42,974 results match your criteria level vitamin


Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.

Free Radic Biol Med 2021 Apr 16. Epub 2021 Apr 16.

Department of Cell Biology, School of Medicine, Taizhou University, Taizhou, PR China. Electronic address:

Background: Clinical studies indicate that vitamin D receptor (VDR) expression is reduced in primary biliary cirrhosis patient livers. However, the mechanism by which activated VDR effect cholestatic liver injury remains unclear.

Methods: Mice were injected intraperitoneally with the VDR agonist paricalcitol or a vehicle 3 days prior to bile duct ligation (BDL) and for 5 or 28 days after surgery. Read More

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Growth performance, tissue precipitation, metallothionein and cytokine transcript expression and economics in response to different dietary zinc sources in growing rabbits.

J Anim Physiol Anim Nutr (Berl) 2021 Apr 19. Epub 2021 Apr 19.

Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

The impact of different dietary zinc sources on the growth, serum metabolites, tissue zinc content, economics and relative expression of cytokine and metallothionein genes was evaluated in this study. A total of 120 35-day-old male New Zealand White (NZW) rabbits were randomly distributed into four dietary experimental groups with 10 replicates per group and 3 animals per replicate. The control group was fed basal diet with a Zn-free vitamin-mineral premix; the other three groups received control basal diet supplemented with 50 mg/kg level with zinc oxide (ZnO; as inorganic source), Zn-methionine (Zn-Met; as organic source) and zinc oxide nanoparticles (nano-ZnO). Read More

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The Risk of Fractures in Primary Hyperparathyroidism: A Meta-Analysis.

JBMR Plus 2021 Apr 16;5(4):e10482. Epub 2021 Mar 16.

Department of Endocrinology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India.

Primary hyperparathyroidism (PHPT) is a common metabolic bone disease affecting 1% of the adult population. Patients with PHPT have reduced BMD, especially at the cortical bone. However, studies evaluating its impact on fracture risk have shown contradictory results. Read More

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High carbon-di-oxide modified atmospheric packaging on quality of ready-to-eat minimally processed fresh-cut iceberg lettuce.

Food Sci Biotechnol 2021 Mar 1;30(3):413-421. Epub 2021 Mar 1.

Department of Chemical and Food Engineering, Dhaka University of Engineering and Technology, Gazipur, 1707 Bangladesh.

Fresh-cut lettuce is a very well-known salad for today's routines because it obliges minimal preparation to minimize the loss of health beneficial vitamins, minerals, antioxidants and other phytochemicals. It is a prodigious challenge to serve its consumers fresh. Quality of freshly processed lettuce under high CO modified atmosphere packaging (MAP) has been investigated as a realistic alternative technique for its preservation. Read More

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Associated neonatal and maternal factors of osteopenia of prematurity in low resource setting: A cross-sectional study.

Ann Med Surg (Lond) 2021 Apr 26;64:102235. Epub 2021 Mar 26.

Department of Child Health, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Objective: Determining neonatal and maternal factors that are associated with the incidence of OFP.

Methods: This study employed a cross-sectional design, in which the participants were identified for clinical variables (sex, gestational age, birth weight, etc.), neonatal morbidity (sepsis, necrotizing enterocolitis (NEC), etc. Read More

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Efficacy of vitamin D supplementation on adult patients with non-alcoholic fatty liver disease: a single-center experience.

Gastroenterol Hepatol Bed Bench 2021 ;14(1):44-52

Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt.

Aim: The aim of this study was to determine the efficacy of a 6-month intramuscular vitamin D supplementation in improving the liver parameters in adult patients with non-alcoholic fatty liver disease (NAFLD).

Background: The association between vitamin D level and NAFLD has not been determined.

Methods: A single-blinded non-randomized controlled trial was conducted in 80 NAFLD patients assigned to receive a monthly single intramuscular dose of 200,000 IU cholecalciferol/vitamin D3 (n= 40), or placebo (n= 40) for six months. Read More

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January 2021

Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris.

Front Endocrinol (Lausanne) 2021 31;12:653685. Epub 2021 Mar 31.

Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.

Background: Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Although serum uric acid (SUA) has potent antioxidant properties, the findings of many epidemiological and experimental studies couldn't draw a clear conclusion on the relation between SUA and bone health. We aim to investigate the association between SUA and bone mineral density (BMD) at different skeletal sites among healthy Qataris. Read More

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Vitamin B3 levels in women who experience first-trimester miscarriage.

Aust N Z J Obstet Gynaecol 2021 Apr 18. Epub 2021 Apr 18.

ANU Medical School, Australian National University, Canberra, Australian Capital Territory, Australia.

