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Asthma and COVID-19: Lessons Learned and Questions that Remain.

Expert Rev Respir Med 2021 Sep 27. Epub 2021 Sep 27.

Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: Asthma is one of the most common chronic diseases worldwide. As a disease of the respiratory tract, the site of entry for the SARS-CoV-2 virus, there may be an important interplay between asthma and COVID-19 disease.

Areas covered: We report asthma prevalence among hospitalized cohorts with COVID-19. Read More

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September 2021

A Decade Later-Progress and Next Steps for Pediatric Simulation Research.

Simul Healthc 2021 Sep 24. Epub 2021 Sep 24.

From the Tufts University School of Medicine (L.A.M.), Boston, MA; Department of Medical Education (L.A.M.), The Hannaford Center for Simulation, Innovation and Education; Section of Hospital Medicine (L.A.M.), Department of Pediatrics, The Barbara Bush Children's Hospital at Maine Medical Center, Portland, ME; Section of Emergency Medicine (C.B.D.), Department of Pediatrics, Baylor College of Medicine; Simulation Center (C.B.D.), Texas Children's Hospital, Pediatric Emergency Medicine, Baylor College of Medicine; Section of Critical Care Medicine (K.I.D.), Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX; Departments of Pediatrics and Emergency Medicine (A.C.), University of Calgary, Calgary, Canada; Division of Pediatric Critical Care (A.W.C.), University of Louisville School of Medicine and Norton Children's Hospital, Louisville, KY; Section of Emergency Medicine (M.A.A.), Yale University School of Medicine, New Haven, CT; Division of Critical Care (J.P.D.), University of Alberta, Alberta, Canada; and Columbia University Vagelos College of Physicians and Surgeons (D.O.K.), New York, NY.

Summary Statement: A decade ago, at the time of formation of the International Network for Pediatric Simulation-based Innovation, Research, and Education, the group embarked on a consensus building exercise. The goal was to forecast the facilitators and barriers to growth and maturity of science in the field of pediatric simulation-based research. This exercise produced 6 domains critical to progress in the field: (1) prioritization, (2) research methodology and outcomes, (3) academic collaboration, (4) integration/implementation/sustainability, (5) technology, and (6) resources/support/advocacy. Read More

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September 2021

50 Years Ago in TheJournalofPediatrics: Pediatric Hyperthyroidism and Atrial Fibrillation: Lessons Learned.

J Pediatr 2021 Oct;237:70

Division of Pediatric Cardiology, Children's Hospital at Montefiore, Bronx, New York.

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October 2021

Seeking progress in disease modification in Parkinson disease.

Parkinsonism Relat Disord 2021 Sep 10. Epub 2021 Sep 10.

The Cure Parkinson's Trust, London, UK.

Objective: Disease modification in Parkinson disease (PD) has remained an elusive goal, in spite of large investments over several decades. Following a large meeting of experts, this review article discusses the state of the science, possible reasons for past PD trials' failures to demonstrate disease-modifying benefit, and potential solutions.

Methods: The National Institute of Neurological Disorders and Stroke (NINDS) convened a meeting including leaders in the field and representatives of key stakeholder groups to discuss drug therapy with the goal of disease modification in PD. Read More

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September 2021

Lessons learned from safe tracheostomy aftercare taskforce implemented during COVID-19 pandemic.

Am J Otolaryngol 2021 Sep 16;43(1):103240. Epub 2021 Sep 16.

Department of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical center, New York, NY 10032, USA. Electronic address:

Purpose: At the height of the COVID-19 pandemic, our institution instituted a Safe Tracheostomy Aftercare Taskforce (STAT) team to care for the influx of patients undergoing tracheostomies. This review was undertaken to understand this team's impact on outcomes of tracheostomy care.

Methods: We compared retrospective data collected from patients undergoing tracheostomies at our institution from February to June 2019, prior to creation of the STAT team, to prospectively collected data from tracheostomies performed from February to June 2020, while the STAT team was in place and performed statistical analysis on outcomes of care such as decannulation prior to discharge, timely tube change, and post-discharge follow-up. Read More

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September 2021

Managing Human Subjects Research During a Global Pandemic at an Academic Center: Lessons Learned from COVID-19.

