76,186 results match your criteria level kidney


Associations between long-term exposure to low-level air pollution and risk of chronic kidney disease-findings from the Malmö Diet and Cancer cohort.

Environ Int 2022 Jan 15;160:107085. Epub 2022 Jan 15.

Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: Associations between air pollution and chronic kidney disease (CKD) have been reported, but studies at low exposure levels and relevant exposure time windows are still warranted. This study investigated clinical CKD at low air pollution levels in the Swedish Malmö Diet and Cancer Cohort in different exposure time windows.

Methods: This study included 30,396 individuals, aged 45-74 at enrollment 1991-1996. Read More

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January 2022

The modulatory effect of carvacrol on viral shedding titer and acute phase response in broiler chickens experimentally infected with infectious bronchitis virus.

Microb Pathog 2022 Jan 15:105410. Epub 2022 Jan 15.

Department of Clinical Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Infectious bronchitis virus (IBV) is one of the major respiratory diseases of broiler causing huge economic losses. The inability to control IBV using different vaccination programs owing to the high mutation rate and recombination ability of the RNA genome generates IBV variants. This study was designed to give a specific perspective of carvacrol effect on early immune response, viral shedding titer, oxidative stress, serum biochemical parameters and clinical consequences in broilers experimentally infected by IBV. Read More

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January 2022

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults.

N Engl J Med 2022 Jan 18. Epub 2022 Jan 18.

From the George Institute for Global Health and the University of New South Wales (S.F., S.M., N.H., L.B., A.D., M.G., Q.L., J. Mysore, M.S., C.T., J. Myburgh), the Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital (N.H., A.D.), the Northern Clinical School (A.D.) and the Central Clinical School (D.G.), University of Sydney, the Intensive Care Unit, Royal Prince Alfred Hospital (D.G.), the Department of Intensive Care, St. George Hospital (M.S., J. Myburgh), and the Intensive Care Unit, Bankstown Hospital (M.S.), Sydney, and the Intensive Care Unit, Austin Hospital (R.B.), the Department of Intensive Care, Royal Melbourne Hospital (R.B.), the Department of Critical Care, University of Melbourne (R.B., P.Y.), and the Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University (R.B., P.Y.), Melbourne, VIC - all in Australia; the School of Public Health, Imperial College London, London (S.F.); and the Medical Research Institute of New Zealand (L.N., D.M., P.Y.) and the Department of Intensive Care, Wellington Regional Hospital (L.N., P.Y.) - both in Wellington.

Background: Whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution (saline) in critically ill patients reduces the risk of acute kidney injury or death is uncertain.

Methods: In a double-blind, randomized, controlled trial, we assigned critically ill patients to receive BMES (Plasma-Lyte 148) or saline as fluid therapy in the intensive care unit (ICU) for 90 days. Read More

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January 2022

Identification of glomerulosclerosis using IBM Watson and shallow neural networks.

J Nephrol 2022 Jan 18. Epub 2022 Jan 18.

Nephrology, Dialysis, and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.

Background: Advanced stages of different renal diseases feature glomerular sclerosis at a histological level which is observed by light microscopy on tissue samples obtained by performing a kidney biopsy. Computer-aided diagnosis (CAD) systems leverage the potential of artificial intelligence (AI) in healthcare to support physicians in the diagnostic process.

Methods: We propose a novel CAD system that processes histological images and discriminates between sclerotic and non-sclerotic glomeruli. Read More

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January 2022

Assessment of cobalt in wheat grains as affected by diverse fertilizers: implications for public health.

Environ Sci Pollut Res Int 2022 Jan 18. Epub 2022 Jan 18.

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Present study was conducted to check the heavy metal content in wheat treated with municipal solid waste, Although municipal solid waste was enriched with organic nutrient, micronutrients, and macro-nutrients, considerable amount of cobalt was also witnessed in municipal solid waste that s why pot experiment was executed. The concentration of cobalt in different parts of wheat (root, shoot, and grain) was analyzed by atomic absorption spectrophotometer (AA-6300 Shimadzu Japan). Highest concentration of cobalt in root, shoot, and grain of wheat was observed in the range of 0. Read More

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January 2022

Knockdown of circRNA-Memo1 Reduces Hypoxia/Reoxygenation Injury in Human Brain Endothelial Cells Through miRNA-17-5p/SOS1 Axis.

Mol Neurobiol 2022 Jan 18. Epub 2022 Jan 18.

