2,338 results match your criteria letters defined


Cutaneous long covid.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

NESMOS Dermatology Department, Sapienza University of Rome, Rome, Italy.

Researchers have defined the term 'long covid' as the inability to recover from the symptoms associated to COVID-19 even after months from the peak of the disease . Fatigue, myalgia, chest pain, shortness of breath, cardiac problems, like post-viral myocarditis, and diarrhea have been reported . Recently, Huang et al. Read More

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Predominantly Persistent Subretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Ophthalmol Retina 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Objective: To describe predominantly persistent subretinal fluid (SRF) in eyes receiving ranibizumab or bevacizumab for neovascular age-related macular degeneration and compare visual acuity (VA) to eyes with non-persistent SRF.

Design: Cohort within randomized clinical trial PARTICIPANTS: Comparison of Age-related Macular Degeneration Treatments Trials patients assigned to pro re nata (PRN) treatment.

Methods: Reading center graders evaluated optical coherence tomography scans at baseline and monthly follow-up visits for SRF. Read More

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Differences in coronavirus disease 2019 screening, diagnosis, and hospitalization rates among U.S. pregnant women with and without a substance use disorder.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics, Gynecology & Reproductive Sciences Magee-Womens Research Institute University of Pittsburgh Pittsburgh, Pennsylvania.

Objective: Pregnant women are at increased risk for severe morbidity and mortality due to respiratory infections like SARS-CoV-2 (COVID-19) during pregnancy. Those with substance use disorders (SUD) may be especially vulnerable due to high rates of smoked tobacco, cannabis and methamphetamine use which adversely affect pulmonary function. However, little is known about differential effects of COVID-19 on pregnant women with and without SUD. Read More

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Analysis and Design of Social Presence in a Computer-Mediated Communication System.

Front Psychol 2021 24;12:641927. Epub 2021 May 24.

Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.

Social presence, or the subjective experience of being present with another existing person, varies with the interaction medium. In general, social presence research has mainly focused on uni-directional aspects of each exchanged message, not on bidirectional interactions. Our primary purpose is to introduce such bidirectional evaluation by quantifying the degree of social presence with a few statistical measures. Read More

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Optic Neuritis-Independent Retinal Atrophy in Neuromyelitis Optica Spectrum Disorder.

J Neuroophthalmol 2021 May 17. Epub 2021 May 17.

Department of Neurology (AGF, ESV, KCF, GK, JL, MAM, EMM, SS, PAC, ESS), Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Electrical and Computer Engineering (YH, YL, JLP), Johns Hopkins University, Baltimore, Maryland; Viela Bio (MAM), Gaithersburg, Maryland; and Department of Neurology (ML), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Background: A limited number of studies have investigated the presence of ongoing disease activity independent of clinical relapses in neuromyelitis optica spectrum disorder (NMOSD), and data are conflicting. The objective of our study was to examine whether patients with aquaporin-4 (AQP4)-IgG seropositive NMOSD exhibit progressive retinal neuroaxonal loss, independently of optic neuritis (ON) attacks.

Methods: In this single-center, longitudinal study, 32 AQP4-IgG+ NMOSD patients and 48 healthy controls (HC) were followed with serial spectral-domain optical coherence tomography and visual acuity (VA) assessments. Read More

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Tree crown injury from wildland fires: Causes, measurement, and ecological and physiological consequences.

New Phytol 2021 Jun 9. Epub 2021 Jun 9.

Tall Timbers Research Station, Tallahassee, FL, 32312, USA.

The dead foliage of scorched crowns is one of the most conspicuous signatures of wildland fires. Globally, crown scorch from fires in savannas, woodlands, and forests causes tree stress and death across diverse taxa. The term crown scorch, however, is inconsistently and ambiguously defined in the literature, causing confusion and conflicting interpretation of results. Read More

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Race/Ethnicity are among the predisposing factors for fetal malpresentation at term.

Am J Obstet Gynecol MFM 2021 Jun 3:100405. Epub 2021 Jun 3.

Department of Obstetrics and Gynecology, Lenox Hill Hospital - Zucker School of Medicine at Hofstra/Northwell, New York, NY.

Objective: Fetal malpresentation complicates approximately 3% to 4% of all term births. It requires special considerations for delivery and exposes the mother and neonate to obstetrical interventions and potential adverse outcomes, such as umbilical cord prolapse, head entrapment and birth trauma, hypoxic ischemic encephalopathy, cesarean delivery and cesarean related complications. We set out to explore maternal and fetal factors associated with non-cephalic malpresentation at term, with specific interest on the impact of maternal race and ethnicity on fetal malpresentation. Read More

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'Fading of the temperature-growth coupling' in treeline trees reflects a conceptual bias.

