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Efficacy and safety of heterologous booster vaccination with Ad26.COV2.S after BNT162b2 mRNA COVID-19 vaccine in haemato-oncological patients with no antibody response.

Br J Haematol 2021 Dec 6. Epub 2021 Dec 6.

Department of Internal Medicine II, Feldkirch Academic Teaching Hospital, Feldkirch, Austria.

Patients with haemato-oncological malignancies are one of the high-risk groups for a severe course in case of COVID-19 infections. Furthermore, vaccination results in significantly lower response rates in haematological malignancies and lower antibody levels in patients with solid cancer. We investigated efficacy and safety of a heterologous booster vaccination with Ad26. Read More

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December 2021

Dietary high-fructose reduces barrier proteins and activates mitogenic signalling in the testis of a rat model: Regulatory effects of kefir supplementation.

Andrologia 2021 Dec 6:e14342. Epub 2021 Dec 6.

Department of Biology, KO Science Faculty, Karamanoglu Mehmetbey University, Karaman, Turkey.

There are limited data on the influence of fructose rich diet on the male reproductive system. Kefir may have health beneficial effects, but its mechanism of action remains mostly unclear. Herein, we investigated the impact of dietary high fructose on tight junction proteins and mitogenic pathways in rat testis as well as their modulation by kefir supplementation. Read More

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December 2021

Association of Overweight and Consistent Anovulation among Infertile Women with Regular Menstrual Cycle: A Case-control Study.

Rev Bras Ginecol Obstet 2021 Nov 6;43(11):834-839. Epub 2021 Dec 6.

Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Hospital das Clínicas, Laboratório de Reprodução Humana, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Objective:  It has been suggested that excess body weight could represent a risk factor for infertility outcomes. The present study aimed to evaluate the association of overweight and anovulation among infertile women with regular menstrual cycles.

Methods:  We conducted a retrospective case-control study with consistently anovulatory patients undergoing assisted reproduction treatment. Read More

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November 2021

Perinatal Outcomes and Factors Associated with Ethnic Group in cases of Preterm Birth: the Multicenter Study on Preterm Birth in Brazil.

Rev Bras Ginecol Obstet 2021 Nov 6;43(11):811-819. Epub 2021 Dec 6.

Department of Obstetrics and Gynecology, Faculdade de Ciências Médicas, Universidade Estaudual de Campinas, Campinas, SP, Brazil.

Objective:  To investigate the characteristics of women who had preterm birth (PTB) and related outcomes according to ethnicity.

Methods:  A secondary analysis of a multicenter cross-sectional study conducted in Brazil. Women who had PTB were classified by self-report as white and non-white. Read More

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November 2021

Effects of washed microbiota transplantation on serum uric acid levels, symptoms and intestinal barrier function in patients with acute and recurrent gout: a pilot study.

Dig Dis 2021 Dec 6. Epub 2021 Dec 6.

Introduction: Gut dysbiosis has been reported to be closely associated with gout. Washed microbiota transplantation (WMT) is considered as an effective way to restore a healthy gut microbiota with less adverse events than the conventional fecal microbiota transplantation. In this study, we aimed to evaluate the effects of WMT on serum uric acid levels, symptoms and the intestinal barrier function in patients with acute and recurrent gout. Read More

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December 2021

Maternal Serum and Cord Blood Leptin Concentrations at Delivery in Normal Pregnancies and in Pregnancies Complicated by Intrauterine Growth Restriction.

Obes Facts 2021 Dec 6:1-8. Epub 2021 Dec 6.

Department of Obstetrics and Gynecology Didactics, Medical University of Warsaw, Warsaw, Poland.

Introduction: Leptin is a polypeptide hormone, and in pregnancy, it is secreted by the placenta and maternal and fetal adipose tissues. Normal leptin production is a factor responsible for uncomplicated gestation, embryo development, and fetal growth. The study compared maternal serum and cord blood leptin concentrations at delivery in normal pregnancies and in pregnancies complicated by intrauterine growth restriction (IUGR). Read More

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December 2021

The Impact of Phenylketonuria on Body Composition in Adults.

Ann Nutr Metab 2021 Dec 6:1-8. Epub 2021 Dec 6.

Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.

Introduction: Patients with phenylketonuria (PKU) must follow a lifelong phenylalanine (Phe)-restricted diet with additional amino acid supplementations, and this may put them at risk for nutritional disturbances. However, the body composition and nutritional status of adult patients with PKU has only been partially explored. The current study aims to assess the body composition of adult patients with PKU using multifrequency bioimpedance analysis (MF-BIA) and to reveal potential correlations between therapy adherence and body composition. Read More

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December 2021

SIGNIFICANCE OF LOW MATERNAL SERUM Β-HCG LEVELS IN THE ASSESSMENT OF THE RISK OF ATYPICAL CHROMOSOMAL ABNORMALITIES.

Fetal Diagn Ther 2021 Dec 6. Epub 2021 Dec 6.

Introduction: The introduction of prenatal cell-free DNA as a screening test has surpassed traditional combined first-trimester screening (cFTS) in the detection of common trisomies. However, its current limitation in detecting only common trisomies is affecting the diagnostic yield for other clinically significant chromosomal abnormalities.

Methods: In efforts to optimize the detection of fetuses with genetic abnormalities, we have analyzed the relationship between the cFTS risk score and biomarkers with atypical chromosomal abnormalities. Read More

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December 2021

Spatiotemporal trends of the global burden of melanoma in 204 countries and territories from 1990 to 2019: Results from the 2019 global burden of disease study.

Neoplasia 2021 Dec 2;24(1):12-21. Epub 2021 Dec 2.

Department of Epidemiology and Health Statistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; Clinical Epidemiology Unit, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, Shandong 250012, China; Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:

This study aimed to estimate the latest magnitudes and temporal trends of melanoma burden at the national, regional, and global levels. The data on melanoma incidence, deaths, and disability-adjusted life-years (DALYs) in 204 countries and territories between 1990 and 2019 came from the Global Burden of Disease 2019 Study. Estimated annual percentage change (EAPC) was calculated to depict the temporal trends and Spearman rank correlation was used to analyze the influential factors of EAPC. Read More

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December 2021

Fat on plastic: Metabolic consequences of an LDPE diet in the fat body of the greater wax moth larvae (Galleria mellonella).

J Hazard Mater 2021 Nov 25;425:127862. Epub 2021 Nov 25.

Department of Biology, Brandon University, Brandon, MB R78 6A9, Canada. Electronic address:

The caterpillar larvae of the greater wax moth (Galleria mellonella) are avid plastivores, as when provided a diet of low-density polyethylene (LDPE) they actively feed on it. Recent work has highlighted the importance of their microbiome in the putative biodegradation of this plastic polymer, though the impact of plastic metabolism on the insect host is less clear. In the present study, we undertook an integrative approach spanning all levels of biological organization to explore the effects of a plastic diet on the metabolic physiology of this animal model of plastic biodegradation. Read More

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November 2021

Deubiquitinase USP13 promotes the epithelial-mesenchymal transition and metastasis in gastric cancer by maintaining Snail protein.

Pathol Res Pract 2021 Nov 24;229:153705. Epub 2021 Nov 24.

Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

The dynamic balance between ubiquitination and deubiquitination is a key mechanism that regulates protein degradation and maintains cell protein homeostasis. Ubiquitin-specific peptidase 13 (USP13), a deubiquitinase (DUB), regulates various physiological and pathological processes, including cancer. A previous study reported that high USP13 mRNA expression confers poor prognosis in gastric cancer (GC). Read More

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November 2021

Prognostication using SpO/FiO in invasively ventilated ICU patients with ARDS due to COVID-19 - Insights from the PRoVENT-COVID study.

J Crit Care 2021 Dec 3;68:31-37. Epub 2021 Dec 3.

Department of Intensive Care, Amsterdam UMC, Location 'AMC', Amsterdam, the Netherlands; Anesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy; Department of Anesthesiology and Intensive Care Medicine, Miulli Regional Hospital, Acquaviva delle Fonti, Italy.

Background: The SpO/FiO is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO/FiO for mortality in patients with ARDS due to COVID-19.

