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Interaction between spatial neglect and attention deficit in patients with right hemisphere damage.

Cortex 2021 May 19;141:331-346. Epub 2021 May 19.

Department of Rehabilitation for the Movement Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama, Japan; Regenerative Rehabilitation Section of Department of Rehabilitation, Hospital of National Rehabilitation Center for Persons with Disabilities, Saitama, Japan. Electronic address:

Unilateral spatial neglect (USN) was originally regarded as a parietal syndrome, but it has become evident that USN is a disturbance in the widespread attention network. Here, we focused on an interaction between spatial neglect and non-spatial aspect of attention deficit, and aimed to establish a novel evaluation approach based on the characteristics of the spatial distribution of reaction times. We tested 174 patients with right hemisphere damage and divided them based on their prescreening scores on the Behavioral Inattention Test (BIT): (1) USN++ (n = 79: BIT<131), (2) USN+ (n = 47: BIT≥131 with history of USN), and (3) RHD (n = 48: without neglect symptom). Read More

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Prevalence of acute dizziness and vertigo in cortical stroke.

Eur J Neurol 2021 Jun 11. Epub 2021 Jun 11.

Centre for Vestibular and Behavioural Neuroscience, Department of Clinical and Movement Neurosciences, Institute of Neurology, University College London, London, WC1N 3BG, UK.

Background: In posterior circulation stroke, vertigo can be a presenting feature. However, whether isolated hemispheric strokes present with vertigo is less clear, despite a few single case-reports in the literature. Here we, a) explored the prevalence of vertigo/dizziness in acute stroke and, b) considered the cortical distribution of these lesions in relation to both the known vestibular cortex and evolution of these symptoms. Read More

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Mini-review: The Role of the Cerebellum in Visuomotor Adaptation.

Cerebellum 2021 Jun 2. Epub 2021 Jun 2.

Motor Learning Lab, Ben Gurion University of the Negev, Be'er Sheva, Israel.

The incredible capability of the brain to quickly alter performance in response to ever-changing environment is rooted in the process of adaptation. The core aspect of adaptation is to fit an existing motor program to altered conditions. Adaptation to a visuomotor rotation or an external force has been well established as tools to study the mechanisms underlying sensorimotor adaptation. Read More

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Explicit Training to Improve Affective Prosody Recognition in Adults with Acute Right Hemisphere Stroke.

Brain Sci 2021 May 20;11(5). Epub 2021 May 20.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Difficulty recognizing affective prosody (receptive aprosodia) can occur following right hemisphere damage (RHD). Not all individuals spontaneously recover their ability to recognize affective prosody, warranting behavioral intervention. However, there is a dearth of evidence-based receptive aprosodia treatment research in this clinical population. Read More

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Bilateral Meningo-Cortical Involvement in Anti-myelin Oligodendrocyte Glycoprotein-IgG Associated Disorders: A Case Report.

Front Neurol 2021 14;12:670349. Epub 2021 May 14.

Department of Neurology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.

Cortical T2-weighted fluid-attenuated inversion recovery (FLAIR)-hyperintense lesions in anti-myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis with seizures (FLAMES) are mostly unilateral and rarely spread to the bilateral cortex and meninges. We describe a case of MOG-immunoglobulin G (IgG) associated disorder (MOGAD) in a 39-year-old male with bilateral meningo-cortical involvement. The patient was hospitalized for epilepsy, fever, and headache. Read More

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Grey and white matter network disruption is associated with sensory deficits after stroke.

Neuroimage Clin 2021 May 11;31:102698. Epub 2021 May 11.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Somatosensory deficits after ischaemic stroke are common and can occur in patients with lesions in the anterior parietal cortex and subcortical nuclei. It is less clear to what extent damage to white matter tracts within the somatosensory system may contribute to somatosensory deficits after stroke. We compared the roles of cortical damage and disruption of subcortical white matter tracts as correlates of somatosensory deficit after ischaemic stroke. Read More

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Intraoperative thalamocortical tract monitoring via direct cortical recordings during craniotomy.

Clin Neurophysiol 2021 Jul 21;132(7):1416-1432. Epub 2021 Apr 21.

Department of Neurosurgery, Massachusetts General Hospital, USA.

Objective: Neuromonitoring of primary motor regions allows preservation of motor strength and is frequently employed during cranial procedures. Less is known about protection of sensory function and ability to modulate movements, both of which rely on integrity of thalamocortical afferents (TCA) to fronto-parietal regions. We describe our experience with TCA monitoring and their cortical relays during brain tumor surgery. Read More

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Choroid plexus carcinoma with leptomeningeal spread in an adult: a case report and  review of the literature.

J Med Case Rep 2021 May 23;15(1):286. Epub 2021 May 23.