Department of Neurology, Hunan Provincial People's Hospitaland The First Affiliated Hospital of Hunan Normal UniversityHunan Province, No.569, Wangjiali Road, Changsha, 410016, People's Republic of China.

Circ-Memo1 has been proved to be upregulated in ischemia-reperfusion induced acute injury of kidney tissues. However, the potential role of circ-Memo1 in cerebral hypoxia/reoxygenation (H/R) injury is still unclear.Blood samples were collected from 25 ischemic stroke patients and 25 healthy controls. Read More

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January 2022

Metabolic alkalosis in infants treated with peritoneal dialysis.

Pediatr Nephrol 2022 Jan 18. Epub 2022 Jan 18.

Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: Acid-base balance is maintained by kidney excretion of titratable acids and bicarbonate reabsorption. Metabolic alkalosis is uncommon in dialysis-treated patients. The aim of this retrospective study was to assess the rate of metabolic alkalosis in pediatric patients treated with peritoneal dialysis. Read More

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January 2022

Phenotypic Drift in Lupus-Prone MRL/lpr Mice: Potential Roles of MicroRNAs and Gut Microbiota.

Immunohorizons 2022 Jan 17;6(1):36-46. Epub 2022 Jan 17.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA;

MRL/lpr mice have been extensively used as a murine model of lupus. Disease progression in MRL/lpr mice can differ among animal facilities, suggesting a role for environmental factors. We noted a phenotypic drift of our in-house colony, which was the progeny of mice obtained from The Jackson Laboratory (JAX; stocking number 000485), that involved attenuated glomerulonephritis, increased splenomegaly, and reduced lymphadenopathy. Read More

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January 2022

Tranexamic acid-induced ureteric clot obstruction in a patient with urothelial cell carcinoma resulting in upper urinary tract perforation.

BMJ Case Rep 2022 Jan 17;15(1). Epub 2022 Jan 17.

Department of Urology, Aberdeen Royal Infirmary, Aberdeen, UK.

This is the first report of upper urinary tract (UUT) perforation secondary to tranexamic acid (TXA) induced ureteric clot obstruction. A 77-year-old woman was referred to the urology department with intermittent, painless visible haematuria from a lesion in the right upper calyx, suspicious of urothelial cell carcinoma. She did not have any flank pain or blood clots in her urine. Read More

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January 2022

Toxicity studies and anti-arthritic effect of mandelic acid (2-hydroxy -2-phenyl acetic acid) using in vitro and in vivo techniques.

Pak J Pharm Sci 2021 Nov;34(6(Supplementary)):2281-2287

Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, USA.

The major concern to search for new anti-arthritic drugs is primarily to prevent systemic complications and to maintain quality of life. As these drugs are prescribed for long duration so the objective is to ensure their safety in terms of toxicity. By keeping in view this concept, the present study was investigated to determine new anti-arthritic potential using in-vitro and in-vivo methods. Read More

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November 2021

3D transesophageal echocardiography for guiding transcatheter aortic valve replacement without prior cardiac computed tomography in patients with renal dysfunction.

Cardiovasc Revasc Med 2022 Jan 13. Epub 2022 Jan 13.

Department of Cardiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA. Electronic address:

Background: Pre-procedural chronic kidney disease (CKD) and in-hospital acute kidney injury (AKI) are associated with worse outcomes following transcatheter aortic valve replacement (TAVR). We tested the feasibility of reducing overall AKI by avoiding pre-procedural cardiac CT angiography (CCTA) by using direct 3D-TEE guidance in TAVR patients with known CKD.

Methods: An institutional TAVR database was examined from January 2016 to June 2020 to identify 396 patients in whom CCTA sizing was performed and 54 patients with creatinine (Cr) of >1. Read More

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January 2022

Differential Afa/Dr Fimbriae Expression in the Multidrug-Resistant Escherichia coli ST131 Clone.

mBio 2022 Jan 18:e0351921. Epub 2022 Jan 18.

School of Chemistry and Molecular Biosciences, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.

Many antibiotic resistant uropathogenic Escherichia coli (UPEC) strains belong to clones defined by their multilocus sequence type (ST), with ST131 being the most dominant. Although we have a good understanding of resistance development to fluoroquinolones and third-generation cephalosporins by ST131, our understanding of the virulence repertoire that has contributed to its global dissemination is limited. Here we show that the genes encoding Afa/Dr fimbriae, a group of adhesins strongly associated with UPEC that cause gestational pyelonephritis and recurrent cystitis, are found in approximately one third of all ST131 strains. Read More

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January 2022

Sclerostin protects against vascular calcification development in mice.

