8,160 results match your criteria leptospira


Comparison of ELISA using recombinant LipL32 and sonicated antigen of leptospira for detecting bovine leptospirosis.

Acta Trop 2021 Oct 20:106214. Epub 2021 Oct 20.

Instituto de Patobiología- UEDD IPVET INTA CONICET, Centro de Investigación en Ciencias Veterinarias y Agronómicas, Instituto Nacional de Tecnología Agropecuaria, Argentina.

Leptospirosis is one of the most widely distributed zoonosis in the world. Bovine leptospirosis is a serious problem in bovine production, causing reproductive losses. The aim of this work was to compare recombinant LipL32 with sonicated antigen for detecting anti-Leptospira IgG antibodies in bovine serum using ELISA. Read More

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October 2021

Detection of Anti-LipL32 Antibodies in Serum Samples from Horses with Chronic Intraocular Infection with spp.

Pathogens 2021 Oct 14;10(10). Epub 2021 Oct 14.

Equine Clinic, Clinical Department, Ludwig Maximilians University, 80539 Munich, Germany.

Equine recurrent uveitis (ERU) is typically caused by chronic intraocular leptospiral infection in warm-blooded horses in central Europe. The most effective therapy for leptospiral-induced ERU is the surgical removal of diseased vitreous (vitrectomy). Since vitrectomy is a highly specialized and invasive surgery, the indication must be determined very carefully. Read More

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October 2021

Application of simplified MLST scheme for direct typing of clinical samples from human leptospirosis cases in a tertiary hospital in the Philippines.

PLoS One 2021 20;16(10):e0258891. Epub 2021 Oct 20.

Pathogen-Host-Environment Interactions Research Laboratory, Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, Philippines.

Despite the major threat of leptospirosis to public health in the Philippines, its epidemiologic data remain scarce. Multilocus sequence typing (MLST) is a method often used for identification of circulating Leptospira species and disease surveillance. Unfortunately, molecular typing of Leptospira isolates is not routinely done in most hospital settings. Read More

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October 2021

Predictors of severe leptospirosis: a multicentre observational study from Central Malaysia.

BMC Infect Dis 2021 Oct 19;21(1):1081. Epub 2021 Oct 19.

Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Background: Leptospirosis is a re-emerging disease with vast clinical presentations, that ranges from subclinical or mild to severe and fatal outcomes. Leptospirosis can be managed well if diagnosed earlier, however, similar clinical presentations by several other febrile illnesses or co-infections, and laboratory diagnostic challenges due to the biphasic nature of the illness, often result in mis- or underdiagnosis, thereby lead to severe illness. Identification of clinical predictors for the severe form of the disease plays a crucial role in reducing disease complication and mortality. Read More

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October 2021

Spatial epidemiology of Leptospira sp. exposure in bovines from Veracruz, México.

Transbound Emerg Dis 2021 Oct 17. Epub 2021 Oct 17.

Facultad de Medicina Veterinaria y Zootecnia, región Veracruz, Universidad Veracruzana, Veracruz, México.

Bovine leptospirosis is a bacterial disease that affects cattle herds, causing economic losses due to reproductive problems which require expensive treatments. The main source of transmission for cattle is still uncertain, but rodents and bats can play an important role in the transmission cycle by being maintenance hosts for the pathogenic species of the bacterium and spreading it through urine. In this study, we characterise possible risk areas for bovine leptospirosis exposure in the state of Veracruz, Mexico, based on the geographical distribution of flying (bats) and terrestrial (rodents and opossums) wild hosts of Leptospira sp. Read More

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October 2021

Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira.

Mol Microbiol 2021 Oct 17. Epub 2021 Oct 17.

Institut Pasteur, Biology of Spirochetes Unit, Paris, France.

Spirochetes can be distinguished from other bacteria by their spiral-shaped morphology and subpolar periplasmic flagella. This study focused on FlhF and FlhG, which control the spatial and numerical regulation of flagella in many exoflagellated bacteria, in the spirochete Leptospira. In contrast to flhF which seems to be essential in Leptospira, we demonstrated that flhG mutants in both the saprophyte L. Read More

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October 2021

[Seroprevalence of Leptospira spp. in draft horses from indigenous communities in the Araucanía Region, Chile].

