5,238 results match your criteria level fas

Anticancer effects of bifidobacteria on colon cancer cell lines.

Cancer Cell Int 2021 May 12;21(1):258. Epub 2021 May 12.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Colorectal cancer (CRC), with a growing incidence trend worldwide, is resistant to apoptosis and has uncontrolled proliferation. It is recently reported that probiotic microorganisms exert anticancer effects. The genus Bifidobacterium, one of the dominant bacterial populations in the gastrointestinal tract, has received increasing attention because of widespread interest in using it as health-promoting microorganisms. Read More

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Getting to the bottom of research funding: Acknowledging the complexity of funding dynamics.

PLoS One 2021 12;16(5):e0251488. Epub 2021 May 12.

Department of Political Science, Danish Centre for Studies in Research and Research Policy, Aarhus University, Aarhus, Denmark.

Research funding is an important factor for public science. Funding may affect which research topics get addressed, and what research outputs are produced. However, funding has often been studied simplistically, using top-down or system-led perspectives. Read More

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Baicalin ameliorates -induced inflammatory injury in the chicken lung through regulating the intestinal microbiota and phenylalanine metabolism.

Food Funct 2021 May;12(9):4092-4104

College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin 150030, Xiangfang District, P. R. China. and Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, 600 Changjiang Road, Harbin 150030, Xiangfang District, P. R. China.

Baicalin shows excellent protective effects against Mycoplasma gallisepticum (MG) induced inflammatory injury as discussed in our previous studies. However, the physiological effects of baicalin are notable in contrast to its low bioavailability, and the critical mechanism for the protective effects of baicalin against MG infection is still unclear. The main objective of this study was to investigate whether baicalin alleviates MG-induced lung inflammatory injury through regulating gut microbiota. Read More

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Clinical, Immunological, and Genetic Features in 780 Patients with Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-like diseases: A Systematic Review.

Pediatr Allergy Immunol 2021 May 8. Epub 2021 May 8.

Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Background: Autoimmune lymphoproliferative syndrome (ALPS) is a group of genetic disorders characterized by early-onset lymphoproliferation, autoimmune cytopenias, and susceptibility to lymphoma. The majority of ALPS patients carry heterozygous germline mutations in the TNFRSF6 gene. In this study, we conducted a systematic review of patients with ALPS and ALPS-like syndrome. Read More

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Short-chain fatty acids can improve lipid and glucose metabolism independently of the pig gut microbiota.

J Anim Sci Biotechnol 2021 May 6;12(1):61. Epub 2021 May 6.

Key Laboratory of Animal Disease-Resistance Nutrition, Chengdu, 611130, Sichuan, China.

Background: Previous studies have shown that exogenous short-chain fatty acids (SCFAs) introduction attenuated the body fat deposition in conventional mice and pigs. However, limited studies have evaluated the effects of exogenously introduced SCFAs on the lipid and glucose metabolism independently of the gut microbiota. This study was to investigate the effects of exogenous introduction of SCFAs on the lipid and glucose metabolism in a germ-free (GF) pig model. Read More

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Novel antiadipogenic effect of menadione in 3T3-L1 cells.

Chem Biol Interact 2021 May 1;343:109491. Epub 2021 May 1.

Instituto de Investigaciones Bioquímicas de Bahía Blanca, Universidad Nacional Del Sur (UNS)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bahía Blanca, Argentina. Departamento de Biología, Bioquímica y Farmacia, UNS, Bahía Blanca, Argentina. Electronic address:

Inhibition of adipocyte differentiation can be used as a strategy for preventing adipose tissue expansion and, consequently, for obesity management. Since reactive oxygen species (ROS) have emerged as key modulators of adipogenesis, the effect of menadione (a synthetic form of vitamin K known to induce the increase of intracellular ROS) on 3T3-L1 preadipocyte differentiation was studied. Menadione (15 μM) increased ROS and lipid peroxidation, generating mild oxidative stress without affecting cell viability. Read More

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The Effect on BSA of Proactive Management versus Reactive Management of Psoriasis With Fixed-Dose Cal/BD Foam in the PSO-LONG Study.