Department of Neurosurgery, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.

Background: Choroid plexus carcinoma is an intraventricular neoplasm originating from the choroid plexus epithelium and is of rare occurrence in adults. However, owing to the low prevalence of choroid plexus carcinoma, there is very limited information about the disease entity and treatment. Here we report a rare case of choroid plexus carcinoma in an adult patient. Read More

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Surgical management outcome of cerebral schistosomiasis: a case report and review of the literature.

J Med Case Rep 2021 May 23;15(1):268. Epub 2021 May 23.

Queens Medical Centre, Nottingham University Hospitals, Nottingham, UK.

Background: Schistosomiasis is a parasitic infection that commonly affects the gastrointestinal and genitourinary tracts. Cerebral schistosomiasis is rare, and few operative cases have been reported in the literature. Diagnosis is usually challenging due to the similarity of the lesion to many other brain conditions. Read More

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Regional Brain Glucose Metabolism and Its Prognostic Value in Pretreatment Extranodal Natural Killer/T-Cell Lymphoma Patients.

Onco Targets Ther 2021 14;14:3179-3191. Epub 2021 May 14.

Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, People's Republic of China.

Objective: To explore regional brain glucose metabolic abnormalities of pretreatment stage I/II extranodal natural killer/T-cell lymphoma (ENKTL) patients using positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (F-FDG PET/CT) and assess its prognostic value.

Methods: Sixty pretreatment stage I/II ENKTL patients were enrolled in this retrospective study and divided into survival (n = 45) and death (n = 15) groups according to their status at the end of follow-up. A control group consisted of 60 healthy subjects. Read More

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Anthrax meningoencephalitis complicated with brain abscess - A case report.

Int J Infect Dis 2021 May 12;108:217-219. Epub 2021 May 12.

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Dr Victor Babes Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania.

Bacillus anthracis is a sporulating gram-positive rod whose main route of entry into the human body is cutaneous. Anthrax meningitis is usually fulminant and fatal. We present here a successfully treated case of anthrax meningoencephalitis complicated with brain abscess. Read More

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Autoimmune gastritis concomitant with gastric adenoma and subacute combined degeneration of the spinal cord.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan

A 62-year-old woman was referred to our department for further investigation of anaemia. Blood test showed macrocytic anaemia. Oesophagogastroduodenoscopy (OGD) revealed proximal-predominant gastric atrophy and flat elevated lesion in the gastric body. Read More

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Correction to Scarpina et al. (2020).

Authors:

Neuropsychology 2021 Mar;35(3):334

Reports an error in "Is bimanual interference affected in the case of a central proprioceptive loss? New insight from a left-brain-damaged single-case study" by Federica Scarpina, Sofia Tagini, Marco Rabuffetti, Giovanni Albani, Francesca Garbarini and Alessandro Mauro (, 2020[May], Vol 34[4], 479-492). In the article "Is Bimanual Interference Affected in the Case of a Central Proprioceptive Loss? New Insight From a Left-Brain-Damaged Single-Case Study," by Federica Scarpina, Sofia Tagini, Marco Rabuffetti, Giovanni Albani, Francesca Garbarini, and Alessandro Mauro (Neuropsychology, 2020, Vol. 34, No. Read More

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Tract-specific MRI measures explain learning and recall differences in multiple sclerosis.

Brain Commun 2021 1;3(2):fcab065. Epub 2021 Apr 1.

Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, CF24 4HQ, UK.

Cognitive difficulties are common and a key concern for people with multiple sclerosis. Advancing knowledge of the role of white matter pathology in multiple sclerosis-related cognitive impairment is essential as both occur early in the disease with implications for early intervention. Consequently, this cross-sectional study asked whether quantifying the relationships between lesions and specific white matter structures could better explain co-existing cognitive differences than whole brain imaging measures. Read More

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A rare cutis verticis gyrata secondary to cerebriform intradermal nevus: case report and literature review.

BMC Surg 2021 May 4;21(1):234. Epub 2021 May 4.

Department of Plastic Surgery, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.

Background: Cutis verticis gyrate (CVG) is a rare morphologic syndrome that presents with hypertrophy and folding of the scalp. CVG can be classified into three forms: primary essential, primary non-essential, and secondary. Cerebriform intradermal nevus (CIN) is a rare cause of secondary CVG. Read More

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Extra-axial, dural-based atypical teratoid/rhabdoid tumor.

Childs Nerv Syst 2021 May 4. Epub 2021 May 4.

Department of Neurosurgery, Postgraduate Institute of Medical Education & Research (PGIMER), Sector 12, Chandigarh, 160012, India.

