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Mortality and functional outcome after pediatric intracerebral hemorrhage: cohort study and meta-analysis.

J Neurosurg Pediatr 2021 Apr 9:1-7. Epub 2021 Apr 9.

1Service d'imagerie Morphologique et Fonctionnelle, GHU Paris Psychiatrie et Neurosciences, Hospitalier Sainte Anne, Institut de Psychiatrie et Neurosciences de Paris, UMR_S1266, INSERM, Université de Paris.

Objective: The clinical outcome of pediatric intracerebral hemorrhage (pICH) is rarely reported in a comprehensive way. In this cohort study, systematic review, and meta-analysis of patients with pICH, the authors aimed to describe the basic clinical outcomes of pICH.

Methods: Children who received treatment for pICH at the authors' institution were prospectively enrolled in the cohort in 2008; data since 2000 were retrospectively included, and data through October 2019 were analyzed. Read More

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Discriminating cognitive motor dissociation from disorders of consciousness using structural MRI.

Neuroimage Clin 2021 Mar 29;30:102651. Epub 2021 Mar 29.

Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address:

An accurate evaluation and detection of awareness after a severe brain injury is crucial to a patient's diagnosis, therapy, and end-of-life decisions. Misdiagnosis is frequent as behavior-based assessments often overlook subtle signs of consciousness. This study aimed to identify brain MRI characteristics of patients with residual consciousness after a severe brain injury and to develop a simple MRI-based scoring system according to the findings. Read More

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Impact of augmented-reality improvement in ablation catheter navigation as assessed by virtual-heart simulations of ventricular tachycardia ablation.

Comput Biol Med 2021 Apr 2;133:104366. Epub 2021 Apr 2.

Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Background: Recently, an augmented reality (AR) solution allows the physician to place the ablation catheter at the designated lesion site more accurately during cardiac electrophysiology studies. The improvement in navigation accuracy may positively affect ventricular tachycardia (VT) ablation termination, however assessment of this in the clinic would be difficult. Novel personalized virtual heart technology enables non-invasive identification of optimal lesion targets for infarct-related VT. Read More

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PILP remineralization of artificial and natural dentin carious lesions evaluated by nanoindentation and microcomputed tomography.

J Dent 2021 Apr 6:103659. Epub 2021 Apr 6.

Department of Preventative and Restorative Dental Sciences, UCSF School of Dentistry, San Francisco, CA, USA. Electronic address:

Objectives: The study evaluates the efficacy to remineralize artificial and natural dentin lesions through restorative dental procedures that include the Polymer-Induced Liquid Precursor (PILP) method comprising polyaspartic acid (pAsp).

Methods: Novel ionomeric cement compositions based on bioglass 45S5 and pAsp mixtures, as well as conditioning solutions (conditioner) containing 5 mg/ml pAsp, were developed and tested on demineralized dentin blocks (3-4 mm thick) on shallow and deep lesions with the thickness of 150 µm ± 50 and 700 µm ± 50, respectively. In the first treatment group, 20 µl of conditioner was applied to demineralized shallow (n = 3) and deep (n = 3) lesion specimens for 20 s before restoration with glass ionomer cement (RMGIC). Read More

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GLOS and HARM in patients with transient neurovascular symptoms with and without ischemic infarction.

J Neuroradiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.

Background And Purpose: Gadolinium leakage in ocular structures (GLOS) on fluid attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke and other neurological disorders.

Methods: In patients with transient neurovascular symptoms who underwent repeated MRI with intravenous contrast agent administration, the presence of acute ischemic lesions on diffusion-weighted images (DWI) as well as the frequency and pattern of blood-brain barrier and blood-retina barrier impairment as demonstrated by the hyperintense acute reperfusion marker (HARM) and GLOS respectively on postcontrast FLAIR were evaluated.

Results: Overall 28 patients with transient neurovascular symptoms (median age 70. Read More

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The role of ex-situ hypothermic oxygenated machine perfusion and cold preservation time in extended criteria DCD and DBD.

Liver Transpl 2021 Apr 9. Epub 2021 Apr 9.

General and Liver Transplant Surgery Unit - Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan.

Hypothermic-oxygenated machine perfusion (HOPE) has the potential to counterbalance the detrimental consequences of cold and warm ischemia time in both brain death donors (DBD) and donors after circulatory death (DCD). Herein, we investigated the protective effects of HOPE in extended criteria (ECD) DBD and over-extended warm ischemia time (WIT) DCD grafts. The present retrospective case-series study included 50 livers subjected to end-ischemic HOPE or dual (D)HOPE in two liver transplant (LT) Centers from January 2018 to December 2019. Read More

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The surgical approach to Pyoderma gangrenosum: A retrospective monocenter study.