J Drugs Dermatol 2021 May;20(5):567-570

Reduction of psoriasis body surface area (BSA) is associated with improved patient quality of life. Post-hoc analyses of the PSO-LONG study compared impact on BSA of proactive management versus reactive management strategies using calcipotriol/betamethasone dipropionate (Cal/BD) foam. Mean BSA values, as well as normalized area under the curves (AUCs) for patient BSA were assessed. Read More

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Down-regulated gga-miR-223 inhibits proliferation and induces apoptosis of MG-infected DF-1 cells by targeting FOXO3.

Microb Pathog 2021 Apr 28;155:104927. Epub 2021 Apr 28.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province, 430070, China. Electronic address:

Mycoplasma gallisepticum (MG) is a major poultry pathogen that can induce Chronic Respiratory Disease (CRD) in chickens, causing serious economic losses in the poultry industry worldwide. Increasing evidence suggests that microRNAs (miRNAs) act as a vital role in resisting microbial pathogenesis and maintaining cellular mechanism. Our previous miRNAs sequencing data showed that gga-miR-223 expression level significantly decreased in MG-infected chicken lungs. Read More

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Bi-FPNFAS: Bi-Directional Feature Pyramid Network for Pixel-Wise Face Anti-Spoofing by Leveraging Fourier Spectra.

Sensors (Basel) 2021 Apr 15;21(8). Epub 2021 Apr 15.

Department of Electrical and Computer Engineering, North South University, Dhaka 1229, Bangladesh.

The emergence of biometric-based authentication using modern sensors on electronic devices has led to an escalated use of face recognition technologies. While these technologies may seem intriguing, they are accompanied by numerous implicit drawbacks. In this paper, we look into the problem of face anti-spoofing (FAS) on a frame level in an attempt to ameliorate the risks of face-spoofed attacks in biometric authentication processes. Read More

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High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol.

BMC Pharmacol Toxicol 2021 Apr 27;22(1):22. Epub 2021 Apr 27.

Department of Emergency, Tongji Hosptial of Tongji Medical College of Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.

Background: Low dose of NP exposure can alter adipose tissue formation, and the intake of high-fat diet (HFD) can also lead to the fatty liver disease. We investigated the combined effect of NP and HFD on the first offspring of rats, and whether this effect can be passed to the next generation and the possible mechanisms involved.

Methods: Pregnant rats had access to be treated with 5 μg/kg/day NP and normal diet. Read More

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Exposure to oxidized soybean oil induces mammary mitochondrial injury in lactating rats and alters the intestinal barrier function of progeny.

Food Funct 2021 Apr;12(8):3705-3719

Department of Food Science, Northeast Agricultural University, Harbin 150030, P. R. China.

Similar to other food contaminants, dietary oxidized soybean oil (OSO) is also a toxic xenobiotic for animal and human nutrition. This research evaluated the effects of maternal OSO exposure during lactation on mammary mitochondrial injury and intestinal barrier of sucking progeny. Twenty-four female adult SD rats were fed a fresh soybean oil (FSO) homozygous diet (7%) or an OSO homozygous diet (7%) during lactation. Read More

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Cord blood soluble Fas ligand linked to allergic rhinitis and lung function in seven-year-old children.

J Microbiol Immunol Infect 2021 Apr 9. Epub 2021 Apr 9.

Community Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Serum or cord blood soluble Fas ligand (FasL) has been related to asthma, allergic rhinitis, and atopic dermatitis in cross-sectional and short-term follow-up studies. However, the association of cord blood soluble FasL with long-term allergic outcomes has seldom been investigated.

Methods: The Prediction of Allergies in Taiwanese Children birth cohort study recruited healthy newborns upon delivery. Read More

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Genome-wide DNA methylation profiling of high-fat emulsion-induced hyperlipidemia mice intervened by a polysaccharide from Cyclocarya paliurus (Batal) Iljinskaja.

Food Chem Toxicol 2021 Apr 18;152:112230. Epub 2021 Apr 18.

Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address:

Genome-wide DNA methylation was used to study the lipid-lowering effect of Cyclocarya paliurus (Batal) Iljinskaja polysaccharide (CPP). The objective of this study was to investigate the hypolipidemic effects and the potential underlying mechanisms of action of CPP-2 in high-fat emulsion (HFE)-induced mice. The results showed that CPP-2 reduced the level of genome-wide DNA methylation in the liver of HFE-induced mice, which had a lipid-lowering effect by regulating the AMP-activated protein kinase (AMPK) signaling-, fatty acid metabolism-, fatty acid biosynthesis- and adipocytokine signaling pathways. Read More

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Ecological and Developmental Perspectives on Social Learning : Introduction to the Special Issue.

Hum Nat 2021 Apr 20. Epub 2021 Apr 20.

Department of Anthropology, University of Oregon, Eugene, OR, USA.

In this special issue of Human Nature we explore the possible adaptive links between teaching and learning during childhood, and we aim to expand the dialogue on the ways in which the social sciences, and in particular current anthropological research, may better inform our shifting understanding of how these processes vary in different social and ecological environments. Despite the cross-disciplinary trend toward incorporating more behavioral and cognitive data outside of postindustrial state societies, much of the published cross-cultural data is presented as stand-alone population-level studies, making it challenging to extrapolate trends or incorporate both ecological and developmental perspectives. Here, contributors explore how human life history, ecological experience, cumulative culture, and ethnolinguistics impact social learning and child development in foraging and transitioning societies around the world. Read More

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IgA autoreactivity towards brain enriched and apoptosis regulating proteins in saliva of athletes after acute concussion and subconcussive impacts.

J Neurotrauma 2021 Apr 15. Epub 2021 Apr 15.

George Mason University, 10900 University Blvd. 4E5, Manassas, Virginia, United States, 20110;

The diagnosis and management of concussion is hindered by its diverse clinical presentation and assessment tools reliant upon subjectively-experienced symptoms. The biomechanical threshold of concussion is also not well understood and asymptomatic or 'subconcussive impacts' of variable magnitudes are common in contact sports. Concerns have risen because athletes returning to activity too soon have an increased risk of prolonged recovery or long-term adverse health consequences. Read More

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Treatment of Osteochondral Lesion of the First Metatarsal Head: Osteochondral Graft Transplantation Combined With Moberg Osteotomy: Case Report.

Foot Ankle Spec 2021 Apr 14:19386400211001972. Epub 2021 Apr 14.

School of Medical Sciences, Belo Horizonte, MG, Brazil.

Most osteochondral lesions of the first metatarsal head are likely traumatic in etiology. The treatment ranges from microfractures to mosaicplasty. In this case report, we describe a central osteochondral lesion of the first metatarsal head treated with osteochondral graft obtained from the head of the same metatarsal in combination with Moberg osteotomy. Read More

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Endoscopic Haglund's Resection and Percutaneous Double-Row Insertional Achilles Repair.

Foot Ankle Spec 2021 Apr 12:19386400211002707. Epub 2021 Apr 12.

Department of Orthopedics, Southeast Orthopedic Specialists, Jacksonville, Florida.

Insertional Achilles tendinopathy can be a debilitating condition that often fails to improve with nonsurgical management such as bracing and physical therapy. Traditional surgical techniques include an open debridement of the diseased tendon and resection of calcaneal spurs. This is followed by repair of the tendon. Read More

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Anti-adipogenic and lipid-lowering activity of piperine and epigallocatechin gallate in 3T3-L1 adipocytes.

Arch Physiol Biochem 2021 Apr 9:1-8. Epub 2021 Apr 9.

Division of Cell Culture and Molecular Biology, Department of Biochemistry, Sri Venkateswara University, Tirupati, India.

The present study was aimed to evaluate the anti-adipogenic activity of piperine (PIP) and epigallocatechin gallate (EGCG) in 3T3-L1 cells. In cytotoxicity studies, PIP and EGCG showed IC values of 260 and 218 µM respectively and in combination (20 µM each) did not show cytotoxicity. Treatment with PIP and EGCG (20 µM each) significantly (<. Read More

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Tumor suppressor gene DLC1: Its modifications, interactive molecules, and potential prospects for clinical cancer application.

Int J Biol Macromol 2021 Apr 6;182:264-275. Epub 2021 Apr 6.

Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences, Shandong Normal University, Jinan, China. Electronic address:

Deleted in liver cancer 1 (DLC1) is a recognized tumor suppressor gene that negatively regulates Rho family proteins by hydrolyzing the active GTP-bound state to its inactive GDP-bound state. Active Rho proteins play a positive role in tumorigenesis. Numerous in vitro and in vivo experiments have shown that DLC1 is downregulated or inactivated in various solid tumors, which may be due to the following five reasons: genomic deletion, epigenetic modification and ubiquitin-dependent proteasomal degradation may cause DLC1 underexpression; phosphorylation at the post-translation level may cause DLC1 inactivation; and failure to localize at focal adhesions (FAs) may prevent DLC1 from exerting full activity. Read More

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Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos.

Mol Cells 2021 Apr;44(4):233-244

Department of Life Science, BK21 Plus Program, Graduate School, Chungnam National University, Daejeon 34134, Korea.

To define novel networks of Parkinson's disease (PD) pathogenesis, the substantia nigra pars compacta of A53T mice, where a death-promoting protein, FAS-associated factor 1 was ectopically expressed for 2 weeks in the 2-, 4-, 6-, and 8-month-old mice, and was subjected to transcriptomic analysis. Compendia of expression profiles and a hierarchical clustering heat map of differentially expressed genes associated with PD were bioinformatically generated. Transcripts level of a particular gene was fluctuated by 20, 60, and 0. Read More

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The Antitumor Effects of Plasma-Activated Saline on Muscle-Invasive Bladder Cancer Cells In Vitro and In Vivo Demonstrate Its Feasibility as a Potential Therapeutic Approach.

Cancers (Basel) 2021 Mar 2;13(5). Epub 2021 Mar 2.

Frank Reidy Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA.

Muscle-invasive bladder cancer (MIBC) is a fast-growing and aggressive malignant tumor in urinary system. Since chemotherapy and immunotherapy are only useable with a few MIBC patients, the clinical treatment of MIBC still faces challenges. Here, we examined the feasibility of plasma-activated saline (PAS) as a fledgling therapeutic strategy for MIBC treatment. Read More

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Peculiarities of Immune Regulation in Men of Perm Region with Atherosclerosis Related to Polymorphism of Candidate Genes.

Bull Exp Biol Med 2021 Mar 31;170(5):645-648. Epub 2021 Mar 31.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia.

The study examined peculiarities of immune regulation and associated polymorphic variants of candidate genes in men with atherosclerosis in Perm region. The revealed deficiency of CD127 lymphocytes and Annexin V-FITC7AAD cells, as well as enhanced level of CD3CD4 lymphocytes against the background of variant alleles of candidate genes FAS (rs1159120), CPOX (rs1131857) and wild-type alleles SULT1A1 (rs9282861), MMP9 (rs17576) are responsible for peculiar features of hereditary determination and pathogenesis of atherosclerosis in examined sample (p<0.05). Read More

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Predisposing Factors for 30-Day Complications Following Leg Amputation.

Foot Ankle Spec 2021 Mar 26:19386400211001980. Epub 2021 Mar 26.

the Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch, Galveston, Texas.

Background: Although amputation rates, morbidity, and mortality have been established for select populations, the impact of general demographic factors on postoperative surgical complications remains little studied.

Methods: The American College of Surgeons' National Surgical Quality Improvement Program database was searched for leg amputations from 2012 to 2017 using CPT codes 27881, 27882, 27884, and 27886, identifying 4162 patients. A total of 29 demographic variables with 4 complications (surgical infection, additional service, and deep-vein thrombosis [DVT], and sepsis) were analyzed. Read More

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Patient Satisfaction Following Hallux Rigidus Treatment With a Synthetic Cartilage Implant.

Foot Ankle Spec 2021 Mar 26:19386400211001993. Epub 2021 Mar 26.

Division of Foot and Ankle Surgery, Department of Orthopaedic Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.

Background: There remains no clear consensus on patient satisfaction and functional outcomes following synthetic cartilage implant (SCI) implantation for hallux rigidus. The purpose of this study was to review our experience at a single academic institution using an SCI for treatment of hallux rigidus.

Methods: A retrospective review was performed of patients who underwent the SCI procedure for treatment of hallux rigidus between January 2017 and May 2019. Read More

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Effect of Anti-TNF Therapy on Mucosal Apoptosis Genes Expression in Crohn's Disease.

