Bioinformatics 2014 Apr 13;30(7):923-30. Epub 2013 Nov 13.
Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Department of Computing and Information Systems and Department of Mathematics and Statistics, The University of Melbourne, Parkville, VIC 3010, Australia.
Motivation: Next-generation sequencing technologies generate millions of short sequence reads, which are usually aligned to a reference genome. In many applications, the key information required for downstream analysis is the number of reads mapping to each genomic feature, for example to each exon or each gene. The process of counting reads is called read summarization. Read More