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[Risk factors of massive introperative blood loss in posterior spinal fusion for adolescent idiopathic scoliosis].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):1002-1008

Department of Anesthesiology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, China.

To investigate the risk factors and prognostic impact of massive introperative blood loss in posterior spinal fusion (PSF) surgery for adolescent idiopathic scoliosis (AIS). Clinical data were collected of 1 896 AIS patients who underwent PSF surgery under general anesthesia in Drum Tower Hospital Affiliated to Nanjing University Medical School from November 2010 to October 2019 and retrospectively analyzed. According to the volume of intraoperative blood loss, the patients were divided into the massive introperative blood loss group [estimated blood loss (EBL)/estimated blood volume (EBV)≥30%] and the non-massive introperative blood loss group (EBL/EBV<30%). Read More

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Detection of Myocardial Infarction by Cardiac Magnetic Resonance in Embolic Stroke Related to First Diagnosed Atrial Fibrillation.

J Stroke Cerebrovasc Dis 2021 Apr 9;30(6):105753. Epub 2021 Apr 9.

Department of Cardiology, Dijon University Hospital, 21000 Dijon, France. Electronic address:

Introduction: Elevated troponin levels are found in a significant number of patients who are diagnosed with acute embolic stroke (AES) after first diagnosed atrial fibrillation (AF). These myocardial injuries, which are known as cardiocerebral infarction (CCI), are potentially caused by coronary embolism and correspond to simultaneous cardiac and cerebral embolisms. However, this severe condition remains poorly understood. Read More

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Evaluation of stress, burnout and hair cortisol levels in health workers at a University Hospital during COVID-19 pandemic.

Psychoneuroendocrinology 2021 Apr 1;128:105213. Epub 2021 Apr 1.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Cátedra de Bioquímica Clínica I, Buenos Aires, Argentina; Universidad de Buenos Aires, Departamento de Bioquímica Clínica, Hospital de Clínicas José de San Martin, Argentina; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Buenos Aires, Argentina. Electronic address:

In the critical context of COVID-19 pandemic, healthcare workers are on the front line, participating directly in the care, diagnosis, and treatment of patients with COVID-19. This exposes them to a higher risk of developing chronic stress, psychological distress, and any other mental health symptoms.

Objective: to evaluate stress and burnout in a health workers population and, in addition, to measure hair cortisol concentration as a current biomarker of stress. Read More

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Protective effects of farnesyltransferase inhibitor on sepsis-induced morphological aberrations of mitochondria in muscle and increased circulating mitochondrial DNA levels in mice.

Biochem Biophys Res Commun 2021 Apr 9;556:93-98. Epub 2021 Apr 9.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA; Shriners Hospitals for Children, Boston, MA, 02114, USA.

Sepsis remains a leading cause of mortality in critically ill patients and is characterized by multi-organ dysfunction. Mitochondrial damage has been proposed to be involved in the pathophysiology of sepsis. In addition to metabolic impairments resulting from mitochondrial dysfunction, mitochondrial DNA (mtDNA) causes systemic inflammation as a damage-associated molecular pattern when it is released to the circulation. Read More

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PAHs and their hydroxylated metabolites in the human fingernails from e-waste dismantlers: Implications for human non-invasive biomonitoring and exposure.

Environ Pollut 2021 Mar 31;283:117059. Epub 2021 Mar 31.

Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Key Laboratory of City Cluster Environmental Safety and Green Development, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

Non-invasive human biomonitoring methods using hair and fingernails as matrices are widely used to assess the exposure of organic contaminants. In this work, a total of 72 human fingernails were collected from workers and near-by residents from a typical electronic waste (e-waste) dismantling site, and were analyzed for human exposure to polycyclic aromatic hydrocarbons (PAHs) and their mono-hydroxyl metabolites (OH-PAHs). The concentrations of PAHs and OH-PAHs were obtained as 7. Read More

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Plasma unesterified eicosapentaenoic acid is converted to docosahexaenoic acid (DHA) in the liver and supplies the brain with DHA in the presence or absence of dietary DHA.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Apr 9:158942. Epub 2021 Apr 9.

Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8.

Recent meta-analyses suggest that high eicosapentaenoic acid (EPA, 20:5n-3) supplements may be beneficial in managing the symptoms of major depression. However, brain EPA levels are hundreds-fold lower than docosahexaenoic acid (DHA, 22:6n-3), making the potential mechanisms of action of EPA in the brain less clear. Using a kinetic model the goal of this study was to determine how EPA impacts brain DHA levels. Read More

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Caspofungin pharmacokinetics and probability of target attainment in ICU patients in China.

J Glob Antimicrob Resist 2021 Apr 9. Epub 2021 Apr 9.

Department of intensive care unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Effective antifungal therapy is important for reducing the mortality of patients with invasive fungal diseases. Numerous factors affect the pharmacokinetic (PK)/pharmacodynamic (PD) parameters in critically ill patients. To guide the individualized administration of the antifungal drug caspofungin in critically ill patients, it is of great significance to investigate the population pharmacokinetics of caspofungin. Read More

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Neurobehavioral, neurochemical and synaptic plasticity perturbations during postnatal life of rats exposed to chloroquine in-utero.

Neurotoxicol Teratol 2021 Apr 9:106982. Epub 2021 Apr 9.

Biotranslational Research Group, University of Ilorin, Ilorin, Nigeria; Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria; Malaria Research Laboratories, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria. Electronic address:

Despite reports that quinoline antimalarials including chloroquine (Chq) exhibit idiosyncratic neuropsychiatric effects even at low doses, the drug continues to be in widespread use during pregnancy. Surprisingly, very few studies have examined the potential neurotoxic action of Chq exposure at different points of gestation or how this phenomenon may affect neurophysiological well-being in later life. We therefore studied behavior, and the expression of specific genes and neurochemicals modulating crucial neural processes in offspring of rats exposed to prophylactic dose of Chq during different stages of gestation. Read More

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The implication of ROCK 2 as a potential senotherapeutic target via the suppression of the harmful effects of the SASP: Do senescent cancer cells really engulf the other cells?

Cell Signal 2021 Apr 9:110007. Epub 2021 Apr 9.

Department of Pharmacology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey. Electronic address:

Chemotherapy-induced senescent cancer cells secrete several factors in their microenvironment called SASP. Accumulated evidence states that SASP is responsible for some of the harmful effects of chemotherapy such as drug resistance and the induction of cancer cell proliferation, migration, and invasion. Therefore, to develop senolytic and/or senomorphic drugs, targeting the senescent cells gains importance as a new strategy for preventing the damage that senescent cancer cells cause. Read More

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Integrated metabolomics and network pharmacology approach to exploring the potential mechanism of Tianxiang Capsule for treating motion sickness.

J Ethnopharmacol 2021 Apr 9:114107. Epub 2021 Apr 9.

School of Pharmacy, Second Military Medical University, Shanghai, 200433, China. Electronic address:

Ethnopharmacological Relevance: Motion sickness is a multi-system syndrome caused by abnormal spatial environmental sensory conflicts. Tianxiang Capsule (TXC) is a traditional Chinese medicine (TCM) formula for the prevention and treatment of motion sickness for years. However, the main active components of TXC and mechanism of its therapeutic effects on motion sickness are still unclear. Read More

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Impacts of pineapple peel powder on growth performance, innate immunity, disease resistance, and relative immune gene expression of Nile tilapia, Oreochromis niloticus.

Fish Shellfish Immunol 2021 Apr 9. Epub 2021 Apr 9.

Fish Nutrition Research Laboratory, Animal Production Department, Faculty of Agriculture, Cairo University, Cairo, Egypt.

An 8-week growth trial was conducted to examine the efficacy of pineapple peel powder (PAPP) on growth rate and immunity of Nile tilapia, O. niloticus. Three hundred Nile tilapia (20. Read More

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Unexpected beta-amyloid production by middle doses of resveratrol through stabilization of APP protein and AMPK-mediated inhibition of trypsin-like proteasome activity in a cell model of Alzheimer's disease.