Miscarriage is the most common complication in early pregnancy. It was recently reported in mice that miscarriage can be prevented through the administration of niacin. We conducted a prospective, exploratory pilot study involving 24 women who were less than 14 weeks pregnant. Read More

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Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic Review and Meta-Analysis.

Complement Med Res 2021 Apr 16:1-14. Epub 2021 Apr 16.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Background: Coenzyme Q10 (CoQ10) has been known as ubiquinone or ubidecarenone, which is a kind of lipid-soluble and vitamin-like antioxidant. It has a potent antioxidant effect against oxidation status via various mechanisms, including its ability to regenerate other antioxidants, such as vitamin E and vitamin C, and to increase antioxidant enzymes. Moreover, CoQ10 can quench free radicals and prevent lipid peroxidation. Read More

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Prenatal and perinatal factors associated with developing multiple sclerosis later in life: A systematic review and meta-analysis.

Autoimmun Rev 2021 Apr 15:102823. Epub 2021 Apr 15.

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Objective: Both genetic and environmental factors play roles in Multiple sclerosis (MS) etiopathogenesis. The relationship between prenatal/perinatal factors/exposures and future MS occurrence in the offspring remains controversial. Here, we aimed to review the available evidence on prenatal/perinatal factors associated with later MS occurrence. Read More

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A prospective cohort study of cord blood 25(OH)D3 and food allergies in 6-month-old Chinese infants.

Asian Pac J Allergy Immunol 2021 Apr 18. Epub 2021 Apr 18.

Department of Children Healthcare, Chongqing Health Center for Women and Children, 120 Longshan Road, Yubei District, Chongqing, China.

Background: Vitamin D is closely related to childhood allergic diseases, such as food allergies, atopic dermatitis, and asthma. However, it is unclear whether vitamin D status in the cord blood from mothers is related to food allergies in infants.

Objective: We performed a prospective cohort study on the relationship between the cord blood vitamin D [i. Read More

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The association between COVID-19 pandemic and maternal isolated hypothyroxinemia in first and second trimesters.

Psychoneuroendocrinology 2021 Apr 6;128:105210. Epub 2021 Apr 6.

School of Social Sciences, Nottingham Trent University, 3633, Burton Street, Nottingham NG1 4BU, UK. Electronic address:

Background: The outbreak of COVID-19 epidemic has induced entire cities in China placed under 'mass quarantine'. The majority of pregnant women have to be confined at home may be more vulnerable to stressors. In our study, we aimed to explore the effects of the epidemic on maternal thyroid function, so as to provide evidence for prevention and intervention of sustained maternal and offspring's health impairment produced by thyroid dysfunction. Read More

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The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial.

BMC Pediatr 2021 Apr 17;21(1):178. Epub 2021 Apr 17.

Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Attention-Deficit / Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, characterized by varying severity in attention deficit and hyperactivity. Studies have shown deficiencies in the serum level of magnesium and vitamin D in people with ADHD. The aim of this study is to determine the effect of vitamin D and magnesium supplementation on mental health in children with ADHD. Read More

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Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children with Cerebral Palsy.

Indian Pediatr 2021 Apr 17. Epub 2021 Apr 17.

Department of Orthopedics, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

Objectives: To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age and gender matched controls.

Methods: A cross-sectional study enrolled thirty children in each group: CP with epilepsy, CP without epilepsy, and healthy controls and bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.

Results: Z scores of BMD [-1. Read More

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Bone mineral density, bone microstructure, and bone turnover markers in females with temporomandibular joint osteoarthritis.

Clin Oral Investig 2021 Apr 16. Epub 2021 Apr 16.

Clinic of Oral Medicine and Orofacial Pain, Institute of Oral Health Science, Ajou University School of Medicine, 164, Worldcup-ro, Yeongtong-gu, Suwon, Gyeonggi-do, 16499, Republic of Korea.

Objective: The pathogenesis of the temporomandibular joint osteoarthritis (TMJ OA) has not been clearly revealed. This study aimed to investigate the pathogenesis of TMJ OA based on bone metabolism.

Methods: Fifty-nine young (mean age 23. Read More

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Relation of vitamin D and BsmI variant with temporomandibular diseases in the Turkish population.

Br J Oral Maxillofac Surg 2020 Aug 28. Epub 2020 Aug 28.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziosmanpasa University, Tokat, Turkey. Electronic address:

Vitamin D (VD) levels and several variants in the vitamin D receptor (VDR) gene are associated with the occurrence of diseases of the bones and cartilage. The aim of this research was to study and compare the association of the BsmI variant in the VDR gene as well as VD levels in disc displacement with reduction (DDR) between patients and healthy controls. This was a case-control study, in which 104 patients of DDR and 102 healthy individuals were studied. Read More

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Decreased circulatory levels of Vitamin D in Vitiligo: a meta-analysis.

