19,166 results match your criteria lesion lung


Oncogenic potential of human pluripotent stem cell-derived lung organoids with HER2 overexpression.

Int J Cancer 2021 Jun 21. Epub 2021 Jun 21.

Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Lung adenocarcinoma (LUAD) is the most common types among lung cancers generally arising from terminal airway and understanding of multistep carcinogenesis is crucial to develop novel therapeutic strategy for LUAD. Here we used human induced pluripotent stem cells (hiPSCs) to establish iHER2-hiPSCs in which doxycycline induced the expression of the oncoprotein HER2/ERBB2. Lung progenitors that differentiated from iHER2-hiPSCs, which expressed NKX2-1/TTF-1 known as a lung lineage maker, were cocultured with human fetal fibroblast and formed Human lung organoids (HLOs) comprising alveolar type 2-like cells. Read More

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Dramatic response to pembrolizumab with chemotherapy followed by salvage surgery in a lung cancer patient.

Thorac Cancer 2021 Jun 21. Epub 2021 Jun 21.

Department of Thoracic Surgery, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.

Immune checkpoint inhibitors with chemotherapy have been shown to exhibit remarkable efficacy for advanced non-small-cell lung carcinoma and are under investigation as an induction therapy. However, the significance of preoperative therapy with pembrolizumab + chemotherapy for surgically resectable non-small-cell lung carcinoma still remains unclear. Here, we report a case of stage IIIB non-small-cell lung carcinoma that underwent salvage surgery after three cycles of pembrolizumab + carboplatin + nab-paclitaxel. Read More

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Study on clinical characteristics of 173 cases of COVID-19 and effect of glucocorticoid on nucleic acid negative conversion.

Am J Transl Res 2021 15;13(5):4251-4265. Epub 2021 May 15.

Department of Pulmonary Disease and Critical Medicine, Tangdu Hospital, The Air Force Military Medical University Xi'an 710038, Shaanxi, China.

: To study the clinical characteristics, changes in relevant test parameters, time of nucleic acid negative conversion, and effect of glucocorticoid treatment in Wuhan area patients with the novel coronavirus pneumonia (COVID-19). : Data of 173 inpatients at Huoshenshan Hospital from February 10 to March 17, 2020, were analyzed retrospectively. Clinical characteristics, partial test results, and the influence of glucocorticoid therapy on the clinical outcomes of nucleic acid negative conversion and changes in lung CT images were compared. Read More

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Giant cavity pulmonary lesion and pneumothorax simultaneously following COVID-19 pneumonia.

Radiol Case Rep 2021 Jun 14. Epub 2021 Jun 14.

Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran.

Cavitary lung formation with spontaneous pneumothorax has been rarely reported as a complication of COVID-19 pneumonia. We report a rare case of a 38 years-old male patient affected by COVID-19 pneumonia, exceptionally complicated by a simultaneous giant cavity in the right upper lung and a small right pneumothorax in the right hemithorax. Whilst pneumothorax emphysema, giant bullae and pneumothorax with alveolar rupture are known to potentially develop in COVID-19 patients as a result of high-flow O support, the exact origin of the giant lung cavitation in our patient could be not confirmed. Read More

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Case Report: A Rare Case of Metachronous Multiple Primary Lung Cancers in a Patient With Successful Management by Switching From Anti-PD-1 Therapy to Anti-PD-L1 Therapy.

Front Immunol 2021 2;12:683202. Epub 2021 Jun 2.

State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Without global standard diagnostic criteria, distinguishing multiple primary lung cancers (MPLCs) from intrapulmonary metastasis or histologic transformation has been a big challenge in clinical practice. Here, we described a rare case of metachronous adenocarcinoma and small cell lung cancer (SCLC) in a patient who developed drug resistance to pembrolizumab. Both DNA-sequencing and RNA-sequencing were performed on primary adenocarcinoma and resistant lesions. Read More

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D2A U-Net: Automatic segmentation of COVID-19 CT slices based on dual attention and hybrid dilated convolution.

