247,316 results match your criteria level evidence


Too unwell to trust? The effect of mental health on social trust in Europe.

Econ Hum Biol 2021 Jun 5;42:101021. Epub 2021 Jun 5.

Department of Industrial Economics, Nottingham University Business School, University of Nottingham, Jubilee Campus, Wollaton Road, Nottingham NG8 1BB, United Kingdom. Electronic address:

Social trust is often thought to be adversely affected by mental health problems. However, rigorous causal evidence required to substantiate this thought is scarce. Here I examine the causal effect of individuals' mental health on social trust using data from the European Social Survey. Read More

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Where did the specialty behavioral health workforce grow between 2011 and 2019? Evidence from census data.

J Subst Abuse Treat 2021 May 19;130:108482. Epub 2021 May 19.

Indiana University, Bloomington, IN, USA; National Bureau of Economic Research, Cambridge, MA, USA.

Importance: Given that mental health and substance use conditions are ongoing major public health problems in the United States, it is important for researchers to understand the behavioral health treatment workforce landscape and to assess whether increases in treatment capacity exist in areas with public health needs.

Objectives: This study quantified national and county-level changes in specialty behavioral health (SBH) workforce outcomes and assessed associations between these measures and age-adjusted drug mortality rate.

Design: Using a novel longitudinal dataset from the U. Read More

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Changes in Scapular Bone Density Vary by Region and are Associated with Age and Sex.

J Shoulder Elbow Surg 2021 Jun 9. Epub 2021 Jun 9.

Department of Orthopaedics and Sports Medicine, University of Washington, Seattle WA, USA.

Background: Decreases in bone density of the scapula due to age and disease can make orthopedic procedures such as arthroplasty and fracture fixation challenging. There is limited information in the literature regarding the effect of age and sex on the patterns of these density changes across the bone. Characterizing these changes could assist the surgeon in planning optimal instrumentation placement. Read More

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Beyond fingerprinting: Choosing predictive connectomes over reliable connectomes.

Neuroimage 2021 Jun 9:118254. Epub 2021 Jun 9.

Department of Psychology and Neuroscience Institute, University of Chicago; Neuroscience Institute, University of Chicago. Electronic address:

Recent years have seen a surge of research on variability in functional brain connectivity within and between individuals, with encouraging progress toward understanding the consequences of this variability for cognition and behavior. At the same time, well-founded concerns over rigor and reproducibility in psychology and neuroscience have led many to question whether functional connectivity is sufficiently reliable, and call for methods to improve its reliability. The thesis of this opinion piece is that when studying variability in functional connectivity-both across individuals and within individuals over time-we should use behavior prediction as our benchmark rather than optimize reliability for its own sake. Read More

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Can the human development level in middle-income regions meet the challenges of natural capital change from the perspective of decoupling? Evidence from Shaanxi Province.

Authors:
Yi Yang Ke Zhang

Environ Sci Pollut Res Int 2021 Jun 12. Epub 2021 Jun 12.

School of Economics and Management, Xi'an University of Technology, Xi'an, 710054, China.

Human activities in middle-income regions (MIRs) accelerate the appropriation of natural capital (NC) through production and living activities. The environmental changes caused by these activities in turn have an impact on human development and challenge the human adaptability of MIRs. Therefore, it is very important to realize the decoupling of NC and human development. Read More

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Validation and psychometric properties of the Indonesian version of the Fear of Missing Out Scale in adolescents.

Psicol Reflex Crit 2021 Jun 12;34(1):15. Epub 2021 Jun 12.

Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan.

Background: This study's main purpose was to examine the psychometric properties of FoMOs' adaptation among the Indonesian adolescents' population. The second aim was to investigate the concurrent validity of the Indonesian version to provide evidence for the validity. Also, FoMOs' difference level between demographic variance analyses was performed. Read More

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Both arthroscopic and open posterior knee capsulotomy are effective in terms of extension recovery and functional improvement-systematic review.

Knee Surg Sports Traumatol Arthrosc 2021 Jun 12. Epub 2021 Jun 12.

Artromedical Orthopaedic Clinic, Antracytowa 1, 97-400, Belchatow, Poland.

