197,530 results match your criteria levels cardiac


KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction.

J Physiol 2022 Jan 26. Epub 2022 Jan 26.

Division of Functional Genetics and Development, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.

Key Points: IUGR is associated with large-scale transcriptional changes in developmental, tissue injury and metabolic gene pathways in fetal skeletal muscle. Levels of the FGF21 co-receptor, KLB, are increased in IUGR fetal muscle, and FGF21 concentrations are increased in IUGR fetal plasma KLB mediates a reduction in muscle development through inhibition of mTOR signaling. These effects of KLB on muscle cells are conserved in pig and human, suggesting a vital role of this protein in the regulation of muscle development and function in mammals. Read More

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January 2022

Emerging Cholesterol Modulators for Atherosclerotic Cardiovascular Disease.

Am J Med Sci 2022 Jan 23. Epub 2022 Jan 23.

College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766-1854, USA. Electronic address:

Experimental and clinical studies have conclusively demonstrated that lowering elevated low-density lipoprotein cholesterol levels results in fewer major adverse cardiac events. Over the past few decades, statins have become the mainstay of lipid-lowering therapy, contributing significantly to the reduction of lipids, and providing patients with a cost-effective approach. However, with growing evidence in support of combination therapies providing increased benefits to certain patient populations, such as those intolerant to statins, there is an urgent need to investigate the safety and efficacy of alternative lipid-lowering drugs. Read More

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January 2022

Prevention and Management of Hypertriglyceridemia-Induced Acute Pancreatitis during Pregnancy: A Systematic Review.

Am J Med 2022 Jan 23. Epub 2022 Jan 23.

Department of Medicine, University of Connecticut, Farmington, CT 06030; The Heart and Vascular Institute, Hartford Hospital, Hartford, CT 06102. Electronic address:

Severe gestational hypertriglyceridemia can lead to acute pancreatitis, with maternal mortality rate ∼ 20%. The recent National Lipid Association part 2 expert panel recommendations provide guidance on monitoring pregnant women at high risk for hyperlipidemia. We suggest that high risk women have triglyceride levels checked once every trimester. Read More

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January 2022

Lifetime cardiovascular risk factors and maternal and offspring birth outcomes: Bogalusa Babies.

PLoS One 2022 26;17(1):e0260703. Epub 2022 Jan 26.

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of America.

Both cardiovascular and reproductive complications may have origins in utero or in early life. Women in the Bogalusa Heart Study (n = 1401) had been linked to birth certificates for birthweight and gestational data, which were examined relative to childhood (ages 4-16) cardiometabolic indicators, indicated by mean levels overall and total risk factor burden as estimated by area under the curve (AUC) computed from longitudinal quadratic random-effects growth models. Women reported the birthweight and gestational age of each of their own pregnancies, and delivery medical records were linked to interview data where possible. Read More

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January 2022

Association Between Vitamin D Deficiency and Neurologic Outcomes in Patients After Cardiopulmonary Resuscitation.

Shock 2022 Jan 25. Epub 2022 Jan 25.

Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Aim: We investigated the association between vitamin D deficiency and neurologic outcomes after cardiopulmonary resuscitation.

Method: Data from the prospective cardiac arrest registry in the emergency department between October 2019 and April 2021 were retrospectively analyzed. Blood samples were obtained during cardiopulmonary resuscitation wherein 25-hydroxyvitamin D serum levels were analyzed; deficiency was defined as levels <10 ng/mL. Read More

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January 2022

del Nido cardioplegia better preserves cardiac diastolic function but histidine-tryptophan-ketoglutarate is better for endothelial function.

Eur J Cardiothorac Surg 2022 Jan 26. Epub 2022 Jan 26.

The Institute of Cardiovascular Diseases & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences, Tianjin, China.

