10,610 results match your criteria leptospirosis

Comparison of ELISA using recombinant LipL32 and sonicated antigen of leptospira for detecting bovine leptospirosis.

Acta Trop 2021 Oct 20:106214. Epub 2021 Oct 20.

Instituto de Patobiología- UEDD IPVET INTA CONICET, Centro de Investigación en Ciencias Veterinarias y Agronómicas, Instituto Nacional de Tecnología Agropecuaria, Argentina.

Leptospirosis is one of the most widely distributed zoonosis in the world. Bovine leptospirosis is a serious problem in bovine production, causing reproductive losses. The aim of this work was to compare recombinant LipL32 with sonicated antigen for detecting anti-Leptospira IgG antibodies in bovine serum using ELISA. Read More

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October 2021

Prediction model to discriminate leptospirosis from hantavirus.

Rev Assoc Med Bras (1992) 2021 Aug;67(8):1102-1108

Universidade de Franca - Franca (SP), Brazil.

Objective: The aim of this study was to build a prediction model to discriminate precociously hantavirus infection from leptospirosis, identifying the conditions and risk factors associated with these diseases.

Methods: A logistic regression model in which the response variable was the presence of hantavirus or leptospirosis was adjusted.

Results: As a result, the method selected the following variables that influenced the prediction formula: sociodemographic variables, clinical manifestations, and exposure to environmental risks. Read More

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Application of simplified MLST scheme for direct typing of clinical samples from human leptospirosis cases in a tertiary hospital in the Philippines.

PLoS One 2021 20;16(10):e0258891. Epub 2021 Oct 20.

Pathogen-Host-Environment Interactions Research Laboratory, Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, Philippines.

Despite the major threat of leptospirosis to public health in the Philippines, its epidemiologic data remain scarce. Multilocus sequence typing (MLST) is a method often used for identification of circulating Leptospira species and disease surveillance. Unfortunately, molecular typing of Leptospira isolates is not routinely done in most hospital settings. Read More

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October 2021

Linking climate and infectious disease trends in the Northern/Arctic Region.

Sci Rep 2021 Oct 19;11(1):20678. Epub 2021 Oct 19.

Department of Energy & Technology, Swedish University of Agricultural Sciences, 750 07, Uppsala, Sweden.

Recognition of climate-sensitive infectious diseases is crucial for mitigating health threats from climate change. Recent studies have reasoned about potential climate sensitivity of diseases in the Northern/Arctic Region, where climate change is particularly pronounced. By linking disease and climate data for this region, we here comprehensively quantify empirical climate-disease relationships. Read More

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October 2021

Predictors of severe leptospirosis: a multicentre observational study from Central Malaysia.

BMC Infect Dis 2021 Oct 19;21(1):1081. Epub 2021 Oct 19.

Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Background: Leptospirosis is a re-emerging disease with vast clinical presentations, that ranges from subclinical or mild to severe and fatal outcomes. Leptospirosis can be managed well if diagnosed earlier, however, similar clinical presentations by several other febrile illnesses or co-infections, and laboratory diagnostic challenges due to the biphasic nature of the illness, often result in mis- or underdiagnosis, thereby lead to severe illness. Identification of clinical predictors for the severe form of the disease plays a crucial role in reducing disease complication and mortality. Read More

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October 2021

The Applicability of Commonly Used Severity of Illness Scores to Tropical Infections in Australia.

Am J Trop Med Hyg 2021 Oct 18. Epub 2021 Oct 18.

Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia.

Many patients with leptospirosis, melioidosis, and rickettsial infection require intensive care unit (ICU) admission in tropical Australia every year. The multi-organ dysfunction associated with these infections results in significantly elevated severity of illness (SOI) scores. However, the accuracy of these SOI scores in predicting death from these tropical infections is incompletely defined. Read More

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October 2021

Spatial epidemiology of Leptospira sp. exposure in bovines from Veracruz, México.

Transbound Emerg Dis 2021 Oct 17. Epub 2021 Oct 17.

