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Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway.

J Nat Prod 2021 May 12. Epub 2021 May 12.

School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212100, People's Republic of China.

1-Deoxynojirimycin, an α-glucosidase inhibitor, possesses various biological activities such as antitumor, antidiabetic, and antiviral effects. However, the application of 1-deoxynojirimycin is restricted by its poor lipophilicity and low bioavailability. In this study, three 1-deoxynojirimycin derivatives (-) comprising 1-deoxynojirimycin and kaempferol were designed and synthesized to modify their pharmacokinetics and improve their antitumor efficacy. Read More

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Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP-exposed SH-SY5Y cells pre-treated with rutin.

Metab Brain Dis 2021 May 12. Epub 2021 May 12.

Department of Medical Biosciences, University of the Western Cape, Robert Sobukwe Road, Private Bag X17, Bellville, 7535, South Africa.

Many plant-derived bioactive compounds such as rutin are reportedly effective in attenuating neuronal death in most neurodegenerative disorders. Parkinson's disease (PD) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra of the midbrain, and has previously been modelled in-vitro through the specific neurotoxic activity of 1-methyl-4-phenylpyridinium (MPP) on dopaminergic neurons. Rutin is a bioflavonoid with multiple pharmacological effects, and this study investigated the neuroprotective effects of rutin in the human dopaminergic SH-SY5Y cell line using the neurotoxin MPP. Read More

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IL-23R gene polymorphisms in rheumatoid arthritis.

Rheumatol Int 2021 May 12. Epub 2021 May 12.

Division of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Denizli, Turkey.

Rheumatoid arthritis (RA) is a common autoimmune disease in which many different genetic variants of functional gene polymorphisms may play a culprit role in the underlying pathogenetic mechanism. The recent studies suggest that interleukin-23 receptor (IL-23R) gene polymorphisms may increase susceptibility to the development of various autoimmune diseases. We aimed to examine the possible relationship of nine single nucleotide polymorphisms (SNPs) in the IL-23R gene to susceptibility to rheumatoid arthritis and their associations with disease characteristics in the South Aegean region of Turkey. Read More

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Redox-related gene expression and sugar accumulation patterns are altered in the edible inflorescence produced by the cultivated form of pacaya palm (Chamaedorea tepejilote).

Ann Bot 2021 May 12. Epub 2021 May 12.

Institut de Recherche pour le Développement (IRD), UMR DIADE, Université de Montpellier, Montpellier, France.

Background And Aims: The pacaya palm is a dioecious neotropical palm species that is exploited in Latin America for its male inflorescence which is edible when immature. It is cultivated, in a non-intensive manner, in Guatemala, where a morphotype occurs that produces much larger, more highly branched inflorescences compared to wild palms. We sought to identify molecular factors underlying this phenotypic divergence, which is likely to be a product of domestication. Read More

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The Hepcidin and 25-OH-Vitamin D Levels in Obese Children as a Potential Mediator of the Iron Status.

Clin Lab 2021 May;67(5)

Background: Obesity is associated with the risk factors such as iron and vitamin D deficiencies. Increased risk of iron deficiency generally correlates with the high levels of serum hepcidin in obese children. Vitamin D deficiency was also linked to an increase in serum hepcidin levels. Read More

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Vitamin E regulates bovine granulosa cell apoptosis via NRF2-mediated defense mechanism by activating PI3K/AKT and ERK1/2 signaling pathways.

Reprod Domest Anim 2021 May 12. Epub 2021 May 12.

College of Animal Science and Technology, Hebei Agricultural University, Baoding, Hebei, 071000, People's Republic of China.

High-yield dairy cows are usually subject to high-intensive cell metabolism and produce excessive reactive oxygen species (ROS). Once ROS is beyond the threshold of scavenging ability, it can induce oxidative stress, imperiling the reproductive performance of cows. The study was to investigate the effects of vitamin E (VE) on H O -induced proliferation and apoptosis of bovine granulosa cells and the underlying molecular mechanism. Read More

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The effect of mild hypothermia plus rutin on the treatment of spinal cord injury and inflammatory factors by repressing TGF-β/smad pathway.

