67,792 results match your criteria levels pain


Neuroendocrine Modulation of Cognitive Performance in the Patients with Fibromyalgia.

Eur Neurol 2021 May 11:1-11. Epub 2021 May 11.

Departments of Neurology (Sleep Disorder), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, China.

Background: Fibromyalgia (FM) is a chronic widespread pain disorder associated with fatigue, tender points, sleep disturbances, and mood disorders. Symptoms associated with FM also include decreased cognitive function in which the neural basis is poorly understood. Neuroendocrine hormones may be correlated with cognitive performance under some ill conditions. Read More

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Return to Sport After Surgical Management of Posterior Shoulder Instability: A Systematic Review and Meta-analysis.

Am J Sports Med 2021 May 11:3635465211011161. Epub 2021 May 11.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Canada.

Background: Posterior shoulder instability accounts for a small proportion of all shoulder instability, although it can affect athletes of all types, from contact to overhead athletes. Surgical treatment is quite successful in these patients; however, the literature reports a wide range of rates of return to sport.

Purpose/hypothesis: The purpose was to determine the return-to-sport rates after surgical stabilization for posterior shoulder instability. Read More

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Prodromal sensory neuropathy in Pink1 SNCA double mutant Parkinson mice.

Neuropathol Appl Neurobiol 2021 May 11. Epub 2021 May 11.

Institute for Clinical Pharmacology, Faculty of Medicine, Goethe-University, Frankfurt, Germany.

Aims: Parkinson's Disease (PD) is frequently associated with a prodromal sensory neuropathy manifesting with sensory loss and chronic pain. We have recently shown that PD-associated sensory neuropathy in patients is associated with high levels of glucosylceramides. Here, we assessed the underlying pathology and mechanisms in Pink1 SNCA double mutant mice. Read More

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[Care of rheumatology patients during the lockdown in early 2020 : Telemedicine, delegation, patient satisfaction and vaccination behavior].

Z Rheumatol 2021 May 11. Epub 2021 May 11.

Klinik für Rheumatologie und Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Background: Telemedicine was implemented in outpatient care during the lockdown between March and May 2020. The aim of the study was to assess patients from a private practice and the university outpatient department with respect to patient satisfaction with telemedicine, COVID-19 worries and vaccination behavior and to compare the teleconsultation by a medical assistant for rheumatology (RFA) and a physician.

Methods: Patients with rheumatoid arthritis, psoriatric arthropathy or spondylarthritis without treatment modifications since the previous presentation were offered a telemedical replacement appointment within the framework of this study in the case of appointment cancellation by the treating center. Read More

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Power-assisted Pedicle Screw Technique Protects Against Risk of Surgeon Overuse Injury: A Comparative Electromyography Study of the Neck and Upper Extremity Muscle Groups in a Simulated Surgical Environment.

Spine (Phila Pa 1976) 2021 May 10. Epub 2021 May 10.

Zimmer Biomet Spine, Westminster, CO Hospital for Special Surgery, New York, NY Children's Hospital Los Angeles, Los Angeles, CA.

Study Design: Cadaveric.

Objective: The aim of this study was to quantify the amplitude and duration of surgeons' muscle exertion from pedicle cannulation to screw placement using both manual and power-assisted tools in a simulated surgical environment using surface electromyography (EMG).

Summary Of Background Data: A survey of Scoliosis Research Society members reported rates of neck pain, rotator cuff disease, lateral epicondylitis, and cervical radiculopathy at 3×, 5×, 10×, and 100× greater than the general population. Read More

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Mid- to Long-Term Outcomes After Resection of Thoracic Dumbbell Tumors Managed by Laminectomy and Unilateral Total Facetectomy Without Instrumented Fusion.

Global Spine J 2021 May 11:21925682211008836. Epub 2021 May 11.

Department of Regenerative and Transplant Medicine, Division of Orthopaedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Study Design: Retrospective multicenter study.

Objective: To evaluate mid- to long-term surgical outcomes of thoracic dumbbell tumors managed by laminectomy and unilateral total facetectomy without instrumented fusion.

