465 results match your criteria level il-33

[Menthol promotes cytokine secretion in human bronchial epithelial BEAS-2B cells by activating transient receptor potential melastatin 8 (TRPM8)].

Yixin Hu Minchao Li

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Jul;37(7):577-584

Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. *Corresponding author, E-mail:

Objective To explore the role of transient receptor potential melastatin 8 (TRPM8) in the expression of airway epithelial-derived cytokines interleukin 25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP) in human bronchial epithelial BEAS-2B cells induced by menthol and its related signal transduction mechanism. Methods BEAS-2B cells were treated with 2 mmol/L menthol for 1, 2, 3 and 4 hours. The groups with the higher expression of IL-25, IL-33, TSLP or Ca were chosen to carry out the following experiments. Read More

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Inflammatory cytokines and appetite in older hospitalized patients.

Appetite 2021 Jun 14:105470. Epub 2021 Jun 14.

Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-Universität Bochum, Germany.

It has already been confirmed that the decline in appetite during disease is a common issue and the biologic players of inflammation such as cytokines may serve as mediators of this effect. This study aimed to investigate the association of appetite with individual cytokines that could be involved in the inflammation-associated loss of appetite in acutely ill older hospitalized patients. 191 patients (mean age 81. Read More

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Effect of IL-33 on pyroptosis of macrophages in mice with sepsis via NF-κB/p38 MAPK signaling pathway.

Acta Cir Bras 2021 14;36(5):e360501. Epub 2021 Jun 14.

PhD. The 2nd Clinical Medical College - Zhejiang Chinese Medical University - Hangzhou - Zhejiang, China.

Purpose: To demonstrate the effect of IL-33 on the macrophage pyroptosis in mice with sepsis through the NF-kB/p38 MAPK signal pathway.

Methods: In total, 24 C57BL/6 mice were divided into the sham operation group (sham) and the cecal ligation and puncture group (CLP). After CLP, 24 IL-33-/- mice were divided into the IL-33-/- group and the IL-33-/- intervention group. Read More

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IL-31, itch and hematological malignancies.

Clin Mol Allergy 2021 Jun 12;19(1). Epub 2021 Jun 12.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125, Messina, Italy.

Pruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and could be due to an unbalanced production of humoral mediators by altered immune effector cells. IL-31 is a pro-inflammatory cytokine produced by CD4 + T helper cells. Read More

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Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver.

Cells 2021 May 24;10(6). Epub 2021 May 24.

Research Center for Endocrine and Metabolic Diseases, School of Medicine, Chungnam National University, 282 Munhwaro, Daejeon 35015, Korea.

Interleukin-4 (IL-4) and IL-13 are the major T helper 2 (Th2) cytokines, and they are involved in the regulation of metabolism in the adipose tissue. The liver contains diverse innate and adaptive immune cells, but it remains to be determined whether Th2 cytokines modulate energy metabolism in the liver. Here, using gene expression data from the Gene Expression Omnibus (GEO) and the BXD mouse reference population, we determined that the Th2 cytokines IL-4 and IL-13 increase the secretion of fibroblast growth factor 21 (FGF21) in the liver. Read More

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IL-16 and BCA-1 Serum Levels Are Associated with Disease Severity of Infection.

Pathogens 2021 May 20;10(5). Epub 2021 May 20.

The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

infection (CDI) is associated with a high risk for complications and death, which requires identifying severe patients and treating them accordingly. We examined the serum level of six cytokines and chemokines (IL-16, IL-21, IL-23, IL-33, BCA-1, TRAIL) and investigated the association between them and patients' disease severity. Concentrations of six cytokines and chemokines were measured using the MILLIPLEXMAP kit (Billerica, MA, USA) in serum samples attained from CDI patients within 24-48 h after laboratory confirmation of presence. Read More

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Plasma Interleukin-33 level in relapsing-remitting multiple sclerosis. Is it negatively correlated with central nervous system lesions in patients with mild disability?

Clin Neurol Neurosurg 2021 Jul 20;206:106700. Epub 2021 May 20.

Department of Otorhinolaryngology and Oncological Laryngology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.

Background: Cytokines and chemokines are undoubtedly involved in the pathogenesis of multiple sclerosis (MS). There are many reports that suggest a significant role for Interleukin-33 (IL-33) in the course of MS development, but it is not clear whether negative or positive. We therefore investigated plasma IL-33 levels in patients with relapsing-remitting MS (RRMS). Read More

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TLR7 Agonist Suppresses ILC2-mediated Inflammation via IL-27-producing Interstitial Macrophages.

