166 results match your criteria liat®


Fixation screw minimizes bone graft loss following autogenous lateral block graft augmentation: An experimental in vivo study.

J Stomatol Oral Maxillofac Surg 2021 Sep 8. Epub 2021 Sep 8.

Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Purpose: Assess the role of tenting screws in the remodeling processes of autogenous bone blocks used for mandibular lateral augmentation in rabbits.

Methods: Eighteen rabbits, approximately 3.5-4. Read More

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September 2021

Clinical Comparison of Three Sample-to-Answer Systems for Detecting SARS-CoV-2 in B.1.1.7 Lineage Emergence.

Infect Drug Resist 2021 17;14:3255-3261. Epub 2021 Aug 17.

Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Purpose: Accurate molecular diagnostic assays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, are needed for epidemiology studies and to support infection-control measures. We evaluated the analytical sensitivity and clinical performance of three sample-to-answer molecular-diagnostics systems for detecting SARS-CoV-2 using 325 nasopharyngeal swab clinical samples from symptomatic patients.

Methods: The BioFire Respiratory Panel 2. Read More

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Ageism and the State of Older People With Mental Conditions During the Pandemic and Beyond: Manifestations, Etiology, Consequences, and Future Directions.

Am J Geriatr Psychiatry 2021 Oct 7;29(10):995-999. Epub 2021 Jul 7.

The Ottawa Hospital (KR), Ottawa, Ontario, Canada; University of Ottawa (KR), Ottawa, Ontario, Canada; International Psychogeriatric Association (IPA) (KR), Milwaukee, WI; Steering Group, Global Alliance on the Rights of Older People (GAROP) (KR); International Longevity Centre (ILC) (KR), Ottawa, Ontario, Canada.

The pandemic has put the spotlight on older people and on the topic of ageism. In early 2021, a call was made for input into the Thematic Report on Ageism and Discrimination to inform the United Nations Independent Expert on the Rights of Older Persons' forthcoming report to the 48th session of the Human Rights Council. The aim of this paper is to articulate the International Psychogeriatric Association (IPA) and the World Psychiatric Association Section of Old Age Psychiatry (WPA-SOAP) response to this call. Read More

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October 2021

Performance characteristics of the Roche Diagnostics cobas® Liat® PCR System as a COVID-19 screening tool for hospital admissions in a regional healthcare delivery system.

J Clin Microbiol 2021 Jul 28:JCM0127821. Epub 2021 Jul 28.

Providence Health and Services; Portland OR.

The COVID-19 pandemic has required rapid implementation of multiple instrumentation platforms to detect SARS-CoV-2.…. Read More

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Participation of Older Persons With Mental Health Conditions and Psychosocial Disabilities in the Labor Market.

Am J Geriatr Psychiatry 2021 Oct 1;29(10):1033-1037. Epub 2021 Jul 1.

World Psychiatric Association Section of Old Age Psychiatry (CML), Jorat-Mézières, Switzerland.

This paper discusses the right to work as a basic human right that should be granted unrelated to chronological age, health or mental health status and disability including declining cognitive functioning. The benefits of continued employment are both at the individual level and at the organizational and societal levels. Nonetheless, there are multiple barriers that prevent older people and particularly older people with mental conditions and psychosocial disabilities from remaining in the workforce and/or from rejoining the workforce. Read More

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October 2021

Climate Change and Mental Health of Older Persons: A Human Rights Imperative.

Am J Geriatr Psychiatry 2021 Oct 30;29(10):1038-1040. Epub 2021 Jun 30.

University of Ottawa (KR), Ottawa, Ontario, Canada.

Climate change threatens the basic prerequisites for wellbeing, including clean air and water, food supply and the adequacy and security of shelter. Climate change is a powerful and ongoing presence in the lives of older persons, both creating and exacerbating vulnerabilities. The absence of a legally binding international instrument specifically protecting the human rights of older persons and minimal references to older persons in key international climate instruments attest to the lack of attention to and visibility of older persons in national and international law. Read More

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October 2021

Rapid and Safe Detection of SARS-CoV-2 and Influenza Virus RNA using Onsite qPCR Diagnostic Testing from Clinical Specimens Collected in Molecular Transport Medium.

J Appl Lab Med 2021 Jun 22. Epub 2021 Jun 22.

Longhorn Vaccines and Diagnostics, San Antonio, Texas, USA.

Background: The ability to rapidly detect SARS-CoV-2 and influenza virus infection is vital for patient care due to overlap in clinical symptoms. Roche's cobas® Liat® SARS-CoV-2 & Influenza A/B Nucleic Acid Test used on the cobas® Liat® was granted approval under FDA's Emergency Use Authorization (EUA) for nasopharyngeal (NP) and nasal swabs collected in viral/universal transport medium (VTM/UTM). However, there is a critical need for media that inactivates the virus, especially when specimens are collected in decentralized settings. Read More

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Comparative Evaluation of Two Automated Multiplex RT-PCR Tests for Rapid Detection of Influenza and Respiratory Syncytial Viruses.