Methods: A total of 15 patients with thoracic dumbbell tumors who underwent primary resection by laminectomy and unilateral total facetectomy without spinal instrumented fusion between 2000 and 2015 were reviewed. Read More

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Association of preoperative pain beliefs with postoperative pain levels in abdominal surgery patients.

J Clin Nurs 2021 May 10. Epub 2021 May 10.

Department of Nursing, Faculty of Health Sciences, Mugla Sıtkı Kocman University, Mugla, Turkey.

Aims And Objectives: This study aimed to analyse the association of preoperative pain beliefs with postoperative pain levels in abdominal surgery patients.

Background: Postoperative pain is related to not only clinical and demographic characteristics but also pain beliefs. The perception, intensity and expression of pain as a subjective experience varies among individuals and cultures. Read More

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TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage.

Neurochem Res 2021 May 10. Epub 2021 May 10.

Department of Anesthesiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510000, Guangdong Province, China.

Reportedly, TWIK-related spinal cord K (TRESK) deficiency in spinal cord neurons positively correlates with the mechanism underlying neuropathic pain (NP). However, the precise effects of TRESK on neurons of the spinal cord remain elusive. In the present study, we investigated the impact of TRESK silencing on spinal cord neurons to further elucidate the downstream mechanisms of TRESK. Read More

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Opioid Prescribing Practices and Quality Improvements Within an Outpatient Orthopedic Practice.

Cureus 2021 Apr 6;13(4):e14332. Epub 2021 Apr 6.

Statistics, Twin Cities Orthopedics, Golden Valley, USA.

Background During the last several decades, the opioid epidemic throughout the United States has been recognized as an increasing problem. The aim of this study was to identify and implement processes throughout a single private orthopedic practice and managed ambulatory surgery centers to reduce opioid prescription pill quantity and strength, while also reducing consumption. Methodology A baseline assessment along with the development of four separate phases was implemented. Read More

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Overuse of diagnostic testing in healthcare: a systematic review.

BMJ Qual Saf 2021 May 10. Epub 2021 May 10.

IQ healthcare, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Background: Overuse of diagnostic testing substantially contributes to healthcare expenses and potentially exposes patients to unnecessary harm. Our objective was to systematically identify and examine studies that assessed the prevalence of diagnostic testing overuse across healthcare settings to estimate the overall prevalence of low-value diagnostic overtesting.

Methods: PubMed, Web of Science and Embase were searched from inception until 18 February 2020 to identify articles published in the English language that examined the prevalence of diagnostic testing overuse using database data. Read More

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Imaging the dynamics and microstructure of fibrin clot polymerization in cardiac surgical patients using spectrally encoded confocal microscopy.

Am J Hematol 2021 May 10. Epub 2021 May 10.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

During cardiac surgery with cardiopulmonary bypass (CPB), altered hemostatic balance may disrupt fibrin assembly, predisposing patients to perioperative hemorrhage. We investigated the utility of a novel device termed spectrally-encoded confocal microscopy (SECM) for assessing fibrin clot polymerization following heparin and protamine administration in CPB patients. SECM is a novel, high-speed optical approach to visualize and quantify fibrin clot formation in three dimensions with high spatial resolution (1. Read More

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[Virtual palliative care : Pilot study of an electronic tool to test cognitive, psychomotor and affective palliative medical and pain therapeutic learning contents during medical training].

Schmerz 2021 May 10. Epub 2021 May 10.

Klinik für Palliativmedizin, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland.

Background: This article describes a first use of an electronic case-based assessment tool in undergraduate palliative care education. It describes the development of the tool presenting strengths and shortcomings in order to contribute to an innovative design of assessment tools in medical education.

Design And Method: An electronic (virtual) case-based assessment tool (the virtual palliative patient, vPp) was developed. Read More

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Developing a real-world evidence base for prescribed cannabis in the United Kingdom: preliminary findings from Project Twenty21.

Psychopharmacology (Berl) 2021 May 10. Epub 2021 May 10.