Food Chem Toxicol 2021 Apr 9:112185. Epub 2021 Apr 9.

Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-do, Korea; Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon, Kangwon-do, Korea. Electronic address:

Resveratrol is a drug candidate used for Alzheimer's disease (AD) and shows beneficial effects in various toxicity and production models, although recent clinical trial data did not show satisfactory results. Here we demonstrated the potential side effects of resveratrol in AD. We demonstrated resveratrol concentration- and time-dependent Aβ production using Aβ secreted cellular model and analyzed resveratrol-related molecular signaling. Read More

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Microplastics in lakeshore and lakebed sediments - External influences and temporal and spatial variabilities of concentrations.

Environ Res 2021 Apr 9:111141. Epub 2021 Apr 9.

Center for Earth System Research and Sustainability (CEN), Universität Hamburg, Bundesstraße 55, 20146 Hamburg, Germany.

Microplastics have been predominantly studied in marine environments compared to freshwater systems. However, the number of studies analyzing microplastic concentrations in water and sediment within lakes and rivers are increasing and are of utmost importance as freshwaters are major pathways for plastics to the oceans. To allow for an adequate risk assessment, detailed knowledge concerning plastic concentrations in different environmental compartments of freshwaters are necessary. Read More

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Transactions between self-esteem and perceived conflict in romantic relationships: A 5-year longitudinal study.

PLoS One 2021 12;16(4):e0248620. Epub 2021 Apr 12.

Department of Psychology, Friedrich-Schiller University, Jena, Germany.

Self-esteem has been shown to be both predictive of and predicted by characteristics of romantic relationships. While there is an increasing number of studies yielding support for reciprocal influences between self-esteem and perceived conflict in romantic relationships, longitudinal transactions between these constructs from both partners' perspectives have not been studied systematically to date. Our aim was to close this gap. Read More

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Local Delivery of Therapeutic Boron for Bone Healing Enhancement.

J Orthop Trauma 2021 May;35(5):e165-e170

Chemical Engineering Department, Ecole Polytechnique de Montreal, Montreal, QC, Canada.

Objectives: To evaluate if local delivery of boron can accelerate bone healing and examine if the bioactive salt impacts the osteogenic response of bone-derived osteoclasts and osteoblasts by the regulation of the Wnt/β-catenin pathway.

Methods: Bilateral femoral cortical defects were created in 32 skeletally mature C57 mice. On the experimental side, boric acid (8 mg/kg concentration) was injected locally, whereas on the control side, saline was used. Read More

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Arthroscopic Soft Tissue Stabilization With Selective Augmentations for Traumatic Anterior Shoulder Instability in Competitive Collision Athletes.

Am J Sports Med 2021 Apr 12:3635465211003091. Epub 2021 Apr 12.

Shoulder and Elbow Service, Funabashi Orthopaedic Sports Medicine and Joint Center, Funabashi, Japan.

Background: Many surgeons prefer bony stabilization including Bristow or Latarjet procedures for shoulder instability in collision athletes, even though several potential complications have been reported. There has been a limited number of studies on the midterm outcomes of arthroscopic soft tissue stabilization for anterior shoulder instability in competitive collision athletes.

Purpose: To assess the outcomes of arthroscopic soft tissue stabilization in combination with selective augmentation procedures for collision athletes with traumatic anterior shoulder instability. Read More

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Bullying, Supervisor Support, Relaxation, and Personal and Work Outcomes: Testing a Moderated Mediation Model.

J Nurs Manag 2021 Apr 12. Epub 2021 Apr 12.

Département de psychologie, Université de Tours, France.

Aim: To test a mediated moderation model in which bullying and supervisor support interact to predict nurses' personal and work outcomes with relaxation during off-job time mediating these effects.

Background: Bullying is a pervasive problem in the nursing profession. We integrate and extend past research addressing the question of how bullying and perceived supervisor support affect nurses' functioning. Read More

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Different modes of delivery and hormonal stress response.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical Univeristy of Lodz, Poland.