Wound Repair Regen 2021 Apr 9. Epub 2021 Apr 9.

Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center, Hannover Medical School, Hannover, Germany.

Pyoderma gangrenosum is a diagnosis of exclusion. It occurs rarely and is frequently misdiagnosed. It can result in severe tissue loss, particularly in surgical units with little experience. Read More

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Efficacy and safety of S-1 following gemcitabine with cisplatin for advanced biliary tract cancer.

Invest New Drugs 2021 Apr 9. Epub 2021 Apr 9.

Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Sunto-gun, Shizuoka, 411-8777, Japan.

Background Combination therapy of gemcitabine with cisplatin (GC) is a standard first-line therapy for unresectable or recurrent biliary tract cancer (BTC). S-1 is often used as a second-line therapy in clinical practice, based on the results of some clinical studies investigating its efficacy and safety following gemcitabine monotherapy. However, few studies have reported on the clinical outcomes of S-1 following GC. Read More

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Laparoscopic anterior hepatic transection for resecting lesions originating in the paracaval portion of the caudate lobe (with videos).

Surg Endosc 2021 Apr 9. Epub 2021 Apr 9.

Institute of Hepatobiliary Surgery, First Affiliated Hospital, Army Medical University, 30 Gaotanyan Main Street, Shapingba District, Chongqing, 400038, China.

Background: The paracaval portion of the caudate lobe is located in the core of the liver. Lesions originating in the paracaval portion often cling to or even invade major hepatic vascular structures. The traditional open anterior hepatic transection approach has been adopted to treat paracaval-originating lesions. Read More

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Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.

Acta Dermatovenerol Croat 2020 Dec;28(7):233-235

Martyna Sławińska MD, PhD, Department of Dermatology, Venereology and Allergology Medical University of Gdańsk, Smoluchowskiego 17 Street, 80-214 Gdańsk;

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. Read More

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December 2020


Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):35-38. Epub 2021 Apr 8.

Cardiothoracic Surgery Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal; Faculdade de Medicina da Universidade do Porto, Portugal.

Background: Placement of chest drain following thoracoscopic procedures has been the gold standard. Nevertheless, a drainless approach may be safe and feasible in selected patients and procedures. In this study we aim to report our clinical experience after drainless video-assisted thoracoscopic surgery. Read More

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Value of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Focal Splenic Lesions.

Cancer Manag Res 2021 1;13:2947-2958. Epub 2021 Apr 1.

Laboratory of Ultrasound Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.

Purpose: To identify and validate contrast-enhanced ultrasound (CEUS) features for differentiating malignant from benign splenic lesions.

Patients And Methods: Splenic lesions in 123 patients who underwent conventional ultrasound (B-mode US) and CEUS were included in this study. Two radiologists evaluated the sonograms of B-mode and CEUS. Read More

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Optimization of the Radiation Dose of Digital Breast Tomosynthesis in Opportunistic Screening by Studying the Effect of Different Combinations of FFDM and DBT Views.

Int J Gen Med 2021 30;14:1147-1154. Epub 2021 Mar 30.

Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Nantong, 226019, Jiangsu, People's Republic of China.

Background: Full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) are used separately or in combination to identify small breast lesions. The dose of the examination depends on the density of the breast and the imaging (FFDM or DBT) performed. We have performed a retrospective review of FFDM and DBT in women with denser breasts in order to demonstrate how varying the combination of FFDM and DBT in CC and MLO views affects lesion detection and the average gland dose. Read More

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Small dome-shaped pigment epithelium detachment in polypoidal choroidal vasculopathy: an under-recognized sign of polypoidal lesions on optical coherence tomography?

Eye (Lond) 2021 Apr 8. Epub 2021 Apr 8.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomographic angiography (SS-OCTA) to identify polypoidal lesions in serous or serosanguinous maculopathy.

Materials And Methods: A retrospective review of patients presenting pigment epithelial detachments (PEDs) with the diagnosis of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and central serous chorioretinopathy (CSC), all of which underwent SD-OCT, SS-OCTA, and indocyanine green angiography (ICGA). Typical features of polypoidal lesions on SD-OCT included sharply peaked PED, notched PED, and hyperreflective ring underneath PED. Read More

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The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia.

Sci Rep 2021 Apr 8;11(1):7752. Epub 2021 Apr 8.

Department of Radiology, First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing, 400016, China.

To explore the clinical application value of chest CT quantitative pulmonary inflammation index (PII) in the evaluation of the course and treatment outcome of COVID-19 pneumonia. One hundred and eighteen patients with COVID-19 pneumonia diagnosed by RT-PCR were analyzed retrospectively. The correlation between chest CT PII, clinical symptoms and laboratory examinations during the entire hospitalization period was compared. Read More

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Buschke-Lowenstein Tumors: A Review and Proposed Classification System.