Objectives: The effectiveness of myocardial protection of cardioplegia has been a matter of debate for decades. This study was designed to compare cardiac and endothelial protection of 3 clinically used cardioplegias: del Nido cardioplegia (DNC), histidine-tryptophan-ketoglutarate (HTK) and blood cardioplegia (BC) followed by HTK (BC + HTK) in a rat model of ischaemia/reperfusion (I/R).

Methods: Sixty male Wistar rats were subjected to either 120 min of global ischaemia at 4°C followed by 90 min of reperfusion (I/R) at 37°C or no I/R (control) in a Langendorff apparatus and were randomly allocated to 5 groups: control, I/R, DNC, HTK and BC + HTK. Read More

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January 2022

Accelerometer derived physical activity patterns in 27.890 middle-aged adults - the SCAPIS cohort study.

Scand J Med Sci Sports 2022 Jan 26. Epub 2022 Jan 26.

Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.

The present study aims to describe accelerometer-assessed physical activity (PA) patterns and fulfilment of PA recommendations in a large sample of middle-aged men and women, and to study differences between sub-groups of socio-demographic, socio-economic and lifestyle-related variables. A total of 27,890 (92.5% of total participants, 52% women, aged 50-64 years) middle-aged men and women with at least four days of valid hip-worn accelerometer data (Actigraph GT3X+, wGT3X+ and wGT3X-BT) from the Swedish CArdioPulmonary bioImage Study, SCAPIS, were included. Read More

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January 2022

Mechanical ventilation during cardiopulmonary bypass in neonates improves postoperative outcome.

Eur J Cardiothorac Surg 2022 Jan 25. Epub 2022 Jan 25.

Department of Cardiac Surgery, Virgen del Rocio Children's Hospital, University Hospitals of Seville, Seville, Spain.

Objectives: Cardiopulmonary bypass generates a systemic inflammatory response. This inflammatory response is reduced if patients are ventilated during bypass, as evidenced by lower levels of postoperative circulating inflammatory mediators. However, this does not appear to make much clinical difference in adults, at least not consistently, but, to our knowledge, has never been assessed in paediatric cardiac surgery, which is the objective of this study. Read More

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January 2022

Effects of tamoxifen inducible MerCreMer on gene expression in cardiac myocytes in mice.

J Cardiovasc Aging 2022 5;2. Epub 2022 Jan 5.

Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.

The Cre-LoxP technology, including the tamoxifen (TAM) inducible MerCreMer (MCM), is increasingly used to delineate gene function, understand the disease mechanisms, and test therapeutic interventions. We set to determine the effects of TAM-MCM on cardiac myocyte transcriptome. Expression of the MCM was induced specifically in cardiac myocytes upon injection of TAM to myosin heavy chain 6-MCM () mice for 5 consecutive days. Read More

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January 2022

Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention.

Am Heart J Plus 2021 Dec 27;12. Epub 2021 Nov 27.

Department of Medicine, University of Florida, Gainesville, FL, USA.

Study Objective: Infarct size is a strong predictor of outcomes after ST elevation myocardial infarction (STEMI). Circulating fibrocytes are bone marrow-derived progenitor cells associated with fibrotic processes. We tested whether fibrocytes correlate with infarct size in STEMI patients treated with primary percutaneous coronary intervention (PCI). Read More

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December 2021

Immune checkpoint inhibitor-related myocarditis: an illustrative case series of applying the updated Cardiovascular Magnetic Resonance Lake Louise Criteria.

Eur Heart J Case Rep 2022 Jan 21;6(1):ytab478. Epub 2022 Jan 21.

Department of Medical Imaging, Peter Munk Cardiac Center, University Health Network, 585 University Avenue, Toronto, Ontario M5G 2N2, Canada.

Background: Immune checkpoint inhibitors (ICIs) have improved outcomes for many types of cancer. However, ICI therapies are associated with the development of myocarditis, an immune-mediated adverse event associated with a high mortality rate. Therefore, prompt diagnosis and early intervention are of outmost importance. Read More

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January 2022

Resolution of coronary arteritis following tuberculosis treatment.