Facultad de Medicina Veterinaria y Zootecnia, región Veracruz, Universidad Veracruzana, Veracruz, México.

Bovine leptospirosis is a bacterial disease that affects cattle herds, causing economic losses due to reproductive problems which require expensive treatments. The main source of transmission for cattle is still uncertain, but rodents and bats can play an important role in the transmission cycle by being maintenance hosts for the pathogenic species of the bacterium and spreading it through urine. In this study, we characterise possible risk areas for bovine leptospirosis exposure in the state of Veracruz, Mexico, based on the geographical distribution of flying (bats) and terrestrial (rodents and opossums) wild hosts of Leptospira sp. Read More

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October 2021

[Seroprevalence of Leptospira spp. in draft horses from indigenous communities in the Araucanía Region, Chile].

Rev Chilena Infectol 2021 Aug;38(4):580-582

Clínica Dávila., Chile.

In the Araucanía Region there are no studies on the seroprevalence of leptospirosis in horses. Serological samples from 100 draft horses from Mapuche communities of four communes in the region were analyzed using the microMAT technique. The seroprevalence was 35% for at least one serovar of Leptospira spp. Read More

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Understanding the Renal Fibrotic Process in Leptospirosis.

Int J Mol Sci 2021 Oct 5;22(19). Epub 2021 Oct 5.

Laboratório de Bacteriologia, Instituto Butantan, Avenida Vital Brasil, 1500, São Paulo 05503-900, Brazil.

Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus . The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, carrier state, and kidney fibrosis due to infection in humans have been the subject of discussion by researchers, the mechanisms involved in these processes are still overlooked, and relatively little is known about the establishment and maintenance of the chronic status underlying this infectious disease. Read More

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October 2021

Comparative genome characterization of Leptospira interrogans from mild and severe leptospirosis patients.

Genomics Inform 2021 Sep 30;19(3):e31. Epub 2021 Sep 30.

Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Leptospirosis is a zoonotic disease caused by spirochetes from the genus Leptospira. In Thailand, Leptospira interrogans is a major cause of leptospirosis. Leptospirosis patients present with a wide range of clinical manifestations from asymptomatic, mild infections to severe illness involving organ failure. Read More

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September 2021

A Survey of Priority Livestock Diseases and Laboratory Diagnostic Needs of Animal Health Professionals and Farmers in Uganda.

Front Vet Sci 2021 23;8:721800. Epub 2021 Sep 23.

Department of Veterinary Epidemiology and Public Health, School of Veterinary Medicine, University of Surrey, Guildford, United Kingdom.

Despite the investments made in veterinary diagnostic laboratory service delivery in Uganda, the scope and level of utilization remains low. This study aimed to determine the priority livestock diseases for which farmers and animal health professionals require veterinary diagnostic laboratory services, document the perceptions and opinions of key stakeholders on veterinary diagnostic laboratory services, and determine the factors that influence the delivery and utilization of animal disease diagnostic services in Uganda. A qualitative study approach involving a survey and key informant interviews was used to collect relevant data from four stakeholder groups: animal health workers, laboratory technologists and technicians, farmers, and key informants. Read More

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September 2021

"Y no quedó nada, nada de la casa, todo salió volando" (And there was nothing left, nothing of the house, everything flew away): a critical medical ecological perspective on the lived experience of hurricane María in Puerto Rico.

BMC Public Health 2021 Oct 9;21(1):1833. Epub 2021 Oct 9.

Department of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Box 668, Rochester, NY, 14642, USA.

Background: Ecological disasters create dramatic changes as man-made and natural ecosystems adapt to their effects. In 2017, Hurricanes Irma and María devastated Puerto Rico. Public focus after such traumatic ecological events often neglects pre-existing community dynamics, heterogeneity of lived experience, and complexity of decision-making in the disaster context. Read More

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October 2021

Effect of environmental variables on incidence of tick-borne encephalitis, leptospirosis and tularaemia.