Clin Lab 2021 Jun;67(6)

Background: Rapid and accurate diagnosis of influenza virus (Flu) and respiratory syncytial virus (RSV) is important for managing both the patient and laboratory. We compared the cobas Influenza A/B & RSV assay (cobas Liat) with the Simplexa Flu A/B & RSV assay (Simplexa) to evaluate which test method is more advantageous considering the resources of the laboratory and results of test performance.

Methods: A total of 236 respiratory specimens from patients referred for respiratory virus testing were retrospectively evaluated; 53 specimens tested positive for each of Flu A, Flu B, and RSV, and 77 specimens tested negative based on the results of the reference method, i. Read More

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Orchard Mapping with Deep Learning Semantic Segmentation.

Sensors (Basel) 2021 May 31;21(11). Epub 2021 May 31.

Institute for Bio-Economy and Agri-Technology (iBO), Centre for Research and Technology-Hellas (CERTH), GR57001 Thessaloniki, Greece.

This study aimed to propose an approach for orchard trees segmentation using aerial images based on a deep learning convolutional neural network variant, namely the U-net network. The purpose was the automated detection and localization of the canopy of orchard trees under various conditions (i.e. Read More

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Research Trends and Future Perspectives in Marine Biomimicking Robotics.

Sensors (Basel) 2021 May 29;21(11). Epub 2021 May 29.

Consiglio Nazionale delle Ricerche (CNR), Istituto di Scienze Marine (ISMAR), 19032 La Spezia, Italy.

Mechatronic and soft robotics are taking inspiration from the animal kingdom to create new high-performance robots. Here, we focused on marine biomimetic research and used innovative bibliographic statistics tools, to highlight established and emerging knowledge domains. A total of 6980 scientific publications retrieved from the Scopus database (1950-2020), evidencing a sharp research increase in 2003-2004. Read More

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Evaluation of six different rapid methods for nucleic acid detection of SARS-COV-2 virus.

J Med Virol 2021 Sep 8;93(9):5538-5543. Epub 2021 Jun 8.

G42 Healthcare, Abu Dhabi, UAE.

In the current coronavirus disease 2019 (COVID-19) pandemic there is a mass screening of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) happening around the world due to the extensive spread of the infections. There is a high demand for rapid diagnostic tests to expedite the identification of cases and to facilitate early isolation and control spread. Hence this study evaluates six different rapid nucleic acid detection assays that are commercially available for SARS-CoV-2 virus detection. Read More

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September 2021

Performance comparison of the Cobas® Liat® and Cepheid® GeneXpert® systems on SARS-CoV-2 detection in nasopharyngeal swab and posterior oropharyngeal saliva.

Expert Rev Mol Diagn 2021 05 28;21(5):515-518. Epub 2021 Apr 28.

Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong Special Administrative Region.

: Nucleic acid amplification tests (NAATs) based methods such as real-time reverse transcription polymerase-chain reaction (real-time RT-PCR) are the gold standard for diagnosis of current infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The cobas® Liat® and cepheid® GeneXpert® systems are two rapid real-time RT-PCR platforms offering rapid, specimen-to-answer detection of SARS-CoV-2.: In this study, we compared the performance of these two systems on SARS-CoV-2 detection in 9 nasopharyngeal swab (NPS) and 70 posterior oropharyngeal saliva specimens collected from 79 patients suspected of SARS-CoV-2 infection between August 2020 and March 2021. Read More

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Point-of-care testing for influenza in a university emergency department: A prospective study.

Influenza Other Respir Viruses 2021 Sep 4;15(5):608-617. Epub 2021 Apr 4.

Emergency and Acute Medicine, Campus Virchow Klinikum and Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.

Background: Seasonal influenza is a burden for emergency departments (ED). The aim of this study was to investigate whether point-of-care (POC) PCR testing can be used to reduce staff sick days and improve diagnostic and therapeutic procedures.

Objectives: The aim of this study was to investigate whether point-of-care (POC) PCR testing can be used to reduce staff sick days and improve diagnostic and therapeutic procedures. Read More

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September 2021

Diagnosis of respiratory syncytial virus and influenza A and B with cobas® Liat® from nasopharyngeal aspirations in pediatrics.

Diagn Microbiol Infect Dis 2021 Jun 1;100(2):115326. Epub 2021 Feb 1.

Laboratory Medicine, Iris Hospitals South, Brussels, Belgium; Faculty of Medicine, Université libre de bruxelles, Brussels, Belgium; Department of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, Namur, Belgium.