Comput Biol Med 2021 Jun 2;135:104526. Epub 2021 Jun 2.

School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100191, China. Electronic address:

Coronavirus Disease 2019 (COVID-19) has become one of the most urgent public health events worldwide due to its high infectivity and mortality. Computed tomography (CT) is a significant screening tool for COVID-19 infection, and automatic segmentation of lung infection in COVID-19 CT images can assist diagnosis and health care of patients. However, accurate and automatic segmentation of COVID-19 lung infections is faced with a few challenges, including blurred edges of infection and relatively low sensitivity. Read More

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A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension.

Am J Physiol Heart Circ Physiol 2021 06 18. Epub 2021 Jun 18.

Department of Mathematics, North Carolina State University, Raleigh, NC, United States.

Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by recurrent or unresolved pulmonary thromboemboli, leading to perfusion defects and increased arterial wave reflections. CTEPH treatment aims to reduce pulmonary arterial pressure and reestablish adequate lung perfusion, yet patients with distal lesions are inoperable by standard surgical intervention. Instead, these patients undergo balloon pulmonary angioplasty (BPA), a multi-session, minimally invasive surgery that disrupts the thromboembolic material within the vessel lumen using a catheter balloon. Read More

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Systematic Review of Spinal Lymphomatoid Granulomatosis Cases.

World Neurosurg X 2021 Jul 30;11:100106. Epub 2021 Apr 30.

Department of Neurosurgery, Nippon Medical School Hospital, Tokyo, Japan.

Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus-associated systemic angiocentric and angiodestructive lymphoproliferative disorder. It commonly involves the lungs and can also affect the skin, liver, kidney, and central nervous system. It can rarely occur in the spine, however, the details are unclear. Read More

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Rosai-Dorfman disease with lung involvement in a 10-year-old patient: A case report.

World J Clin Cases 2021 Jun;9(17):4285-4293

The Second Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China.

Background: Rosai-Dorfman disease (RDD) is a rare benign proliferative disease whose etiology is not clear and may be related to infection or unexplained immune dysfunction. The authors present a case of RDD with lung involvement in a 10-year-old patient.

Case Summary: A 10-year-old girl found that her left cervical lymph nodes were enlarged for more than 7 mo, and the largest range was about 6. Read More

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Undifferentiated intimal sarcoma of the pulmonary artery: A case report.

World J Clin Cases 2021 Jun;9(16):3960-3965

Department of Ultrasonography, Chinese People's Liberation Army General Hospital-Sixth Medical Center, Beijing 100048, China.

Background: Since 1923, only a few hundred cases of pulmonary arterial sarcoma (PAS) have been reported. It is easy for PAS to be misdiagnosed as pulmonary thromboembolism, which makes treatment difficult. The median survival time without surgical treatment for PAS is only 1. Read More

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Clinical value of FDG PET/MRI in muscle-invasive, locally advanced, and metastatic bladder cancer.

Urol Oncol 2021 Jun 14. Epub 2021 Jun 14.

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

Objective: Metastatic bladder cancer is an aggressive disease that can often be difficult to diagnose and stage with conventional cross-sectional imaging. The primary objective of this study was to determine the clinical value of fluorine-18 2-fluoro-2-deoxy-D-glucose (F-FDG) PET/MRI for surveillance and restaging of patients with muscle-invasive, locally advanced, and metastatic bladder cancer compared to conventional imaging methods.

Materials And Methods: This retrospective study enrolled patients with muscle-invasive, locally advanced and metastatic bladder cancer in a single institute evaluated with F-FDG PET/MRI. Read More

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[Erlotinib plus Bevacizumab Therapy for Postoperative Recurrence of Adenosquamous Cell Carcinoma Harboring EGFR Mutation-A Case Report].

Gan To Kagaku Ryoho 2021 Jun;48(6):841-843

Dept. of General Thoracic Surgery, Japanese Red Cross Maebashi Hospital.