Glob Chang Biol 2021 Jun 5. Epub 2021 Jun 5.

University of Basel, Department of Environmental Sciences, Botany, Schönbeinstrasse 6, 4056, Switzerland.

The global treeline phenomenon follows a common high elevation or high latitude isotherm (Körner 2012). Because treeline position (not necessarily the growth rate of trees) is defined by temperature irrespective of season length (beyond a minimum of three months), treeline elevation can be modelled with surprisingly high precision (Paulsen and Körner 2014). Read More

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Direct nanoscopic observation of plasma waves in the channel of a graphene field-effect transistor.

Light Sci Appl 2020 Jun 4;9(1):97. Epub 2020 Jun 4.

Physikalisches Institut, Johann Wolfgang Goethe-Universität, Max-von-Laue-Str. 1, D-60438, Frankfurt am Main, Germany.

Plasma waves play an important role in many solid-state phenomena and devices. They also become significant in electronic device structures as the operation frequencies of these devices increase. A prominent example is field-effect transistors (FETs), that witness increased attention for application as rectifying detectors and mixers of electromagnetic waves at gigahertz and terahertz frequencies, where they exhibit very good sensitivity even high above the cut-off frequency defined by the carrier transit time. Read More

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Association of Second-Opinion Strategies in the Histopathologic Diagnosis of Cutaneous Melanocytic Lesions With Diagnostic Accuracy and Population-Level Costs.

JAMA Dermatol 2021 Jun 2. Epub 2021 Jun 2.

David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles.

Importance: Diagnostic variation among pathologists interpreting cutaneous melanocytic lesions could lead to suboptimal care.

Objective: To estimate the potential association of second-opinion strategies in the histopathologic diagnosis of cutaneous melanocytic lesions with diagnostic accuracy and 1-year population-level costs in the US.

Design, Setting, And Participants: Decision analysis with 1-year time horizon including melanocytic lesion diagnoses available from US pathologists participating in the Melanoma Pathology Study (M-Path) and from the study panel of reference pathologists who classified cases using the MPATH-Dx classification tool. Read More

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Measuring the Emergence of Specific Abilities in Young Children with Autism Spectrum Disorders: The Example of Early Hyperlexic Traits.

Brain Sci 2021 May 25;11(6). Epub 2021 May 25.

Department of Psychiatry, Faculty of Medicine, University of Geneva, 1206 Geneva, Switzerland.

The presence of a restricted interest in written materials, including an early ability to name and recognize letters and numbers, is regularly reported in preschoolers with autism spectrum disorders (ASDs). There is, however, scarce information on this early ability akin to emerging hyperlexic traits in preschoolers with ASD younger than 3 years old. Here, we defined a measure of early naming and recognition of letters and numbers in 155 preschoolers with ASD using a sliding window approach combined with a 90th percentile threshold criterion, and subsequently compared the profiles of children with ASD with and without early hyperlexic traits. Read More

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Endometrial adenocarcinoma with gastrointestinal differentiation - a newly described entity, with morphologic diversity.

Pol J Pathol 2021 ;72(1):84-86

Department of Gynecology and Obstetrics, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania.

Gastrointestinal type of endometrial carcinoma is a newly described entity for which clearly defined diagnostic criteria have only recently been published. Among morphologic criteria, gastrointestinal mucinous adenocarcinoma of endometrium must not show a typical endometrioid component. We present a case with morphologic diversity, with areas showing gastric and intestinal differentiation as well as an endometrioid-like component. Read More

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Brolucizumab vs aflibercept and ranibizumab for neovascular age-related macular degeneration: a cost-effectiveness analysis.

J Manag Care Spec Pharm 2021 Jun;27(6):743-752

Retina Consultants of Houston, Retina Consultants of America, and Blanton Eye Institute and Houston Methodist Hospital, Houston, TX.

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide and is the most common cause of blindness in developed countries. Despite antivascular endothelial growth factor (anti-VEGF) therapy demonstrating improvements in visual and anatomical outcomes, unmet needs remain. Brolucizumab-dbll (ie, brolucizumab), a VEGF inhibitor for treatment of neovascular (wet) AMD and recently approved by the FDA for its treatment of wet AMD, attempts to mitigate treatment burden through less frequent injections. Read More

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Clinical Characteristics and Prognostic Factors of Posterior Segment Intraocular Foreign Body: Canadian Experience from a Tertiary University Hospital in Quebec.

J Ophthalmol 2021 17;2021:9990290. Epub 2021 May 17.

Department of Ophthalmology, Centre Universitaire d'Ophtalmologie, CHU de Québec-Université Laval, Québec, Canada.