Acad Med 2021 Sep 21. Epub 2021 Sep 21.

D.F. Stiles is vice president, Research Operations, and policy and chief operating officer, Office of the Executive Vice President for Research, Columbia University, New York, New York; ORCID: https://orcid.org/0000-0001-9845-6804. B.L. Ruotolo is associate vice president, Human Research Protection, Columbia University, New York, New York. H. Kim is associate vice president, Clinical Trials, Columbia University, New York, New York. J. Cho is associate director, Regulatory Science, Clinical Trials Office, Columbia University, New York, New York. P.S. Appelbaum is Elizabeth K. Dollard Professor of psychiatry, medicine, and law, Department of Psychiatry, Columbia University Irving Medical Center, New York, New York; ORCID: https://orcid.org/0000-0002-1940-0042. N.S. Green is professor, Department of Pediatrics, and associate dean, Faculty Operations, Columbia University Irving Medical Center, New York, New York; ORCID: https://orcid.org/0000-0002-9877-1561.

By March 2020, New York City became the early epicenter of the COVID-19 pandemic in the United States. Consequently, Columbia University, with its large portfolio of human subjects research, had to address the challenges of protecting thousands of research participants and research staff from potential exposure to COVID-19 while facilitating essential biomedical research, especially pandemic-related studies. The authors describe, from the perspective of Columbia's research administration leadership, how the university and its primary teaching hospital ramped down-and later ramped up-human subjects research, and reflect on the lessons learned. Read More

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September 2021

The CopeNYP program: A model for brief treatment of psychological distress among healthcare workers and hospital staff.

Gen Hosp Psychiatry 2021 Sep 6;73:24-29. Epub 2021 Sep 6.

Weill Cornell Medicine, Department of Psychiatry, New York Presbyterian Hospital, USA.

In the midst of the Spring 2020 initial surge of the COVID-19 pandemic in New York, members of the Psychiatry Department of Weill Cornell Medicine/NewYork-Presbyterian Hospital rapidly created and implemented a brief, behavioral skills-based intervention program, "CopeNYP", to address the immediate mental health needs of the employees of the hospital and medical school. We describe the development, implementation and evolution of this telehealth-delivered program staffed primarily by in-house clinical psychologists, postdoctoral fellows, pre-doctoral interns and counselors who were redeployed or volunteered their time to provide urgent support for employees. We discuss the challenges and lessons learned in providing brief, skills-based psychological interventions for employees subjected to chronic stress. Read More

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September 2021

Lessons learned developing and testing family-based interoceptive exposure for adolescents with low-weight eating disorders.

Int J Eat Disord 2021 Sep 15. Epub 2021 Sep 15.

Eating and Weight Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Anorexia nervosa (AN) usually develops in early adolescence and is characterized by high rates of morbidity and mortality. Family-based therapy (FBT) is the leading evidence-based treatment for adolescents with AN, but not all patients experience sufficient improvement. The purpose of this manuscript is to describe the development and subsequent experience with a Family-Based Interoceptive Exposure (FBT-IE) for adolescents with a broader form of low-weight eating disorders. Read More

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September 2021

The Campaign for Universal Free Lunch in New York City: Lessons Learned.

Pediatrics 2021 Sep 15. Epub 2021 Sep 15.

Community Food Advocates, New York, New York.

The New York City (NYC) Department of Education is the largest public school system in the United States, with an enrollment of >1.1 million students. Students who participate in school meal programs can have higher dietary quality than nonparticipating students. Read More

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September 2021

UNICEF's lessons learned from the education response to the COVID-19 crisis and reflections on the implications for education policy.

Int J Educ Dev 2021 Sep 12;85:102429. Epub 2021 May 12.

Regional Education Advisor in UNICEF East Asia and the Pacific in Bangkok, Thailand.