Imperial College London, Burlington Danes Building, Hammersmith Hospital, Du Cane Rd, White City, London, W12 0NN, UK.

The therapeutic potential of medical cannabis to treat a variety of conditions is becoming increasingly recognised. Globally, a large number of countries have now legalised cannabis for medical uses and a substantial number of patients are able to access their medications. Yet in the UK, where medical cannabis was legalised in November 2018, only a handful of NHS prescriptions have been written, meaning that most patients are unable to access the medicine. Read More

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Autologous platelet-rich plasma repairs burn wound and reduces burn pain in rats.

J Burn Care Res 2021 May 10. Epub 2021 May 10.

Department of transfusion medicine, PLA Rocket Force Characteristic Medical Center, Beijing, China.

Objective: To investigate the effects of autologous platelet-rich plasma (PRP) on burn wound and burn pain in rats.

Methods: Rats were treated with high-temperature copper rod to induce skin burn. During treatment, the wound area of rats was recorded on days 0, 3, 7, 10, 14 and healing rates were calculated. Read More

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False negative point-of-care urine pregnancy tests in an urban academic emergency department: a retrospective cohort study.

J Am Coll Emerg Physicians Open 2021 Jun 1;2(3):e12427. Epub 2021 May 1.

Department of Emergency Medicine Boston Medical Center Boston University School of Medicine Boston Massachusetts USA.

Study Objective: To determine the prevalence of false negative point-of-care (POC) urine pregnancy tests among emergency department (ED) patients and among those with abdominal pain or vaginal bleeding.

Methods: We identified all female patients, ages 14-50 years without prior hysterectomy who had a negative POC urine pregnancy test (beta subunit of human chorionic gonadotropin [β-hCG]) performed by trained clinical staff in the ED between September 1, 2017 and December 31, 2018, as well as a subgroup we defined a priori as "high risk" for early pregnancy complications based on a triage chief complaint (text) of abdominal pain or vaginal bleeding. We identified those with a positive urine β-hCG, serum β-hCG >5 mIU/mL, or a diagnosis of pregnancy within 3 months of the initial ED visit (index visit). Read More

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Mechanism of and Ameliorates Hypertensive Renal Damage.

Biomed Res Int 2021 21;2021:5598351. Epub 2021 Apr 21.

Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.

Hypertensive-induced renal damage (HRD) is an important public health and socioeconomic problem worldwide. The herb pair - (RA-) (RS) is a common prescribed herbal formula for the treatment of HRD. However, the underlying mechanisms are unclear. Read More

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Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level: A case report.

World J Clin Cases 2021 May;9(13):3219-3226

Department of Internal Medicine, São Paulo State University (Unesp), Medical School, Botucatu 18618687, São Paulo, Brazil.

Background: Acute severe ulcerative colitis (ASUC) is a complication of ulcerative colitis associated with high levels of circulating tumor necrosis factor alpha, due to the intense inflammation and faster stool clearance of anti-tumor necrosis factor drugs. Dose-intensified infliximab treatment can be beneficial and is associated with lower rates of colectomy. The aim of the study was to present a case of a patient with ASUC and megacolon, treated with hydrocortisone and accelerated scheme of infliximab that was monitored by drug trough level. Read More

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Intramuscular hematoma in rhabdomyolysis patients treated with low-molecular-weight heparin: Report of two cases.

World J Clin Cases 2021 Apr;9(12):2838-2844

Department of Critical Care Medicine, Nanping First Hospital Affiliated to Fujian Medical University, Nanping 353000, Fujian Province, China.

Background: Rhabdomyolysis is a serious complication of heat stroke. Unlike that in acute kidney injury, the risk of muscle bleeding in rhabdomyolysis is often ignored and can substantially increase the widespread use of anticoagulants, leading to the formation of intramuscular hematoma.

Case Summary: During the summer, a middle-aged man and an elderly man were diagnosed with heat stroke, rhabdomyolysis, and acute renal impairment. Read More

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Plasma Metabolites Alert Patients With Chest Pain to Occurrence of Myocardial Infarction.

