728 results match your criteria levels irisin


Irisin attenuates lipopolysaccharide-induced acute lung injury by downregulating inflammatory cytokine expression through miR-199a-mediated Rad23b overexpression.

Exp Cell Res 2021 May 4:112593. Epub 2021 May 4.

Department of Emergency Surgery, Shaanxi Provincial People's Hospital, Xi'an, 710068, China. Electronic address:

Aims: Acute lung injury (ALI) is a leading cause of mortality as a result of inflammatory cytokine overexpression and increased rates of apoptosis. Therapies for ALI are yet to be thoroughly investigated. Recent evidence has shown that irisin exerts protective effects against many types of pathologies. Read More

View Article and Full-Text PDF

Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells.

Biol Chem 2021 May 20;402(6):703-715. Epub 2021 Jan 20.

Department of Pathophysiology, Guizhou Medical University, No. 9 Beijing Road, Yunyan District, Guiyang City550004, Guizhou Province, China.

Liver fibrosis is a common consequence of chronic liver diseases involved with the activation of hepatic stellate cells (HSCs) and endoplasmic reticulum (ER) stress. Irisin is a small polypeptide hormone that shows beneficial effects on metabolic disorders. The current study aimed to investigate the biological function of irisin on hepatic fibrosis. Read More

View Article and Full-Text PDF

Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy.

Int J Mol Sci 2021 Apr 16;22(8). Epub 2021 Apr 16.

International Clinical Research Center, St. Anne's University Hospital, 656 91 Brno, Czech Republic.

Studies over the past 30 years have revealed that adipose tissue is the major endocrine and paracrine organ of the human body. Arguably, adiopobiology has taken its reasonable place in studying obesity and related cardiometabolic diseases (CMDs), including Alzheimer's disease (AD), which is viewed herein as a neurometabolic disorder. The pathogenesis and therapy of these diseases are multiplex at basic, clinical and translational levels. Read More

View Article and Full-Text PDF

Ferulic Acid Stimulates Adipocyte-Specific Secretory Proteins to Regulate Adipose Homeostasis in 3T3-L1 Adipocytes.

Molecules 2021 Apr 1;26(7). Epub 2021 Apr 1.

Grassland and Forage Division, National Institute of Animal Science, Rural Development Administration, Cheonan 330-801, Korea.

Obesity has recently emerged as a public health issue facing developing countries in the world. It is caused by the accumulation of fat in adipose, characterized by insulin resistance, excessive lipid accumulation, inflammation, and oxidative stress, leading to an increase in adipokine levels. Herein, we investigated the capacity of a bioactive polyphenolic compound (ferulic acid (FA)) to control adipocyte dysfunction in 3T3-L1 adipocytes (in vitro). Read More

View Article and Full-Text PDF

Circulating IL-6, clusterin and irisin in obese subjects with different grades of obesity: association with insulin resistance and sexual dimorphism.

Arch Endocrinol Metab 2021 Feb 24. Epub 2021 Feb 24.

Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, Egypt,

Objective: There are discrepancies about the relationship of IL-6, clusterin and irisin with obesity and obesity associated insulin resistance and also about their sexual dimorphism. This study aimed at evaluating the circulating levels of IL-6, clusterin and irisin in obese subjects of both sexes who had different grades of obesity and examining their sexual dimorphism and their association with insulin resistance.

Methods: This study included 176 non-diabetic subjects of both sexes who were classified according to their sex into two groups; the male and the female groups. Read More

View Article and Full-Text PDF
February 2021

Associations of circulating irisin with 24-h blood pressure, total and visceral fat, and metabolic parameters in young adult hypertensives.

Arch Endocrinol Metab 2021 Feb 24. Epub 2021 Feb 24.

Division of Epidemiology, Biostatistics and Public Health Practice, University of British Columbia, Vancouver, Canada.

Objective: Some experimental and clinical studies suggest a possible role of irisin in central and peripheral regulation of blood pressure. The purpose of the study was to assess the associations between serum irisin levels, total and visceral fat, metabolic parameters, and blood pressure pattern during 24-h monitoring (ABPM).