Purpose: To assess the recovery of extension and improvement in functional scores after an arthroscopic or open posterior knee capsulotomy in the setting of an extension deficit.

Methods: A systematic search of articles published between 1980 and 2020 was performed in the MEDLINE/PubMed database, EMBASE/Ovid database and Web of Science database. The inclusion criteria consisted of patients with primary extension deficits > 5° who underwent an arthroscopic or open posterior knee capsulotomy. Read More

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In vivo kinematic comparison between an ultra-congruent and a posterior-stabilized total knee arthroplasty design by RSA.

Knee Surg Sports Traumatol Arthrosc 2021 Jun 12. Epub 2021 Jun 12.

Dipartimento di Scienze per la Qualità della Vita QUVI, University of Bologna, Corso D'Augusto 237, 47921, Rimini, RN, Italy.

Purpose: The aim of the present study was to compare the in vivo under weight-bearing kinematic behavior of a posterior-stabilized (PS) and an ultra-congruent (UC) total knee arthroplasty (TKA) model during a sit-to-stand motor task, a common activity of daily life.

Methods: A cohort of 16 randomly selected patients (8 PS Persona Zimmer, 8 UC Persona Zimmer) was evaluated through dynamic radiostereometric analysis (RSA) at a minimum of 9 months after TKA, during the execution of a sit-to-stand. The anteroposterior (AP) translation of the femoral component and the AP translation of the low point of medial and lateral femoral compartments were compared through Student's t test (p < 0. Read More

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"BreaThink": breathing affects production and perception of quantities.

Exp Brain Res 2021 Jun 12. Epub 2021 Jun 12.

Cognitive Sciences Division, Psychology Department, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam, Germany.

Cognition is shaped by signals from outside and within the body. Following recent evidence of interoceptive signals modulating higher-level cognition, we examined whether breathing changes the production and perception of quantities. In Experiment 1, 22 adults verbally produced on average larger random numbers after inhaling than after exhaling. Read More

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Quantitative Susceptibility Mapping for Staging Acute Cerebral Hemorrhages: Comparing the Conventional and Multiecho Complex Total Field Inversion magnetic resonance imaging MR Methods.

J Magn Reson Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: The perceived acuity of intracerebral hemorrhage (ICH) impacts the management of patients, both within emergent and outpatient/urgent settings. Morphology enabled dipole inversion (MEDI) quantitative susceptibility imaging (QSM) has improved characterization of ICH acuity, despite outstanding limitations in distinguishing blood products.

Purpose/hypothesis: Using improved susceptibility quantification, novel postprocessing QSM method from multiecho complex total field inversion (mcTFI) may better discriminate between acute and subacute ICH, compared to MEDI. Read More

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Predictors of Respiratory Dysfunction at Diagnosis of Robin Sequence.

Laryngoscope 2021 Jun 12. Epub 2021 Jun 12.

Department of Plastic and Craniofacial Surgery, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objectives/hypothesis: Robin sequence (RS) consists of associated micrognathia, glossoptosis, and respiratory dysfunction, with or without cleft palate. Studies on how different patient characteristics impact the severity of respiratory dysfunction are scarce and contradictory; this study investigates how different features affect respiratory obstruction severity at diagnosis of RS in controlled analysis.

Study Design: Retrospective cohort study that enrolled 71 RS patients under 90 days old who received care in our institution from 2009 to 2020. Read More

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Impact of Adjuvant Medical Therapies on Surgical Outcomes in Idiopathic Subglottic Stenosis.

Laryngoscope 2021 Jun 12. Epub 2021 Jun 12.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.

Objectives/hypothesis: Adjuvant medications including proton pump inhibitors (PPI), antibiotics (trimethoprim/sulfamethoxazole [TMP-SMX]), and inhaled corticosteroids (ICS) may be prescribed for patients with idiopathic subglottic stenosis (iSGS). We describe medication use with endoscopic dilation (ED) or endoscopic resection with medical treatment (ERMT) and evaluate impact on outcomes.

Study Design: International, prospective, 3-year multicenter cohort study of 810 patients with untreated, newly diagnosed, or previously treated iSGS. Read More

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The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.