Objectives: The aim of the study was to determine how the type of delivery affects the stress response cycle and the level of cortisol, progesterone and corticoliberin.

Material And Methods: The study was conducted among 26 pregnant women admitted to the Gynecology and Obstetrics Ward due to an approaching delivery date or the onset of labor. The participants were aged between 20 and 41 years, with a mean age of approximately 30 years. Read More

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Examining the Factors that Contribute to Non-Monotonic Growth of the [Formula: see text] Otoacoustic Emission in Humans.

J Assoc Res Otolaryngol 2021 Apr 12. Epub 2021 Apr 12.

Department of Speech and Hearing Sciences, Indiana University, IN, 47405-7000, Bloomington, USA.

Cubic distortion product otoacoustic emission input-output functions in humans show a complex pattern of growth. To further investigate the growth of the [Formula: see text] otoacoustic emission, magnitude and phase input-output functions were obtained from human subjects using a range of stimulus levels, frequencies, and frequency ratios. Three factors related to cochlear nonlinearity may produce non-monotonic input-output functions: a two-component interaction, an operating point shift, and two-tone suppression. Read More

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The CXCL13 chemokine serves as a potential biomarker to diagnose systemic lupus erythematosus with disease activity.

Clin Exp Med 2021 Apr 12. Epub 2021 Apr 12.

Center of Clinical Laboratory, Zhongshan Hospital, School of Medicine, Xiamen University, Xiamen, 361004, China.

The aim of our study was to assess the regulatory response of the chemokine CXCL13 in the serum of systemic lupus erythematosus (SLE) patients with disease activity and to evaluate its influence on the inflammatory process in SLE. Serum samples from 97 SLE patients, 49 non-SLE patients (23 patients with other autoimmune diseases and 26 patients with rheumatoid arthritis) and 50 healthy controls were analyzed for the concentration of CXCL13 using ELISA. The results indicated that the serum levels of CXCL13 were significantly higher in SLE patients than in non-SLE patients and healthy controls (p < 0. Read More

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Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress.

Biosci Rep 2021 Apr 12. Epub 2021 Apr 12.

Jilin university, Changchun, China.

Hydroxyurea (HU) is an FDA-approved drug used to treat a variety of diseases, especially malignancies, but is harmful to fertility. We used porcine oocytes as an experimental model to study the effect of HU during oocyte maturation. Exposure of cumulus-oocyte complexes (COCs) to 20 µM (p < 0. Read More

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Treatment of wastewater from a dairy plant by adsorption using synthesized copper oxide nanoparticles: kinetics and isotherms modeling optimization.

Water Sci Technol 2021 Apr;83(7):1591-1604

Department of Chemical Engineering, Al-Huson University College, Al-Balqa Applied University, Salt, Jordan E-mail:

Dairy plants produce 1 to 4 L of wastewater per 1 L of processed milk. The wastewater contains high values of chemical oxygen demand (COD) and biochemical oxygen demand (BOD) concentrations, in addition to high levels of dissolved solids. In this study, synthesized copper oxide nanoparticles (CuONPs) coupled with Sophora Japonica fruit, were used as an adsorbent, for the first time, to treat the effluent of dairy plants in a batch adsorption process. Read More

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MELATONIN AND GRHELIN AS "EARLY" PROGNOSIS MARKERS OF PROGRESSION OF ARTERIAL HYPERTENSION AND OSTEOARTHRITIS IN THE CASE OF THEIR COMORBIDITY.

Wiad Lek 2021 ;74(3 cz 2):697-701

BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE.

Objective: The aim: Of the study was to investigate the effect of melatonin on the serum levels of ghrelin in patients with hypertension combined with osteoarthritis in order to identify them as informative and reliable markers of early diagnosis of progression of these comorbid diseases.

Patients And Methods: Material and methods: To achieve the goals and objectives of this study, 60 patients with hypertension combined with osteoarthritis were involved and examined, in particular, serum ghrelin and melatonin levels were determined twice and divided into two groups.

