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Long working hours, sedentary work, noise, night shifts and risk of ischaemic heart disease.

Heart 2022 Aug 8. Epub 2022 Aug 8.

Research Centre for Hauora and Health, Massey University - Wellington Campus, Wellington, New Zealand.

Objective: Ischaemic heart disease (IHD) is a leading cause of death in Western countries. The aim of this study was to examine the associations between occupational exposure to loud noise, long working hours, shift work, and sedentary work and IHD.

Methods: This data linkage study included all New Zealanders employed and aged 20-64 years at the time of the 2013 census, followed up for incident IHD between 2013 and 2018 based on hospitalisation, prescription and death records. Read More

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The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization.

Life Sci Alliance 2022 Dec 8;5(12). Epub 2022 Aug 8.

Departamento de Biología, Centro FONDAP de Regulación del Genoma, Facultad de Ciencias, Universidad de Chile, Santiago, Chile

Actin filament polymerization can be branched or linear, which depends on the associated regulatory proteins. Competition for actin monomers occurs between proteins that induce branched or linear actin polymerization. Cell specialization requires the regulation of actin filaments to allow the formation of cell type-specific structures, like cuticular hairs in , formed by linear actin filaments. Read More

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December 2022

Educational inequalities in adult mortality: a systematic review and meta-analysis of the Asia Pacific region.

BMJ Open 2022 Aug 8;12(8):e059042. Epub 2022 Aug 8.

Centre for Global Health Inequalities Research, Department of Sociology and Political Science, Norwegian University of Science and Technology, Trondheim, Norway.

Objectives: In this study, we aim to analyse the relationship between educational attainment and all-cause mortality of adults in the high-income Asia Pacific region.

Design: This study is a comprehensive systematic review and meta-analysis with no language restrictions on searches. Included articles were assessed for study quality and risk of bias using the Joanna Briggs Institute critical appraisal checklists. Read More

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Percentage of Age-Predicted Cardiorespiratory Fitness May Be a Stronger Risk Indicator for Incident Type 2 Diabetes Than Absolute Levels of Cardiorespiratory Fitness.

J Cardiopulm Rehabil Prev 2022 Aug 4. Epub 2022 Aug 4.

National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, and Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning & Research Building (Level 1), Southmead Hospital, Bristol, England (Dr Kunutsor); Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, England (Drs Kunutsor and Seidu); Leon H. Charney Division of Cardiology, New York University Langone Health, New York (Dr Khan); Department of Medicine, Central Finland Health Care District Hospital District, Jyväskylä, Finland District, Jyväskylä, and Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, and Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland (Dr Laukkanen).

Purpose: There are inverse and independent associations between cardiorespiratory fitness (CRF) and several adverse cardiometabolic outcomes. The percentage of age-predicted CRF (%age-predicted CRF) is comparable to absolute CRF as a risk indicator for some of these outcomes, but the association between %age-predicted CRF and risk of type 2 diabetes (T2D) has not been previously investigated. We aimed to assess the association between %age-predicted CRF and T2D in a prospective cohort study. Read More

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Gender equity in academic rheumatology, current status and potential for improvement: a cross-sectional study to inform an EULAR task force.

RMD Open 2022 Aug;8(2)

NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK

Objectives: Evidence on the current status of gender equity in academic rheumatology in Europe and potential for its improvement is limited. The EULAR convened a task force to obtain empirical evidence on the potential unmet need for support of female rheumatologists, health professionals and non-clinical scientists in academic rheumatology.

Methods: This cross-sectional study comprised three web-based surveys conducted in 2020 among: (1) EULAR scientific member society leaders, (2) EULAR and Emerging EULAR Network (EMEUNET) members and (3) EULAR Council members. Read More

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Ameliorative effect of dandelion (Taraxacum officinale) peptides on benzo(a)pyrene-induced oxidative stress and inflammation in human umbilical vein endothelial cells.

J Pept Sci 2022 Aug 8:e3447. Epub 2022 Aug 8.