Methods: In 206 patients with essential hypertension receiving standard antihypertensive treatments, we assessed anthropometric indices; serum irisin, blood lipids (total cholesterol, LDL-C, HDL-C, and triglycerides), glucose and insulin; body composition including lean mass and total, visceral, android and gynoid fat using a dual-energy x-ray absorptiometry; ABPM; and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). Read More

View Article and Full-Text PDF
February 2021

[Effects of irisin on lipid in mice and glycolipid metabolism in obese mice induced by diet].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(16):1165-1170

Department of Radiology, Zhongda Hospital (Jiangsu Key Laboratory of Molecular and Functional Imaging), Nanjing 210009,China.

To explore the role of low-dose irisin in the browning of white adipose tissue (WAT) and activation of brown adipose tissue (BAT) in mice, and its effect on the metabolic function of diet induced obesity. A total of 22 C57/BLKS/J male mice fed with normal diet and 8 fed with high fat diet were separately divided into experimental and control group. The experimental group was given irisin (0. Read More

View Article and Full-Text PDF

Impact of Acute Circuit Training on Irisin in Younger and Older Overweight Adults.

Appl Physiol Nutr Metab 2021 Apr 22. Epub 2021 Apr 22.

University of New Brunswick, 3427, Cardiometabolic Exercise & Lifestyle Lab, Faculty of Kinesiology, Fredericton, New Brunswick, Canada;

Studies show aerobic exercise increases irisin and leads to health benefits. The impact of circuit training (CT) on irisin in overweight younger and older adults is unknown. The objectives were to determine whether, during an acute bout of CT, changes in irisin differed between overweight younger and older adults, and if irisin is associated with body composition, fitness level, or muscle strength. Read More

View Article and Full-Text PDF

Prediction of sarcopenia using a battery of circulating biomarkers.

Sci Rep 2021 Apr 21;11(1):8632. Epub 2021 Apr 21.

Department of Cardiology, Post Graduate Medical Institute, Hayatabad Medical Complex, Peshawar, Pakistan.

Loss of muscle mass and strength with aging, termed sarcopenia is accelerated in several comorbidities including chronic heart failure (CHF) and chronic obstructive pulmonary diseases (COPD). However, the effective circulating biomarkers to accurately diagnose and assess sarcopenia are not known. We recruited male healthy controls and patients with CHF and COPD (n = 81-87/group), aged 55-74 years. Read More

View Article and Full-Text PDF

Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging.

Exp Biol Med (Maywood) 2021 Apr 22:15353702211006049. Epub 2021 Apr 22.

Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, P. R. China.

This study aimed to track and evaluate the effect of low-dose irisin on the browning of white adipose tissue (WAT) in mice using magnetic resonance imaging (MRI) noninvasively . Mature white adipocytes extracted from mice were cultured, induced and characterized before being treated by irisin. The volume and fat fraction of WAT were quantified using MRI in normal chow diet and high fat mice after injection of irisin. Read More

View Article and Full-Text PDF

Serum sclerostin concentration is associated with specific adipose, muscle and bone tissue markers in lean adolescent females with increased physical activity.

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.

Objectives: Sclerostin is an important regulator of bone mass involving the Wnt/β-catenin signalling pathway. Relatively few studies have investigated the relationships of circulating sclerostin levels with adiposity-related and muscle-related biochemical factors in individuals with increased energy metabolism. The aim of this study was to investigate the associations of circulating sclerostin with adipokines, myokines, osteokines and body composition values in lean adolescent females with increased physical activity. Read More

View Article and Full-Text PDF

Irisin Regulating Skeletal Response to Endurance Exercise in Ovariectomized Mice by Promoting Akt/β-Catenin Pathway.

Front Physiol 2021 25;12:639066. Epub 2021 Mar 25.

College of Physical Education, Yangzhou University, Yangzhou, China.