An Bras Dermatol 2021 Mar 24. Epub 2021 Mar 24.

Department of Biochemistry, All India Institute of Medical Sciences, Bibinagar, India.

Background: The serum Vitamin D status in patients with vitiligo is ambiguous when compared to controls. A systematic review and updated meta-analysis were conducted to evaluate the association between Vitamin D and vitiligo.

Methods: Relevant studies were identified by searching PubMed and other databases. Read More

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Cyanocobalamin and/or calcitriol mitigate renal damage-mediated by tamoxifen in rats: Implication of caspase-3/NF-κB signaling pathways.

Life Sci 2021 Apr 16;277:119512. Epub 2021 Apr 16.

Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Aim: Tamoxifen (TAMO) is a chemotherapeutic drug used for the treatment of breast cancer. Nevertheless, there is a lack of information available in regarding its nephrotoxicity. The purpose of this work was to investigate the impact of cyanocobalamin (COB) and/or calcitriol (CAL) injections on TAMO-induced nephrotoxicity. Read More

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Diagnostic and Therapeutic Implications of Vitamin D Deficiency in Patients with Warts: A Case Controlled Study.

J Cosmet Dermatol 2021 Apr 15. Epub 2021 Apr 15.

Department of Dermatology, National Research Centre, Egypt.

Background: Cutaneous warts are frequent conditions that possess much challenge to treat.

Objective: To verify the potential role of vitamin D in the pathogenesis of viral warts by measuring the serum levels of vitamin D in patients diagnosed with viral warts compared to healthy controls and to verify whether oral vitamin D supplementation of those vitamin D- deficient patients would result in wart clearance.

Methods: To evaluate the serum vitamin D levels, the study recruited 80 subjects, including 40 patients diagnosed with viral warts and 40 age and sex matched healthy controls. Read More

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Molecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in late gestation.

Pediatr Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridgeshire, UK.

Background: In the fetus, the appropriate balance of prooxidants and antioxidants is essential to negate the detrimental effects of oxidative stress on lung maturation. Antioxidants improve respiratory function in postnatal life and adulthood. However, the outcomes and biological mechanisms of antioxidant action in the fetal lung are unknown. Read More

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The Relationship of Vitamin D Deficiency with Severity and Outcome of Acute Stroke.

Rom J Intern Med 2021 Apr 13. Epub 2021 Apr 13.

M.D., General Physician, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

: There are currently conflicting results regarding the link between vitamin D deficiency and increased risk for stroke and its poor prognosis. The present study aimed to assess the relationship between vitamin D deficiency and prognosis of acute stroke.: This bi-center cross-sectional study was performed on 140 consecutive patients who referred to two general hospitals in Iran with the diagnosis of acute stroke. Read More

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Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis.

Front Nutr 2021 29;8:660420. Epub 2021 Mar 29.

Department of Child Health, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.

This systematic review and meta-analysis aimed to assess whether low serum 25-hydroxyvitamin D (25-OHD) level is associated with susceptibility to COVID-19, severity, and mortality related to COVID-19. Systematic literature searches of PubMed, Scopus, and Embase database up until 9 December 2020. We include published observational prospective and retrospective studies with information on 25-OHD that reported main/secondary outcome. Read More

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Association between deficient levels of circulating vitamin D, dietary intake of vitamin D, calcium and retinol, and risk of colorectal cancer in an Iranian population: A case control study.

Asia Pac J Clin Oncol 2021 Apr 14. Epub 2021 Apr 14.

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Aim: We aimed to assess the association between deficient levels of circulating vitamin D, dietary intake of vitamin D, calcium and retinol, and risk of colorectal cancer in an Iranian population.

Methods: In this retrospective case-control study that was conducted between 2012 and 2015, 278 first incident colorectal cancer cases (colon cancer = 103; rectal cancer = 175), and 278 sex and age matched healthy controls (HCs) were recruited. Serum 25(OH)D, dietary vitamin D, and calcium intake were assessed. Read More

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PECULIARITIES OF CHANGES IN HOMOCYSTEINE LEVELS DEPENDING ON VITAMIN STATUS IN PATIENTS WITH CHRONIC PANCREATITIS AND TYPE 2 DIABETES.

Wiad Lek 2021 ;74(1):98-101

STATE HIGHER EDUCATIONAL INSTITUTION «UZHHOROD NATIONAL UNIVERSITY» UZHHOROD, UKRAINE.