Atypical teratoid/rhabdoid tumors (ATRTs) are malignant central nervous system tumors that affect early childhood (< 3 years), and mostly located in the infratentorial space. Owing to an infrequent occurrence, their radiological features have not been completely defined. Nevertheless, these are characteristically intra-axial except for few instances in the cerebellopontine angle region. Read More

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Abdominal actinomycosis mimicking a transverse colon malignancy: a case report and review of the literature.

J Med Case Rep 2021 May 3;15(1):224. Epub 2021 May 3.

Department of Surgery, National Hospital of Sri Lanka, Colombo 10, Sri Lanka.

Background: Actinomycosis is a rare inflammatory bacterial disease caused by Actinomyces species which can infrequently affect the large intestine. Disseminated actinomycosis is reported as a rare complication associated with intrauterine devices. We report a case of intra-abdominal actinomycosis mimicking a transverse colon malignancy. Read More

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Lesions that do or do not impair digit span: a study of 816 stroke survivors.

Brain Commun 2021 10;3(2):fcab031. Epub 2021 Mar 10.

Wellcome Centre for Human Neuroimaging, University College London, London WC1N 3AR, UK.

Prior studies have reported inconsistency in the lesion sites associated with verbal short-term memory impairments. Here we asked: How many different lesion sites can account for selective impairments in verbal short-term memory that persist over time, and how consistently do these lesion sites impair verbal short-term memory? We assessed verbal short-term memory impairments using a forward digit span task from the Comprehensive Aphasia Test. First, we identified the incidence of digit span impairments in a sample of 816 stroke survivors (541 males/275 females; age at stroke onset 56 ± 13 years; time post-stroke 4. Read More

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Evaluation of the Anatomical Locations of Stroke Events From Computed Tomography Scan Examinations in a Tertiary Facility in Ghana.

Cureus 2021 Mar 25;13(3):e14097. Epub 2021 Mar 25.

Medical Imaging, University of Cape Coast School of Medical Sciences, Cape Coast, GHA.

Introduction Stroke events are leading causes of mortalities globally and currently increasing alarmingly in low- and middle-income nations including Ghana, thus overburdening national healthcare delivery sectors. This trend is predicted to ultimately have an impact on the socio-economic development of these countries, thus gaining the attention of policy-makers and implementers. This study was therefore conducted to evaluate the anatomical locations of stroke events from CT scan examinations and the possibly associated variables to assist in managing this non-communicable pandemic. Read More

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A rare histopathological fi nding after lung resection in a child.

Klin Onkol 2021 ;34(2):142-146

Background: The authors present a case of a patient with an extremely rare lung tumor in a child.

Case: A 9-year-old girl with a 3-day history of dyspnea and stabbing pain in the xiphoid region, irradiating to the area under the left costal margin, both in rest and in physical activities. She was primarily examined in a regional hospital with bounded homogenous focus of the superior right lung lobe on the X-ray. Read More

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January 2021

A Case of CNS Actinomycosis: Rarer than Rare!

Neurol India 2021 Mar-Apr;69(2):475-477

Neurosciences (Neurology and Neurosurgery), Nanavati Superspeciality Hospital, Mumbai, Maharashtra, India.

We report a case of cerebral actinomycosis in a 62-year-old male who presented with right-sided weakness and focal convulsions. MRI scan showed a solid intra axial space occupying lesion in the left frontal lobe. Left parietal craniotomy with intra-operative USG guided aspiration and excision of the mass (containing necrotic material) was done. Read More

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Brain microstructural and metabolic alterations detected in vivo at onset of the first demyelinating event.

Brain 2021 Apr 27. Epub 2021 Apr 27.

NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.

In early multiple sclerosis, a clearer understanding of normal-brain tissue microstructural and metabolic abnormalities will provide valuable insights into its pathophysiology. We used multi-parametric quantitative MRI to detect alterations in brain tissues of patients with their first demyelinating episode. We acquired neurite orientation dispersion and density imaging [to investigate morphology of neurites (dendrites and axons)] and 23Na MRI (to estimate total sodium concentration, a reflection of underlying changes in metabolic function). Read More

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Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.

Lancet Neurol 2021 06 23;20(6):448-459. Epub 2021 Apr 23.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: Post-stroke cognitive impairment (PSCI) occurs in approximately half of people in the first year after stroke. Infarct location is a potential determinant of PSCI, but a comprehensive map of strategic infarct locations predictive of PSCI is unavailable. We aimed to identify infarct locations most strongly predictive of PSCI after acute ischaemic stroke and use this information to develop a prediction model. Read More

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Dystypia Associated with Diaschisis of the Middle Frontal Gyri after Left Angular Infarction.

J Stroke Cerebrovasc Dis 2021 Jul 20;30(7):105803. Epub 2021 Apr 20.