Thought irisin is recognized as a pivotal modulator for bone formation, its role in regulating skeletal response to exercise training remains unknown. Therefore, we aimed to determine the change of irisin in response to 8-week exercise training and its role in regulating the effects of exercise on bone loss in ovariectomized (Ovx) mice. Forty 3-month old female C57BL/6 mic were randomly allocated into four groups: (1) Sham-operated (Sham); (2) ovariectomized; (3) Ovx plus 8-week downhill running exercise (Ex); (4) Ovx plus exercise and received twice weekly injection of cyclo RGDyk protein (a putative anti-irisin receptor agents) (ExRg). Read More

View Article and Full-Text PDF

Lower levels of irisin in patients with type 2 diabetes mellitus: A meta-analysis.

Diabetes Res Clin Pract 2021 Apr 1;175:108788. Epub 2021 Apr 1.

Department of Pharmacy, Peking University People's Hospital, Beijing 100044, China. Electronic address:

Aims: This study aimed to provide evidence on the levels of circulating irisin in patients with type 2 diabetes mellitus (T2DM).

Methods: A meta-analysis was conducted to compare the irisin levels in patients with T2DM with the levels in control patients. PubMed, Embase, CENTRAL databases, and other sources were searched from inception through September 2020. Read More

View Article and Full-Text PDF

SIRT1 Expression and Regulation in the Primate Testis.

Int J Mol Sci 2021 Mar 22;22(6). Epub 2021 Mar 22.

Platform Degenerative Diseases, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, D-37077 Göttingen, Germany.

The epigenetic mechanisms controlling germ cell development and differentiation are still not well understood. Sirtuin-1 (SIRT1) is a nicotinamide adenosine dinucleotide (NAD)-dependent histone deacetylase and belongs to the sirtuin family of deacetylases. It catalyzes the removal of acetyl groups from a number of protein substrates. Read More

View Article and Full-Text PDF

Effects of Christian Orthodox Fasting Versus Time-Restricted Eating on Plasma Irisin Concentrations Among Overweight Metabolically Healthy Individuals.

Nutrients 2021 Mar 25;13(4). Epub 2021 Mar 25.

First Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.

Irisin has been recently identified as an adipomyokine produced during physical activity and involved in the browning of adipose tissue. Despite the emerging evidence suggesting an inverse relationship between irisin plasma concentrations and adverse metabolic outcomes, the exact impact of diet on irisin levels remains obscure. Thus, we aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on circulating irisin levels among overweight, metabolically healthy, adults. Read More

View Article and Full-Text PDF

Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Int J Environ Res Public Health 2021 03 3;18(5). Epub 2021 Mar 3.

Faculty of Health Sciences, Universidad Europea del Atlántico, 39011 Santander, Spain.

Irisin seems to play an important role in several chronic diseases, however, the interactions between chronic training and irisin are still unclear. The purpose of this systematic review and meta-analysis was to examine the effect of chronic resistance training on circulating irisin in adults. Literature search was conducted in PubMed, Web of Science and EBSCOhost (Academic Search Complete) until December 2020. Read More

View Article and Full-Text PDF

The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity.

Int J Endocrinol 2021 18;2021:6572342. Epub 2021 Mar 18.

Center for Gene and Immunotherapy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China.

Obesity is a worldwide health problem due to the imbalance of energy intake and energy expenditure. Irisin, a newly identified exercise-responsive myokine, which is produced by the proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has emerged as a promising therapeutic strategy to combat obesity and obesity-related complications. Various studies in mice have shown that irisin could respond to systematic exercise training and promote white-to-brown fat transdifferentiation, but the role and function of irisin in humans are controversial. Read More

View Article and Full-Text PDF

Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration.

Sci Rep 2021 Mar 29;11(1):7097. Epub 2021 Mar 29.

Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland.