Objective: The aim: To determine the peculiarities of changes in the homocysteine levels in the patients with chronic pancreatitis and type 2 diabetes blood serum depending on the vitamin status.

Patients And Methods: Materials and methods: We investigated 36 patients with chronic pancreatitis and type 2 diabetes, who were included in the first group of the patients examined; Group 2 consisted of 34 patients with chronic pancreatitis; and Group 3 of the patients examined consisted of 40 patients with type 2 diabetes.

Results: Results: All patients examined were diagnosed with type 2 diabetes mellitus of moderate severity. Read More

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Hemostatic rebalance in neonatal intrahepatic cholestasis with citrin deficiency.

Pediatr Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Pediatrics, Nara Medical University, Kashihara, Nara, 634-8522, Japan.

Background: Neonatal intrahepatic cholestasis with citrin deficiency (NICCD) results in coagulopathy due to decreased levels of vitamin (V)K-dependent clotting factors, similar to biliary atresia (BA). However, the involvement of VK-independent coagulant and anticoagulant factor(s) remains unknown.

Aims: To examine relationships between coagulant and anticoagulant potential, with addition to the influence of nutritional treatment, in NICCD. Read More

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Gestational Folate and Folic Acid Intake among Women in Canada at Higher Risk of Pre-Eclampsia.

J Nutr 2021 Apr 13. Epub 2021 Apr 13.

OMNI Research Group, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Background: Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube defects; however, the extent to which recommendations are met through dietary sources and supplements is not clear.

Objectives: Our objective was to evaluate the dietary and supplemental intakes of FA in a Canadian pregnancy cohort and to determine the proportions of pregnant women exceeding the Estimated Average Requirement (EAR) and Tolerable Upper Intake Level (UL).

Methods: FACT (the Folic Acid Clinical Trial) was an international multicenter, randomized, double-blinded, placebo-controlled, phase III trial investigating FA for the prevention of pre-eclampsia in high-risk pregnancies. Read More

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The Relationship Between Vitamin D Status and Cardiovascular Diseases.

Curr Probl Cardiol 2021 Mar 19;46(7):100836. Epub 2021 Mar 19.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, UK; Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK. Electronic address:

With cardiovascular conditions being a leading cause of mortality and morbidity globally, several studies have identified that there is an important correlation between the level of Vitamin D and cardiovascular diseases, including an increased risk of hypertension, heart failure, and coronary artery diseases. Current published studies are in the form of both in vivo and in vitro studies and they primarily showed the evidence of how Vitamin D can downregulate Renin-Angiotensin-Aldosterone system activity and therefore providing a cardioprotective role. Nevertheless, most of these studies are observational, and there yet to be large-scale randomized controlled trials which would increase the evidence of the findings. Read More

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Screening for Vitamin D Deficiency in Adults: US Preventive Services Task Force Recommendation Statement.

JAMA 2021 04;325(14):1436-1442

Tufts University School of Medicine, Boston, Massachusetts.

Importance: Vitamin D is a fat-soluble vitamin that performs an important role in calcium homeostasis and bone metabolism and also affects many other cellular regulatory functions outside the skeletal system. Vitamin D requirements may vary by individual; thus, no one serum vitamin D level cutpoint defines deficiency, and no consensus exists regarding the precise serum levels of vitamin D that represent optimal health or sufficiency.

Objective: To update its 2014 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a systematic review on screening for vitamin D deficiency, including the benefits and harms of screening and early treatment. Read More

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A case report of acquired methemoglobinemia rescued by veno-venous extracorporeal membrane oxygenation.

Medicine (Baltimore) 2021 Apr;100(15):e25522

Division of Cardiovascular Surgery, Department of Surgery, China Medical University Hospital, Taichung, Taiwan.

Rationale: Severe methemoglobinemia (Met-Hb) is rare. The delayed diagnosis and treatment often cause further damage. The management of cellular hypoxemia is challenging and the use of extra-corporeal membrane oxygenation (ECMO) has never been reported. Read More

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Hypercalcemia associated with the interaction between all trans retinoic acid and posaconazole in an acute promyelocytic leukemia case.

J Oncol Pharm Pract 2021 Apr 13:10781552211007889. Epub 2021 Apr 13.

Department of Hematology, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Introduction: All-trans retinoic acid (ATRA) is a physiological metabolite of vitamin A and it is used for the treatment of acute promyelocytic leukemia (APL). Hypercalcemia is a rare side effect of ATRA and it may be potentiated after interaction of ATRA with azole group antifungals. Herein, we have reported an APL case with hypercalcemia that is caused by the interaction of ATRA and posaconazole. Read More

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