Acta Cir Bras 2021 7;36(3):e360307. Epub 2021 May 7.

PhD. Department of Spine Surgery - Guizhou Orthopedic Hospital - Guizhou Province, China.

Purpose: To probe the mechanism of mild hypothermia combined with rutin in the treatment of spinal cord injury (SCI).

Methods: Thirty rats were randomized into the following groups: control, sham, model, mild hypothermia (MH), and mild hypothermia plus rutin (MH+Rutin). We used modified Allen's method to injure the spinal cord (T10) in rats, and then treated it with MH or/and rutin immediately. Read More

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Hesperetin ameliorates hepatic oxidative stress and inflammation the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.

Food Funct 2021 May;12(9):3898-3918

Institute of Biomedical Research, School of Life Sciences, Shandong University of Technology, Zibo, Shandong, China.

Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease. Dietary supplementation has become a promising strategy for managing NAFLD. Hesperetin, a citrus flavonoid, is mainly found in citrus fruits (oranges, grapefruit, and lemons) and possesses multiple pharmacological properties, including anti-cancer, anti-Alzheimer and anti-diabetic effects. Read More

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Comparative evaluation of cardioprotective activity of and juice against isoprenaline-induced cardiotoxicity in rats.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

Objectives: Comparative evaluation of cardioprotective activity of and juice against isoprenaline induced cardiotoxicity in rats.

Methods: Rats (125-150 g) were orally administered (GA) and (FA) apple juice (3 mL/day, per oral) for 13 days. Myocardial injury was inducted on 14th and 15th day by the administration of Isoprenaline (85 mg/kg/day, subcutaneous). Read More

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Apelin-13 protects human neuroblastoma SH-SY5Y cells against amyloid-beta induced neurotoxicity: Involvement of anti oxidant and anti apoptotic properties.

J Basic Clin Physiol Pharmacol 2021 May 10. Epub 2021 May 10.

Golestan Neuroscience Research Center (GNRC), Department of Anatomy, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Objectives: We investigated the effect of apelin-13 on the cellular model of AD, amyloid-β (Aβ) treated SH-SY5Y cells in rats.

Methods: The SH-SY5Y cells were pretreated with different doses of apelin-13 (1, 2.5, 5, and 10 μg/mL), half an hour before adding 50% Aβ treatment. Read More

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Circulating inflammatory biomarkers in adolescents: evidence of interactions between chronic pain and obesity.

Pain Rep 2021 1;6(1):e916. Epub 2021 Apr 1.

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.

Introduction: The negative effects of chronic pain and obesity are compounded in those with both conditions. Despite this, little research has focused on the pathophysiology in pediatric samples.

Objective: To examine the effects of comorbid chronic pain and obesity on the concentration of circulating inflammatory biomarkers. Read More

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Dual Size/Charge-Switchable Nanocatalytic Medicine for Deep Tumor Therapy.

Adv Sci (Weinh) 2021 05 1;8(9):2002816. Epub 2021 Mar 1.

State Key Lab of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China.

Elevating intratumoral levels of highly toxic reactive oxygen species (ROS) by nanocatalytic medicine for tumor-specific therapy without using conventional toxic chemodrugs is recently of considerable interest, which, however, still suffers from less satisfactory therapeutic efficacy due to the relatively poor accumulation at the tumor site and largely blocked intratumoral infiltration of nanomedicines. Herein, an ultrasound (US)-triggered dual size/charge-switchable nanocatalytic medicine, designated as Cu-LDH/HMME@Lips, is constructed for deep solid tumor therapy via catalytic ROS generations. The negatively charged liposome outer-layer of the nanomedicine enables much-prolonged blood circulation for significantly enhanced tumoral accumulation, while the positively charged Fenton-like catalyst Cu-LDH released from the liposome under the US stimulation demonstrates much enhanced intratumoral penetration via transcytosis. Read More

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Heterogeneous magnitude of immunological memory to SARS-CoV-2 in recovered individuals.