Methods: This was a post-hoc analysis of a national multicenter cohort study in invasively ventilated patients with ARDS due to COVID-19. Read More

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December 2021

Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation.

Biochem Biophys Res Commun 2021 Dec 1;587:99-106. Epub 2021 Dec 1.

Department of General Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. Electronic address:

Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apoptosis, led to mitochondrial shrinkage, and increased the intracellular accumulation of Fe and MDA. Read More

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December 2021

AtHAD1, A haloacid dehalogenase-like phosphatase, is involved in repressing the ABA response.

Biochem Biophys Res Commun 2021 Nov 29;587:119-125. Epub 2021 Nov 29.

Department of Biology Education, Pusan National University, Busan, 46241, Republic of Korea. Electronic address:

Abscisic acid (ABA) plays an important role in seed germination, stomatal closure, and seedling growth inhibition in plants. Among downstream genes whose expression levels are regulated by AFA1 (Arabidopsis F-box Protein Hypersensitive to ABA 1), one gene, AtHAD1 upregulated by ABA was selected from Arabidopsis. AtHAD1 was induced by drought and salt stresses as well as by ABA and was found in dry seeds. Read More

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November 2021

Diverse risk-avoidance behaviors in DISC1 mice are associated with different neuronal firing patterns in BLA neurons.

Biochem Biophys Res Commun 2021 Nov 29;587:107-112. Epub 2021 Nov 29.

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China; University of Chinese of Academy of Sciences, Beijing, 100049, China. Electronic address:

It is very important to maintain normal levels of risk avoidance in daily life. We found that DISC1-N mice, which are a model for mental disorders, had a phenotype marked by a risk-avoidance impairment as measured in an open-field test (OFT). We used optogenetic methods to modulate glutamatergic neurons in the basolateral amygdala (BLA) in an attempt to rescue this risk-avoidance impairment. Read More

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November 2021

The role of bullying victimization in the pathway between autistic traits and psychotic experiences in adolescence: Data from the Tokyo Teen Cohort study.

Schizophr Res 2021 Dec 4;239:111-115. Epub 2021 Dec 4.

Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Autistic traits are associated with psychotic experiences in adolescence; however, the mechanisms underlying this relationship are not well understood. Prior research indicates that bullying victimization increases the risk of psychotic experiences in general adolescent populations, and autistic youth are at higher risk of being bullied than their non-autistic peers. Using longitudinal data from general population adolescents aged 10-14 in the Tokyo Teen Cohort study, we tested the hypothesis that bullying is responsible for the association between autistic traits and psychotic experiences in adolescence. Read More

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December 2021

Novel target sites for soybean yield enhancement by photosynthesis.

J Plant Physiol 2021 Nov 29;268:153580. Epub 2021 Nov 29.

Collaborative Innovation Center of Henan Grain Crops, Henan Agricultural University, Zhengzhou, 450006, China. Electronic address:

Photosynthesis plays an important role in plant growth and development. Increasing photosynthetic rate is a main objective of improving crop productivity. Chlorophyll fluorescence is an effective method for quickly evaluating photosynthesis. Read More

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November 2021

Differential modulation of photosynthesis, ROS and antioxidant enzyme activities in stress-sensitive and -tolerant rice cultivars during salinity and drought upon restriction of COX and AOX pathways of mitochondrial oxidative electron transport.

J Plant Physiol 2021 Nov 29;268:153583. Epub 2021 Nov 29.

Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur, 610 005, India.

Drought and salt stresses are two major abiotic stress factors that hamper crop growth and productivity. Three rice cultivars with different sensitivity and tolerance towards abiotic stress were used in the current study. While cultivar Aiswarya is salt- and drought-sensitive, cultivar Vyttila is salt-tolerant and cultivar Vaisakh is drought-tolerant. Read More

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November 2021

Influence of rapeseed, canola meal and glucosinolate metabolite (AITC) as potential antimicrobials: effects on growth performance, and gut health in Salmonella Typhimurium challenged broiler chickens.

Poult Sci 2021 Oct 20;101(1):101551. Epub 2021 Oct 20.