J Bone Miner Res 2022 Jan 17. Epub 2022 Jan 17.

Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Belgium.

Sclerostin is a negative regulator of the Wnt/β-catenin signaling and is, therefore, an important inhibitor of bone formation and turnover. Since ectopic vascular calcification develops in a similar way to bone formation, one might reasonably attribute a role to sclerostin in this pathological process. Ectopic calcification, especially vascular calcification, importantly contributes to mortality in elderly and patients with diabetes, osteoporosis, chronic kidney disease (CKD) and hypertension. Read More

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January 2022

Single-pass albumin dialysis and hemoadsorption for bilirubin and bile acids removal for a child with hyperbilirubinemia after ventricular assist device implantation.

J Artif Organs 2022 Jan 17. Epub 2022 Jan 17.

Department of Paediatrics and Adolescent Medicine, The Hong Kong Children's Hospital, Doctor's Office, 9/F, Tower B, 1 Shing Cheong Road, Kowloon Bay, Kowloon, Hong Kong SAR.

We report the successful management of hyperbilirubinemia using two different modalities of extracorporeal bilirubin removal therapy for a pediatric patient. A 13-year-old boy with dilated cardiomyopathy requiring veno-arterial extracorporeal membrane oxygenation (VA-ECMO) developed acute kidney injury and was dependent on continuous renal replacement therapy. He developed hyperbilirubinemia with a peak total bilirubin level of 786 μmol/L after implantation of biventricular assist device (BiVAD). Read More

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January 2022

Survival Rate of Renal Transplant and Factors Affecting Renal Transplant Failure.

Exp Clin Transplant 2022 Jan 14. Epub 2022 Jan 14.

From the Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: The most important complication in kidney transplant is acute/chronic rejection. In this study, we investigated the factors affecting kidney rejection and transplant survival.

Materials And Methods: In this survival analysis study, 352 patients (mean follow-up of 12. Read More

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January 2022

Factors Affecting Knowledge Levels and Protective Behaviors to Prevent the Development of Skin Cancer in Organ Transplant Recipients as a High-Risk Group.

Exp Clin Transplant 2022 Jan 14. Epub 2022 Jan 14.

From the Department of Surgical Nursing, Dokuz Eylül University Nursing Faculty, Izmir, Turkey.

Objectives: Organ transplant recipients are at high risk of skin cancer due to immunosuppressant therapy. This study investigated the factors affecting organ transplant recipients' knowledge and protective behaviors to prevent the development of skin cancer.

Materials And Methods: This was a cross-sectional descriptive study of kidney (n = 82) and liver (n = 31) transplant recipients seen at our hospitals in Turkey from June 2019 to February 2020. Read More

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January 2022

Impact of early life development on later onset chronic kidney disease and hypertension and the role of evolutionary trade-offs.

Exp Physiol 2021 Dec 17. Epub 2021 Dec 17.

Department of Pediatrics, The University of Virginia, Charlottesville, Virginia, USA.

New Findings: What is the topic of this review? In this report, we summarize the latest clinical evidence linking developmental programming in the kidney to later life blood pressure and kidney disease. What advances does it highlight? Population-level studies now show convincingly that low birth weight, fetal growth restriction and preterm birth are associated with and have a synergistic impact on the risk of kidney disease in later life. A new approach also considers how evolutionary selection pressure might fail to select for long-term robustness of kidney function. Read More

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December 2021

Serum Creatinine Reference Limits in Pediatric Population-A Single Center Electronic Health Record-Based Database in Taiwan.

Front Pediatr 2021 30;9:793446. Epub 2021 Dec 30.

Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan.

To assess age- and sex-specific serum creatinine levels in a pediatric population using a hospital-based database in Taiwan. Data on serum creatinine levels were obtained from the National Taiwan University Hospital-integrated Medical Database (NTUH-iMD). Due to the possibility of having acute kidney injury or chronic kidney disease, individuals with multiple serum creatinine measurements were excluded, and outliers in each age- and sex-specific group were also subsequently removed. Read More

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December 2021

Assessment of the effect of sub-lethal acute toxicity of Emamectin benzoate in using multiple biomarker approach.

Toxicol Rep 2022 5;9:102-110. Epub 2022 Jan 5.

Department of Agricultural Chemicals, Faculty of Agriculture, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia, 741252 West Bengal, India.