Clin Transl Immunology 2021 6;10(5):e1281. Epub 2021 May 6.

Department of Experimental and Clinical Medicine University of Florence Florence Italy.

Objective: Although the adaptive immune response to SARS-CoV-2 has been characterised in the acute and early convalescent phase of the disease, few studies explore whether natural infection elicits long-lasting immunological memory in recovered individuals. In this work, we aimed to assess the maintenance of immunological memory to SARS-CoV-2.

Methods: We evaluated the long-term virus-specific cellular and humoral immune response in the members of an Italian Serie A football team, who experienced a cluster of COVID-19 in March 2020, which was strictly evaluated in the following months. Read More

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Maternal soy protein isolate diet during lactation programs deleterious effects on hepatic lipid metabolism, atherogenic indices, and function of adrenal in adult rat offspring.

J Dev Orig Health Dis 2021 May 12:1-10. Epub 2021 May 12.

Department of Nutrition, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.

The benefits of consuming soy and its protein have been reported in many studies. However, its phytoestrogen content raises concerns about consumption during lactation and gestation We therefore examined the effects of soybean or soy protein isolate on the parameters-related cardiovascular pathophysiology in lactating mothers and their offsprings at weaning and adulthood. Lactating rats were divided: casein control (C); soy protein isolate (SPI); and soybean (S). Read More

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Cerebral Venous Thrombosis Associated with COVID-19 Infection: An Observational, Multicenter Study.

Cerebrovasc Dis Extra 2021 May 11;11(2):55-60. Epub 2021 May 11.

Rashid Hospital, Dubai, United Arab Emirates.

Background And Purpose: Coronavirus disease 2019 (CO-VID-19) has an increased propensity for systemic hypercoagulability and thromboembolism. An association with cerebrovascular diseases, especially cerebral venous thrombosis (CVT), has been reported among these patients. The objective of the present study was to identify risk factors for CVT as well as its presentation and outcome in COVID-19 patients. Read More

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Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish.

Ecotoxicol Environ Saf 2021 May 8;218:112308. Epub 2021 May 8.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

Accumulating studies have revealed the toxicity of antimony (Sb) to soil-dwelling and aquatic organisms at the individual level. However, little is known about the neurotoxic effects of antimony and its underlying mechanisms. To assess this issue, we investigated the neurotoxicity of antimony (0, 200, 400, 600 and 800 mg/L) in zebrafish embryos. Read More

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Assessment of the effect of long-term exposure to microplastics and depuration period in Sparus aurata Linnaeus, 1758: Liver and blood biomarkers.

Sci Total Environ 2021 May 3;786:147479. Epub 2021 May 3.

Instituto Español de Oceanografía, Centro Oceanográfico de Baleares, Muelle de Poniente s/n, E-07015 Palma de Mallorca, Balearic Islands, Spain. Electronic address:

The constant increase in plastic pollution has attracted great attention in recent years due to its potential detrimental effects on organisms and ecosystems. While the consequences of ingestion of large plastic litter are mostly understood, the impacts resulting from a long-term exposure and a recovery period of microplastics (MPs) are still limited. The aims were to monitor oxidative stress, detoxification and inflammatory biomarkers in liver, plasma and erythrocytes of Sparus aurata exposed during 90 days to low-density polyethylene (LDPE)-MPs enriched diet (10% by weight) followed by 30 days of depuration. Read More

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Regulation of plasmodesmata in leaves of Arabidopsis: ATP, NADPH and chlorophyll b levels matter.

J Exp Bot 2021 May 11. Epub 2021 May 11.

Laboratory of Molecular and Ecological Physiology, Komarov Botanical Institute, Russian Academy of Sciences, ul. Professora Popova 2, 197376 St.-Petersburg, Russia.