Front Cardiovasc Med 2021 23;8:652746. Epub 2021 Apr 23.

Laboratory of Metabolomics, Jiangsu Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.

Myocardial infarction (MI) is one of the leading causes of death worldwide, and knowing the early warning signs of MI is lifesaving. To expand our knowledge of MI, we analyzed plasma metabolites in MI and non-MI chest pain cases to identify markers for alerting about MI occurrence based on metabolomics. A total of 230 volunteers were recruited, consisting of 146 chest pain patients admitted with suspected MI (85 MIs and 61 non-MI chest pain cases) and 84 control individuals. Read More

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Abdominal Pain as the Manifestation of Chylomicronemia Syndrome During Pregnancy: A Challenging Diagnosis.

Cureus 2021 Apr 6;13(4):e14317. Epub 2021 Apr 6.

Internal Medicine: Critical Care, Hospital De Cascais, Cascais, PRT.

Hypertriglyceridemia is a frequent cause of acute pancreatitis. Levels higher than 1000 mg/dL are often associated with a genetic predisposition that can be aggravated by other factors such as pregnancy and poorly controlled diabetes. The authors report a 19-year-old primigravida that presented with abdominal pain, emesis and a pruritic rash, along with severely increased plasma triglyceride levels. Read More

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Case Report: Rare presentation of adult intussusception at Orotta National Referral Hospital, Eritrea.

F1000Res 2019 14;8:55. Epub 2019 Jan 14.

Faculty of Medicine, Institute of Social and Preventive Medicine (ISPM), Bern, 3012, Switzerland.

A 38-year-old woman presented at Orotta National Referral Hospital emergency department in May 2017 with pain in the epigastric region and vomiting. Physical examination revealed no pertinent findings. Blood and urine tests were normal, and erect abdominal x-ray revealed a distended small intestine with multiple layers of "air-fluid levels". Read More

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January 2019

Practical and Clinical Approaches Using Pacing to Improve Selfregulation in Special Populations such as Children and People with Mental Health or Learning Disabilities.

J Rehabil Med Clin Commun 2021 4;4:1000058. Epub 2021 May 4.

School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.

For special populations such as people with a mental health issue or learning disability, a disconnect between the ability to accurately monitor and regulate exercise behaviour can lead to reduced levels of physical activity, which, in turn, is associated with additional physical or mental health problems. Activity pacing is a strategy used in clinical settings to address issues of pain amelioration, while self-pacing research is now well addressed in sport and exercise science literature. It has been proposed recently that these overlapping areas of investigation collectively support the development of self-regulatory, lifestyle exercise skills across broad population groups. Read More

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Botulinum Neurotoxin Therapy for Depression: Therapeutic Mechanisms and Future Perspective.

Front Psychiatry 2021 23;12:584416. Epub 2021 Apr 23.

Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Depression is one of the most common mental disorders, which causes global burden. Antidepressants and psychotherapies are the mainstay of treatment for depression, which have limited efficacy. Thus, alternative approaches for preventing and treating depression are urgently required. Read More

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Monitored Anesthesia Care and Soft-Tissue Infiltration with Local Anesthesia (MAC-STILA): An Anesthetic Option for High Risk Patients with Hip Fractures.

J Orthop Trauma 2021 Mar 16. Epub 2021 Mar 16.

NYU Langone Health, NYU Langone Orthopedic Hospital, Division of Orthopedic Trauma Surgery, Department of Orthopedic Surgery, 301 East 17 Street, New York, NY 10003, Phone: 212-598-6000 Jamaica Hospital Medical Center, Department of Orthopedic Surgery, 8900 Van Wyck Expressway, Queens, NY 11418, Phone: 718-206-6923.

Objectives: To examine the feasibility of a novel anesthetic option for hip fracture fixation with short cephalomedullary nails.

Design: Retrospective cohort study.