Emamectin benzoate (EMB) is a potent neurotoxin agent, widely used for ectoparasites control in aquaculture, but their detailed toxicological implications in are unknown. Thus, this study was conceptualized to determine the LC and to investigate the effects of two sub-lethal concentrations 1/50th of 96 h LC (1.82 μgL) and 1/10thof 96 h LC (9. Read More

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January 2022

Higher ambient nitrogen dioxide is associated with an elevated risk of hospital-acquired acute kidney injury.

Clin Kidney J 2022 Jan 7;15(1):95-100. Epub 2021 Sep 7.

Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China.

Background: Previous studies have suggested that long-term exposure to air pollution increases the risk of chronic kidney disease and its progression. However, the effect of air pollution on the risk of acute kidney injury (AKI) has not been studied. We aim to evaluate the transient effect of air pollution on the risk of hospital-acquired AKI (HA-AKI). Read More

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January 2022

Prevalence and factors associated with hyperkalaemia in stable kidney transplant recipients.

Clin Kidney J 2022 Jan 10;15(1):43-50. Epub 2021 Jul 10.

Clinic of Nephrology and Renal Transplantation, Laiko General Hospital, National and Kapodistrian University, Medical School of Athens, Athens, Greece.

Background: Hyperkalaemia is a frequent and potentially life-threatening condition in patients with chronic kidney disease (CKD). Even after successful kidney transplantation (KTx), KTx recipients have mild to severe CKD. Moreover, they share comorbid conditions and frequently use medications that predispose to hyperkalaemia. Read More

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January 2022

Biostatistics of VHL-Gene Transfection in the Health Informatics Analysis of Renal Cell Carcinoma.

Comput Math Methods Med 2022 7;2022:5297580. Epub 2022 Jan 7.

Department of Urology Surgery, Fuxin Centre Hospital, Fuxin 123000, China.

Objective: In this paper, we study the role of the VHL gene in regulating the proliferation and apoptosis of renal cell carcinoma, as well as the safety and transfection efficiency of ultrasound microbubble gene transfection technology.

Method: We use kidney cancer cell lines as an in vitro research object and apply ultrasound microbubble gene transfection technology to transfect the VHL gene into kidney cancer cell line (786-0). The proliferation and apoptosis of cells were measured to clarify the inhibitory effect of the VHL gene in renal cell carcinoma. Read More

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January 2022

The Role and Mechanism of SIRT6 in Regulating Phenotype Transformation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm.

Comput Math Methods Med 2022 6;2022:3200798. Epub 2022 Jan 6.

Department of Vascular Surgery, Affiliated Hospital of Qingdao University, Qingdao 266700, China.

Background: Data mining of current gene expression databases has not been previously performed to determine whether sirtuin 6 (SIRT6) expression participates in the pathological process of abdominal aortic aneurysm (AAA). The present study was aimed at investigating the role and mechanism of SIRT6 in regulating phenotype transformation of vascular smooth muscle cells (VSMC) in AAA.

Methods: Three gene expression microarray datasets of AAA patients in the Gene Expression Omnibus (GEO) database and one dataset of SIRT6-knockout (KO) mice were selected, and the differentially expressed genes (DEGs) were identified using GEO2R. Read More

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January 2022

Clinical efficacy of linagliptin combined with irbesartan in patients with diabetic nephropathy.

Pak J Med Sci 2022 Jan-Feb;38(1):52-56

Wei-xuan Du Department of Education, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, China.

Objective: To determine the clinical efficacy of linagliptin combined with irbesartan in patients with diabetic nephropathy (DN).

Methods: Seventy-two patients who were admitted to our department of endocrinology in our hospital during January 2018 and June 2019 were randomly divided into a control group (administered with irbesartan only, n=36) and a treatment group (treated with irbesartan and linagliptin, n=36). The course of treatment lasted for three months. Read More

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Transcriptome Profiling of Atlantic Salmon () Parr With Higher and Lower Pathogen Loads Following Infection.

Front Immunol 2021 31;12:789465. Epub 2021 Dec 31.

Department of Ocean Sciences, Memorial University of Newfoundland, St. John's, NL, Canada.