Zdeněk Hubálek

Cent Eur J Public Health 2021 Sep;29(3):187-190

Institute of Vertebrate Biology, Czech Academy of Sciences, Brno, Czech Republic.

Objectives: Potential effect of three environmental variables (population density of rodents, global weather in the form of the North Atlantic Oscillation (NAO) index, and acorn crop) on human morbidity rate of three zoonoses: tick-borne encephalitis (TBE), leptospirosis and tularaemia were analysed in the Czech Republic for the period 1970-1990.

Methods: The Pearson's correlation analysis was used.

Results: The correlation analysis revealed that the significant factor for explaining annual morbidity rates of these zoonoses was the abundance of common voles (Microtus arvalis) in the current year (for leptospirosis) or in the previous calendar year (for TBE and tularaemia). Read More

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September 2021

Unhappy Triad: Infection with spp. and Associated with an Unusual Manifestation of Portal Vein Thrombosis.

Case Rep Gastroenterol 2021 May-Aug;15(2):598-602. Epub 2021 Jul 6.

Department of Infectious Diseases, Tropical Medicine, Nephrology and Rheumatology, St. Georg Hospital, Leipzig, Germany.

Portal vein thrombosis (PVT) is a rare disease with an incidence of 0.7/100,000 inhabitants per year. Septic PVT (pylephlebitis) usually occurs secondary to infection in the anatomic region drained by the portal venous system. Read More

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Evaluation of a genus-specific rGroEL IgM-ELISA and commercial ELISA kits during the course of leptospirosis in Thailand.

Sci Rep 2021 Oct 5;11(1):19785. Epub 2021 Oct 5.

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

In the present study, we developed a genus-specific rGroEL IgM-ELISA assay for use in screening diagnosis of suspected leptospirosis among acute undifferentiated febrile illness patients during acute fever. The diagnostic accuracies of the rGroEL IgM-ELISA, commercial Panbio IgM-ELISA, and Virion-Serion Classic IgG-ELISA were evaluated using 133 Thai leptospirosis sera and 210 controls. Sensitivities were 91. Read More

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October 2021

Expression and preliminary characterization of the potential vaccine candidate LipL32 of leptospirosis.

Appl Nanosci 2021 Sep 30:1-15. Epub 2021 Sep 30.

Department of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj University, Madurai-21, Tamil Nadu India.

Leptospirosis is a globally re-emerging infectious disease mainly for mammals. The infection is caused by the spirochete Gram-negative bacterium , which affects animals and humans worldwide. In our previous studies, recombinant protein production has been obtained from the bacterial expression system. Read More

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September 2021

Hantavirus Cardiopulmonary Syndrome and Diffuse Alveolar Hemorrhage in the Era of COVID-19.

Case Rep Infect Dis 2021 24;2021:8800500. Epub 2021 Sep 24.

Infectious Disease, Sanford USD Medical Center, Sioux Falla, SD, USA.

Hantavirus Cardiopulmonary Syndrome (HCPS) can occur after infection with Hantavirus which can occur by inhaling aerosolized rodent urine, feces, and saliva contaminated with the virus. It presents with the rapid development of pulmonary edema, respiratory failure, and cardiogenic shock with the hallmark being microvascular leakage. We report a patient with a history of alcohol abuse and recent exposure to mice and sick kittens who presented with cough with sputum production, shortness of breath, orthopnea, and new-onset lower extremity edema. Read More

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September 2021

Seroprevalence and Associated Risk Factors of Serogroup Serovar in Dairy Farms in and around Jimma Town, Southwestern Ethiopia.

Vet Med Int 2021 17;2021:6061685. Epub 2021 Sep 17.

Jimma University, School of Veterinary Medicine, Jimma, Ethiopia.

A cross-sectional study was conducted on selected dairy farms in and around Jimma town, Oromia, southwestern Ethiopia from November 2019 to May 2020 to determine the seroprevalence of (). Furthermore, information was gathered on individual animal and herd level by using pretested semistructured questionnaire to assess associated risk factors. A stratified and simple random sampling procedure was used for the selection of dairy farms and individual animal's, respectively. Read More

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September 2021

Gut microbiota involved in leptospiral infections.