The study investigated the effect of single and chronic (10 sessions) whole-body cryotherapy (WBC; 3-min, - 110 °C) on amino acid (AA) profile, myostatin, fibroblast growth factor 21 (FGF21), and concentrations of brain-derived neurotrophic factor (BDNF), irisin and adiponectin in relation to glucose homeostasis. Thirty-five, healthy men were randomly split into experimental (young: 28 ± 7 years and middle-aged: 51 ± 3 years) and control groups. Blood samples were taken before and 1 h after the first and last (10th) WBC session. Read More

View Article and Full-Text PDF

No evidence for change in expression of and genes in cultured human adipocytes stimulated by myokines and adipokines.

Adipocyte 2021 12;10(1):153-159

Department of Internal Medicine and Nephrodiabetology, Medical University of Łódź and Military Medical Academy Memorial Teaching Hospital of the Medical University of Łódź - Central Veteran Hospital, Łódź, Poland.

TBC1D1 and TBC1D4 proteins play analogous, but not identical role in governing insulin-signalling pathway. Little is known about changes in expression levels of and genes in mammals, including humans. Number of factors were studied, but data remain controversial. Read More

View Article and Full-Text PDF
December 2021

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.

Neuropathol Appl Neurobiol 2021 Mar 26. Epub 2021 Mar 26.

Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.

Aims: Irisin is a hormone cleaved from fibronectin type-III domain-containing protein 5 in response to exercise and may be therapeutic in Alzheimer's disease (AD). Irisin is shown to repair damage caused by midlife cardiometabolic risk factors for AD (i.e. Read More

View Article and Full-Text PDF

Salivary irisin: potential inflammatory biomarker in recurrent apthous stomatitis patients.

Eur Rev Med Pharmacol Sci 2021 Mar;25(5):2252-2259

Department of Nutrition and Dietetics, Ordu Unıversıty, Ordu, Turkey.

Objective: Recurrent Aphthous Stomatitis (RAS) is the most common inflammatory condition of the oral mucosa characterised by recurrent onset of single or multiple painful ulcers mainly affecting the nonkeratinized oral mucosa. RAS mostly occurs in healthy individuals with no associated systemic diseases. Irisin is a newly identified adipomyokine and research has revealed that it has anti-inflammatory effects. Read More

View Article and Full-Text PDF

NAD-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin.

Theranostics 2021 25;11(9):4381-4402. Epub 2021 Feb 25.

Department of Pharmacology, School of Pharmacy, Second Military Medical University/Naval Medical University, Shanghai, China.

Nicotinamide adenine dinucleotide (NAD)-boosting therapy has emerged as a promising strategy to treat various health disorders, while the underlying molecular mechanisms are not fully understood. Here, we investigated the involvement of fibronectin type III domain containing 5 (Fndc5) or irisin, which is a novel exercise-linked hormone, in the development and progression of nonalcoholic fatty liver disease (NAFLD). NAD-boosting therapy was achieved by administrating of nicotinamide riboside (NR) in human and mice. Read More

View Article and Full-Text PDF
February 2021

FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-α pathway.

J Cell Mol Med 2021 Apr 10;25(7):3585-3600. Epub 2021 Mar 10.

Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Obesity is associated with biological dysfunction in skeletal muscle. As a condition of obesity accompanied by muscle mass loss and physical dysfunction, sarcopenic obesity (SO) has become a novel public health problem. Human fibroblast growth factor 19 (FGF19) plays a therapeutic role in metabolic diseases. Read More

View Article and Full-Text PDF

Ameliorative effects of garlic oil on FNDC5 and irisin sensitivity in liver of streptozotocin-induced diabetic rats.

J Pharm Pharmacol 2021 Apr;73(6):824-834

Department of Anatomy, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Objectives: This study was aimed to investigate the effects of garlic oil (GO), an important natural constituent used in alleviating diabetes and its complications, on the expression levels of irisin and related genes.