COVID-19 triggered mass innovation that grew flexible learning modalities and pathways that can be built upon in future sector plans to make education systems more resilient. These tools must be paired with investments in the people expected to use them and strengthened data systems. To ensure plans are rooted in ever-pressurised budgets, Education Ministers will increasingly need to turn to economic analysis. Read More

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September 2021

Learning from disease registries during a pandemic: Moving toward an international federation of patient registries.

Clin Dermatol 2021 May-Jun;39(3):467-478. Epub 2021 Apr 6.

St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

High-quality dermatology patient registries often require considerable time to develop and produce meaningful data. Development time is influenced by registry complexity and regulatory hurdles that vary significantly nationally and institutionally. The rapid emergence of the coronavirus disease 2019 (COVID-19) global pandemic has challenged health services in an unprecedented manner. Read More

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A Roadmap for Successful State Sepsis Regulations-Lessons From New York.

Crit Care Explor 2021 Sep 3;3(9):e0521. Epub 2021 Sep 3.

CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.

New York state implemented the first state-level sepsis regulations in 2013. These regulations were associated with improved mortality, leading other states to consider similar steps. Our objective was to provide insight into New York state's sepsis policy making process, creating a roadmap for policymakers in other states considering similar regulations. Read More

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September 2021

Governance in the Face of Extreme Events: Lessons from Evolutionary Processes for Structuring Interventions, and the Need to Go Beyond.

Ecosystems 2021 Sep 7:1-15. Epub 2021 Sep 7.

Department of Agricultural and Resource Economics, University of California, Davis, California 95616 USA.

The increasing frequency of extreme events, exogenous and endogenous, poses challenges for our societies. The current pandemic is a case in point; but "once-in-a-century" weather events are also becoming more common, leading to erosion, wildfire and even volcanic events that change ecosystems and disturbance regimes, threaten the sustainability of our life-support systems, and challenge the robustness and resilience of societies. Dealing with extremes will require new approaches and large-scale collective action. Read More

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September 2021

Adaptation and restructuring of an academic anesthesiology department during the COVID-19 pandemic in New York City: Challenges and lessons learned.

Best Pract Res Clin Anaesthesiol 2021 Oct 10;35(3):425-435. Epub 2020 Dec 10.

Montefiore Medical Center, 111 E. 210th Street, Bronx, NY, 10467, USA.

The novel SARS-CoV-2 pandemic starting in 2019 profoundly changed the world, and thousands of residents of New York City were affected, leading to one of the most acute surges in regional hospital capacity. As the largest academic medical center in the Bronx, Montefiore Medical Center was immediately impacted, and the entire hospital was mobilized to address the needs of its community. In this article, we describe our experiences as a large academic anesthesiology department during this pandemic. Read More

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October 2021

Changes in pediatric hospital care during the COVID-19 pandemic: a national qualitative study.

BMC Health Serv Res 2021 09 11;21(1):953. Epub 2021 Sep 11.

Department of Pediatrics, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA.

Background: The COVID-19 pandemic has necessitated rapid changes in healthcare delivery in the United States, including changes in the care of hospitalized children. The objectives of this study were to identify major changes in healthcare delivery for hospitalized children during the COVID-19 pandemic, identify lessons learned from these changes, and compare and contrast the experiences of children's and community hospitals.

Methods: We purposefully sampled participants from both community and children's hospitals serving pediatric patients in the six U. Read More

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September 2021

Viral forgetting, or how to have ignorance in an syndemic.

Cult Health Sex 2021 Sep 11:1-14. Epub 2021 Sep 11.

Political Science, Queens College, City University of New York, New York, NY, USA.

This paper argues for the concept of viral forgetting to understand how and why the lessons of HIV were not easy to remember in the context of COVID. Building on recently drawn analogies between the two epidemics, we argue that new normative injunctions to 'flatten the curve' and 'stay at home' individualise responses to COVID that make memory of the first decade of HIV vital in recent viral times. Individualistic responses, including those that bind individuals to social identity groups, obscure the ways in which effective care for others and the self requires a recognition of the partiality of community, the inevitability of vulnerability, and a complex interpretation of scientific evidence and human ontology. Read More

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September 2021

Lessons from Medicare's Bundled Payments for Care Improvement initiative for postacute care.