Setting: An urban, academic level 1 trauma center, a tertiary care academic medical center, and an orthopedic specialty hospitalPatients/Participants: 20 recent and 40 risk-matched (1:1:1 by anesthesia type) historical hip fracture patients. Read More

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Pain, symptom distress, and pain barriers by age among patients with cancer receiving hospice care: Comparison of baseline data.

J Geriatr Oncol 2021 May 6. Epub 2021 May 6.

Department of Biobehavioral Nursing Science and Center for Palliative Care Research and Education, College of Nursing, University of Florida, Gainesville, FL, USA. Electronic address:

Objectives: Age group differences have been reported for pain and symptom presentations in outpatient and inpatient oncology settings, but it is unknown if these differences occur in hospice. We examined whether there were differences in pain, symptom distress, pain barriers, and comorbidities among three age groups (20-64 years, 65-84 years, and 85+) of hospice patients with cancer.

Materials And Methods: Participants were recruited from two hospices. Read More

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The Tampon Test as a Primary Outcome Measure in Provoked Vestibulodynia: A Mixed Methods Study.

J Sex Med 2021 May 6. Epub 2021 May 6.

Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway; Department of Neurology, Oslo University Hospital, Oslo Norway.

Background: Provoked vestibulodynia (PVD) is characterized by severe pain, often induced by penetrative sex. This may lead to women abstaining from sexual intercourse, hence the recording of pain intensity levels in PVD research is often challenging. The standardized tampon test was designed as an alternative outcome measure to sexual intercourse pain and has frequently been used in clinical studies. Read More

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Is there any relationship between platelet indices and myocarditis in children?

Cardiol Young 2021 May 10:1-5. Epub 2021 May 10.

Kütahya Health Sciences University, Department of Pediatric Cardiology, Kütahya, Turkey.

Background: Platelet indices are used to evaluate platelet activation and function which change in inflammatory diseases. We hypothesise that platelet indices such as plateletcrit, mean platelet volume, and platelet distribution width may be more useful as prognostic indicators for myopericarditis in children.

Methods: A total of 60 children were included in this study. Read More

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Randomized trial of the application value of comprehensive nursing intervention in the perioperative period of ruptured bleeding of ectopic pregnancy.

Ann Palliat Med 2021 Apr;10(4):4593-4600

Department of Gynaecology and Obstetrics, Zhuji Fifth People's Hospital, Zhuji, China.

Background: The purpose of this study was to explore the value of comprehensive nursing intervention in the perioperative period of ruptured bleeding of ectopic pregnancy.

Methods: From January 2015 to January 2020, 164 patients with rupture and bleeding of ectopic pregnancy who needed laparoscopic treatment in the department of gynecology at our hospital were selected and randomly divided into the basic nursing group and the comprehensive nursing group, with 82 cases each. During the perioperative period, comprehensive nursing intervention or basic nursing intervention were performed, and the nursing effects of the two nursing interventions were compared. Read More

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Factors influencing implementation of the GLA: D Back, an educational/exercise intervention for low back pain: a mixed-methods study.

JBI Evid Implement 2021 May 10. Epub 2021 May 10.

Department of Sports Science and Clinical Biomechanics, University of Southern Denmark Nordic Institute of Chiropractic and Clinical Biomechanics, Odense M, Denmark.

Introduction And Aims: Guidelines for low back pain (LBP) management recommend patient education and exercises. GLA:D Back, a structured group-based patient-education exercise program for LBP, facilitates evidence-based care implementation. This study aimed to inform on the implementation processes, assessing clinician-related factors. Read More

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NMDAR1-Src-Pannexin1 signal pathway in the trigeminal ganglion contributed to orofacial ectopic pain following inferior alveolar nerve transection.

Neuroscience 2021 May 6. Epub 2021 May 6.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

The N-methyl-D-aspartate receptor (NMDAR) is a glutamate-gated receptor channel that plays a role in peripheral neuropathic pain. Src, a protein tyrosine kinase, can regulate the activation of NMDARs in chronic pain conditions. Pannexin 1 (Panx1), a plasma membrane channel, plays an important role in neuropathic pain and functionally interacts with NMDARs in the pathological condition of epilepsy. Read More

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