The cobas® Liat® Influenza A/B and respiratory syncytial virus assay was tested on nasopharyngeal aspirates. The resolution of invalid samples was performed using a preanalytical step. cobas® Liat® can be used on nasopharyngeal aspirates with a preanalytical processing step, with a slightly diminished performances in detecting respiratory syncytial virus but not for influenza. Read More

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Associations Between Relative Viral Load at Diagnosis and Influenza A Symptoms and Recovery.

Open Forum Infect Dis 2020 Nov 16;7(11):ofaa494. Epub 2020 Oct 16.

Department of Epidemiology and Biostatistics and Health Informatics Institute and Center for the Ecology of Infectious Diseases, The University of Georgia, Athens, Georgia, USA.

Background: Rapid point-of-care polymerase chain reaction (PCR) diagnostic tests generally provide a qualitative result of positive or negative only. Additional information about the relative viral load could be calculated. Such quantitative information might be useful for making treatment decisions. Read More

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November 2020

Clinical Performance of the Point-of-Care cobas Liat for Detection of SARS-CoV-2 in 20 Minutes: a Multicenter Study.

J Clin Microbiol 2021 01 21;59(2). Epub 2021 Jan 21.

Department of Pathology and Laboratory Medicine, University of California Davis, California, USA

Highly accurate testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the point of care (POC) is an unmet diagnostic need in emergency care and time-sensitive outpatient care settings. Reverse transcription-PCR (RT-PCR) technology is the gold standard for SARS-CoV-2 diagnostics. We performed a multisite U. Read More

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January 2021

Point-of-care tests for influenza A and B viruses and RSV in emergency departments - indications, impact on patient management and possible gains by syndromic respiratory testing, Capital Region, Denmark, 2018.

Euro Surveill 2020 11;25(44)

Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

BackgroundPoint-of-care tests (POCT) for influenza A and B viruses and respiratory syncytial virus (RSV) were implemented in emergency departments of all hospitals in the Capital Region of Denmark in 2018.AimTo establish whether POC testing for influenza viruses or RSV is based on a valid respiratory symptom indication, whether changes in patient management based on a positive result are safe and whether syndromic POC testing may benefit patients with influenza or RSV.MethodsSamples from 180 children (< 18 years) and 375 adults tested using POCT between February and July 2018 were retested for 26 respiratory pathogens. Read More

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November 2020

Gender differences and influenza-associated mortality in hospitalized influenza A patients during the 2018/19 season.

Infection 2021 Feb 22;49(1):103-110. Epub 2020 Oct 22.

Department for Infectious Diseases, Kaiser-Franz-Josef-Hospital (KFJ), Kundratstraße 3, 1100, Vienna, Austria.

Background: In this study we analyzed gender differences in the clinical presentation of patients with molecular confirmed influenza A. Additionally, we tried to identify predictors of influenza-associated mortality.

Materials/methods: In this prospective observational multi-center-study we included all influenza-positive patients ≥ 18 years who were hospitalized and treated on flu-isolation-wards in three hospitals in Vienna during the 2018/19 influenza season. Read More

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February 2021

Evaluation of cobas Influenza A/B & RSV Test for Diagnosis of Equine Influenza.

J Equine Vet Sci 2020 11 12;94:103249. Epub 2020 Sep 12.

Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.

A rapid and sensitive diagnostic method is needed to help prevent the spread of equine influenza virus. The cobas Influenza A/B & RSV test for the cobas Liat system (Roche Diagnostics) is based on real-time reverse transcription polymerase chain reaction and is designed to broadly detect influenza A virus RNA within 20 minutes. It detected a broad range of equine influenza virus strains, and detected equine influenza virus RNA from nasal swabs of infected horses at the same level as real-time reverse transcription polymerase chain reaction, although it returned some invalid results (7. Read More

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November 2020

Performance Comparison of a Novel Rapid Stand-alone Molecular Test and a 2-Step Diagnostic Algorithm for Clostridioides difficile Detection in Children.

Pediatr Infect Dis J 2021 02;40(2):169-172

From the Institut de Recerca Sant Joan de Deu, Barcelona, Spain.

Background: We aimed to evaluate diagnostic performance of the cobas® Liat® Cdiff test, a novel single-step automated polymerase chain reaction (PCR) assay for rapid diagnosis of toxigenic Clostridioides difficile infection (CDI) in stool samples from children with clinical symptoms of CDI.

Methods: Assessment of cobas Liat Cdiff diagnostic yield, time of analytical process and agreement of results with those of a 2-step diagnostic algorithm. The sequential algorithm combined an enzyme immunoassay (EIA) targeting antigen glutamate dehydrogenase (GDH), enterotoxin-A and cytotoxin-B, and a confirmatory PCR in EIA GDH-positive and toxin-negative samples. Read More

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February 2021

Sinus augmentation - autograft vs. fresh frozen allograft: Bone density dynamics and implant stability.