J Am Geriatr Soc 2021 Sep 12. Epub 2021 Sep 12.

Department of Orthopaedics, University of Rochester, Rochester, New York, USA.

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September 2021

Changes and Compromises in Health Choices during COVID-19 Lockdown in Kathmandu Valley: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2020 Dec 31;58(232):1046-1051. Epub 2020 Dec 31.

Annapurna Neurological Institute and Allied Sciences, Kathmandu, Nepal.

Introduction: Nepal government enforced a lockdown as a social distancing measure to curb the COVID-19 pandemic. The lockdown has led to compromises in day to day choices like food, exercise, sleep, self-care routines and utilization of healthcare facilities - directly and indirectly influencing aspects of health. Identification of compromised health choices can assist in better planning of inevitable future crises. Read More

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December 2020

Speaking with One Voice: Lessons Learned on Effective Communication of Environmental Health Risk.

Environ Justice 2021 Aug 12;14(4):235-242. Epub 2021 Aug 12.

Dr. Maida P. Galvez is a Professor of Environmental Medicine and Public Health & Pediatrics at Icahn School of Medicine at Mount Sinai, New York, New York, USA. Dr. Anne Herlache is a Senior Management and Program Analyst (Social Scientist) at Internal Revenue Service, Washington, District of Columbia, USA. Dr. Laura Anderko is Robert and Kathleen Scanlon Endowed Chair in Values Based Health Care & Professor at School of Nursing & Health Studies, Georgetown University, Washington, District of Columbia, USA; Co-Director, Mid-Atlantic Center for Children's Health and the Environment (Region 3 PEHSU) at M. Fitzpatrick College of Nursing, Villanova University, Washington, District of Columbia, USA. Surili Sutaria Patel is a Director, Center for Climate, Health & Equity at American Public Health Association, Washington, District of Columbia, USA. Carla Azar is a Director of Communications in the Department of Environmental Medicine and Public Health at Icahn School of Medicine at Mount Sinai, New York, New York, USA. Kevin Ardon Casco is a medical student at Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras. Wendy Mindel Rubinstein is a Public Health Intern in the Department of Environmental Medicine and Public Health at Icahn School of Medicine at Mount Sinai, New York, New York, USA. Doug Farquhar is a Director of Government Affairs at National Environmental Health Association (NEHA), Denver, Colorado, USA. Suzanne Condon is an Environmental Health Consultant in Quincy, Massachusetts, USA.

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Microfluidic devices for behavioral screening of multiple Zebrafish Larvae: Design investigation process.

Biotechnol J 2021 Sep 4:e2100076. Epub 2021 Sep 4.

Department of Mechanical Engineering, York University, Toronto, Ontario, Canada.

Microfluidic devices have been introduced for phenotypic screening of zebrafish larvae in both fundamental and pre-clinical research. One of the remaining challenges for the broad use of microfluidic devices is their limited throughput, especially in behavioural assays. Previously, we introduced the tail locomotion of a semi-mobile zebrafish larva evoked on-demand with electric signal in a microfluidic device. Read More

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September 2021

Neurologic Safety Monitoring of COVID-19 Vaccines: Lessons From the Past to Inform the Present.

Neurology 2021 Sep 2. Epub 2021 Sep 2.

Department of Neurology, Columbia University Irving Medical Center and New York Presbyterian Hospital.

The spread of the SARS-CoV-2 virus has triggered a global effort to rapidly develop and deploy effective and safe COVID-19 vaccination(s). Vaccination has been one of the most effective medical interventions in human history, though potential safety risks of novel vaccines must be monitored, identified, and quantified. Adverse events must be carefully assessed to define whether they are causally associated with vaccination or coincidence. Read More

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September 2021

Acute Kidney Injury: Lessons from Pericardiectomy.