J Cell Mol Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Despite the previous evidence showing that SHC adaptor protein 1 (SHC1) could encode three distinct isoforms (p46SHC, p52SHC and p66SHC) that function in different activities such as regulating life span and Ras activation, the precise underlying role of SHC1 in lung cancer also remains obscure. In this study, we firstly found that SHC1 expression was up-regulated both in lung adenocarcinoma (LUAD) and in lung squamous cell carcinoma (LUSC) tissues. Furthermore, compared to patients with lower SHC1 expression, LUAD patients with higher expression of SHC1 had poorer overall survival (OS). Read More

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MMP-7 affects peritoneal ultrafiltration associated with elevated aquaporin-1 expression via MAPK/ERK pathway in peritoneal mesothelial cells.

J Cell Mol Med 2021 Jun 11. Epub 2021 Jun 11.

Division of Nephrology, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Peritoneal membrane dysfunction and the resulting ultrafiltration failure are the major disadvantages of long-term peritoneal dialysis (PD). It becomes increasingly clear that mesothelial cells play a vital role in the pathophysiological changes of the peritoneal membrane. Matrix metalloproteinases (MMPs) function in the extracellular environment of cells and mediate extracellular matrix turnover during peritoneal membrane homeostasis. Read More

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Quantifying Bone Marrow Fat Fraction and Iron by MRI for Distinguishing Aplastic Anemia from Myelodysplastic Syndromes.

J Magn Reson Imaging 2021 Jun 11. Epub 2021 Jun 11.

Radiology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Background: Bone marrow of patients with aplastic anemia (AA) is different from that of patients with myelodysplastic syndrome (MDS) and is difficult to identify by blood examination. IDEAL-IQ (iterative decomposition of water and fat with echo asymmetry and least-squares estimation) imaging might be able to quantify fat fraction (FF) and iron content in bone tissues.

Purpose: To determine if IDEAL-IQ measurements of bone marrow FF and iron content can distinguish between patients with AA and MDS. Read More

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Chronic restraint stress induces changes in the cerebral Galpha 12/13 and Rho-GTPase signaling network.

Pharmacol Rep 2021 Jun 11. Epub 2021 Jun 11.

Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.

Background: Evidence indicates that Gα12, Gα13, and its downstream effectors, RhoA and Rac1, regulate neuronal morphology affected by stress. This study was aimed at investigating whether repeated stress influences the expression of proteins related to the Gα12/13 intracellular signaling pathway in selected brain regions sensitive to the effects of stress. Furthermore, the therapeutic impact of β(1)adrenergic receptors (β1AR) blockade was assessed. Read More

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A Novel Study on Alar Mobility of HAN Female by 3dMD Dynamic Surface Imaging System.

Aesthetic Plast Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aim: The aim of this study is to conduct a quantitative analysis on alar mobility of HAN females and provided referenced materials for alar dynamic aesthetic.

Methods: One hundred and fifty healthy HAN females without rhinoplasty, nasal injury, nasal deformity and craniofacial deformity were included in this study. 3dMD surface imaging system was used for anthropometric analysis. Read More

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Defining the minimal clinically important difference for the knee society score following revision total knee arthroplasty.

Knee Surg Sports Traumatol Arthrosc 2021 Jun 11. Epub 2021 Jun 11.

Department of Orthopaedic Surgery, Singapore General Hospital, 20 College Road, Academia, Level 4, Singapore, 169856, Singapore.

Background: No previous study has evaluated the MCID for revision total knee arthroplasty (TKA). This study aimed to identify the MCID for the Knee Society Score (KSS), for revision TKA.

Methods: Prospectively collected data from 270 patients who underwent revision TKA at a single institution was analysed. Read More

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Integrated I-125 Seed Implantation Combined with Transarterial Chemoembolization for Treatment of Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombus.

Cardiovasc Intervent Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Interventional Radiology, First Affiliated Hospital, Soochow University, No. 188 Shizi Road, Suzhou, 215006, China.

Purpose: To compare the safety and efficacy of integrated iodine-125 (I-125) seed implantation (sequential implantation of helical I-125 seed implant into the main portal vein and of I-125 seeds into the branch tumor thrombus directly forming main portal vein tumor thrombus (MPVTT)) combined with transarterial chemoembolization (TACE) versus TACE alone for hepatocellular carcinoma (HCC) with MPVTT.