J Clin Tuberc Other Mycobact Dis 2022 Feb 19;26:100295. Epub 2022 Jan 19.

Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Background: Coronary artery aneurysm (CAA) in an uncommon condition usually associated with atherosclerosis, but systemic vasculitides constitute important differential diagnoses. A less recognized cause of CAA, tuberculosis (TB) has also been noted to occur simultaneously in patients with such vascular abnormalities.

Case Report: A 60-year-old female presented to the Emergency Department with a non-ST segment elevation myocardial infarction. Read More

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February 2022

Resilience of patients with coronary heart diseases in Jordan: A cross-sectional study.

Int J Nurs Sci 2022 Jan 20;9(1):86-91. Epub 2021 Dec 20.

Department of Community and Mental Health Nursing, Jordan University of Science & Technology/Faculty of Nursing, Jordan.

Objectives: This study aimed to assess the level of resilience and related factors among patients with coronary heart disease.

Methods: A cross-sectional was used to determine the factors associated with the level of resilience. A convenience sampling technique was used to recruit 134 patients with coronary heart disease who attended the out-patients cardiology clinics at two leading public hospitals in Jordan from July to September 2017. Read More

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January 2022

Studying the clinical, radiological, histological, microbiological, and immunological evolution during the different COVID-19 disease stages using minimal invasive autopsy.

Sci Rep 2022 Jan 25;12(1):1360. Epub 2022 Jan 25.

Department of Immunology and Infection, Faculty of Medicine and Life Sciences, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.

The WHO defines different COVID-19 disease stages in which the pathophysiological mechanisms differ. We evaluated the characteristics of these COVID-19 disease stages. Forty-four PCR-confirmed COVID-19 patients were included in a prospective minimal invasive autopsy cohort. Read More

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January 2022

A novel intelligent system based on adjustable classifier models for diagnosing heart sounds.

Sci Rep 2022 Jan 25;12(1):1283. Epub 2022 Jan 25.

Department of Information Engineering, Nanyang Institute of Technology, 473004, Nanyang, China.

A novel intelligent diagnostic system is proposed to diagnose heart sounds (HSs). The innovations of this system are primarily reflected in the automatic segmentation and extraction of the first complex sound [Formula: see text] and second complex sound [Formula: see text]; the automatic extraction of the secondary envelope-based diagnostic features [Formula: see text], [Formula: see text], and [Formula: see text] from [Formula: see text] and [Formula: see text]; and the adjustable classifier models that correspond to the confidence bounds of the Chi-square ([Formula: see text]) distribution and are adjusted by the given confidence levels (denoted as [Formula: see text]). The three stages of the proposed system are summarized as follows. Read More

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January 2022

Coding and regulatory variants are associated with serum protein levels and disease.

Nat Commun 2022 Jan 25;13(1):481. Epub 2022 Jan 25.

Icelandic Heart Association, Holtasmari 1, IS-201 Kopavogur, Kopavogur, Iceland.

Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep serum proteome survey recently revealed close associations between serum protein networks and common disease. In the current study, 54,469 low-frequency and common exome-array variants were compared to 4782 protein measurements in the serum of 5343 individuals from the AGES Reykjavik cohort. Read More

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January 2022

A genome-wide association study of serum proteins reveals shared loci with common diseases.

Nat Commun 2022 Jan 25;13(1):480. Epub 2022 Jan 25.

Icelandic Heart Association, Holtasmari 1, 201, Kopavogur, Iceland.

With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of most disease associated alleles is not understood. The measurement of protein level variation in solid tissues and biofluids integrated with genetic variants offers a path to deeper functional insights. Here we present a large-scale proteogenomic study in 5,368 individuals, revealing 4,035 independent associations between genetic variants and 2,091 serum proteins, of which 36% are previously unreported. Read More

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January 2022

Enhanced oxidative stress and presence of ventricular aneurysm for risk prediction in cardiac sarcoidosis.