Heart Surg Forum 2021 Jul 27;24(4):E656-E661. Epub 2021 Jul 27.

Department of Cardiothoracic Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Road, Nanning, Guangxi, China.

Background: Acute kidney (renal) injury (AKI) is a severe and common complication that occurs in ~40% of patients undergoing cardiac surgery. AKI has been associated with increased mortality and worse prognosis. This prospective study was conducted to determine the risk factors for AKI after pericardiectomy and decrease the operative risk of mortality and morbidity. Read More

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Exploring the Psychological Aspects of Palliative Care: Lessons Learned from an Interdisciplinary Seminar of Experts.

J Palliat Med 2021 Sep;24(9):1274-1279

Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Palliative care has been shown to help patients live well with serious illness, but the specific psychological factors that contribute to this benefit remain investigational. Although support of patient coping has emerged as a likely factor, it is unclear how palliative care helps patients to cope with serious illness. The therapeutic relationship has been proposed as a key element in beneficial patient outcomes, possibly undergirding effective patient and family coping. Read More

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September 2021

Addressing the Social Determinants of Health in the Aftermath of COVID-19: Lessons From the 2008 Great Recession.

Am J Public Health 2021 08;111(8):1433-1435

Wasie Karim and Peter A. Muennig are with the Department of Health Policy and Management, Columbia University Mailman School of Public Health, New York, NY. Emilie Courtin is with the Department of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, UK.

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Documenting Educational Impact in the Promotion Dossier with an Enhanced Curriculum Vitae.

J Contin Educ Health Prof 2021 Aug 27. Epub 2021 Aug 27.

Dr. Hobson: Professor, Department of Pediatrics and Associate Vice President for Health Sciences Education, University of Utah, Salt Lake City, UT. Dr. Gordon: Associate Professor, Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY. Dr. Cabaniss: Professor of Clinical Psychiatry, Department of Psychiatry, Columbia University Medical Center, New York, NY. Dr. Richards: Professor (Lecturer), Department of Pediatrics, and Director of Educational Research and Scholarship, University of Utah, Salt Lake City, UT.

Abstract: Faculty with a career focus on education in the health professions often have difficulty representing their academic accomplishments for due consideration in promotion decisions at their respective institutions. This problem occurs because the traditional curriculum vitae (CV) format which is most often used tends to focus on peer-reviewed accomplishments easily presented in lists, such as grants and publications. In some institutions, an educator portfolio is required in place of or in addition to the CV. Read More

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Mouse Models of Germinal Center Derived B-Cell Lymphomas.

Front Immunol 2021 12;12:710711. Epub 2021 Aug 12.

Institute for Cancer Genetics, Columbia University, New York, NY, United States.

Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these cancers. Dissecting how the involved genes contribute to the physiology and pathology of germinal center (GC) B cells -the origin of most B-cell lymphomas- will be key to advance our ability to diagnose and treat these patients. Genetically engineered mouse models (GEMM) that faithfully recapitulate lymphoma-associated genetic alterations offer a valuable platform to investigate the pathogenic roles of candidate oncogenes and tumor suppressors , and to pre-clinically develop new therapeutic principles in the context of an intact tumor immune microenvironment. Read More

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Characterization of Ultralow Density Cellular Solids: Lessons from 30 years of Bone Biomechanics Research.

Adv Eng Mater 2021 Jul 20;23(7). Epub 2021 Mar 20.

Department of Materials Science and Engineering, Cornell University, Ithaca, NY.

Advances in additive manufacturing techniques have enabled the development of micro-architectured materials displaying a combination of low-density and lightweight structures with high specific strength and toughness. The mechanical performance of micro-architectured materials can be assessed using standard techniques; however, when studying low- and ultralow density micro-architectured materials, standard characterization techniques can be subject to experimental artifacts. Additionally, quantitative assessment and comparisons of microarchitectures with distinct lattice patterns is not always straightforward. Read More

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