Methods: Thirty-two rats were divided into four groups: Control, Diabetes-Control, Diabetes+GO 100 mg/kg/day and Control+GO 100 mg/kg/day for 45 days. The measurements included: changes in liver Peroxisome proliferator-activated receptor-gamma-coactivator (PGC)-1α, Fibronectin Type-III-Domain-Containing5 (FNDC5), irisin expression, mRNA expression of p38 and TNF-α (Tumour necrosis factor-α), total-antioxidant-status (L-TAS; S-TAS), total-oxidant-status (L-TOS; S-TOS) in liver and serum, respectively. Read More

View Article and Full-Text PDF

Diagnostic and Prognostic Relevance of Serum Irisin Level in Patients with Pulmonary Embolism.

Clin Lab 2021 Mar;67(3)

Background: We aimed to determine the diagnostic and prognostic value of serum irisin level in patients with acute pulmonary embolism (PE) admitted to the emergency department.

Methods: Ninety patients who underwent computed tomography pulmonary angiography (CTPA) due to suspected PE were included in the study. Demographic data, PE risk factors, and associated diseases, vital signs, Wells score, Revised Geneva score, pulmonary embolism severity index (PESI), and simplified PESI (sPESI) were recorded. Read More

View Article and Full-Text PDF

Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus - A Case-control Study.

Z Geburtshilfe Neonatol 2021 Mar 16. Epub 2021 Mar 16.

Medical Biology, Bozok University Faculty of Medicine, Yozgat, Turkey.

Objective: The objective of this study was to assess the levels of serum myonectin and irisin in pregnant women with and without gestational diabetes mellitus (GDM).

Method: A total of 80 pregnant women participated in our study (which consisted of 40 patients with GDM, 40 participants as the control group). Myonectin and irisin levels were analyzed through the ELISA technique, in addition to metabolic parameters in the serum samples of the participants. Read More

View Article and Full-Text PDF

Serum Levels of Irisin and Omentin-1 in Breast Neoplasms and Their Association with Tumor Histology.

Int J Endocrinol 2021 22;2021:6656671. Epub 2021 Feb 22.

First Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Breast cancer is associated with obesity, possibly due to direct effects of adipokines and myokines, such as omentin-1 and irisin. In this study, we aimed to evaluate omentin-1 and irisin levels in women with benign and/or malignant breast neoplasms vs. healthy controls. Read More

View Article and Full-Text PDF
February 2021

Effects of increased physical activity and/or weight loss diet on serum myokine and adipokine levels in overweight adults with impaired glucose metabolism.

J Diabetes Complications 2021 May 25;35(5):107892. Epub 2021 Feb 25.

Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey. Electronic address:

Aim: The purpose of this study was to investigate the changes in serum irisin, fibroblast growth factor-21 (FGF21), visfatin, follistatin like protein-1 (FSTL1), and meteorin-like protein (Metrnl) levels in response to increased physical activity and/or diet interventions in overweight subjects with impaired glucose metabolism (IGM).

Methods: A total of 60 subjects (BMI > 25.0 kg/m) with IGM were recruited in this single-centered interventional study. Read More

View Article and Full-Text PDF

Effects of competitive physical activity on serum irisin levels and bone turnover markers.

J Endocrinol Invest 2021 Mar 6. Epub 2021 Mar 6.

Department of Clinical and Experimental Medicine, University of Catania, AOU Policlinico "G. Rodolico - San Marco", Via S. Sofia 78, 95123, Catania, Italy.

Background: Irisin, a myokine, is a polypeptide derived from the cleavage of the extracellular domain of fibronectin domain-containing protein 5, a receptor that is present on different tissues (skeletal muscle, pericardium, myocardium, and brain), whose functions are not yet fully defined.

Purpose: The main aim of our study was to evaluate the effect of competitive physical activity on serum irisin levels and bone turnover markers.

Methods: Fifteen male footballers and an equal number of subjects of the same age and gender, but with a predominantly sedentary lifestyle, had their serum levels of irisin and bone turnover markers measured. Read More

View Article and Full-Text PDF

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice.

Biomolecules 2021 02 20;11(2). Epub 2021 Feb 20.

College of Pharmacy, Chonnam National University, Gwangju 61186, Korea.

Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among previous correlation studies in humans are related to the heterogeneity of the study population. Read More

View Article and Full-Text PDF
February 2021