Department of Interventional Radiology, Guangzhou Panyu Central Hospital, China.

Dandelion (Taraxacum officinale) is widely consumed as a health food and a traditional medicine. However, the protective effect of dandelion bio-active peptides (DPs) against polycyclic aromatic hydrocarbon-induced blood vessel inflammation and oxidative damage is not well documented. In the current study, four novel DPs were isolated using an activity tracking method. Read More

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Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4 T-cell migration in SLE.

Lupus Sci Med 2022 Aug;9(1)

Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany

Objective: SLE is an autoimmune disease with a complex pathogenesis. T-cell infiltration into organs contributes to inflammation and organ damage in SLE. Recently, G-protein signalling modulator 2 (GPSM2) has been shown to be implicated in T-cell migration. Read More

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Impact of Starmerella bacillaris and Zygosaccharomyces bailii on ethanol reduction and Saccharomyces cerevisiae metabolism during mixed wine fermentations.

Food Res Int 2022 Sep 8;159:111649. Epub 2022 Jul 8.

Institute for Integrative Systems Biology, I2SysBio, University of Valencia-CSIC, Paterna, Spain. Electronic address:

The bulk of grape juice fermentation is carried out by the yeast Saccharomyces cerevisiae, but non-Saccharomyces yeasts can modulate many sensorial aspects of the final products in ways not well understood. In this study, some of such non-conventional yeasts were screened as mixed starter cultures in a defined growth medium in both simultaneous and sequential inoculations. One strain of Starmerella bacillaris and another of Zygosaccharomyces bailii were chosen by their distinct phenotypic footprint and their ability to reduce ethanol levels at the end of fermentation. Read More

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September 2022

Effects of inoculation timing and mixed fermentation with Pichia fermentans on Oenococcus oeni viability, fermentation duration and aroma production during wine malolactic fermentation.

Food Res Int 2022 Sep 1;159:111604. Epub 2022 Jul 1.

College of Enology, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China; Ningxia Helan Mountain's East Foothill Wine Experiment and Demonstration Station of Northwest A&F University, Yongning, Ningxia 750104, China. Electronic address:

There has been a growing interest in developing co-inoculum of Oenococcus oeni and Saccharomyces cerevisiae/non-Saccharomyces for simultaneous malolactic fermentation (MLF) and alcoholic fermentation (AF) of wines. This study sought to elucidate the effects of two crucial factors (inoculation timing and paired yeast) on the fermentation performance and aroma production of Merlot wine. O. Read More

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September 2022

Transcriptome analysis revealed the role of capsular polysaccharides in desiccation tolerance of foodborne Staphylococcus aureus.

Food Res Int 2022 Sep 30;159:111602. Epub 2022 Jun 30.

School of Life Sciences, Anhui Agricultural University, Hefei, Anhui 230036, China; Food Procession Research Institude, Anhui Agricultural University, Hefei, Anhui 230036, China. Electronic address:

Staphylococcus aureus (S. aureus) is a momentous factor affecting food safety. It can survive under long-term desiccation stress and contaminate foods that have intermediate to low water activities. Read More

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September 2022

Chemical and LC-MS-based lipidomics analyses revealed changes in lipid profiles in hairtail (Trichiurus haumela) muscle during chilled storage.

Food Res Int 2022 Sep 30;159:111600. Epub 2022 Jun 30.

Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, College of Food Science and Pharmacy, Zhejiang Ocean University, PR China; Pisa Marine Graduate School, Zhejiang Ocean University, PR China. Electronic address:

Chemical and liquid chromatography-mass spectrometry (LC-MS)-based lipidomics techniques were used to investigate the alternations of lipid profiles in hairtail (Trichiurus haumela) muscle after chilled storage for six days. The chemical results showed that the peroxide values (PVs) and thiobarbituric acid reactive species (TBARS) content in the muscle increased significantly, from 0.43 meq/kg of lipids and 0. Read More

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September 2022

Effect of germination on the main chemical compounds and 5-methyltetrahydrofolate metabolism of different quinoa varieties.