In mature leaves, cell-to-cell transport via plasmodesmata (PD) between mesophyll cells links assimilate production in photosynthesis with their export to sink organs. This study addresses the question how signals derived from chloroplasts and photosynthesis influence PD permeability. Cell-to-cell transport was analyzed in leaves of Arabidopsis chlorophyll b-less ch1-3 mutant, the same mutant complemented with a cyanobacterial CAO gene (PhCAO) over-accumulating chlorophyll b, the trxm3 mutant lacking plastidial thioredoxin m3, and the ntrc mutant lacking functional NADPH : thioredoxin reductase C. Read More

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Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences.

Disabil Rehabil 2021 May 11:1-8. Epub 2021 May 11.

Division of Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Germany.

Purpose: Previously we demonstrated the feasibility of a six-week-long combination of high-intensity interval endurance and strength training (HIT/HIRT) for women with nonmetastatic breast cancer leading to improvements in psychological well-being and performance. Now we report results of a 24-month follow-up.

Methods: Previous intervention (IG,  = 10; 58. Read More

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Purposefulness and daily life in a pandemic: Predicting daily affect and physical symptoms during the first weeks of the COVID-19 response.

Psychol Health 2021 May 11:1-17. Epub 2021 May 11.

Department of Psychology, University of British Columbia, Vancouver, BC, Canada.

Objective: Sense of purpose has been associated with greater health and well-being, even in daily contexts. However, it is unclear whether effects would hold in daily life during COVID-19, when people may have difficulty seeing a path towards their life goals.

Design: The current study investigated whether purposefulness predicted daily positive affect, negative affect, and physical symptoms. Read More

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Von Willebrand factor collagen-binding capacity predicts in-hospital mortality in COVID-19 patients: insight from VWF/ADAMTS13 ratio imbalance.

Angiogenesis 2021 May 11. Epub 2021 May 11.

Université de Paris, Innovative Therapies in Haemostasis, INSERM, 75006, Paris, France.

Background: Microthrombosis is a hallmark of COVID-19. We previously described von willebrand factor (VWF) and their high molecular weight multimers (HMWMs) as potential trigger of microthrombosis.

Objectives: Investigate VWF activity with collagen-binding assay and ADAMTS13 in COVID-19. Read More

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Triazole-Based Half-Sandwich Ruthenium(II) Compounds: From Antiproliferative Potential to Toxicity Evaluation.

Inorg Chem 2021 May 11. Epub 2021 May 11.

Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal.

A new series of half-sandwich ruthenium(II) compounds [(η-arene)Ru(L)Cl][CFSO] bearing 1,2,3-triazole ligands (arene = -cymene, L = (); arene = -cymene, L = (); arene = benzene, L = (); arene = benzene, (); = 2-[1-(-tolyl)-1-1,2,3-triazol-4-yl]pyridine and = 1,1'-di--tolyl-1,1'-4,4'-bi(1,2,3-triazole) have been synthesized and fully characterized by H and C NMR and IR spectroscopy, mass spectrometry, and elemental analysis. The molecular structures of , , and have been determined by single-crystal X-ray diffraction. The cytotoxic activity of - was evaluated using the MTS assay against human tumor cells, namely ovarian carcinoma (A2780), colorectal carcinoma (HCT116), and colorectal carcinoma resistant to doxorubicin (HCT116dox), and against normal primary fibroblasts. Read More

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Phenolic profile of jujube fruit subjected to gut microbiota fermentation and its antioxidant potential against ethyl carbamate-induced oxidative damage.

J Zhejiang Univ Sci B 2021 May;22(5):397-409

Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China.

Objectives: To evaluate the composition of bioactive substances and the antioxidant effects of jujube fruit under gut microbiota fermentation (GMF), and the inhibitory effect on cytotoxicity caused by ethyl carbamate (EC).

Methods: Changes in the contents of flavonoids, polyphenols, total sugars, and reducing sugars of jujube fruit after GMF (0, 2, 6, 12, 24, and 48 h) were determined. The oxidation resistance of fermented jujube fruits (from 0 to 48 h fermentation) was evaluated using in vitro 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) and ferric reducing antioxidant power (FRAP) assays. Read More

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Mortality in Ankylosing Spondylitis According to Treatment: A Nationwide Retrospective Cohort Study of 5900 Patients from Israel.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel.