A 59-year-old man clinically diagnosed with primary lung cancer underwent left lower lobectomy and lymph node dissection( ND2a-2). The postoperative pathological stage was ⅠB(pT2aN0M0), and the lesion was positive for epidermal growth factor receptor(EGFR)exon 21 L858R mutation. Thirty months after surgery, the patient developed pleural dissemination and effusion in the left pleural cavity. Read More

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A case of resected hepatocellular carcinoma with gallbladder metastasis.

Surg Case Rep 2021 Jun 17;7(1):145. Epub 2021 Jun 17.

Division of Gastroenterological Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Background: Advanced hepatocellular carcinoma (HCC) can often spread as intrahepatic metastases. Extrahepatic metastasis (e.g. Read More

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Early prediction of lung lesion progression in COVID-19 patients with extended CT ventilation imaging.

Eur J Nucl Med Mol Imaging 2021 Jun 17. Epub 2021 Jun 17.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China.

Purpose: In the prediction of COVID-19 disease progression, a clear illustration and early determination of an area that will be affected by pneumonia remain great challenges. In this study, we aimed to predict and visualize the progression of lung lesions in COVID-19 patients in the early stage of illness by using chest CT.

Methods: COVID-19 patients who underwent three chest CT scans in the progressive phase were retrospectively enrolled. Read More

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Simultaneous uniportal video-assisted thoracic surgery for pulmonary nodules and synchronous mediastinal lesions.

Wideochir Inne Tech Maloinwazyjne 2021 Jun 27;16(2):390-396. Epub 2020 Nov 27.

Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.

Introduction: Video-assisted thoracic surgery (VATS) has been widely accepted in the diagnosis and treatment of thoracic diseases for the past three decades due to its small incision, minimal trauma, and rapid recovery after surgery. A growing number of patients with concurrent pulmonary nodules and mediastinal lesions have been detected. Simultaneous ipsilateral resection of coexisting lesions is a preferred procedure. Read More

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Anatomically aided PET image reconstruction using deep neural networks.

Med Phys 2021 Jun 15. Epub 2021 Jun 15.

Department of Biomedical Engineering, University of California, Davis, CA, USA.

Purpose: The developments of PET/CT and PET/MR scanners provide opportunities for improving PET image quality by using anatomical information. In this paper, we propose a novel co-learning 3D convolutional neural network (CNN) to extract modality-specific features from PET/CT image pairs and integrate complementary features into an iterative reconstruction framework to improve PET image reconstruction.

Methods: We used a pre-trained deep neural network to represent PET images. Read More

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The contribution of the immune response to enhanced colibacillosis upon preceding viral respiratory infection in broiler chicken in a dual infection model.

Vet Immunol Immunopathol 2021 May 27;238:110276. Epub 2021 May 27.

Division of Infectious Diseases and Immunology, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, the Netherlands.

Colibacillosis in chickens caused by avian pathogenic Escherichia coli (APEC) is known to be aggravated by preceding infections with infectious bronchitis virus (IBV), Newcastle disease virus (NDV) and avian metapneumovirus (aMPV). The mechanism behind these virus-induced predispositions for secondary bacterial infections is poorly understood. Here we set out to investigate the immunopathogenesis of enhanced respiratory colibacillosis after preceding infections with these three viruses. Read More

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Isolated Middle-Third Clavicle Fracture Causing Horner's Syndrome: A Case Report and Literature Review.

Front Surg 2021 28;8:640900. Epub 2021 May 28.

Department of Orthopedics, China Medical University Hospital, China Medical University, Taichung, Taiwan.

The pathophysiology of Horner's syndrome arises due to compression or destruction of the oculosympathetic nerve pathway. Traumatic Horner's syndrome may indicate lethal neurovascular injury, such as brain stem lesion, cervical spine injury, or carotid artery dissection. The middle-third is the most common type of clavicle fracture. Read More

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COVID-index: A texture-based approach to classifying lung lesions based on CT images.