J Stomatol Oral Maxillofac Surg 2020 Sep 29. Epub 2020 Sep 29.

Department of Oral and Maxillofacial Surgery and Periodontology. School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. Electronic address:

Objectives: Compare bone density changes and initial implant stability following sinus augmentation with autogenous bone (AB) vs. fresh frozen bone (FFB).

Materials And Methods: Randomized, prospective, split mouth study. Read More

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September 2020

Integrated pharmaceutical logistics system implementation in selected health facilities of Ethiopia: The case of four WOLLEGA ZONES.

Res Social Adm Pharm 2021 05 6;17(5):956-968. Epub 2020 Aug 6.

Department of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia. Electronic address:

Background: The pharmaceutical supply chain management system of Ethiopia has several problems including non-availability, poor storage, weak stock management and irrational use. However, few studies were conducted on progress and challenges towards implementation of Integrated Pharmaceuticals Logistics System (IPLS) in the study area. Therefore, this study aimed to assess the progress and challenges towards the implementation of IPLS in selected health facilities of Wollega zones, Western Ethiopia. Read More

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Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus.

ERJ Open Res 2020 Jul 17;6(3). Epub 2020 Aug 17.

NIHR Newcastle In Vitro Diagnostics Co-operative, Translational and Clinical Research Institute, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Respiratory syncytial virus is a common cause of bronchiolitis. Historically, point-of-care tests have involved antigen detection technology with limited sensitivity. The aim of this study was to prospectively evaluate the diagnostic accuracy and model the economic impact of the Roche cobas® Liat® point-of-care influenza A/B and respiratory syncytial virus test. Read More

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Detection of Group A in the Saliva of Children Presenting With Pharyngitis Using the cobas Liat PCR System.

Clin Pediatr (Phila) 2020 09 19;59(9-10):856-858. Epub 2020 May 19.

University of Wisconsin, Madison, WI, USA.

Rapid turnaround real-time polymerase chain reaction (PCR) has recently become available as a point-of-care test for group A (GAS) in children presenting with pharyngitis. Our aim in this pilot study was to determine if GAS can be detected in the saliva of children with sore throat using swabs inoculated by children sucking on them as they would a lollipop. Twenty children with positive rapid antigen detection tests for GAS from pharyngeal swabs were enrolled. Read More

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September 2020

Peri-implant disease affects systemic complete blood count values-an experimental in vivo study.

Clin Oral Investig 2020 Dec 16;24(12):4531-4539. Epub 2020 May 16.

Department of Oral and Maxillofacial Surgery, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Objectives: To assess complete blood count (CBC) dynamics following ligature removal and open flap debridement in experimental peri-implantitis in dogs.

Materials And Methods: Seven male beagle dogs were included in the study. Four rough-surface implants were placed pair-wise in both sides of the mandible 14 weeks after tooth extraction. Read More

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December 2020

Author Spotlight: Liat Gutin.

Authors:
Liat Gutin

Dig Dis Sci 2020 06;65(6):1576

Kaiser Permanente San Francisco, San Francisco, USA.

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Studying Surfactant Effects on Hydrate Crystallization at Oil-Water Interfaces Using a Low-Cost Integrated Modular Peltier Device.

J Vis Exp 2020 03 18(157). Epub 2020 Mar 18.

Department of Chemical Engineering, San José State University;

We introduce an approach to study the formation and growth of hydrates under the influence of nonionic surfactants. The experimental system includes a temperature regulator, visualization techniques, and inner pressure measurements. The temperature control system contains a low-cost, programmable temperature regulator made with solid-state Peltier components. Read More

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C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT.

Health Technol Assess 2020 03;24(15):1-108

Primary Care and Vaccines Collaborative Clinical Trials Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Background: Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed antibiotics, but these may not be beneficial, and they can cause side effects and increase the risk of subsequent resistant infections. Point-of-care tests (POCTs) could safely reduce inappropriate antibiotic prescribing and antimicrobial resistance.

Objective: To determine whether or not the use of a C-reactive protein (CRP) POCT to guide prescribing decisions for AECOPD reduces antibiotic consumption without having a negative impact on chronic obstructive pulmonary disease (COPD) health status and is cost-effective. Read More

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Performance and ease of use of a molecular point-of-care test for influenza A/B and RSV in patients presenting to primary care.

Eur J Clin Microbiol Infect Dis 2020 Aug 14;39(8):1453-1460. Epub 2020 Mar 14.

NIHR Community Healthcare MIC, Nuffield Department of Primary Care Health Sciences, University of Oxford, Woodstock Road, Oxford, Oxfordshire, OX26GG, UK.

Annual influenza epidemics cause substantial morbidity and mortality, and the majority of patients with influenza-like illness present to primary care. Point-of-care influenza tests could support treatment decisions. It is critical to establish analytic performance of these platforms in real-life patient samples before uptake can be considered. Read More

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