Heart 2022 Jan 25. Epub 2022 Jan 25.

Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Objective: Sudden cardiac death (SCD) is the major cause of death in cardiac sarcoidosis (CS). We aimed to identify the prognostic markers for sustained ventricular tachycardia (sVT) and SCD in patients with CS.

Methods: We performed a prospective observational cohort study for patients with CS diagnosed according to the Japanese or Heart Rhythm Society guidelines between June 2008 and March 2020 in our hospital. Read More

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January 2022

Health technology tools used to increase physical activity and improve cardiovascular parameters in older adults: A review.

Enferm Clin (Engl Ed) 2022 Jan 22. Epub 2022 Jan 22.

Facultad de Enfermería de Cuenca, Edificio Melchor Cano, Universidad de Castilla-La Mancha, Cuenca, Spain.

Introduction: Ageing is a period of physical and psychological changes. Inactivity is one of the biggest problems among the older adult population increasing the risk of sarcopenia and chronic diseases. Physical activity is an effective intervention to improve health outcomes. Read More

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January 2022

Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events.

Biomarkers 2022 Jan 26:1-17. Epub 2022 Jan 26.

Erasmus MC, University Medical Center Rotterdam, Department of Cardiology, the Netherlands.

Higher soluble ST2 (sST2) levels at admission are associated with adverse outcome in acute coronary syndrome (ACS) patients. We studied the dynamics of sST2 over time in post-ACS patients prior to a recurrent ACS or cardiac death. We used the BIOMArCS case-cohort, consisting of 187 patients who underwent serial blood sampling during one year follow-up post-ACS. Read More

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January 2022

The impact of sources of perceived social support on readmissions in patients with heart failure.

J Psychosom Res 2022 Jan 14;154:110723. Epub 2022 Jan 14.

Department of Psychology, National Chung Cheng University, Chiayi, Taiwan No.168, Sec. 1, University Rd., Minhsiung, Chiayi 62102, Taiwan. Electronic address:

Background: Lower levels of perceived social support have been known as an independent predictor of hospital readmissions in patients with heart failure (HF). However, the impact of sources of perceived social support on readmissions remain unexplored.

Purpose: The main purpose of this study was to investigate and compare the relative importance of social support from significant other, family, and friends on all-cause readmission and cardiac readmission in patients with HF. Read More

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January 2022

The impact of partial-oral endocarditis treatment on anxiety and depression in the POET trial.

J Psychosom Res 2022 Jan 13;154:110718. Epub 2022 Jan 13.

Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Background: The Partial-Oral versus Intravenous Antibiotic Treatment of Endocarditis Trial (POET) found that partial-oral outpatient treatment was non-inferior to conventional in-hospital intravenous treatment in patients with left-sided infective endocarditis. We examined the impact of treatment strategy on levels of anxiety and depression.

Methods: Patients completed the Hospital Anxiety and Depression Scale (HADS) at randomization, at antibiotic completion, and after month 3 and month 6. Read More

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January 2022

Sleep deprivation is associated with increased circulating levels of endogenous ouabain: Potential role in bipolar disorder.

Psychiatry Res 2022 Jan 17;309:114399. Epub 2022 Jan 17.

Department of Physiology, School of Medicine, University of Maryland Baltimore, 685 West Baltimore Street, Baltimore, MS 21201, USA.

Endogenously produced cardiac glycosides, like endogenous ouabain (EO), are putative hormones that have been implicated in the pathophysiology of bipolar disorder. Individuals with bipolar disorder appear to be unable to sufficiently upregulate production of EO in situations of increased need. This study was performed to determine the effect of sleep deprivation on the circulating levels of EO. Read More

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January 2022

Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca mishandling and preventive role of Klotho in mice to its potential mortality prediction in human.

Transl Res 2022 Jan 22. Epub 2022 Jan 22.