Pattern Recognit 2021 Nov 6;119:108083. Epub 2021 Jun 6.

Department of Information Systems, Federal University of Piauí R. Cícero Duarte, 905, Junco, Picos 64607-670, PI, Brazil.

COVID-19 is an infectious disease caused by a newly discovered type of coronavirus called SARS-CoV-2. Since the discovery of this disease in late 2019, COVID-19 has become a worldwide concern, mainly due to its high degree of contagion. As of April 2021, the number of confirmed cases of COVID-19 reported to the World Health Organization has already exceeded 135 million worldwide, while the number of deaths exceeds 2. Read More

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November 2021

Gelfoam slurry tract occlusion after computed tomography-guided percutaneous lung biopsy: Does it prevent major pneumothorax?

J Med Imaging Radiat Oncol 2021 Jun 13. Epub 2021 Jun 13.

Monash Medical Centre, Melbourne, Victoria, Australia.

Introduction: Computed tomography (CT)-guided lung biopsy is a frequently performed procedure in the diagnostic workup for suspicious lung nodules that can be complicated by pneumothorax. This retrospective study assessed the efficacy of biopsy tract occlusion with a gelatin sponge slurry for preventing post-biopsy pneumothorax.

Methods: Retrospective analysis was conducted on consecutive adult patients who underwent CT-guided lung biopsy over a 10-year period. Read More

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[Tc]Tc-Galacto-RGD integrin αβ-targeted imaging as a surrogate for molecular phenotyping in lung cancer: real-world data.

EJNMMI Res 2021 Jun 13;11(1):59. Epub 2021 Jun 13.

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, China.

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical value of [Tc]Tc-Galacto-RGD single-photon emission computed tomography (SPECT/CT) in patients with lung cancer, integrin αβ expression, and neovascularization in lung cancer subtypes was also addressed.

Methods: A total of 185 patients with lung cancer and 25 patients with benign lung diseases were enrolled in this prospective study from January 2013 to December 2016. Read More

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A Solitary Necrotizing Sarcoid Granulomatosis-like Pulmonary Lesion Possibly Associated with Propionibacterium Acnes and Mycobacterium Avium.

Intern Med 2021 Jun 12. Epub 2021 Jun 12.

Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.

We report a case of a pulmonary necrotizing sarcoid granulomatosis (NSG)-like lesion possibly associated with coinfection of Mycobacterium avium and Propionibacterium acnes. A solitary nodule in the right middle lobe of the lung was notable for coagulative necrosis with aggregates of sarcoid-like epithelioid granulomas. Small arteries were damaged by granulomas. Read More

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A Prediction Model to Optimize Invasive Mediastinal Staging Procedures for Non-Small Cell Lung Cancer in Patients with a Radiologically Normal Mediastinum: the Quebec Prediction Model.

Chest 2021 Jun 10. Epub 2021 Jun 10.

Department of Pulmonology and Thoracic Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec, Canada. Electronic address:

Background: Current guidelines recommended criteria for invasive mediastinal staging in patients with a radiologically normal mediastinum fail to identify a significant proportion of patients with occult mediastinal disease (OMD) despite leading to a large number of invasive staging procedures.

Research Question: Which variables available preoperatively predict the probability of OMD in patients with a radiologically normal mediastinum?

Study Design And Methods: We identified all cTxN0/N1M0 NSCLC staged by CT and PET-CT in our institution between 2014 and 2018 who underwent gold standard surgical lymph node dissection or were demonstrated to have OMD preoperatively by invasive mediastinal staging techniques, and divided them into a derivation and an independent validation cohort to create the Quebec Prediction Model (QPM), which allows to calculate the probability of OMD.

Results: 803 patients were identified (development n=502, validation n=301) with a prevalence of OMD of 9. Read More

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Risk factors associated with postoperative respiratory failure in tuberculous empyema patients.

Medicine (Baltimore) 2021 Jun;100(23):e25754

Department of Thoracic Surgery.