Am J Respir Cell Mol Biol 2021 May 18. Epub 2021 May 18.

Keio University School of Medicine, Pulmonary Medicine, Shinjuku-ku, Japan.

Group 2 innate lymphoid cells (ILC2s) play an important role in the pathophysiology of asthma via the robust production of type 2 cytokines. Recent studies have demonstrated that Toll-like receptor 7 (TLR7) signaling skews toward a type 1 inflammatory response in asthma, which may lead to the development of novel treatment strategies. However, the effect of TLR7 signaling on ILC2-dependent non-allergic eosinophilic inflammation remains unclear. Read More

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Efficacy of parasternal block to decrease intraoperative opioid use in coronary artery bypass surgery via sternotomy: a randomized controlled trial.

Reg Anesth Pain Med 2021 May 14. Epub 2021 May 14.

Clinical Research Department, CMC Ambroise Paré, Neuilly-sur-Seine, France.

Objective: This study aims to assess the effect of a preoperative parasternal plane block (PSB) on opioid consumption required to maintain hemodynamic stability during sternotomy for coronary artery bypass graft surgery.

Methods: This double-blind, randomized, placebo-controlled trial prospectively enrolled 35 patients scheduled for coronary artery bypass graft surgery under general anesthesia with propofol and remifentanil. Patients were randomized to receive preoperative PSB using either ropivacaine (PSB group) or saline solution (placebo group) (1:1 ratio). Read More

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Aggravation of airway inflammation in RSV-infected asthmatic mice following infection-induced alteration of gut microbiota.

Ann Palliat Med 2021 May 10;10(5):5084-5097. Epub 2021 May 10.

Department of Traditional Chinese Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: This study aimed to confirm the relationship between asthma, respiratory syncytial virus (RSV) infection, and the gut environment by analyzing the alterations in the gut microbiota of RSV-infected asthmatic mice.

Methods: Twenty-four male BALB/c mice were randomly separated into a control group (CON), ovalbumin (OVA) group, and an OVA + RSV group, (n=8 mice/group). At the end of experiments, we evaluated the RSV-infected asthma model using Wright-Giemsa staining, histopathology and immunoglobulin E (IgE) level using enzyme-linked immunosorbent assays (ELISA). Read More

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Effect of sodium butyrate regulating IRAK1 (interleukin-1 receptor-associated kinase 1) on visceral hypersensitivity in irritable bowel syndrome and its mechanism.

Bioengineered 2021 Dec;12(1):1436-1444

Department of Gastroenterology, Daping Hospital, Army Medical University, Chongqing, PR China.

The current study aimed to investigate the effects of sodium butyrate on the level of colonic protein IRAK1 (interleukin-1 receptor-associated kinase 1) in irritable bowel syndrome (IBS) models as well as revealing the relationship between IRAKI level and visceral sensitivity during the progression of IBS. IBS symptoms were induced using TNBS (2,4,6-trinitrobenzene sulfonic acid) in mice and using IL-33 in HT-29 cells, which were then hanlded with sodium butyrate (100 mM for each mice and 0.05 M for HT-29 cells). Read More

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December 2021

Immunoregulatory Effects of Somatic Extract of on Airway Inflammations in Murine Model.

Iran J Parasitol 2020 Oct-Dec;15(4):500-510

Victor Caeiro Laboratory of Parasitology, MED-Mediterranean Institute for Agriculture, Environment and Development, Department of Veterinary Medicine, IIFA, University of Évora, Pólo da Mitra, Évora, Portugal.

Background: The immunomodulatory role of many parasites is well-documented. The current study designed to assess the immunoregulatory effects of the somatic extract (SE) of on murine model of airway inflammations.

Methods: The experiment was performed in department of parasitology of Tarbiat Mo-dares University, Tehran, Iran from November 2018 to May 2019. Read More

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IL-33 as a Novel Serum Prognostic Marker of Intracerebral Hemorrhage.

Oxid Med Cell Longev 2021 26;2021:5597790. Epub 2021 Mar 26.

Department of Breast Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000 Liaoning Province, China.

Objective: Interleukin 33 (IL-33) is a key cytokine involved in inflammation and oxidative stress. The significance of serum IL-33 levels on the prognosis of patients with intracerebral hemorrhage (ICH) has not been well studied. The purpose of this study is to determine whether there is a relationship between the serum IL-33 level and the prognosis of patients with ICH upon admission. Read More

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Hybrid cytokine IL233 renders protection in murine acute graft vs host disease (aGVHD).

Cell Immunol 2021 Jun 23;364:104345. Epub 2021 Mar 23.