Department of Poultry Science, University of Georgia, Athens, GA, 30602, USA. Electronic address:

Poultry is the major sources of foodborne salmonellosis. Antibiotic resistance and a surge in zoonotic diseases warrant the use of natural alternatives. Glucosinolates (GLs) are naturally occurring antimicrobial compounds in rapeseed and canola. Read More

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October 2021

The effects of cannabis use on physical health: A co-twin control study.

Drug Alcohol Depend 2021 Nov 27;230:109200. Epub 2021 Nov 27.

Institute for Behavioral Genetics, University of Colorado Boulder, United States; Department of Psychology and Neuroscience, University of Colorado Boulder, United States.

Background: Research on the influence of cannabis use on anthropometrics, cardiovascular and pulmonary function, and other indicators of physical health has reported mixed results. We examined whether cannabis frequency is associated with physical health outcomes phenotypically and after controlling for shared genetic and environmental factors via a longitudinal co-twin control design.

Methods: We tested the phenotypic associations of adolescent, young adult, and adult cannabis frequency with adult physical health. Read More

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November 2021

A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2.

EBioMedicine 2021 Dec 3;74:103729. Epub 2021 Dec 3.

Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia; Department of Microbiology, Royal Melbourne Hospital, Melbourne, Australia.

Background: As vaccines against SARS-CoV-2 are now being rolled out, a better understanding of immunity to the virus, whether from infection, or passive or active immunisation, and the durability of this protection is required. This will benefit from the ability to measure antibody-based protection to SARS-CoV-2, ideally with rapid turnaround and without the need for laboratory-based testing.

Methods: We have developed a lateral flow POC test that can measure levels of RBD-ACE2 neutralising antibody (NAb) from whole blood, with a result that can be determined by eye or quantitatively on a small instrument. Read More

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December 2021

Effects of solvent osmolarity and viscosity on cartilage energy dissipation under high-frequency loading.

J Mech Behav Biomed Mater 2021 Nov 30;126:105014. Epub 2021 Nov 30.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA; Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, USA; Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, USA. Electronic address:

Articular cartilage is a spatially heterogeneous, dissipative biological hydrogel with a high fluid volume fraction. Although energy dissipation is important in the context of delaying cartilage damage, the dynamic behavior of articular cartilage equilibrated in media of varied osmolarity and viscosity is not widely understood. This study investigated the mechanical behaviors of cartilage when equilibrated to media of varying osmolarity and viscosity. Read More

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November 2021

L-Methionine prevents β-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats.

Acta Histochem 2021 Dec 3;124(1):151820. Epub 2021 Dec 3.

Laboratory of Epigenetics and Diseases, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar (Mohali), Punjab 160062, India. Electronic address:

L-Methionine (L-Met) is an essential sulphur-containing amino acid having a vital role in various key cellular processes. Here we investigated the effect of L-Met on streptozotocin-induced β-cell damage model of diabetes mellitus in Sprague Dawley rats. At the end of study biochemical parameters, immunoblotting, qRT-PCR and ChIP-qPCR are performed. Read More

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December 2021

Hypercrosslinked polymer microspheres decorated with anion- and cation-exchange groups for the simultaneous solid-phase extraction of acidic and basic analytes from environmental waters.

J Chromatogr A 2021 Nov 29;1661:462715. Epub 2021 Nov 29.

Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Sescelades Campus, Marcel·lí Domingo s/n, 43007 Tarragona, Spain.

Mixed-mode ion-exchange sorbents were introduced to improve the selectivity and retention of solid-phase extraction (SPE) sorbents. Mixed-mode ion-exchange sorbents integrate reversed-phase chemistry with ion-exchange groups to promote favourable interactions with ionic species. Nevertheless, a need to extract analytes with acidic and basic properties simultaneously within the same SPE cartridge led to the introduction of novel amphoteric/zwitterionic sorbents, which incorporate cation- and anion-exchange moieties within the same functional group attached to the polymeric network. Read More

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November 2021

ZnT1 is a neuronal Zn/Ca exchanger.

Cell Calcium 2021 Nov 23;101:102505. Epub 2021 Nov 23.