ISME J 2021 Sep 29. Epub 2021 Sep 29.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, 130062, PR China.

Leptospirosis is a re-emerging zoonotic disease worldwide. Intestinal bleeding is a common but neglected symptom in severe leptospirosis. The regulatory mechanism of the gut microbiota on leptospirosis is still unclear. Read More

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September 2021

Identification of pathogenic Leptospira species and serovars in New Zealand using metabarcoding.

PLoS One 2021 29;16(9):e0257971. Epub 2021 Sep 29.

Molecular Epidemiology and Public Health Laboratory, School of Veterinary Sciences, Massey University, Palmerston North, New Zealand.

Leptospirosis is a zoonotic disease of global importance. The breadth of Leptospira diversity associated with both human and animal disease poses major logistical challenges to the use of classical diagnostic techniques, and increasingly molecular diagnostic tools are used for their detection. In New Zealand, this has resulted in an increase in positive cases reported nationally that have not been attributed to the infecting serovar or genomospecies. Read More

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September 2021

Complete Genome Sequencing of Isolates from Malaysia Reveals Massive Genome Rearrangement but High Conservation of Virulence-Associated Genes.

Pathogens 2021 Sep 15;10(9). Epub 2021 Sep 15.

Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

The ability of Leptospirae to persist in environments and animal hosts but to cause clinically highly variable disease in humans has made leptospirosis the most common zoonotic disease. Considering the paucity of data on variation in complete genomes of human pathogenic Leptospirae, we have used a combination of Single Molecule Real-Time (SMRT) and Illumina sequencing to obtain complete genome sequences of six human clinical isolates from Malaysia. All six contained the larger (4. Read More

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September 2021

Current Evidence on the Antimicrobial Treatment and Chemoprophylaxis of Human Leptospirosis: A Meta-Analysis.

Pathogens 2021 Sep 2;10(9). Epub 2021 Sep 2.

Infectious Diseases Unit, Department of Internal Medicine, Albacete University Hospital, 02006 Albacete, Spain.

Background: Leptospirosis is a worldwide zoonotic infection, and its management needs to be refined. This study aims to discern which antibiotic would be the best option to treat leptospirosis disease and analyze the efficacy of chemoprophylaxis regimens to prevent this illness.

Methods: systematic review and meta-analysis on the efficacy of antibiotic treatment and chemoprophylaxis of leptospirosis in humans. Read More

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September 2021

Immunoinformatic Study of Recombinant LigA/BCon1-5 Antigen and Evaluation of Its Diagnostic Potential in Primary and Secondary Binding Tests for Serodiagnosis of Porcine Leptospirosis.

Pathogens 2021 Aug 26;10(9). Epub 2021 Aug 26.

Department of Animal Science, Centurion University of Technology and Management, Paralakhemundi 761211, India.

Leptospirosis is responsible for hampering the productivity of swine husbandry worldwide. The aim of this study was to assess the efficacy of bioinformatics tools in predicting the three-dimensional structure and immunogenicity of recombinant LigBCon1-5 (rLigBCon1-5) antigen. A battery of bioinformatics tools such as I-TASSER, ProSA and SAVES v6. Read More

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The Seroepidemiology of a Neglected Zoonotic and Livestock Pathogen in Free-Ranging Bovids: Leptospirosis in African Buffaloes ().

Pathogens 2021 Aug 24;10(9). Epub 2021 Aug 24.

DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 8000, South Africa.

Multi-host pathogens are challenging to control and are responsible for some of the most important diseases of humans, livestock, and wildlife. spp. are some of the most common multi-host pathogens and represent an important cause of zoonotic infections and livestock productivity loss in the developing world, where contact with wildlife species is common. Read More

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In Vivo Biofilm Formation of Pathogenic spp. in the Vitreous Humor of Horses with Recurrent Uveitis.