Department of Neurology, National Hospital Organization Higashi-ohmi General Medical Center, 255 Gochi, Higashi-ohmi, Shiga 527-8505, Japan. Electronic address:

Dystypia without aphasia, agraphia, or apraxia is a rare symptom and has been suggested to result from a lesion in the left middle frontal cortex. We herein describe a man with dystypia with agraphia due to infarction of the left angular gyrus. His dystypia seemed to result from the convergence failure of the kana into the alphabetical spellings. Read More

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Brain abscess in a rheumatoid arthritis patient treated with leflunomide - A case presentation and review.

Surg Neurol Int 2021 17;12:97. Epub 2021 Mar 17.

Department of Neurology, Papageorgiou Hospital of Thessaloniki, Periferiaki Odos N. Efkarpia, Thessaloniki, Central Macedonia, Greece.

Background: Immunosuppression is a significant parameter in the pathogenesis of brain abscesses (BA) and it could be the result of severe infections such as acquired immunodeficiency syndrome or drug-induced, by several medications used for systemic autoimmune diseases. Leflunomide is a pyrimidine synthesis inhibitor that affects the proliferation of lymphocytes and is used as a disease-modifying antirheumatic drug. Mild infections, particularly those of the respiratory tract and herpes zoster, are one of its most common adverse effects. Read More

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Catamenial pneumothorax with bubbling up on the diaphragmatic defects: a case report.

BMC Womens Health 2021 04 20;21(1):167. Epub 2021 Apr 20.

Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Zhengzhou, 450052, Henan Province, China.

Background: Catamenial pneumothorax is characterized by spontaneous recurring pneumothorax during menstruation, which is a common clinical manifestation of thoracic endometriosis syndrome. There are still controversies about its pathogenesis.

Case Presentation: A 43-year-old woman with a history of endometriosis came to our hospital due to recurring pneumothorax during menstruation. Read More

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Pathological structure of visuospatial neglect: A comprehensive multivariate analysis of spatial and non-spatial aspects.

iScience 2021 Apr 16;24(4):102316. Epub 2021 Mar 16.

Department of Rehabilitation for the Movement Functions, Research Institute of National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama, Japan.

Visuospatial neglect (VSN) is a neurological syndrome of higher brain functions in which an individual fails to detect stimuli on a space that is contralateral to a hemispheric lesion. We performed a comprehensive multivariate analysis based on the principal component analysis (PCA) and cluster analysis in patients with right hemisphere stroke and then performed a determination of different elements of VSN. PCA-based cluster analysis detected distinct aspects of VSN as follows: cluster 1: low arousal and attention state, cluster 2: exogenous neglect, cluster 3: spatial working memory (SWM) deficit. Read More

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A century of prosopometamorphopsia studies.

Cortex 2021 Jun 12;139:298-308. Epub 2021 Mar 12.

Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, Camberwell, London, UK. Electronic address:

Prosopometamorphopsia is an extremely rare disorder of visual perception characterised by facial distortions. We here review 81 cases (eight new ones and 73 cases published over the past century) to shed light on the perception of face gestalts. Our analysis indicates that the brain systems underlying the perception of face gestalts have genuine network properties, in the sense that they are widely disseminated and built such that spatially normal perception of faces can be maintained even when large parts of the network are compromised. Read More

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Eyelid closing and opening disorders in patients with unilateral brain lesions: A case report with video neuroimage and a systematic review of the literature.

J Clin Neurosci 2021 May 12;87:69-73. Epub 2021 Mar 12.

Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.

Eyelid closing or opening disorders have been only sporadically described in patients with focal brain lesions over the last decades. Furthermore, the restricted number of reports and the lack of uniform clinical assessment of affected individuals did not allow to define more in depth the clinical features and the underlying neural correlates of these uncommon clinical disorders. Here we report an 89-years old woman with a right hemispheric lesion who showed a contralesional defect of eyelid closure. Read More

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The posterior parietal cortex processes visuo-spatial and extra-retinal information for saccadic remapping: A case study.

Cortex 2021 Jun 19;139:134-151. Epub 2021 Mar 19.

IMPACT Team, Lyon Neuroscience Research Center, INSERM, U1028, CNRS, UMR5292, University of Lyon, Bron Cedex, France. Electronic address:

Optimally collecting information and controlling behaviour require that we constantly scan our visual environment through eye movements. How the dynamic interaction between short-lived retinal images and extra-retinal signals of eye motion results in our subjective experience of visual stability remains a major issue in Cognitive Neuroscience. The present study aimed to assess and determine the nature of the contribution of the posterior parietal cortex (PPC) to the saccadic remapping mechanisms which contribute to such perceptual visual constancy. Read More

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