Cardiorenal Translational Laboratory, Institute of Research i+12, Hospital Universitario 12 de Octubre, Madrid, Spain; CIBER-CV, Hospital Universitario 12 de Octubre, Madrid, Spain. Electronic address:

Biomarkers of mineral bone disorders (MBD) including phosphorus, fibroblast growth factor (FGF)-23 and Klotho are strongly altered in patients with acute kidney injury (AKI) who have high cardiac outcomes and mortality rates. However, the crosslink between MBD and cardiac damage after an AKI episode still remains unclear. We tested MBD and cardiac biomarkers in an experimental AKI model after 24 or 72 hours of folic acid injection and we analyzed structural cardiac remodeling, intracellular calcium (Ca) dynamics in cardiomyocytes and cardiac rhythm. Read More

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January 2022

Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles.

J Control Release 2022 Jan 22. Epub 2022 Jan 22.

CDL Research, UMC Utrecht, Utrecht, the Netherlands. Electronic address:

Lipid Nanoparticles (LNPs) are a promising drug delivery vehicle for clinical siRNA delivery. Modified mRNA (modRNA) has recently gained great attention as a therapeutic molecule in cardiac regeneration. However, for mRNA to be functional, it must first reach the diseased myocardium, enter the target cell, escape from the endosomal compartment into the cytosol and be translated into a functional protein. Read More

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January 2022

The influence of mandibular stretching on athletes subjected to high intensity workout.

Arch Ital Biol 2022 Jan;159(3-4):178-186

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Perugia, Italy - Email:

The use of oral appliances is considered effective in improving sport performance. Jaw clenching or stretching, improved breathing or positioning of the jaw have been proposed to explain the improvement. In this study, we reported the effects of regularly practiced mandibular stretching at submaximal opening of the jaw in Crossfit athletes. Read More

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January 2022

Association of longitudinal trends in thyroid function with incident carotid atherosclerosis in middle-aged and older euthyroid subjects: the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) cohort study.

Age Ageing 2022 Jan;51(1)

Background: Previous studies have posited that an association exists between thyroid function and the heart and vasculature. It remains unclear, however, whether longitudinal trends in thyroid function contribute to the development of atherosclerosis. We conducted a cohort study to examine the association of longitudinal trends in thyroid function with incident carotid atherosclerosis (CA) in middle-aged and older euthyroid subjects. Read More

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January 2022

Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice.

PLoS One 2022 25;17(1):e0262821. Epub 2022 Jan 25.

Department of Medicine, Diakonhjemmet Hospital, Oslo, Norway.

Aims: Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the potential cardiac impact of an experimental model of RA in mice subjected to HF by constriction of the ascending aorta. Read More

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January 2022

Topiroxostat versus allopurinol in patients with chronic heart failure complicated by hyperuricemia: A prospective, randomized, open-label, blinded-end-point clinical trial.

PLoS One 2022 25;17(1):e0261445. Epub 2022 Jan 25.

Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan.

Background: The benefits of xanthine oxidase inhibitors to chronic heart failure (CHF) patients is controversial. We investigated the beneficial effects of a novel xanthine oxidoreductase inhibitor, topiroxostat, in patients with CHF and hyperuricemia (HU), in comparison to allopurinol.

Methods And Results: The prospective, randomized open-label, blinded-end-point study was performed in 141 patients with CHF and HU at 4 centers. Read More

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January 2022

The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity.

J Cardiovasc Pharmacol Ther 2022 Jan-Dec;27:10742484221074585

Department of Gastroenterology and Liver Diseases, 26746Soroka University Medical Center, Beer-Sheva, Israel.

Introduction: Studies suggest that non-alcoholic fatty liver disease (NAFLD) is associated with an independent risk of cardiovascular disease (CVD). We utilized a large cohort of patients undergoing myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) to determine the association between alanine aminotransferase (ALT) as a surrogate marker for presumed NAFLD, and the presence of myocardial ischemia and mortality.

Methods: We retrospectively assessed SPECT-MPI results and medical records of individuals evaluated between 1997 and 2008. Read More

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January 2022