Rev Chilena Infectol 2021 Aug;38(4):580-582

Clínica Dávila., Chile.

In the Araucanía Region there are no studies on the seroprevalence of leptospirosis in horses. Serological samples from 100 draft horses from Mapuche communities of four communes in the region were analyzed using the microMAT technique. The seroprevalence was 35% for at least one serovar of Leptospira spp. Read More

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Understanding the Renal Fibrotic Process in Leptospirosis.

Int J Mol Sci 2021 Oct 5;22(19). Epub 2021 Oct 5.

Laboratório de Bacteriologia, Instituto Butantan, Avenida Vital Brasil, 1500, São Paulo 05503-900, Brazil.

Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus . The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, carrier state, and kidney fibrosis due to infection in humans have been the subject of discussion by researchers, the mechanisms involved in these processes are still overlooked, and relatively little is known about the establishment and maintenance of the chronic status underlying this infectious disease. Read More

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October 2021

Comparative genome characterization of Leptospira interrogans from mild and severe leptospirosis patients.

Genomics Inform 2021 Sep 30;19(3):e31. Epub 2021 Sep 30.

Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Leptospirosis is a zoonotic disease caused by spirochetes from the genus Leptospira. In Thailand, Leptospira interrogans is a major cause of leptospirosis. Leptospirosis patients present with a wide range of clinical manifestations from asymptomatic, mild infections to severe illness involving organ failure. Read More

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September 2021

Effect of environmental variables on incidence of tick-borne encephalitis, leptospirosis and tularaemia.

Authors:
Zdeněk Hubálek

Cent Eur J Public Health 2021 Sep;29(3):187-190

Institute of Vertebrate Biology, Czech Academy of Sciences, Brno, Czech Republic.

Objectives: Potential effect of three environmental variables (population density of rodents, global weather in the form of the North Atlantic Oscillation (NAO) index, and acorn crop) on human morbidity rate of three zoonoses: tick-borne encephalitis (TBE), leptospirosis and tularaemia were analysed in the Czech Republic for the period 1970-1990.

Methods: The Pearson's correlation analysis was used.

Results: The correlation analysis revealed that the significant factor for explaining annual morbidity rates of these zoonoses was the abundance of common voles (Microtus arvalis) in the current year (for leptospirosis) or in the previous calendar year (for TBE and tularaemia). Read More

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September 2021

Unhappy Triad: Infection with spp. and Associated with an Unusual Manifestation of Portal Vein Thrombosis.

Case Rep Gastroenterol 2021 May-Aug;15(2):598-602. Epub 2021 Jul 6.

Department of Infectious Diseases, Tropical Medicine, Nephrology and Rheumatology, St. Georg Hospital, Leipzig, Germany.

Portal vein thrombosis (PVT) is a rare disease with an incidence of 0.7/100,000 inhabitants per year. Septic PVT (pylephlebitis) usually occurs secondary to infection in the anatomic region drained by the portal venous system. Read More

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Expression and preliminary characterization of the potential vaccine candidate LipL32 of leptospirosis.

Appl Nanosci 2021 Sep 30:1-15. Epub 2021 Sep 30.

Department of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj University, Madurai-21, Tamil Nadu India.

Leptospirosis is a globally re-emerging infectious disease mainly for mammals. The infection is caused by the spirochete Gram-negative bacterium , which affects animals and humans worldwide. In our previous studies, recombinant protein production has been obtained from the bacterial expression system. Read More

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September 2021

Draft Genome Sequence of Leptospira yasudae Strain BJ3, Isolated from the Soil of an Wild Animal Conservation Area.

Microbiol Resour Announc 2021 Sep 30;10(39):e0072321. Epub 2021 Sep 30.

Department of Community Health, Universiti Kebangsaan Malaysia, Cheras, Malaysia.