Center for Immunity, Inflammation and Regenerative Medicine (CIIR), Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA. Electronic address:

Previously, we generated IL233, a hybrid cytokine composed of interleukin (IL)-2 and IL-33, with better therapeutic potential than either cytokine in multiple inflammatory diseases, in part through promoting T-regulatory cells (Tregs). Here we test the potential of IL233 pretreatment in a murine model of excessive Th1 activation, the parent-into-F1 model of acute GVHD (aGVHD). Five days of IL233 pretreatment of the recipients blocked or delayed the aGVHD-linked loss of B cells as seen in either the peripheral blood (day-11) or lymph nodes (day-14). Read More

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Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2.

Int J Mol Sci 2021 Mar 30;22(7). Epub 2021 Mar 30.

Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.

The IL-1 family cytokine IL-33 activates and re-shapes mast cells (MCs), but whether and by what mechanisms it elicits cytokines in MCs from human skin remains poorly understood. The current study found that IL-33 activates CCL1, CCL2, IL-5, IL-8, IL-13, and TNF-α, while IL-1β, IL-6, IL-31, and VEGFA remain unaffected in cutaneous MCs, highlighting that each MC subset responds to IL-33 with a unique cytokine profile. Mechanistically, IL-33 induced the rapid (1-2 min) and durable (2 h) phosphorylation of p38, whereas the phosphorylation of JNK was weaker and more transient. Read More

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Influence of extract on umbilical cord cells and potential treating cutaneous wound.

Heliyon 2021 Mar 8;7(3):e06248. Epub 2021 Mar 8.

Hue University of Sciences, Viet Nam.

This research aimed to test the effects of L. from Vietnam on fibroblasts and UC-derived mesenchymal stem cells (UC-MSCs) from human umbilical cord (UC) on the scratch assay. We tested the extract at different concentrations and then assessed the level of expression of the factors involved in the inflammatory process on fibroblasts including IL-33, VCAM, CD248 by assay real time qPCR. Read More

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Analysis and validation of human targets and treatments using a hepatocellular carcinoma-immune humanized mouse model.

Hepatology 2021 Mar 18. Epub 2021 Mar 18.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.

Background & Aims: Recent development of multiple treatments for human hepatocellular carcinoma (HCC) has allowed us to select combination therapy to enhance the effectiveness of monotherapy. Optimal selection of therapies bases on both HCC and its microenvironment. Therefore, it is critical to develop and validate new pre-clinical animal models for testing clinical therapeutic solutions. Read More

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Biological Therapies for Atopic Dermatitis: A Systematic Review.

Dermatology 2021 Mar 18:1-11. Epub 2021 Mar 18.

Department of Dermatology, The 305 Hospital of PLA, Beijing, China.

Background: Atopic dermatitis (AD) is a widely acquired, relapsing inflammatory skin disease. Biologics are now widely used in patients with moderate-to-severe AD.

Objective: This work aims to summarize both label and off-label biologics on AD treatment in phase II and phase III stages, and compile evidence on the efficacy of the most-studied biologics. Read More

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Association between plasma interleukin-33 level and acute exacerbation of chronic obstructive pulmonary disease.

BMC Pulm Med 2021 Mar 15;21(1):86. Epub 2021 Mar 15.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seochogu, Seoul, 06591, Republic of Korea.

Background: The role of interleukin (IL)-33 in patients with chronic obstructive pulmonary disease (COPD) has not been well elucidated. The aim of this study is to analyze the association between plasma IL-33 level and acute exacerbation of COPD.

Methods: Plasma IL-33 was measured in 62 COPD patients during their stable state. Read More

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Interleukin (IL)-1 family cytokines could differentiate primary immune thrombocytopenia from systemic lupus erythematosus-associated thrombocytopenia.

Ann Transl Med 2021 Feb;9(3):222

Department of Hematology, Zhongshan Hospital Fudan University, Shanghai, China.

Background: Primary immune thrombocytopenia (ITP) is an autoimmune-mediated disorder characterized by a decreased platelet count. Systemic lupus erythematosus (SLE) is also an autoimmune disease in which thrombocytopenia is a common hematologic manifestation. Interleukin (IL)-1 family cytokines are major proinflammatory and immunoregulatory mediators. Read More

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February 2021

Optimal human pathogenic T2 cell effector function requires local epithelial cytokine signaling.

J Allergy Clin Immunol 2021 Mar 1. Epub 2021 Mar 1.

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Wash. Electronic address:

Background: IL-33 is an emerging key factor in development of allergic diseases. The IL-33 receptor (suppressor of tumorigenicity [ST2]) is a differentially expressed gene in pathogenic T2 cells, but its role in T-cell effector function has not been elucidated.