Abstract: Our objective was to identify independent risk factors for predicting which patients in the Chinese population would likely develop respiratory failure.A descriptive analysis was conducted of demographic and clinical data of patients with tuberculous empyema (TE) admitted to the Beijing Chest Hospital, Capital Medical University between January 2001 and January 2020. Risk factors associated with postsurgical respiratory failure in TE patients were identified based on results of analyses based on univariable and multivariable logistic regression models. Read More

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IgA Vasculitis in a Lung Cancer Patient During Chemoradiotherapy.

Ther Clin Risk Manag 2021 3;17:571-575. Epub 2021 Jun 3.

Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan.

A 72-year-old man with locally advanced lung squamous cell carcinoma experienced red purpura on the lower legs and hematuria when the disease progressed during definitive chemoradiotherapy. He had renal dysfunction and proteinuria. Biopsy specimens of the skin lesion and kidney revealed immunoglobulin A vasculitis. Read More

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Prognostic value of PET parameters in patients with pleomorphic lung cancer: Results from a single institution.

Lung Cancer 2021 May 27;158:40-46. Epub 2021 May 27.

Division of Nuclear Medicine, IEO European Institute of Oncology, IRCCS, Milan, Italy.

Objectives: Pleomorphic lung carcinoma (PLC) is a rare histotype of non-small cell lung cancer (NSCLC) characterized by aggressive clinical course, poor response to therapy and poor prognosis. Therefore, aim of our study is to analyze with 18F-FDG PET/CT a subset of patients affected by PLC to evaluate their metabolic characteristics in terms of SUVmax, MTV and TLG, in order to correlate them with overall survival (OS) and disease-free survival (DFS).

Material And Methods: We retrospectively analyzed 49 consecutive patients with histologically defined PLC occurred to our Institution between 2003 and 2014. Read More

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Protein signatures of remodeled airways in transplanted lungs with Bronchiolitis Obliterans Syndrome obtained using laser capture microdissection.

Am J Pathol 2021 Jun 7. Epub 2021 Jun 7.

Lung Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden. Electronic address:

Bronchiolitis obliterans syndrome (BOS), a common form of chronic lung allograft dysfunction, is the major limitation to long-term survival after lung transplantation. The histological correlate is progressive, fibrotic occlusion of small airways, obliterative bronchiolitis lesions, ultimately leading to organ failure. The molecular composition of these lesions is unknown. Read More

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Trapezial Acrometastasis as the First Presentation of Occult Lung Cancer: A Case Report.

JBJS Case Connect 2021 06 10;11(2). Epub 2021 Jun 10.

Orthopedic Specialists of Central Pennsylvania, Lancaster, Pennsylvania.

Case: Acrometastasis is extremely rare, accounting for 0.1% of all skeletal metastases. Metastases to the carpus are rarer still. Read More

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Case report of osteolytic lesions in a patient with multisystem granulomatous disease.

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

School of Medicine, University of Notre Dame, Fremantle, Western Australia, Australia.

We present a case of a 70-year-old Caucasian woman with multisystem granulomatous disease involving her lungs, bones and lymph nodes. The patient initially presented with cervical lymphadenopathy and subsequently developed progressive breathlessness. Imaging revealed extensive mediastinal, hilar and intra-abdominal lymphadenopathy as well as bilateral pulmonary parenchymal infiltrates. Read More

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A survey of cardiopulmonary resuscitation in COVID-19 patients.

J Anaesthesiol Clin Pharmacol 2021 Jan-Mar;37(1):47-50. Epub 2021 Apr 10.

University Hospital of Cologne, Köln, Germany.

Background And Aims: The novel coronavirus 2 (SARS-CoV-2) pandemic has placed severe resource constraints on hospitals. High mortality rates of the COVID-19 have overwhelmed the resuscitation services. The constant fear of virus infection during cardiopulmonary resuscitation (CPR) has placed severe restrictions on the resuscitation services. Read More

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