1,194 results match your criteria letters hybrid

CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients.

J Hematol Oncol 2021 Jun 9;14(1):90. Epub 2021 Jun 9.

School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.

The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and clinical efficacy have become the major obstacles which limit the application of CAR-T in clinics. To explore the potential biomarkers in plasma for evaluating CRS and clinical efficacy, we performed metabolomic and lipidomic profiling of plasma samples from 17 relapsed or refractory MM patients received CAR-T therapy. Read More

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Implementation of a complex intervention to improve hospital discharge: process evaluation of a cluster randomised controlled trial.

BMJ Open 2021 05 27;11(5):e049872. Epub 2021 May 27.

Institute of Primary Care, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Objectives: To study the implementation of a cluster randomised controlled effectiveness-implementation hybrid trial testing the effectiveness of a medication review at hospital discharge combined with a communication stimulus between hospital physicians (HPs) and general practitioners (GPs) on rehospitalisation of multimorbid older patients.

Design: Extension of Grant's mixed method process evaluation framework to trials with multilevel clustering.

Setting: General internal medicine wards in Swiss hospitals. Read More

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The efficacy and acceptability of hybrid electroconvulsive therapy compared with standard electroconvulsive therapy for schizophrenia patients: A parallel-group, double-blind, randomized, controlled trial.

Brain Stimul 2021 May-Jun;14(3):737-739. Epub 2021 May 4.

Brain Function and Psychosomatic Medicine Institute, Second People's Hospital of Huizhou, Huizhou, Guangdong, China; Department of Psychiatry, Shenzhen Kangning Hospital, and Shenzhen Mental Health Center, Shenzhen, Guangdong, China. Electronic address:

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Benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma on the leg.

J Dermatol 2021 May 3. Epub 2021 May 3.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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Brain-Computer Interface Speller Based on Steady-State Visual Evoked Potential: A Review Focusing on the Stimulus Paradigm and Performance.

Brain Sci 2021 Apr 1;11(4). Epub 2021 Apr 1.

College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China.

The steady-state visual evoked potential (SSVEP), measured by the electroencephalograph (EEG), has high rates of information transfer and signal-to-noise ratio, and has been used to construct brain-computer interface (BCI) spellers. In BCI spellers, the targets of alphanumeric characters are assigned different visual stimuli and the fixation of each target generates a unique SSVEP. Matching the SSVEP to the stimulus allows users to select target letters and numbers. Read More

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Challenging steroid-induced worsening of hyperglycaemia in type 1 diabetes with advanced hybrid closed-loop systems.

Acta Diabetol 2021 Apr 27. Epub 2021 Apr 27.

Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medical Sciences, A.O.U. Città della Salute e della Scienza- Le Molinette Hospital, University of Turin, Corso Bramante 88, 10126, Turin, Italy.

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In situ observation of sponge trails suggests common sponge locomotion in the deep central Arctic.

Curr Biol 2021 Apr;31(8):R368-R370

Max Planck Institute of Marine Microbiology, 28359 Bremen, Germany; Alfred Wegener Helmholtz Centre for Polar and Marine Research, 27570 Bremerhaven, Germany.

In 2016, the research ice-breaker Polarstern surveyed the submerged peaks of the permanently ice-covered Langseth Ridge, a tectonic feature comprising the Karasik seamount and two deeper seamount peaks, abutting the Gakkel ultra-slow spreading ridge (87°N 62°E to 85.5°N 57.4°E). Read More

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School closures reduced social mixing of children during COVID-19 with implications for transmission risk and school reopening policies.

J R Soc Interface 2021 04 14;18(177):20200970. Epub 2021 Apr 14.

College of Letters and Science, University of California, Berkeley, CA, USA.

School closures may reduce the size of social networks among children, potentially limiting infectious disease transmission. To estimate the impact of K-12 closures and reopening policies on children's social interactions and COVID-19 incidence in California's Bay Area, we collected data on children's social contacts and assessed implications for transmission using an individual-based model. Elementary and Hispanic children had more contacts during closures than high school and non-Hispanic children, respectively. Read More

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Using organization theory to position middle-level managers as agents of evidence-based practice implementation.

Implement Sci 2021 Apr 9;16(1):37. Epub 2021 Apr 9.

Warwick Business School, University of Warwick, Coventry, CV4 7AL, UK.

Middle-level managers (MLMs; i.e., healthcare professionals who may fill roles including obtaining and diffusing information, adapting information and the intervention, mediating between strategy and day-to-day activities, and selling intervention implementation) have been identified as having significant influence on evidence-based practice (EBP) implementation. Read More

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Telegenetics for inherited retinal diseases in the COVID-19 environment.

Int J Retina Vitreous 2021 Mar 29;7(1):25. Epub 2021 Mar 29.

Molecular Surgery Laboratory, Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, 94304, USA.

Inherited retinal diseases (IRDs) are visually debilitating conditions that affect families worldwide. They require extensive clinical testing, examination, and patient and family counseling, which are frequently accomplished over single-day extended clinic visits. However, the COVID-19 pandemic has limited the number of patients and staff allowed in clinics, leading to interruptions in care. Read More

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Clinical utility of hybrid (SPECT/CT) imaging in calciphylaxis.

Nefrologia (Engl Ed) 2021 Mar 25. Epub 2021 Mar 25.

Department of Internal medicine, Saint Vincent Hospital, Worcester, Massachusetts, United States of America.

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Aorto-pulmonary and aorto-digestive fistula after hybrid aortic arch aneurysm repair.