Purpose: To identify predictive factors for visual outcomes of patients presenting with a posterior segment intraocular foreign body (IOFB).

Methods: A retrospective chart review was performed for all consecutive patients operated for posterior segment IOFB removal between January 2009 and December 2018. Data were collected for patient demographics, clinical characteristics at presentation, IOFB characteristics, surgical procedures, and postoperative outcomes. Read More

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Two examples of Renbök phenomenon in dermatophytosis sparing congenital nevi.

J Eur Acad Dermatol Venereol 2021 May 29. Epub 2021 May 29.

Nirvan Skin Clinic, Vadodara, India.

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Immunogenicity of a first dose of mRNA- or vector-based SARS-CoV-2 vaccination in dialysis patients: a multicenter prospective observational pilot study.

J Nephrol 2021 May 29. Epub 2021 May 29.

Diaverum Renal Care Center, 14469, Potsdam, Germany.

Background: Dialysis patients are at risk for lower SARS-CoV-2-vaccine immunogenicity than the normal population. We assessed immunogenicity to a first mRNA- or vector-based SARS-CoV-2-vaccination dose in dialysis patients.

Methods: In a multicenter observational pilot study, 2 weeks after a first vaccination (BNT162b2/Pfizer-BioNTech [Comirnaty] or ChAdOx1 nCoV-19/Oxford-Astra-Zeneca [Vaxzevria]), hemodialysis patients (N = 23), peritoneal dialysis patients (N = 4) and healthy staff (N = 14) were tested for SARS-CoV-2-spike IgG/IgM, Nucleocapsid-protein-IgG-antibodies and plasma ACE2-receptor-binding-inhibition capacity. Read More

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Aerosols should not be defined by distance travelled.

J Hosp Infect 2021 May 25. Epub 2021 May 25.

Institute for Applied Environmental Health, School of Public Health, University of Maryland, USA.

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Smartphone-based remote monitoring of vision in macular disease enables early detection of worsening pathology and need for intravitreal therapy.

BMJ Health Care Inform 2021 May;28(1)

NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, UK

Background/aims: To assess the outcomes of home monitoring of distortion caused by macular diseases using a smartphone-based application (app), and to examine them with hospital-based assessments of visual acuity (VA), optical coherence tomography-derived central macular thickness (CMT) and the requirement of intravitreal injection therapy.

Design: Observational study with retrospective analysis of data.

Methods: Participants were trained in the correct use of the app (Alleye, Oculocare, Zurich, Switzerland) in person or by using video and telephone consultations. Read More

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Endoscopic onlay repair for ventral hernia and rectus abdominis diastasis repair: Why so many different names for the same procedure? A qualitative systematic review.

Surg Endosc 2021 May 24. Epub 2021 May 24.

Department of Surgery, Montefiore Medical Center, Bronx, NY, USA.

Background: A subcutaneous endoscopic onlay repair for ventral hernia with an anterior plication of diastasis recti (DR) has been published under different names in different countries. The aim of this systematic review is to assess the safety and feasibility of different named techniques with the same surgical concept.

Methods: The PRISMA guidelines were followed during all stages of this systematic review. Read More

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Methodological approaches for analysing data from therapeutic efficacy studies.

Malar J 2021 May 21;20(1):228. Epub 2021 May 21.

Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Unité Mixte de Recherche Vecteurs-Infections Tropicales et Méditerranéennes (VITROME), Marseille, France.

Several anti-malarial drugs have been evaluated in randomized clinical trials to treat acute uncomplicated Plasmodium falciparum malaria. The outcome of anti-malarial drug efficacy studies is classified into one of four possible outcomes defined by the World Health Organization: adequate clinical and parasitological response, late parasitological failure, late clinical failure, early treatment failure. These four ordered categories are ordinal data, which are reduced to either a binary outcome (i. Read More

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On experimental tests for studying altruism in capuchin monkeys.

Behav Processes 2021 May 17;189:104424. Epub 2021 May 17.

Department of Psychology, Graduate School of Letters, Kyoto University, Kyoto, 606-8501, Japan.

Altruism is often considered as the ultimate form of prosociality and is defined as any act that benefits others without direct benefit to the actor. Many nonhuman species have been reported to express different forms of altruism, although their expression in experimental studies is highly dependent on the paradigm used. Tufted capuchin monkeys are one of the most studied species; however, the evidence for altruism in this species remains inconclusive. Read More

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Contrast Sensitivity Loss in Patients With Posttreatment Lyme Disease.

