic analyses of the developing mouse colon at different embryonic stages (embryonic day 14. Read More

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Virus-associated organosulfur metabolism in human and environmental systems.

Cell Rep 2021 Aug;36(5):109471

Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address:

Viruses influence the fate of nutrients and human health by killing microorganisms and altering metabolic processes. Organosulfur metabolism and biologically derived hydrogen sulfide play dynamic roles in manifestation of diseases, infrastructure degradation, and essential biological processes. Although microbial organosulfur metabolism is well studied, the role of viruses in organosulfur metabolism is unknown. Read More

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Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi.

Cell Rep 2021 Aug;36(5):109492

Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Division of Aging and Regeneration, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address:

Early differential diagnosis between malignant and benign tumors and their underlying intrinsic differences are the most critical issues for life-threatening cancers. To study whether human acral melanomas, deadly cancers that occur on non-hair-bearing skin, have distinct origins that underlie their invasive capability, we develop fate-tracing technologies of melanocyte stem cells in sweat glands (glandular McSCs) and in melanoma models in mice and compare the cellular dynamics with human melanoma. Herein, we report that glandular McSCs self-renew to expand their migratory progeny in response to genotoxic stress and trauma to generate invasive melanomas in mice that mimic human acral melanomas. Read More

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HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases.

Structure 2021 Jul 30. Epub 2021 Jul 30.

Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 2Y2, Canada; Life Sciences Institute, Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address:

There is considerable interest in developing antibodies as modulators of signaling pathways. One of the most important signaling pathways in higher eukaryotes is the phosphoinositide 3-kinase (PI3K) pathway, which plays fundamental roles in growth, metabolism, and immunity. The class IB PI3K, PI3Kγ, is a heterodimeric complex composed of a catalytic p110γ subunit bound to a p101 or p84 regulatory subunit. Read More

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First detection of Hematodinium sp. in spiny king crab Paralithodes brevipes, and new geographic areas for the parasite in tanner crab Chionoecetes bairdi, and red king crab Paralithodes camtschaticus.

J Invertebr Pathol 2021 Aug 1:107651. Epub 2021 Aug 1.

A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Science, Vladivostok 69041, Russia.

A parasitic dinoflagellate of the genus Hematodinium was found off the Pacific coast of Kamchatka in three species of crabs: red king crab Paralithodes camtschaticus, tanner crab Chionoecetes bairdi, and spiny king crab Paralithodes brevipes. This is the first detection of Hematodinium in spiny king crab. The results of the genetic analysis showed that the pathogen found in P. Read More

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Interleukin enhancer binding factor 2 (IEBF 2) was involved in the regulation of the antibacterial immune reactions in fresh water crayfish, Procambarus clarkii.

Dev Comp Immunol 2021 Aug 1:104226. Epub 2021 Aug 1.

School of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia autonomous region, 014010, China. Electronic address:

Although interleukin and interleukin analogues which play important immunomodulatory roles in mammals have not yet been reported in invertebrates, interleukin enhancer binding factor (IEBF) which acts as a transcription factor has been recently studied in several crustaceans and it may be involved in innate immune defence against pathogens. In this study, an IEBF 2 homologue was identified in the fresh water crayfish, Procambarus clarkii. The significantly changed expression levels of Pc-iebf 2 after bacterial challenge revealed the possibility of its participation in defence against bacterial infection. Read More

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Structure prediction and discovery of inhibitors against phosphopantothenoyl cysteine synthetase of .

J Biomol Struct Dyn 2021 Aug 4:1-13. Epub 2021 Aug 4.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

is an extremely dangerous multidrug-resistant (MDR) gram-negative pathogen which poses a serious life-threatening risk in immunocompromised patients. Phosphopantothenoyl cysteine synthetase (PPCS) catalyzes the formation of an amide bond between L-cysteine and phosphopantothenic acid (PPA) to form 4'- Phosphopantothenoylcysteine during Coenzyme A (CoA) biosynthesis. CoA is a crucial cofactor for cellular survival and inhibiting its synthesis will result in cell death. Read More

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Pyraclostrobin induced AMPK/mTOR pathways mediated autophagy in RAW264.7 macrophages.

J Environ Sci Health B 2021 Aug 4:1-8. Epub 2021 Aug 4.

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China.