Objective: We investigated the role of IL-33 in modulating circulating allergen-specific T-cell responses. Read More

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The Role of Interleukin-33 in Head and Neck Squamous Cell Carcinoma Is Determined by Its Cellular Sources in the Tumor Microenvironment.

Front Oncol 2020 9;10:588454. Epub 2021 Feb 9.

Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Objectives: To investigate the role of interleukin-33 (IL-33) in head and neck squamous cell carcinoma (HNSCC).

Materials And Methods: RNA-seq data of 520 cases of HNSCC were retrieved from The Cancer Genome Atlas. The tumor microenvironment was deconstructed by xCell using bulk RNA-seq data. Read More

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February 2021

The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma.

Technol Cancer Res Treat 2021 Jan-Dec;20:1533033821995282

Department of Gastrointestinal Surgery, Wuhan Union Hospital, Wuhan, Hubei, China.

This study was performed to investigate the role of interleukin-1 receptor accessory protein (IL1RAP) in stomach carcinoma in vitro and in vivo, determine whether IL1RAP knockdown could regulate the development of stomach carcinoma, and elucidate the relationship between IL1RAP knockdown and inflammation by tumor microenvironment-related inflammatory factors in stomach carcinoma. We first used TCGA and GEPIA systems to predict the potential function of IL1RAP. Second, western blot and RT-PCR were used to analyze the expression, or mRNA level, of IL1RAP at different tissue or cell lines. Read More

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February 2021

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins.

Front Immunol 2020 1;11:615236. Epub 2021 Feb 1.

Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically regulates mast cell responses to complement anaphylatoxins. We sought to understand whether C3a and C5a differentially activate primary human mast cells, and probe whether IL-33 regulates C3a/C5a-induced mast cell activities. Read More

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February 2021

Glucagon-like peptide 1 receptor (GLP-1R) agonist relieved asthmatic airway inflammation via suppression of NLRP3 inflammasome activation in obese asthma mice model.

Pulm Pharmacol Ther 2021 Apr 12;67:102003. Epub 2021 Feb 12.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background: Obesity is a correctable factor for uncontrolled bronchial asthma. However, the effects of glucagon-like peptide-1 receptor (GLP-1R) agonist, a recently approved antiobestic drug, on airway hyperresponsiveness (AHR) and immune responses are not known.

Methods: Mice were fed with high-fat diet (HFD, 60% fat) for 8 weeks to induce obesity. Read More

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Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism.

Gut 2021 Feb 10. Epub 2021 Feb 10.

Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Stockholm, Sweden

Objective: Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions between tumour stromal components in metastasis and to provide a new paradigm for PDAC therapy.

Design: Two unselected cohorts of 154 and 20 patients with PDAC were subjected to correlation between interleukin (IL)-33 and CXCL3 levels and survivals. Read More

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February 2021

Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults.

J Transl Med 2021 02 4;19(1):52. Epub 2021 Feb 4.

Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Background: Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. However, whether its circulating level is correlated with obesity and metabolic disorders in humans remains largely unknown. We aimed to address this gap by determining IL-33 serum level and its downstream type 2 inflammatory cytokines interleukin-5 (IL-5) and interleukin-13 (IL-13) in overweight/obese population, and analyzing the specific associations between IL-33 and obesity metabolic phenotypes. Read More

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February 2021

The role of peripheral type 2 innate lymphoid cells in bronchiolitis.

Sci Rep 2021 Jan 29;11(1):2668. Epub 2021 Jan 29.

Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.

Our aim was to detect type 2 innate lymphoid cells (ILC2s)-related cytokines of infants with bronchiolitis by using Elisa, Liquidchip technology and RT-PCR and investigated its correlation with bronchiolitis. We recruited 26 infants with bronchiolitis and 20 healthy infants as control from Xiangya Hospital. Compared to the control group, the serum levels of interleukin-5 (IL-5) [41. Read More

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January 2021

Downregulation of miR-3934 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Its Potential Diagnostic Value.

Biomed Res Int 2021 9;2021:8888280. Epub 2021 Jan 9.

Department of Respiratory and Critical Medicine, The Second Affiliated Hospital of Harbin Medical University, China.

Background: The present study focused on the potential clinical significance of miR-3934 in the occurrence and development of asthma.

Methods: 80 asthma and 80 healthy controls were recruited in this study. The peripheral blood mononuclear cells (PBMCs) and serum samples of the asthma patients as well as the healthy controls were isolated, and the expression levels of miR-3934 in PBMCs were examined by RT-qPCR methods. Read More

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