Materials And Methods: From December 2016 to January 2020, 46 HCC patients with MPVTT were analyzed. In the combination group, 21 patients received helical I-125 seed implantation in the main portal vein through a patent small portal vein branch and TACE in a single session. Read More

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Salt reduction to prevent hypertension: the reasons of the controversy.

Eur Heart J 2021 Jun 12. Epub 2021 Jun 12.

Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

There is a causal relationship between dietary salt intake and blood pressure. A reduction in salt intake from the current world average of ∼10 g/day to the WHO recommended level of <5 g/day, lowers blood pressure and reduces the risk of cardiovascular disease and all-cause mortality. However, a few cohort studies have claimed that there is a J-shaped relationship between salt intake and cardiovascular risk, i. Read More

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Evidence of the interplay of genetics and culture in Ethiopia.

Nat Commun 2021 Jun 11;12(1):3581. Epub 2021 Jun 11.

Research Department of Genetics, Evolution & Environment, University College London, London, UK.

The rich linguistic, ethnic and cultural diversity of Ethiopia provides an unprecedented opportunity to understand the level to which cultural factors correlate with-and shape-genetic structure in human populations. Using primarily new genetic variation data covering 1,214 Ethiopians representing 68 different ethnic groups, together with information on individuals' birthplaces, linguistic/religious practices and 31 cultural practices, we disentangle the effects of geographic distance, elevation, and social factors on the genetic structure of Ethiopians today. We provide evidence of associations between social behaviours and genetic differences among present-day peoples. Read More

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Performance of a Novel Temporary Arterial Shunt in a Military-Relevant Controlled Hemorrhage Swine Model.

J Trauma Acute Care Surg 2021 May 18. Epub 2021 May 18.

San Antonio Uniformed Services Health Education Consortium, JBSA Ft. Sam Houston, TX Brooke Army Medical Center, JBSA Ft. Sam Houston, TX Office of the Chief Scientist, Wilford Hall Ambulatory Surgical Center, JBSA Lackland, TX Uniformed Services University.

Background: In military trauma, temporary vascular shunts (TVSs) restore arterial continuity until delayed vascular reconstruction, often for a period of hours. A novel US Air Force-developed trauma specific vascular injury shunt (TS-VIS) incorporates an accessible sideport for intervention or monitoring which may improve patency under adverse hemodynamic conditions. Our objective was to evaluate TS-VIS patency in the setting of volume-limited resuscitation from hemorrhagic shock. Read More

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Automated Medical Avatar Animation for Warfighter Mission Simulation.

J Trauma Acute Care Surg 2021 May 18. Epub 2021 May 18.

CFD Research Corporation, Huntsville, AL Biophysics and Biomedical Modeling Division, US Army Research Institute of Environmental Medicine, Natick, MA Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ.

Background: Virtual representations of human internal anatomy are important for military applications such as protective equipment design, injury severity prediction, thermal analysis, and physiological simulations. High-fidelity volumetric models based on imaging data are typically in static postures, and difficult to utilize in simulations of realistic mission scenarios. This study aimed to investigate a hybrid approach to reposition medical avatars that preserves internal anatomy but allows rapid repositioning of full 3D meshes. Read More

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NPWT Resource Use Compared With Conventional Wound Treatment in Subcutaneous Abdominal Wounds With Healing Impairment After Surgery: SAWHI Randomized Clinical Trial Results.

Ann Surg 2021 Jun 10. Epub 2021 Jun 10.

Institute for Research in Operative Medicine, University of Witten/Herdecke, Cologne, Germany.

Objective: To compare resource utilization of NPWT and CWT for SAWHI after surgery.

Summary Of Background Data: NPWT is widely used in the management of complex wounds but high-level evidence of its resource use remains sparse.

Methods: The multicenter, multinational, randomized clinical SAWHI study enrolled a total of 539 consecutive, compliant adult patients with SAWHI after surgery without fascial dehiscence between August 2, 2011, and January 31, 2018. Read More

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Autoimmune Disease and Breast Implants: Systematic Review of Outcomes.