Microorganisms 2021 Sep 9;9(9). Epub 2021 Sep 9.

Equine Clinic, Clinical Department, Ludwig-Maximilians-University, 80539 Munich, Germany.

Equine recurrent uveitis (ERU) causes painful inflammatory attacks and oftentimes blindness in the affected eyes. The disease is considered a late sequela of systemic leptospirosis. The most effective therapy is the surgical removal of the vitreous (vitrectomy), which is not only therapeutic, but provides vitreous material that can be assessed diagnostically. Read More

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September 2021

High Diversity of Species Infecting Bats Captured in the Urabá Region (Antioquia-Colombia).

Microorganisms 2021 Sep 7;9(9). Epub 2021 Sep 7.

Basic Science Research Group, Graduate School-CES University, Medellín 50021, Colombia.

Leptospirosis is a globally distributed zoonotic disease caused by pathogenic bacteria of the genus . This zoonotic disease affects humans, domestic animals and wild animals. Colombia is considered an endemic country for leptospirosis; Antioquia is the second department in Colombia, with the highest number of reported leptospirosis cases. Read More

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September 2021

Exposure of Free-Ranging Wild Animals to Zoonotic Sensu Stricto in Slovenia.

Animals (Basel) 2021 Sep 17;11(9). Epub 2021 Sep 17.

Institute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.

A total of 249 serum samples from 13 wild animal species namely fallow deer (, = 1), roe deer (, = 80), red deer (, = 22), chamois (, = 21), mouflon ( = 4), brown hare (, = 2), nutria (, = 1), red fox (, = 97), stone marten (, = 12), European badger (, = 2), golden jackal (, = 2) Eurasian lynx (, = 2) and grey wolf (, = 3) were analysed for the presence of antibodies against sensu stricto. Serum samples were examined via the microscopic agglutination test for the presence of specific antibodies against serovars Icterohaemorrhagiae, Bratislava, Pomona, Grippotyphosa, Hardjo, Sejroe, Australis, Autumnalis, Canicola, Saxkoebing and Tarassovi. Antibodies to at least one of the pathogenic serovars were detected in 77 (30. Read More

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September 2021

Influence of Season, Population and Individual Characteristics on the Prevalence of spp. in Bank Voles in North-West Germany.

Biology (Basel) 2021 Sep 18;10(9). Epub 2021 Sep 18.

Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, 04103 Leipzig, Germany.

Leptospirosis is a worldwide zoonotic disease with more than 1 million human cases annually. Infections are associated with direct contact to infected animals or indirect contact to contaminated water or soil. As not much is known about the prevalence and host specificity of spp. Read More

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September 2021

Identification and validation of circulating miRNAs as potential new biomarkers for severe liver disease in patients with leptospirosis.

PLoS One 2021 27;16(9):e0257805. Epub 2021 Sep 27.

Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Leptospirosis, a global zoonotic infectious disease, has various clinical manifestations ranging from mild self-limiting illness to life-threatening with multi-organ damage, including liver involvement. This study was aimed at identifying circulating microRNAs (miRNAs) as novel biomarkers for predicting severe liver involvement in patients with leptospirosis.

Methods: In a discovery set, 12 serum samples of patients with anicteric and icteric leptospirosis at initial clinical presentation were used for miRNA profiling by a NanoString nCounter miRNA assay. Read More

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September 2021

Seroprevalence trends of Scrub typhus among the febrile patients of Northern India: A prospective cross-sectional study.

J Family Med Prim Care 2021 Jul 30;10(7):2552-2557. Epub 2021 Jul 30.

Department of Microbiology, SGPGIMS, Lucknow, U.P, India.

Background: Rickettsial infections remain one of the most neglected and underdiagnosed tropical diseases in the developing countries. Scrub typhus can prove to an important diagnosis in pyrexia of unknown origin (PUO) patients and is transmitted by a species of trombiculid mites ("chiggers"). The disease leads to a plethora of symptoms like fever, rash, headache, nausea, abdominal pain, thrombocytopenia, etc. Read More

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