Transl Vis Sci Technol 2021 Mar;10(3):27

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: Posttreatment Lyme disease (PTLD) is marked by neurologic symptoms, cognitive impairment, and significant symptom burden, including fatigue and ocular complaints. The purpose of this study was to determine whether contrast sensitivity (CS) is altered in patients with PTLD compared with healthy controls and, second, whether CS is associated with cognitive and/or neurologic deficits.

Methods: CS was measured using a Pelli-Robson chart with forced-choice procedures, and the total number of letters read was recorded for each eye. Read More

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Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial.

Trials 2021 May 17;22(1):343. Epub 2021 May 17.

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty Heinrich-Heine-University Duesseldorf, Moorenstr. 5, D-40225, Duesseldorf, Germany.

Objectives: Currently, there are no approved treatments for early disease stages of COVID-19 and few strategies to prevent disease progression after infection with SARS-CoV-2. The objective of this study is to evaluate the safety and efficacy of convalescent plasma (CP) or camostat mesylate administered within 72 h of diagnosis of SARS-CoV-2 infection in adult individuals with pre-existing risk factors at higher risk of getting seriously ill with COVID-19. Camostat mesylate acts as an inhibitor of the host cell serine protease TMPRSS2 and prevents the virus from entering the cell. Read More

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Randomized clinical trial to evaluate safety and efficacy of convalescent plasma use among hospitalized patients with COVID-19 (PERUCONPLASMA): a structured summary of a study protocol for a randomized controlled trial.

Trials 2021 May 17;22(1):342. Epub 2021 May 17.

School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru.

Objectives: The general objective of this study is to test the hypothesis that administration of convalescent plasma from donors with previous diagnosis of severe COVID-19 pneumonia is safe and associated with a decrease in all-cause in-hospital mortality among hospitalized patients with COVID-19 at 30 days in comparison with standard treatment alone. The secondary objectives are as follows: (1) to assess the efficacy of convalescent plasma to reduce the length of hospitalization, (2) to assess the efficacy of convalescent plasma to reduce the length of ICU stay, and (3) to assess the efficacy of convalescent plasma on reducing the requirement of invasive mechanical ventilation or ICU stay.

Trial Design: PERUCONPLASMA is a IIb phase open label, randomized, superiority clinical trial with 1:1 allocation taking place in real life routine clinical practice at public hospitals in Lima, Peru. Read More

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CT defined prognostic factors for local recurrence after sigmoid resection - How relevant are they?

Eur J Surg Oncol 2021 May 9. Epub 2021 May 9.

Department of Colorectal Surgery, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, 400012, India. Electronic address:

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PERSPECTIVE: Pollen Cryopreservation for Plant Breeding and Genetic Resources Conservation.

Cryo Letters 2020 May-Jun;41(3):115-127

Brazilian Agricultural Research Corporation, Embrapa Southeast Livestock, Brazil.

Pollen conservation is an important tool for the maintenance of plant genetic resources and can promote improved efficiency in breeding programs and germplasm conservation and exchange. This review aims to understand the importance of pollen cryopreservation and how to use it for distinct species in order to encourage the use of this methodology in germplasm banks and plant breeding programs. Pollen from many plant species have already been successfully cryopreserved in liquid nitrogen. Read More

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Successful salvage therapy for refractory primary cutaneous gamma-delta T-cell lymphoma with a combination of brentuximab vedotin and gemcitabine.

Exp Hematol Oncol 2021 May 13;10(1):32. Epub 2021 May 13.

Service and Central Laboratory of Hematology, University Hospital Lausanne (CHUV), Rue du Bugnon 46, CH - 1011, Lausanne, Switzerland.

Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very rare lymphoma with an aggressive clinical course and a dismal outcome. The prognosis is linked to a pronounced resistance to chemotherapy and radiotherapy. No standard treatment approach is defined due to the low frequency of the disease and lack of prospective studies. Read More

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Cryopreservation of Dog Spermatozoa Using Essential and Non-Essential Amino Acids Solutions in An Egg Yolk-Free Polyvinyl Alcohol Extender.

Cryo Letters 2021 Jan-Feb;42(1):44-52

Laboratory of Theriogenology and Reproductive Biotechnology, College of Veterinary Medicine and Bio-safety Research Institute, Jeonbuk National University, Iksan, Republic of Korea.

Background: Amino acids (AAs) have been indicated to have cryoprotective and antioxidative effects on sperm freezing using egg yolk (EY)-based extender. However, EY-based extender is difficult to be standardized for the effect of amino acids because the EY composition varies with the animal's diet.

Objective: To test the effect of AAs in EY-free polyvinyl alcohol (EY-free PVA) extender and develop a chemically defined extender for dog sperm cryopreservation. Read More

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