Ann Plast Surg 2021 Jun 10. Epub 2021 Jun 10.

From the Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY Division of Plastic and Reconstructive Surgery, NorthShore University HealthSystem, Chicago, IL Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI Medical Library, Memorial Sloan Kettering Cancer Center, New York, NY.

Abstract: Given that the use of breast implants for both cosmetic and reconstructive purposes is growing in the United States, an evaluation of factors that may affect the outcome of breast implant surgery is needed. A systematic review was conducted to evaluate the question: Does a personal or family history of autoimmune disease affect outcomes in breast implant surgery? The literature search yielded 2425 records, but after removal of duplicates, abstract screening, and full-text assessment, only 2 studies met the inclusion criteria for the final review. Both studies provided level III evidence and the average Methodological Index for Non-Randomized Studies score was 16. Read More

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Safeguarding Skin Grafts: An Evidence-Based Summary of Fixation Techniques.

Ann Plast Surg 2021 Jun 10. Epub 2021 Jun 10.

From the Department of Plastic Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Background: Effective skin graft fixation is vital in preventing sheering forces, seroma, and hematoma from compromising graft take. Yet, selecting the ideal technique for securing skin grafts remains a contentious subject, with significant variation in practice existing between surgeons. There is, therefore, benefit to be derived from assessing the literature for evidence-based recommendations to guide the decision-making process. Read More

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Childhood cross-ethnic exposure predicts political behavior seven decades later: Evidence from linked administrative data.

Sci Adv 2021 Jun 11;7(24). Epub 2021 Jun 11.

Institute for Quantitative Social Science and Department of Government, Harvard University, 1737 Cambridge Street, Cambridge, MA 02138, USA.

Does contact across social groups influence sociopolitical behavior? This question is among the most studied in the social sciences with deep implications for the harmony of diverse societies. Yet, despite a voluminous body of scholarship, evidence around this question is limited to cross-sectional surveys that only measure short-term consequences of contact or to panel surveys with small samples covering short time periods. Using advances in machine learning that enable large-scale linkages across datasets, we examine the long-term determinants of sociopolitical behavior through an unprecedented individual-level analysis linking contemporary political records to the 1940 U. Read More

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Big food and the World Health Organization: a qualitative study of industry attempts to influence global-level non-communicable disease policy.

BMJ Glob Health 2021 Jun;6(6)

Tobacco Control Research Group, Department for Health, University of Bath, Bath, UK.

Introduction: There is an urgent need for effective action to address the over 10 million annual deaths attributable to unhealthy diets. Food industry interference with policies aimed at reducing non-communicable diseases (NCDs) is widely documented at the national level but remains under-researched at the global level. Thus, this study explores how ultra-processed food industry actors have attempted to influence NCD policy at WHO. Read More

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What Is the 30-Day Mortality Burden After Elective Total Hip Arthroplasty? An Analysis of 194,062 Patients.

J Arthroplasty 2021 May 24. Epub 2021 May 24.

Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH.

Background: This study aims to answer the following questions regarding elective total hip arthroplasty (THA): What is (1) the overall 30-day mortality rate; (2) the mortality rate when stratified by age, comorbidities, and preoperative diagnosis; and (3) the distribution of patient demographics, comorbidities, and preoperative diagnoses between the mortality and mortality-free cohorts?

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was reviewed for all patients undergoing elective primary THA (2011-2018). A total of 194,062 patients were categorized based on the incidence of 30-day mortality (mortality: n = 206 vs mortality-free: n = 193,856). Patient demographics, comorbidities, and preoperative diagnosis (osteoarthritis [OA] vs non-OA) were recorded. Read More

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Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the management of peritoneal surface malignancies - An evidence-based review.

Curr Probl Cancer 2021 Apr 15:100737. Epub 2021 Apr 15.

Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Background: Traditionally, peritoneal surface malignancies (PSM) were considered terminal diseases because of their advanced nature, therefore, systemic chemotherapy was given with palliative intent only. As a result, very poor survival outcomes were observed. But with the introduction of complete Cytoreductive surgery (CRS) and Hyperthermic intraperitoneal chemotherapy (HIPEC), the scenario has changed dramatically. Read More

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