Sex Transm Dis 2021 Apr 1. Epub 2021 Apr 1.

Associate Professor of Surgery, Department of Surgery, LSU School of Medicine Associate Professor of Surgery, Department of Surgery, LSU School of Medicine Associate Professor of Pathology, Department of Pathology, LSU School of Medicine Associate Professor of Surgery Department of Urology, Tulane School of Medicine Professor of Surgery, Department of Surgery, LSU School of Medicine.

Abstract: Buschke-Lowenstein tumors (B-L) or giant condyloma are large fungating lesions that are caused by HPV and develop in the anogenital region. While uncommon, physicians and surgeons who treat sexually transmitted diseases or other diseases involving the anogenital area will encounter these patients. The purpose of this study is to review the current literature regarding these lesions. Read More

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A clinicopathological reappraisal of intraductal papillary neoplasm of the bile duct (IPNB): a continuous spectrum with papillary cholangiocarcinoma in 181 curatively resected cases.

HPB (Oxford) 2021 Mar 18. Epub 2021 Mar 18.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Background: Intraductal papillary neoplasm of the bile-duct (IPNB) has recently been further subclassified into "so-called IPNBs" (Type-1) and "narrow-sense papillary cholangiocarcinomas" (Type-2), but their differential diagnosis is challenging. This study aimed to reevaluate Type-1 and Type-2 IPNBs.

Methods: Consecutive patients who underwent papillary bile-duct tumor resection were included. Read More

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Therapeutic outcome and related predictors of stereotactic body radiotherapy for small liver-confined HCC: a systematic review and meta-analysis of observational studies.

Radiat Oncol 2021 Apr 8;16(1):68. Epub 2021 Apr 8.

Department of Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing Cancer Institute, Chongqing Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing, 400030, China.

Background And Purpose: Stereotactic body radiotherapy (SBRT) is a promising ablative modality for hepatocellular carcinoma (HCC) especially for those with small-sized or early-stage tumors. This study aimed to synthesize available data to evaluate efficacy and explore related predictors of SBRT for small liver-confined HCC (≤ 3 lesions with longest diameter ≤ 6 cm).

Materials And Methods: A systematic search were performed of the PubMed and Cochrane Library databases. Read More

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Customized self-expanding bare metal Y stents in the treatment of malignant carinal stenosis: a retrospective analysis.

Ann Palliat Med 2021 Mar 29. Epub 2021 Mar 29.

Department of Respiratory and Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Self-expanding Y metal stent insertion is a safe and effective palliative method for malignant lesions involving the lower trachea, tracheal carina, and the main-stem bronchi. However, the length and degree of airway stenosis in different patients tend to vary, which leads to a call for a customized Y stent that could achieve a better treatment effect.

Methods: This retrospective analysis included patients who received customized self-expanding bare metallic Y stents for malignant carinal stenosis at Beijing Tiantan Hospital, Capital Medical University between January 2007 and June 2020. Read More

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[Complications of Da Vinci robot thyroid surgery by bilateral axillo-breast approach].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;56(4):363-368

Department of Thyroid and Breast Surgery, the 960th Hospital of the People's Liberation Army of China, Jinan 250031, China.

To evaluate the complications of Da Vinci robotic thyroid surgery by bilateral axillo-breast approach. A retrospective analysis of complications was conducted on 1, 198 cases of Da Vinci robotic thyroid surgery by bilateral axillo-breast approach of the 960 th Hospital of the People's Liberation Army from February 2014 to March 2020. There were 263 men and 935 women, age ranged from 9 to 68 years old, and included 288 benign lesions and 910 malignancies according to preoperative imaging examination, FNAC, and intraoperative frozen pathology. Read More

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A novel 125I seeds fixed on gastric tube for treatment of inoperable esophageal carcinoma: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25410

Department of Cardiothoracic Surgery, First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.

Abstract: To explore the treatment benefit of 125I seeds fixed on a gastric tube in the early inoperable esophageal carcinoma (EC).Three senile patients with early inoperable EC who were treated with brachytherapy between October 2017 and February 2019 were included in this study. 125I seeds were fixed on the gastric tube, which was then inserted on the surface of the EC. Read More

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[Clinical features of 141 fatal cases of coronavirus disease in Jinyintan Hospital in Wuhan, China].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Apr;44(4):354-359

Department of Respiratory Disease and Intensive Care, Changsha Central Hospital, Changsha 410001, China.