Salmonid rickettsial septicemia (SRS), caused by , is one of the most devastating diseases of salmonids. However, the transcriptomic responses of Atlantic salmon () in freshwater to an EM-90-like isolate have not been explored. Here, we infected Atlantic salmon parr with an EM-90-like isolate and conducted time-course qPCR analyses of pathogen load and four biomarkers (, , , ) of innate immunity on the head kidney samples. Read More

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December 2021

Artificial Intelligence Algorithm-Based Lumbar and Spinal MRI for Evaluation of Efficacy of Chinkuei Shin Chewan Decoction on Lumbar Spinal Stenosis.

Contrast Media Mol Imaging 2021 29;2021:2700452. Epub 2021 Dec 29.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

The study aimed to explore the application value of lumbar Magnetic Resonance Imaging (MRI) images processed by artificial intelligence algorithms in evaluating the efficacy of chinkuei shin chewan decoction (a traditional Chinese medicine to nourish the kidney) in the treatment of lumbar spinal stenosis (LSS). Specifically, 110 LSS patients admitted to the hospital were selected as the research subjects. They were randomly divided into the control group ( = 55) and experimental group ( = 55) according to different treatment methods. Read More

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December 2021

Severe Anion Gap Metabolic Acidosis Resulting from Combined Chronic Acetaminophen Toxicity and Starvation Ketosis: A Case Report and Literature Review.

Authors:
Thomas Kalinoski

Am J Case Rep 2022 Jan 17;23:e934410. Epub 2022 Jan 17.

Department of Internal Medicine, Olive View - UCLA Medical Center, Sylmar, CA, USA.

BACKGROUND Chronic acetaminophen toxicity has been known to cause an anion gap metabolic acidosis (AGMA) due to accumulation of 5-oxoproline metabolites. This diagnosis requires a high index of suspicion when evaluating a patient with AGMA as occasional acetaminophen use is very common among patients, whom oftentimes are not entirely truthful about the extent of ingestion and have multiple comorbid conditions complicating diagnosis.  CASE REPORT A 68-year-old male with multiple medical comorbidities presented to the emergency room with recurrent generalized weakness. Read More

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January 2022

Detection of the mineral constituents in human renal calculi by vibrational spectroscopic analysis combined with allied techniques Powder XRD, TGA, SEM, IR imaging and TXRF.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jan 7;270:120867. Epub 2022 Jan 7.

Energy and Biophotonics Laboratory, Department of Physics, AMET, Kanathur, Chennai 603 112, India.

Detection of the mineral constituents in a batch of 310 samples of human urinary calculi (kidney stones-235 and bladder stones-75) combined with a semi-quantitative analysis has been presented on the basis of Fourier Transform based IR and Raman spectral measurements. Some of the observed characteristic IR and Raman bands have been proposed as 'Marker Bands' for the most reliable identification of the constituents. A detailed vibrational spectral analysis combined with a DFT level calculation for the functional groups in Calcium Oxalate Monohydrate (COM), Magnesium Ammonium Phosphate Hexahydrate (MAPH), Calcium Hydrogen Phosphate Dihydrate (CHPD), Penta-Calcium Hydroxy-Triphosphate (PCHT) and Uric Acid (UA) has been proposed. Read More

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January 2022

Protective effects of Polygonatum kingianum polysaccharides and aqueous extract on uranium-induced toxicity in human kidney (HK-2) cells.

Int J Biol Macromol 2022 Jan 13. Epub 2022 Jan 13.

Institute of Materials, China Academy of Engineering Physics, Mianyang 621907, China. Electronic address:

The current detoxification options of uranium, a toxic radioactive heavy metal, have obvious side effects. Polygonatum kingianum (PK), a natural product with the function of antioxidant, may be effective in detoxification and prevention of uranium-induced nephrotoxicity. Here, we studied the protective effects of PK polysaccharides (PKP) and aqueous extract (PKAE) on uranium-induced toxicity in human kidney (HK-2) cells. Read More

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January 2022

Analysis of the Performance of Daily Surgery Score (CASUS) in Patients with Mixed Racial Profile after Cardiac Surgery: A Single-Center Retrospective Study.

J Cardiothorac Vasc Anesth 2021 Dec 7. Epub 2021 Dec 7.

Medical Research Center, Hamad Medical Corporation, Doha, Qatar. Electronic address:

Objective: The aim was to look at the Cardiac Surgery Score (CASUS) assessment after cardiac surgery, and compare it with the intensive care unit (ICU) mortality and morbidity, in a racially diverse group of patients, in a single center.

Design: Clinical retrospective study analyzing data from 319 patients over a 1-year duration.

Setting: Cardiothoracic intensive care unit (CTICU) of a tertiary care center. Read More

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December 2021