Pyraclostrobin(PCT) is a highly effective and broad-spectrum strobilurin fungicide. The mode action of PCT is inhibiting mitochondrial respiration. With the widespread use of PCT in preventing and controlling crop diseases, its potential safety risks to mammals have gradually attracted attention. Read More

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Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies.

MAbs 2021 Jan-Dec;13(1):1958663

Systems Biology Department, Sandia National Laboratories, Livermore, USA.

The respiratory virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected nearly every aspect of life worldwide, claiming the lives of over 3.9 million people globally, at the time of this publication. Neutralizing humanized nanobody (VH)-based antibodies (VH-huFc) represent a promising therapeutic intervention strategy to address the current SARS-CoV-2 pandemic and provide a powerful toolkit to address future virus outbreaks. Read More

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Becoming a mother in the context of sex work: Women's experiences of bonding with their children.

Health Care Women Int 2021 Aug 4:1-23. Epub 2021 Aug 4.

Faculty of Health & Medicine, Lancaster University, Bailrigg, UK.

Many females engaged in sex work are mothers, often experiencing poverty, violence, marginalization, and psychological distress, factors also found to affect parental bonds. However, little is known about how this context impacts the bonding process. Given the ubiquity of sex work across geographical territories, understanding the relationship it has with mother-child bonding is an important international consideration in providing healthcare for sex working mothers and their children. Read More

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"I Know It Is Going to Ruin Their Life:" Fortune-Telling, Agency, and Harm Reduction in Narratives Concerning Injection Initiation Assistance.

Subst Use Misuse 2021 Aug 4:1-9. Epub 2021 Aug 4.

Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Background: Considering most people who inject drugs (PWID) received help with the first injection, understanding the perspective of potential 'initiators' is a priority to inform harm reduction interventions. This paper examines how PWID narrate their experiences with injection initiation and assistance from the lens of their lived experience and perceptions of harm reduction.

Methods: In-depth interviews were conducted with individuals who reported injection drug use and recent (past 30 days) opioid use in Baltimore ( = 19) and Anne Arundel County ( = 4), Maryland and analyzed using a narrative approach. Read More

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Anti-inflammatory Effects of GLP-1 in Patients with COVID-19.

Expert Rev Anti Infect Ther 2021 Aug 4. Epub 2021 Aug 4.

Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Introduction: Understanding the pathogenesis and risk factors to control the coronavirus disease 2019 (COVID-19) is necessary. Due to the importance of the inflammatory pathways in the pathogenesis of COVID-19 patients, evaluating the effects of anti-inflammatory medications is important. Glucagon-like peptide 1 receptor agonist (GLP-1RA) is a well-known glucose-lowering agent with anti-inflammatory effects. Read More

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Blood eosinophil count and FeNO to predict benralizumab effectiveness in real-life severe asthma patients.

J Asthma 2021 Aug 4:1-12. Epub 2021 Aug 4.

Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.

Benralizumab is a promising drug for severe uncontrolled asthma. This study aimed to clarify the effectiveness of benralizumab in a real-life setting. Subjects included 24 patients with severe type 2 asthma who received benralizumab between April 2018 and July 2019. Read More

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Flavonoids and other phenolics from chi flowers.

Nat Prod Res 2021 Aug 4:1-8. Epub 2021 Aug 4.

School of Life and Pharmaceutical Sciences, Key Laboratory of Tropical Biological Resources of Ministry Education, Hainan University, Haikou, China.

From Chi flowers four undescribed flavonoids, nitidissimol A, nitidissimol B, sexangularetin 3-O-(6''--coumarolyglucopyranoside) and sexangularetin 3-O-(2''--coumarolyglucopyranoside) (), and two previously unreported phenolics, nitidissimol C, D (), were isolated first time along with ten known compounds, kaempferol 3--(6''----coumaroyl)--D- glucopyranoside (), kaempferol-3--rhamnoside (), Quercetin-3'---D-glucoside (), kaempferol-7---D-glucoside (), erythro-guaiacylglycerol--4'-coniferyl ether (), threo-guaiacylglycerol--4'-coniferyl ether (), protocatechuic acid (), 1,2-Diethoxybenzene (), ethyl shikimate (), 2,4,6-trihydroxybenzoic acid 4--allopyranoside (). The structures of the isolated compounds were elucidated by spectroscopic analysis of 1 D- and 2 D-NMR and MS data. Moreover, all isolated compounds () were tested for the antibacterial activity against pv. Read More

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