Previously, a novel strain (BJ3) was isolated from the soil of an wild animal conservation area in Perak, Malaysia. Molecular identification via whole-genome sequencing confirmed that the strain was Leptospira yasudae. Here, we report the draft genome sequence of strain BJ3. Read More

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September 2021

Seroprevalence and Associated Risk Factors of Serogroup Serovar in Dairy Farms in and around Jimma Town, Southwestern Ethiopia.

Vet Med Int 2021 17;2021:6061685. Epub 2021 Sep 17.

Jimma University, School of Veterinary Medicine, Jimma, Ethiopia.

A cross-sectional study was conducted on selected dairy farms in and around Jimma town, Oromia, southwestern Ethiopia from November 2019 to May 2020 to determine the seroprevalence of (). Furthermore, information was gathered on individual animal and herd level by using pretested semistructured questionnaire to assess associated risk factors. A stratified and simple random sampling procedure was used for the selection of dairy farms and individual animal's, respectively. Read More

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September 2021

Gut microbiota involved in leptospiral infections.

ISME J 2021 Sep 29. Epub 2021 Sep 29.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, 130062, PR China.

Leptospirosis is a re-emerging zoonotic disease worldwide. Intestinal bleeding is a common but neglected symptom in severe leptospirosis. The regulatory mechanism of the gut microbiota on leptospirosis is still unclear. Read More

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September 2021

Identification of pathogenic Leptospira species and serovars in New Zealand using metabarcoding.

PLoS One 2021 29;16(9):e0257971. Epub 2021 Sep 29.

Molecular Epidemiology and Public Health Laboratory, School of Veterinary Sciences, Massey University, Palmerston North, New Zealand.

Leptospirosis is a zoonotic disease of global importance. The breadth of Leptospira diversity associated with both human and animal disease poses major logistical challenges to the use of classical diagnostic techniques, and increasingly molecular diagnostic tools are used for their detection. In New Zealand, this has resulted in an increase in positive cases reported nationally that have not been attributed to the infecting serovar or genomospecies. Read More

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September 2021

Ofloxacin Induced Hemolysis in G6PD-deficient Patient: A Rare Cause of Pigment Nephropathy.

Indian J Nephrol 2021 Jul-Aug;31(4):410-413. Epub 2021 Feb 20.

Assistant Professor, Department of Medicine, Shree Krishna Hospital, Karamsad, India.

Thrombotic microangiopathy (TMA) commonly presents as a triad of acute kidney injury (AKI), jaundice, and hemolysis; however, tropical infections such as malaria, dengue, leptospira, and drugs like antimalarials can also have a similar presentation. They can cause AKI for many reasons including pre-renal causes but an important yet not relatively uncommon genetic cause of hemolytic anemia, that is, glucose 6-phosphate deficiency (G6PD) manifesting as jaundice, hemolysis, and AKI secondary to pigment nephropathy after receiving offending drugs needs to be worked up while evaluating such patients. Ofloxacin is not usually included in the lists of unsafe drugs in G6PD deficiency. Read More

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February 2021

Contribution of Viral Respiratory Infections to Dengue-Like Illness Presentation at a Community Clinic in Southern Malaysia.

Am J Trop Med Hyg 2021 Sep 27. Epub 2021 Sep 27.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia.

This study explored the contribution of viral respiratory infections (VRIs) in dengue-like illness (DLI) patients and their distinguishing clinicolaboratory parameters. Two hundred DLI patients were prospectively recruited (1 July-1 October 2019) from a community clinic in Southern Malaysia. Patients ≥18 years with acute fever and fulfilling the WHO criteria of probable dengue were recruited. Read More

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September 2021

Complete Genome Sequencing of Isolates from Malaysia Reveals Massive Genome Rearrangement but High Conservation of Virulence-Associated Genes.

Pathogens 2021 Sep 15;10(9). Epub 2021 Sep 15.

Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

The ability of Leptospirae to persist in environments and animal hosts but to cause clinically highly variable disease in humans has made leptospirosis the most common zoonotic disease. Considering the paucity of data on variation in complete genomes of human pathogenic Leptospirae, we have used a combination of Single Molecule Real-Time (SMRT) and Illumina sequencing to obtain complete genome sequences of six human clinical isolates from Malaysia. All six contained the larger (4. Read More

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September 2021

The Seroepidemiology of a Neglected Zoonotic and Livestock Pathogen in Free-Ranging Bovids: Leptospirosis in African Buffaloes ().

Pathogens 2021 Aug 24;10(9). Epub 2021 Aug 24.

DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 8000, South Africa.

Multi-host pathogens are challenging to control and are responsible for some of the most important diseases of humans, livestock, and wildlife. spp. are some of the most common multi-host pathogens and represent an important cause of zoonotic infections and livestock productivity loss in the developing world, where contact with wildlife species is common. Read More

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In Vivo Biofilm Formation of Pathogenic spp. in the Vitreous Humor of Horses with Recurrent Uveitis.

Microorganisms 2021 Sep 9;9(9). Epub 2021 Sep 9.

Equine Clinic, Clinical Department, Ludwig-Maximilians-University, 80539 Munich, Germany.

Equine recurrent uveitis (ERU) causes painful inflammatory attacks and oftentimes blindness in the affected eyes. The disease is considered a late sequela of systemic leptospirosis. The most effective therapy is the surgical removal of the vitreous (vitrectomy), which is not only therapeutic, but provides vitreous material that can be assessed diagnostically. Read More

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September 2021

High Diversity of Species Infecting Bats Captured in the Urabá Region (Antioquia-Colombia).

Microorganisms 2021 Sep 7;9(9). Epub 2021 Sep 7.

Basic Science Research Group, Graduate School-CES University, Medellín 50021, Colombia.

Leptospirosis is a globally distributed zoonotic disease caused by pathogenic bacteria of the genus . This zoonotic disease affects humans, domestic animals and wild animals. Colombia is considered an endemic country for leptospirosis; Antioquia is the second department in Colombia, with the highest number of reported leptospirosis cases. Read More

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September 2021

Exposure of Free-Ranging Wild Animals to Zoonotic Sensu Stricto in Slovenia.

Animals (Basel) 2021 Sep 17;11(9). Epub 2021 Sep 17.

Institute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.

A total of 249 serum samples from 13 wild animal species namely fallow deer (, = 1), roe deer (, = 80), red deer (, = 22), chamois (, = 21), mouflon ( = 4), brown hare (, = 2), nutria (, = 1), red fox (, = 97), stone marten (, = 12), European badger (, = 2), golden jackal (, = 2) Eurasian lynx (, = 2) and grey wolf (, = 3) were analysed for the presence of antibodies against sensu stricto. Serum samples were examined via the microscopic agglutination test for the presence of specific antibodies against serovars Icterohaemorrhagiae, Bratislava, Pomona, Grippotyphosa, Hardjo, Sejroe, Australis, Autumnalis, Canicola, Saxkoebing and Tarassovi. Antibodies to at least one of the pathogenic serovars were detected in 77 (30. Read More

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September 2021

Influence of Season, Population and Individual Characteristics on the Prevalence of spp. in Bank Voles in North-West Germany.

Biology (Basel) 2021 Sep 18;10(9). Epub 2021 Sep 18.

Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, 04103 Leipzig, Germany.

Leptospirosis is a worldwide zoonotic disease with more than 1 million human cases annually. Infections are associated with direct contact to infected animals or indirect contact to contaminated water or soil. As not much is known about the prevalence and host specificity of spp. Read More

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September 2021

Prevalence of anti-leptospiral antibodies and frequency distribution of serovars in small ruminants in enzootic South Peninsular India.

Vet World 2021 Aug 6;14(8):2023-2030. Epub 2021 Aug 6.

Indian Council of Agricultural Research-National Institute of Veterinary Epidemiology and Disease Informatics, Yelahanka, Bengaluru, Karnataka, India.