Results: Results: It was found that in patients of group I on the background of the four-week main course of treatment with the addition of melatonin (3 mg 1 time per day before bedtime), the average value of ghrelin increased by an average of ± 2. Read More

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January 2021

Consumer-Based Activity Trackers as a Tool for Physical Activity Monitoring in Epidemiological Studies During the COVID-19 Pandemic: Development and Usability Study.

JMIR Public Health Surveill 2021 Apr 3. Epub 2021 Apr 3.

Department of Community Medicine, UiT The Arctic University of Norway, Postboks 6050 langnes, Tromsø, NO.

Background: Consumer-based physical activity trackers increase in popularity. The widespread use of these devices and the long-term nature of the recorded data provides a valuable source of physical activity data for epidemiological research. Challenges include the large heterogeneity between activity tracker models, in terms of available data types, the accuracy of recorded data, and how this data can be shared between different providers and third-party systems. Read More

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Identification and validation of the prognostic value of cyclic GMP-AMP synthase-stimulator of interferon (cGAS-STING) related genes in gastric cancer.

Bioengineered 2021 Dec;12(1):1238-1250

Department of General Surgery, People's Hospital of Jingjiang, Yangzhou University Medical Academy, Jingjiang, China.

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway play a significant role in the production of inflammatory cytokines and type I interferons. This study aims to develop a cGAS-STING pathway-related genes (CSRs) prediction model to predict prognosis in gastric cancer (GC). In the present study, we used The Cancer Genome Atlas (TCGA), Gene Expression Omnibus databases (GEO), CIBERSORT and Tumor Immune Estimation Resource databases (TIMER). Read More

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December 2021

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells.

Autophagy 2021 Apr 12:1-20. Epub 2021 Apr 12.

College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China.

Zinc oxide nanoparticles (ZnONPs) hold great promise for biomedical applications. Previous studies have revealed that ZnONPs exposure can induce toxicity in endothelial cells, but the underlying mechanisms have not been fully elucidated. In this study, we report that ZnONPs can induce ferroptosis of both HUVECs and EA. Read More

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Bushen Yijing Decoction (BSYJ) exerts an anti-systemic sclerosis effect via regulating MicroRNA-26a /FLI1 axis.

Bioengineered 2021 Dec;12(1):1212-1225

Department of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Systemic sclerosis (SSc) refers to a group of autoimmune rheumatic diseases. Bushen Yijing decoction (BSYJ) is used for treating SSc. However, its underlying mechanism remains unknown. Read More

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December 2021

Lactobacillus rhamnosus JB3 inhibits Helicobacter pylori infection through multiple molecular actions.

Helicobacter 2021 Apr 11:e12806. Epub 2021 Apr 11.

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

Background: Eradication of Helicobacter pylori infection is the most direct and effective way for preventing gastric cancer. Lactic acid bacteria are considered as alternative therapeutic agents against H. pylori infection. Read More

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Grainyhead-like transcription factors: guardians of the skin barrier.

Vet Dermatol 2021 Apr 12. Epub 2021 Apr 12.

Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia.

There has been selective pressure to maintain a skin barrier since terrestrial animals evolved 360 million years ago. These animals acquired an unique integumentary system with a keratinized, stratified, squamous epithelium surface barrier. The barrier protects against dehydration and entry of microbes and toxins. Read More

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The impact of artisanal gold mining, ore processing and mineralization on water quality in Marmato, Colombia.

Environ Geochem Health 2021 Apr 11. Epub 2021 Apr 11.

Gran Colombia Gold Corp., Medellín, Colombia.

Marmato, Colombia, has been an important centre of gold mining since before the first Spanish colonizers arrived in 1536. The Marmato deposit is hosted in a dacite and andesite porphyry stock as sheeted sulphide-rich veinlet systems. The district is currently experiencing a surge in both major mining projects and artisanal mining, driven by sustained high gold prices. Read More

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