Food Res Int 2022 Sep 1;159:111601. Epub 2022 Jul 1.

College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address:

This study determined the content of macronutrients and micronutrients to investigate the nutritional value and health benefits of six varieties of quinoa seeds and sprouts. Germination markedly increased the contents of proteins, reducing sugars, free amino acids, vitamins, and phytochemicals such as phenolic and carotenoid compounds, with variation among different quinoa varieties. Relatively high levels of 5-methyltetrahydrofolate (5-MTHF) were found in 6-day-old quinoa sprouts, especially in the LL-1 variety (1747. Read More

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September 2022

Nanoemulsified clove essential oils-based edible coating controls Pseudomonas spp.-causing spoilage of tilapia (Oreochromis niloticus) fillets: Working mechanism and bacteria metabolic responses.

Food Res Int 2022 Sep 30;159:111594. Epub 2022 Jun 30.

Department of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore; National University of Singapore (Suzhou) Research Institute, 377 Lin Quan Street, Suzhou Industrial Park, Suzhou, Jiangsu 215123, PR China. Electronic address:

Fish products suffer Pseudomonas-causing spoilage quickly during refrigeration storage, which could be solved by applying edible coating derived from nanoemulsified clove essential oils and fish gelatin (NCEO-FG). This study aimed to evaluate the effects and mechanism of NCEO-FG in preserving tilapia (Oreochromis niloticus) fillets that were inoculated with Pseudomonas spp. (Pseudomonas sp. Read More

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September 2022

Regional prediction of multi-mycotoxin contamination of wheat in Europe using machine learning.

Food Res Int 2022 Sep 27;159:111588. Epub 2022 Jun 27.

Wageningen Food Safety Research, Akkermaalsbos 2, 6721 WB Wageningen, the Netherlands. Electronic address:

Wheat is susceptible to fungal infection and mycotoxin contamination during its cultivation period, under opportune environmental conditions. The presence of mycotoxins, such as deoxynivalenol and zearalenone, in wheat destined for feed and food can affect animal and human health. This study aimed to develop a machine learning algorithm to predict the risk levels of one or more mycotoxins in wheat on a regional basis in Europe using crop phenological data, weather data, and satellite images as input. Read More

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September 2022

The impact of indigenous Saccharomyces cerevisiae and Schizosaccharomyces japonicus on typicality of crystal grape (Niagara) wine.

Food Res Int 2022 Sep 27;159:111580. Epub 2022 Jun 27.

Province Key Laboratory of Fermentation Engineering and Biopharmacy, School of Liquor and Food Engineering, Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou University, Guiyang 550025, China. Electronic address:

Schizosaccharomyces japonicus have been found as dominant yeast species coexisting with Saccharomyces cerevisiae during late stages of spontaneous fermentation of local grapes in Guizhou, China. Therefore, this study further investigated the impacts of the two indigenous yeast species on typicality of crystal grape (Niagara) wine. Five indigenous and one commercial S. Read More

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September 2022

Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation.

Food Res Int 2022 Sep 16;159:111522. Epub 2022 Jun 16.

Graduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil; Graduate Program on Food Science and Technology, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil; Integrated Center for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil. Electronic address:

We hypothesized that norbixin, which is a carotenoid used as an orange/red natural food coloring additive, has anti-atherogenic properties. An in vitro oxidation assay with human LDL and a rabbit model of atherosclerosis were used to test this hypothesis. Norbixin inhibited the oxidation of isolated human LDL in a concentration-dependent manner. Read More

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September 2022

The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial.

Food Res Int 2022 Sep 9;159:111632. Epub 2022 Jul 9.

