6 results match your criteria lepa2

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Effects of androgens on the leptin system in immature male Atlantic salmon parr.

Gen Comp Endocrinol 2018 02 19;257:122-129. Epub 2017 Aug 19.

Department of Organismal Biology, Comparative Physiology, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden. Electronic address:

Leptin modulates all levels of the reproductive endocrine axis in mammals, and in turn, both leptin and the leptin receptor are regulated by sex steroids. The aim of this study was to investigate if sex steroids regulate the leptin system also in fish. Immature one-year old male Atlantic salmon parr were implanted with Silclear capsules that were either empty or filled with 11-ketoandrostenedione (11KA) or testosterone (T) and the effects of 35-days treatment were investigated on measures of maturation, gene expression of leptin (lepa1, lepa2), leptin receptor (lepra1) and circulating plasma leptin. Read More

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February 2018

Seasonal Differences in Relative Gene Expression of Putative Central Appetite Regulators in Arctic Charr (Salvelinus alpinus) Do Not Reflect Its Annual Feeding Cycle.

PLoS One 2015 30;10(9):e0138857. Epub 2015 Sep 30.

Department of Arctic and Marine Biology, UiT-The Arctic University of Norway, Tromsø, Norway.

The highly seasonal anadromous Arctic charr (Salvelinus alpinus) was used to investigate the possible involvement of altered gene expression of brain neuropeptides in seasonal appetite regulation. Pro-opiomelanocortin (POMCA1, POMCA2), Cocaine and amphetamine regulated transcript (CART), Agouti related Peptide (AgRP), Neuropeptide Y (NPY) and Melanocortin Receptor 4 (MC4-R) genes were examined. The function of centrally expressed Leptin (Lep) in fish remains unclear, so Lep (LepA1, LepA2) and Leptin Receptor (LepR) genes were included in the investigation. Read More

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Sex steroids stimulate leptin gene expression in Atlantic salmon parr hepatocytes in vitro.

Gen Comp Endocrinol 2015 Sep 30;221:156-64. Epub 2015 Jan 30.

Department of Organismal Biology, Comparative Physiology, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden. Electronic address:

In mammals, leptin plays an important role in puberty and reproduction and leptin is regulated by sex steroids. Elevated leptin levels have been associated with sexual maturation in some teleosts such as Atlantic salmon. In the present study, primary cultures of Atlantic salmon hepatocytes were used to investigate the direct effects of different sex steroids on expression of the two salmon leptin-a genes, lepa1 and lepa2. Read More

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September 2015

Regulation of the seasonal leptin and leptin receptor expression profile during early sexual maturation and feed restriction in male Atlantic salmon, Salmo salar L., parr.

Gen Comp Endocrinol 2014 Aug 10;204:60-70. Epub 2014 May 10.

Department of Organismal Biology, Comparative Physiology, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden. Electronic address:

In mammals, leptin acts as an adiposity signal and is a crucial link between nutritional status and the reproductive axis. So far the link between leptin and energy balance during sexual maturation in teleosts has been poorly investigated. In this study, seasonal gene expression changes in two leptin genes (lepa1 and lepa2) and the leptin receptor were investigated during early sexual maturation in male Atlantic salmon parr under fully fed (control) and feed restricted conditions from April through September. Read More

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Short-term, but not long-term feed restriction causes differential expression of leptins in Atlantic salmon.

Gen Comp Endocrinol 2013 Mar 27;183:83-8. Epub 2012 Nov 27.

Department of Biology, University of Bergen, Bergen High Technology Centre, Bergen, Norway.

Atlantic salmon was used to investigate the effect of long- and short-term dietary ration on the tissue expression levels of leptins. Compared to ad libitum fed fish (0.8-3kg), 6months of dietary restriction (60%) resulted in significantly lower body mass and adiposity, but did not produce a clear effect on the expression levels of either lepa1 or lepa2. Read More

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Effects of long-term restricted feeding on plasma leptin, hepatic leptin expression and leptin receptor expression in juvenile Atlantic salmon (Salmo salar L.).

Gen Comp Endocrinol 2012 Jan 12;175(1):92-9. Epub 2011 Oct 12.

Evolutionary Biology Centre, Department of Organismal Biology/Comparative Physiology, Uppsala University, SE-752 36 Uppsala, Sweden.

Leptin is a pleiotropic hormone and plays a key role in body weight regulation, energy homeostasis and lipid store utilization in mammals. In this study, we investigated the effect of feed-restriction on leptin genes (lepa1 and lepa2), leptin receptor (lepr) gene expression and plasma leptin levels in juvenile Atlantic salmon parr. Feed restriction was performed from late April to mid-June, in order to gain insight into the role of the leptin system in energy balance regulation and adiposity in juvenile salmon. Read More

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January 2012
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