Objectives: In this large population-based study we aimed to assess:(1)mortality in ankylosing-spondylitis(AS) patients compared to the general population.Considering demographics,comorbidities and treatment.(2)factors associated with mortality within AS patients. Read More

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FERONIA restricts Pseudomonas in the rhizosphere microbiome via regulation of reactive oxygen species.

Nat Plants 2021 May 10. Epub 2021 May 10.

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

Maintaining microbiome structure is critical for the health of both plants and animals. By re-screening a collection of Arabidopsis mutants affecting root immunity and hormone crosstalk, we identified a FERONIA (FER) receptor kinase mutant (fer-8) with a rhizosphere microbiome enriched in Pseudomonas fluorescens without phylum-level dysbiosis. Using microbiome transplant experiments, we found that the fer-8 microbiome was beneficial. Read More

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Effects of cadmium stress on growth and physiological characteristics of sassafras seedlings.

Sci Rep 2021 May 10;11(1):9913. Epub 2021 May 10.

Institute of Ecology and Forestry, College of Forestry, Sichuan Agricultural University, Chengdu, 611130, China.

The effects of cadmium stress on the growth and physiological characteristics of Sassafras tzumu Hemsl. were studied in pot experiments. Five Cd levels were tested [CT(Control Treatment) : 0 mg/kg, Cd5: 5 mg/kg, Cd20: 20 mg/kg, Cd50: 50 mg/kg, and Cd100: 100 mg/kg]. Read More

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Genetically predicted circulating C-reactive protein concentration and colorectal cancer survival: A Mendelian randomization consortium study.

Cancer Epidemiol Biomarkers Prev 2021 May 10. Epub 2021 May 10.

Public Health Sciences, Fred Hutchinson Cancer Research Center.

Background: A positive association between circulating C-reactive protein (CRP) and colorectal cancer (CRC) survival was reported in observational studies, which are susceptible to unmeasured confounding and reverse causality. We used a Mendelian randomization approach to evaluate the association between genetically-predicted CRP concentrations and CRC-specific survival.

Methods: We used individual-level data for 16,918 eligible CRC cases of European ancestry from 15 studies within the International Survival Analysis of Colorectal Cancer Consortium. Read More

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Effect of Direct Antiviral Agents on Atherosclerosis in Patients with Chronic Hepatitis C.

Arch Med Res 2021 May 7. Epub 2021 May 7.

Internal Medicine Department, Hospital General de Zona 30, Instituto Mexicano del Seguro Social, Eje 4 Sur, Avenida Plutarco Elias Calles 473, Santa Anita, Iztacalco, 08300, Mexico City, Mexico.

Background: Chronic hepatitis C is an independent risk factor for atherosclerosis and is associated with cardiovascular events. Mechanisms include inflammatory cytokines, endothelial dysfunction, and increased oxidative stress.

Aim Of The Study: The objective was to evaluate the response of carotid atherosclerosis to treatment with direct-antiviral agents. Read More

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Effects of supplementing a healthy diet with pecan nuts or extra-virgin olive oil on inflammatory profile of patients with stable coronary artery disease: a randomized clinical trial.

Br J Nutr 2021 May 11:1-27. Epub 2021 May 11.

Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia do Rio Grande do Sul (IC/FUC). 395 Princesa Isabel Avenue, 90040-371, Porto Alegre, Rio Grande do Sul, Brazil.

The consumption of nuts and extra-virgin olive oil has been associated with suppression of inflammatory pathways that contribute to atherosclerosis, but its role on the modulation of the inflammatory profile in patients with established coronary artery disease (CAD) is unclear. The aim of this study was to evaluate the effects of adding pecan nuts or extra-virgin olive oil to a healthy diet on inflammatory markers in patients with stable CAD. In this randomized clinical trial, 204 patients were enrolled to three study groups: 67 to control group (CG: healthy diet), 68 to pecan nuts group (PNG: 30g/day of pecans + healthy diet) and 69 to extra-virgin olive oil group (OOG: 30ml/day of extra-virgin olive oil + healthy diet). Read More

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