Department of Physiology and Cell Biology, and the Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Faculty of Health Sciences, POB 653, Beer-Sheva 84108, Israel. Electronic address:

Zinc transporter 1 (ZnT1; SLC30A1) is present in the neuronal plasma membrane, critically modulating NMDA receptor function and Zn neurotoxicity. The mechanism mediating Zn transport by ZnT1, however, has remained elusive. Here, we investigated ZnT1-dependent Zn transport by measuring intracellular changes of this ion using the fluorescent indicator FluoZin-3. Read More

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November 2021

Parental subjective assessment of gait limitations: Comparison with objective gait variables.

Gait Posture 2021 Nov 30;92:218-222. Epub 2021 Nov 30.

Gait Laboratory, Central Remedial Clinic, Clontarf, Dublin 3, Ireland.

Background: Subjective assessment is an important part of clinical examination providing quality insights into impairments of body structure and functions. Research into the associations between parental perceptions of gait in children with cerebral palsy (CP) and objective clinical gait measures is limited.

Research Question: What are the parental perceived gait limitations in children with CP and are these perceptions associated with objective clinical gait analysis?

Methods: Parent questionnaires were retrospectively analysed for children with CP who attended our gait analysis laboratory over a 24-month period. Read More

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November 2021

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based assay for the simultaneous quantification of 18-hydroxycorticosterone, 18-hydroxycortisol and 18-oxocortisol in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Nov 23;1188:123030. Epub 2021 Nov 23.

Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai 200032, PR China. Electronic address:

18-hydroxycorticosterone (18-OHB), 18-hydroxycortisol (18-OHF) and 18-oxocortisol (18-OXOF) are important biomarkers for the diagnosis of subtypes of primary aldosteronism. The detection of these three analytes by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is free from structurally similar compounds. The aim of this study was to develop and validate a new LC-MS/MS assay for the simultaneous quantification of 18-OHB, 18-OHF and 18-OXOF in plasma and to establish a reference intervals for apparently healthy population. Read More

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November 2021

Liquid-liquid extraction combined with online cleanup for the simultaneous determination of PAHs by GC-MS/MS and their hydroxylated metabolites by LC-MS/MS in human fingernails.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Nov 24;1188:123057. Epub 2021 Nov 24.

Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution control, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China; Synergy Innovation Institute of GDUT, Shantou 515041, PR China. Electronic address:

A method was developed for the simultaneous determination of polycyclic aromatic hydrocarbons (PAHs) and their hydroxylated metabolites (OH-PAHs) in human fingernails using liquid-liquid extraction and online purification. After surface decontamination by rinsing with acetone, the fingernails were digested with sodium hydroxide and subjected to liquid-liquid extraction with a mixture of n-hexane and methyl tertbutyl ether. The organic extract was then fractionated using a silica-based solid-phase extraction (SPE) cartridge to obtain a PAH fraction eluted with n-hexane/dichloromethane (v/v, 95:5) and an OH-PAH fraction eluted with dichloromethane/ethyl acetate (v/v, 50:50). Read More

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November 2021

Quantification of the janus kinase 1 inhibitor upadacitinib in human plasma by LC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Dec 1;1188:123076. Epub 2021 Dec 1.

Institute of Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany.

Upadacitinib is a selective janus-kinase-1 inhibitor effective in the treatment of autoimmune related diseases like rheumatoid arthritis or psoriatic arthritis. Here, we described a LC-MS/MS method for the quantification of upadacitinib in human plasma applicable for therapeutic drug monitoring. Pexidartinib was used as internal standard. Read More

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December 2021

Pre- and post-industrial levels of polycyclic aromatic hydrocarbons in sediments from the Estuary and Gulf of St. Lawrence (eastern Canada).

Mar Pollut Bull 2021 Dec 3;174:113219. Epub 2021 Dec 3.

Geotop and Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montréal, Québec H4B 1R6, Canada.

The concentrations of 23 polycyclic aromatic hydrocarbons (PAHs; 16 parent PAHs and 7 alkyl-PAHs) were determined in 45 surface sediment and 7 basal sediment box core samples retrieved from the Estuary and Gulf of St. Lawrence in eastern Canada. The concentration sums of 16 priority PAHs (ΣPAHs) in the surface sediments (representing modern times or at least younger than the last decade) ranged from 71 to 5672 ng g. Read More

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December 2021