To describe the epidemiological characteristics and clinical features of patients with fatal coronavirus disease (COVID-19), in order to provide evidence for clinical diagnosis and treatment. In this retrospective study, we analyzed data on 141 fatal cases of confirmed COVID-19 that occurred among patients in Jinyintan Hospital in Wuhan, China, from January 20 to March 6, 2020. We analyzed their epidemiological characteristics, clinical and radiological features, laboratory results, and treatment. Read More

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Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study.

PLoS One 2021 8;16(4):e0249862. Epub 2021 Apr 8.

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Aim: To evaluate the effectiveness of non-aromatic very rich in steranes (NAVS) naphthalan in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS). Null hypothesis was that there would be no difference between NAVS and topical steroids in the treatment of OLP and RAS.

Methods: The study consisted of two sub-trials conducted as randomized, double-blind controlled studies: first included OLP patients and second patients with RAS. Read More

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An endoscopic endonasal approach to craniopharyngioma via the infrachiasmatic corridor: a single center experience of 84 patients.

Acta Neurochir (Wien) 2021 Apr 8. Epub 2021 Apr 8.

Neurosurgery Department, Pituitary Research Center, Kocaeli University, Kocaeli, Turkey.

Object: The infrachiasmatic corridor is the most important surgical access route for craniopharyngiomas and was identified and used in clinical series. The aims of this study were to describe the characteristics that assist dissection and resection rates in endoscopic surgery of solid, cystic, and recurrent cases and their importance in the infrachiasmatic corridor in endoscopic surgery.

Methods: One hundred operations on 84 patients with pathologically identified craniopharyngioma were included in the study. Read More

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Prediction of the debulking effect of rotational atherectomy using optical frequency domain imaging.

Heart Vessels 2021 Apr 8. Epub 2021 Apr 8.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Whether predicting the rotational atherectomy (RA) effect based on the position of optical frequency domain imaging (OFDI) is accurate remains uncertain. The aim of this study was to evaluate the predictive accuracy of OFDI in identifying RA location and area. Twenty-five patients who underwent RA with OFDI were included. Read More

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Relation between Serum Magnesium Level and Migraine.

Mymensingh Med J 2021 Apr;30(2):301-306

Dr Md Rezaul Karim, Registrar (Neurology), Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail:

Migraine is one of the most disabling types of headache. It affects 4-6% of men and 13-18% of women; more than 80% of them are under 30 years. Many theories to explain mechanism of migraine are present; role of serum magnesium is one of them. Read More

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[Application of MRI-based Radiomics Models in the Assessment of Hepatic Metastasis of Rectal Cancer].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):311-318

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Obejective: To explore the clinical value of using radiomics models based on different MRI sequences in the assessment of hepatic metastasis of rectal cancer.

Methods: 140 patients with pathologically confirm edrectal cancer were included in the study. They underwent baseline magnetic resonance imaging (MRI) between April 2015 and May 2018 before receiving any treatment. Read More

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Ground glass opacity featured lung adenocarcinoma in teenagers.

J Cancer Res Clin Oncol 2021 Apr 7. Epub 2021 Apr 7.

Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.

Introduction: Ground glass opacity (GGO) nodules were found incidentally by computed tomography (CT) scan in some teenagers, which turned out to be lung cancer. The purpose of this study is to summarize the characteristics of teenage patients with GGO featured lung adenocarcinoma.

Methods: Patients aging from 13 to 20 who were incidentally diagnosed with lung cancer were reviewed between February 2015 to December 2020. Read More

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Dual-layer dual-energy CT for characterization of adrenal nodules: can virtual unenhanced images replace true unenhanced acquisitions?

Abdom Radiol (NY) 2021 Apr 8. Epub 2021 Apr 8.

Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, White 270, Boston, MA, 02114-2696, USA.

Purpose: To investigate the diagnostic performance of dual-layer dual-energy CT (dlDECT) in the evaluation of adrenal nodules.

Methods: In this retrospective study, 66 patients with triphasic dlDECT (unenhanced, venous phase (VP), delayed phase (DP)) for suspected adrenal lesions were included. Virtual unenhanced images (VUE) were derived from VP acquisitions. Read More

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Detection and Classification of Breast Lesions With Readout-Segmented Diffusion-Weighted Imaging in a Large Chinese Cohort.

Front Oncol 2021 22;11:636471. Epub 2021 Mar 22.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

To evaluate the performance of readout-segmented echo-planar imaging DWI (rs-EPI DWI) in detecting and characterizing breast cancers in a large Chinese cohort with comparison to dynamic contrast-enhanced MRI (DCE-MRI). The institutional review board approved this retrospective study with waived written informed consent. A total of 520 women (mean age, 43. Read More

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