J Med Vasc 2021 Apr 5;46(2):100-101. Epub 2021 Mar 5.

Université Côte d'Azur, CHU, Inserm U1065, C3M, Nice, France; Department of Clinical Biochemistry, University Hospital of Nice, Nice, France.

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Chunkflow: hybrid cloud processing of large 3D images by convolutional nets.

Nat Methods 2021 04;18(4):328-330

Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.

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Reply: How should coronary computed tomography angiography co-registration be applied in the chronic total occlusion hybrid algorithm?

EuroIntervention 2021 03;16(16):1374-1375

Center for Coronary Artery Disease, Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern, Minneapolis, MN, USA.

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Letter: How should coronary computed tomography angiography co-registration be applied in the chronic total occlusion hybrid algorithm?

EuroIntervention 2021 03;16(16):1372-1373

Department of Interventional Cardiology and Angiology, National Institute of Cardiology, Warsaw, Poland.

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Assessment of Endovascular Team Performances Using a Comprehensive Data Capture Platform in the Hybrid Room: A Pilot Study.

Eur J Vasc Endovasc Surg 2021 Jun 17;61(6):1028-1029. Epub 2021 Mar 17.

Department of Thoracic and Vascular Surgery, Ghent University Hospital, Ghent, Belgium. Electronic address:

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Study of 17 X-STRs in Native American and Mestizo populations of Central America for forensic and population purposes.

Int J Legal Med 2021 Mar 19. Epub 2021 Mar 19.

BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.

In the present work, an extensive analysis of the X-chromosomal pool of Native American and Mestizo groups of Central America (Guatemala, El Salvador, Nicaragua, and Panama) has been carried out. Allele and haplotype frequency databases, as well as other forensic parameters for these populations, are presented. The admixture analysis supports the tri-hybrid composition in terms of ancestry in the Mestizo populations, with a predominant Native American contribution (54-69%), followed by European (19-28%) and African contributions (12-19%). Read More

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Do we need yet another cognitive test? Free-Cog, a novel, hybrid, cognitive screening instrument.

J Neurol Neurosurg Psychiatry 2021 Mar 15. Epub 2021 Mar 15.

Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, Liverpool, UK

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Healthy Lifestyle Management of Pediatric Obesity with a Hybrid System of Customized Mobile Technology: The PediaFit Pilot Project.

Nutrients 2021 Feb 16;13(2). Epub 2021 Feb 16.

Pediatrics Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.

Pediatric obesity management strategies suffer from a high rate of dropout and persistence of weight excess, despite the use of new tools, such as automated mobile technology (MT). We aimed to compare the efficacy of two 6-month personalized MT protocols in terms of better engagement, adherence to follow-up visits and improved anthropometric and lifestyle parameters. MT contacts consisted of three personalized/not automated What's App self-monitoring or challenge messages per week. Read More

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February 2021

Text Messaging and Web-Based Survey System to Recruit Patients With Low Back Pain and Collect Outcomes in the Emergency Department: Observational Study.

JMIR Mhealth Uhealth 2021 03 4;9(3):e22732. Epub 2021 Mar 4.

Institute for Musculoskeletal Health, The University of Sydney and Sydney Local Health District, Sydney, Australia.

Background: Low back pain (LBP) is a frequent reason for emergency department (ED) presentations, with a global prevalence of 4.4%. Despite being common, the number of clinical trials investigating LBP in the ED is low. Read More

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Reply: When is a hybrid no longer a hybrid?

J Thorac Cardiovasc Surg 2021 Feb 26. Epub 2021 Feb 26.

Division of Congenital Heart Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Tex.

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February 2021

Facile synthesis and antimycobacterial activity of isoniazid, pyrazinamide and ciprofloxacin derivatives.

Chem Biol Drug Des 2021 Jun 16;97(6):1137-1150. Epub 2021 Mar 16.

School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.

Several rationally designed isoniazid (INH), pyrazinamide (PZA) and ciprofloxacin (CPF) derivatives were conveniently synthesized and evaluated in vitro against H37Rv Mycobacterium tuberculosis (M. tb) strain. CPF derivative 16 displayed a modest activity (MIC = 16 µg/ml) and was docked into the M. Read More

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Efficacy of sustained low-efficiency dialysis in the management of sodium valproate overdose.

Intern Med J 2021 02;51(2):295-296

Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.

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February 2021

Breaking a species barrier by enabling hybrid recombination.

Curr Biol 2021 Feb;31(4):R180-R181

Experimental Evolution Research Group, Max Planck Institute for Evolutionary Biology, Plön 24306, Germany; Centre for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.

Hybrid sterility maintains reproductive isolation between species by preventing them from exchanging genetic material. Anti-recombination can contribute to hybrid sterility when different species' chromosome sequences are too diverged to cross over efficiently during hybrid meiosis, resulting in chromosome mis-segregation and aneuploidy. The genome sequences of the yeasts Saccharomyces cerevisiae and Saccharomyces paradoxus have diverged by about 12% and their hybrids are sexually sterile: nearly all of their gametes are aneuploid and inviable. Read More

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February 2021

Rebuttal: Misconceptions in crossboss/stingray catheter use-Clarification from the hybrid group.

Eugene B Wu

Catheter Cardiovasc Interv 2021 Feb 18. Epub 2021 Feb 18.

Prince of Wales Hospital, Chinese University, Hong Kong.

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February 2021

Misconception in CrossBoss/stingray catheter use-clarification from the hybrid group.

Catheter Cardiovasc Interv 2021 Feb 15. Epub 2021 Feb 15.

University of Washington, Seattle, Washington, USA.

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February 2021