Front Immunol 2021 9;12:615539. Epub 2021 Mar 9.

Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Crohn's disease (CD) is a chronic immune-mediated disorder for which there is not a fully effective treatment. Moreover, biological therapy with anti-tumor necrosis factor-α (anti-TNF-α) monoclonal antibodies leads to an effective response in only 60-70% of patients. Our previous data suggested that specific polymorphism of the , and genes could be a predictor of the primary non-response to anti-TNF therapy in CD patients. Read More

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Copper(II) and iron(III) complexes of chiral dehydroabietic acid derived from natural rosin: metal effect on structure and cytotoxicity.

Metallomics 2021 04;13(4)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, China.

A novel optically pure dinuclear copper(II) complex of a rosin derivative dehydroabietic acid (DHA, HL) was synthesized and fully characterized. The in vitro antitumor activities of the copper(II) complex Cu2(µ2-O)(L)4(DMF)2 (1) were explored and compared with those of a trinuclear iron(III) complex [Fe3(µ3-O)(L)6(CH3OH)2(CH3O)]·H2O (2). 1 was more cytotoxic than 2, and the in vitro cytotoxicity of 1 was comparable to that of cisplatin and oxaliplatin. Read More

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Functional evaluation of a recombinant fungal immunomodulatory protein from L. rhinocerus produced in P. pastoris and E. coli host expression systems.

Appl Microbiol Biotechnol 2021 Apr 25;105(7):2799-2813. Epub 2021 Mar 25.

Department of Biotechnology, Faculty of Applied Sciences, UCSI University, No.1, Jalan Menara Gading, UCSI Heights, 56000, Cheras, Wilayah Persekutuan Kuala Lumpur, Malaysia.

Fungal immunomodulatory proteins (FIPs) are bioactive proteins with immunomodulatory properties. We previously reported the heterologous production in Escherichia coli of FIP-Lrh from Tiger milk mushroom (Lignosus rhinocerus) with potent cytotoxic effect on cancer cell lines. However, protein produced in E. Read More

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Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways.

Eur Rev Med Pharmacol Sci 2021 Mar;25(5):2206-2220

School of Life Sciences, Manipal Academy of Higher Education, Dubai, UAE.

Objective: Chrysin, one of the main active constituents of flavonoids, is known for demonstrating protective effects against various types of cancer including cervical cancer. The aim of this study was to determine apoptosis induction and antiproliferative action of chrysin on human cervical cancer cells.

Materials And Methods: In this study, attempts have been made to establish anticancer role of chrysin on HeLa cells. Read More

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Outcomes of First Metatarsophalangeal Joint Fusion Using a Precontoured Plate.

Foot Ankle Spec 2021 Mar 23:19386400211000594. Epub 2021 Mar 23.

Cork University Hospital, Cork, Ireland.

Background: The purpose of this study was to determine the results of an arthrodesis technique of the first metatarsophalangeal joint (MTPJ) using a precontoured dorsal plate to correct the hallux valgus deformity.

Methods: This was a retrospective analysis of outcomes for first MTPJ arthrodesis performed using 2 precontoured dorsal plates. Radiographic outcomes (intermetatarsal angle [IMA] and hallux valgus angle [HVA]) and patient-reported functional outcome measures (Short-Form 12 and Foot and Ankle Outcome Score) were recorded and compared. Read More

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Intraosseous Anchorage of a Collagen Matrix Graft to Enhance Repair of Peroneus Brevis Tendon Degeneration.

Foot Ankle Spec 2021 Mar 22:19386400211000264. Epub 2021 Mar 22.

Division of Podiatric Surgery, Department of Surgery, Mount Auburn Hospital, Cambridge, Massachusetts.

Introduction: Chronic degeneration of the peroneus brevis tendon (PBT) at its insertion to the base of the fifth metatarsal is uncommon; however, when present it can be a challenge to treat. Repair of the PBT often requires tubularization with or without a peroneus longus tendon transfer. These repairs, however, may not provide resultant full muscle strength, especially if ostectomy of the fifth metatarsal base is required. Read More

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