Biomarkers and Nutrimetabolomics Laboratory, Department de Nutrició, Ciències de l'Alimentació i Gastronomia, Food Innovation Network (XIA), Institut de Recerca en Nutrició i Seguretat Alimentària (INSA), Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB), 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid 28029, Spain. Electronic address:

A polyphenol-rich diet reduced intestinal permeability (IP) in older adults. Our aim was to evaluate if participants categorized according to urolithin metabotypes (UMs) exhibited different responses in the MaPLE trial. Fifty-one older adults (mean age: 78 years) completed an 8-week randomized-controlled-crossover trial comparing the effects of a polyphenol-rich vs. Read More

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September 2022

Influence of modified governing liquid on shelf-life parameters of high-moisture mozzarella cheese.

Food Res Int 2022 Sep 8;159:111627. Epub 2022 Jul 8.

School of Bioscience and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy. Electronic address:

The roles of mesophilic lactobacilli in cheese manufacturing and ripening have been widely studied, but their impacts, especially as additives in preserving liquids, on the high-moisture mozzarella cheese quality parameters remained underexplored. The current study studied and compared the effects of four preserving liquid formulations - brine solution (sodium chloride, as control), a salt mixture solution, and two lactobacilli solutions (Lactiplantibacillus plantarum IMC 509 in brine solution) or SYNBIO® (a 1:1 ratio of Lacticaseibacillus rhamnosus IMC 501 and Lacticaseibacillus paracasei IMC 502) - on the microbial, chemical (volatile fatty acids), physicochemical (moisture, weight, pH, colour), texture (adhesiveness, hardness, cohesiveness, gumminess, springiness, chewiness) and sensorial qualities of mozzarella stored for 30 days at 4 °C. The quality of the governing solution, including microbial content, lactobacilli viability, pH, turbidity, and smell, was also monitored. Read More

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September 2022

Two Laminaria japonica polysaccharides with distinct structure characterization affect gut microbiota and metabolites in hyperlipidemic mice differently.

Food Res Int 2022 Sep 5;159:111615. Epub 2022 Jul 5.

School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China. Electronic address:

Our previous study found dietary mannogluconic acid (MA) and fucogalactan sulfate (FS) from Laminaria japonica have distinct structure characterization and potential hypolipidemic effects in vitro. Herein, we compared the benefits of MA and FS on hyperlipidemia. The result showed only FS treatment decreased body weight and serum cholesterol levels. Read More

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September 2022

A sourdough process based on fermented chickpea extract as leavening and anti-staling agent for improving the quality of gluten-free breads.

Food Res Int 2022 Sep 30;159:111593. Epub 2022 Jun 30.

Department of Food Science and Technology, School of Agriculture, Aristotle University of Thessaloniki, P.O. Box 235, 54124 Thessaloniki, Greece. Electronic address:

The use of a sourdough (SD) preparation based on a fermented chickpea extract (FCE) starter as a leavening and anti-staling agent in gluten-free breads was explored in this study. The FCE starter was prepared by a submerged fermentation (at 37 °C for 15 h) of coarsely ground chickpeas and the gluten-free bread formulations, based on rice and corn flours, were made using a rice sourdough produced with the FCE starter as additional leavening agent; the FCE-SD breads and samples containing merely baker's yeast as microbial leavener (control) were both prepared at three different levels of added water, i.e. Read More

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September 2022

Prognostic significance of complement factors in severely ill patients with COVID-19.

J Investig Med 2022 Aug 8. Epub 2022 Aug 8.

Clinical Pathology Department, Alexandria University, Alexandria, Egypt.

Coagulopathy, cytokine release, platelet hyperactivity and endothelial activation are regarded as potential major contributors to COVID-19 morbidity. Complement activation might provide a bridge linking these factors in severe COVID-19 illness. In this study, we investigated the prognostic significance of selected complement factors in hospitalized patients with severe COVID-19 infection. Read More

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Rodent models in translational circadian photobiology.

Prog Brain Res 2022 21;273(1):97-116. Epub 2022 Mar 21.

Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Electronic address:

Over the last decades remarkable advances have been made in the understanding of the photobiology of circadian rhythms. The identification of a third photoreceptive system in the mammalian eye, in addition to the rods and cones that mediate vision, has transformed our appreciation of the role of light in regulating physiology and behavior. These photosensitive retinal ganglion cells (pRGCs) express the blue-light sensitive photopigment melanopsin and project to the suprachiasmatic nuclei (SCN)-the master circadian pacemaker-as well as many other brain regions. Read More

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Skeletal muscle deconditioning during partial weight-bearing in rodents - A systematic review and meta-analysis.

Life Sci Space Res (Amst) 2022 Aug 29;34:68-86. Epub 2022 Jul 29.

Aerospace Medicine and Rehabilitation Laboratory, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, United Kingdom.

Space agencies are planning to send humans back to the Lunar surface, in preparation for crewed exploration of Mars. However, the effect of hypogravity on human skeletal muscle is largely unknown. A recently established rodent partial weight-bearing model has been employed to mimic various levels of hypogravity loading and may provide valuable insights to better understanding how human muscle might respond to this environment. Read More

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Immature platelet fraction in rheumatoid arthritis with interstitial lung disease.

Reumatol Clin (Engl Ed) 2022 Aug-Sep;18(7):406-409

Aydin Adnan Menderes University Medical Faculty, Department of Rheumatology, Aydın, Turkey.

Background: Platelets have an effect on the hemostatic defense of the lung. Immature platelet fractions (iPF) reflects the number of young platelets containing ribonucleic acid in the circulation and real-time production. Information about their roles in rheumatic diseases is limited and there are no studies on iPF in RA with interstitial lung disease (ILD). Read More

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December 2020

Red cell distribution width and mean platelet volume in rheumatoid arthritis patients: Its association with disease activity.

Reumatol Clin (Engl Ed) 2022 Aug-Sep;18(7):399-405

Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt. Electronic address:

Introduction: Hemogram parameters have been recently proposed as markers of inflammation in various studies from different parts of the world. Two of these hemogram parameters are red cell distribution width (RDW) and mean platelet volume (MPV).

Aim: To evaluate the relation between RDW and MPV with disease activity of rheumatoid arthritis. Read More

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January 2021

Comparison of the Biomechanical Effect of the FFX Device Compared With Other Lumbar Fusion Devices: A Finite Element Study.

Int J Spine Surg 2022 Aug 8. Epub 2022 Aug 8.

Hôpitaux Civils de Colmar, Colmar, France

Background: Lumbar decompression can result in postsurgical instability and spondylolisthesis in patients with lumbar spinal stenosis (LSS). While pedicle screw (PS) constructs improve stability and support fusion, their use can lead to adjacent level degeneration due to rigidity and resultant overload of anatomical structures. The FFX device is a facet spacer designed to be a less invasive alternative for obtaining fusion compared with PS. Read More

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Burnout Among Respiratory Therapists in a tertiary hospital in Saudi Arabia.

Respir Care 2022 Aug 8. Epub 2022 Aug 8.

Department of Respiratory Therapy, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Respiratory therapists (RTs) provide various types of patient care in different clinical settings. Burnout can have an undesirable effect on RTs and their patients. Managing the COVID-19 pandemic, specifically in hospitals, could induce stress in RTs and increase the likelihood of burnout. Read More

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Detection and validation of cis-regulatory motifs in osmotic stress-inducible synthetic gene switches via computational and experimental approaches.

Funct Plant Biol 2022 Aug 9. Epub 2022 Aug 9.

Synthetic cis-regulatory modules can improve our understanding of gene regulatory networks. We applied an ensemble approach for de novo cis motif discovery among the promoters of 181 drought inducible differentially expressed soybean (Glycine max L.) genes. Read More

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3.0-T closed MR-guided microwave ablation for HCC located under the hepatic dome: a single-center experience.

Int J Hyperthermia 2022 Dec;39(1):1044-1051

Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Purpose: To analyze the clinical safety and efficacy of 3.0-T closed MR-guided microwave ablation (MWA) for the treatment of HCC located under the hepatic dome.

Methods: From May 2018 to October 2020, 49 patients with 74 HCCs located under the hepatic dome underwent MWA using 3. Read More

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December 2022