Background And Aim: For understanding the epidemiology of leptospirosis, the confined abundance of several species of pathogenic leptospires and knowledge on the serovar(s) prevalent in the reservoir and carrier hosts may be a useful indicator of transmission to incidental/accidental hosts in a geographical niche. The present study was carried out to ascertain the frequency distribution of serovars and the prevalence of anti-leptospiral antibodies in small ruminants (sheep and goats) in the epidemiological units (villages) in the coastal districts of enzootic regions in South Peninsular India.

Materials And Methods: A total of 1167 serum samples (sheep n=299 and goats n=868) from apparently healthy animals, randomly collected from various epidemiological units were tested in microscopic agglutination test (MAT) using 18 reference serovars antigens. Read More

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Antigen-Specific Urinary Immunoglobulin in Reservoir Hosts of Leptospirosis.

Vet Sci 2021 Sep 1;8(9). Epub 2021 Sep 1.

Infectious Bacterial Diseases Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA.

Domestic and wildlife animal species act as reservoir hosts of leptospirosis, a global zoonotic disease affecting more than 1 million people annually and causing significant morbidity and mortality in domestic animals. In contrast to incidental hosts which present with an array of clinical manifestations, reservoir hosts are typically asymptomatic and can shed leptospires from chronically infected kidneys via urine for extended periods of time. Renal excretion of leptospires occurs despite evidence of a humoral and cellular immune response and is reflective of the unique biological equilibrium that exists between certain animal species and specific serovars of . Read More

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September 2021

Are infectious reproductive pathogens of large ruminants a threat to improving food security? An investigation from Cambodia.

Trop Anim Health Prod 2021 Sep 24;53(5):480. Epub 2021 Sep 24.

The University of Sydney, Sydney School of Veterinary Science, 425 Werombi Road, Camden, NSW, 2570, Australia.

In Cambodia, information on common pathogens causing reproductive losses in cattle and buffalo are lacking, despite there being a need to address livestock health to enhance food security. We analysed stored buffalo (n = 29) and cattle (n = 471) serum samples collected in 2016 using commercially available enzyme-linked immunosorbent assay kits. Antibodies to Neospora caninum, bovine viral diarrhoea virus (BVDV), Leptospira interrogans serovar Hardjo and Brucella abortus were detected in buffalo samples at 79. Read More

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September 2021

The spleen bacteriome of wild rodents and shrews from Marigat, Baringo County, Kenya.

PeerJ 2021 2;9:e12067. Epub 2021 Sep 2.

Basic Science Laboratory, United States Army Medical Research Directorate-Africa, Kisumu, Kenya.

Background: There is a global increase in reports of emerging diseases, some of which have emerged as spillover events from wild animals. The spleen is a major phagocytic organ and can therefore be probed for systemic microbiome. This study assessed bacterial diversity in the spleen of wild caught small mammals so as to evaluate their utility as surveillance tools for monitoring bacteria in an ecosystem shared with humans. Read More

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September 2021

Seroprevalence and risk factors of Leptospira sp. among different groups in the Jordanian population: first study.

Trans R Soc Trop Med Hyg 2021 Sep 23. Epub 2021 Sep 23.

Department of Global Health, Milken Institute School of Public Health, George Washington University, 950 New Hampshire Ave. NW, Washington, DC, USA.

Background: Leptospirosis is re-emerging as a major public health problem worldwide. However, there are limited data on the disease from the Middle East, including from Jordan, despite recent outbreaks occurring in Jordan's neighbouring countries.

Methods: Sera samples from 809 participants in 11 governorates were tested for Leptospira sp. Read More

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September 2021

Draft Genome Sequences of Four Different Strains Belonging to Leptospira interrogans Serovar Pomona Isolated from Mammals in the Island of Sardinia, Italy.

Microbiol Resour Announc 2021 Sep 23;10(38):e0069821. Epub 2021 Sep 23.

Istituto Zooprofilattico Sperimentale of Sardinia, Animal Health Department, Sassari, Italy.

Leptospirosis is a zoonotic disease of global importance caused by a pathogenic group of bacteria belonging to the genus . Here, we report four draft genome sequences of Leptospira interrogans serovar Pomona isolated in Sardinia (Italy) from four different species of mammals (i.e. Read More

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September 2021