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Sampling rate influences the regularity analysis of temporal domain measures of walking more than spatial domain measures.

Gait Posture 2021 Jun 4;88:216-220. Epub 2021 Jun 4.

Center for Research in Human Movement Variability, Department of Biomechanics, University of Nebraska at Omaha, 6160 University Drive, Omaha, NE, 68182-0860, United States; VA Nebraska-Western Iowa Health Care System, VA Research Service, 4104 Woolworth Avenue (112), Omaha, NE, 68105, United States; Department of Health and Kinesiology, Texas A&M University, 2929 Research Parkway, College Station, TX, 77843, United States. Electronic address:

Background: The spatiotemporal dynamics of stepping can provide useful information about walking performance. Most often, the identification of gait motion is performed using 3-D cinematography. The sampling rate of motion capture systems may influence the accuracy of these measures albeit in varying degrees for measures within the spatial versus temporal domain. Read More

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Infections and patterns of antibiotic utilization in support and comfort care patients: A tertiary care center experience.

J Infect Public Health 2021 May 26;14(7):839-844. Epub 2021 May 26.

Department of Health Informatics, CPHHI, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Data and Business Intelligence Management Department, ISID, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Purpose: Little is known regarding the burden of infections and clinical practice towards hospitalized patients with limits on life-sustaining measures. We aim to describe the infectious syndromes, clinical care, the emergence of multi-drug resistant organisms and outcomes in this population.

Patients And Methods: Retrospective cohort of patients labeled as support or comfort care in a tertiary care center between 2016-2019. Read More

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Age-related differences in corneal nerve regeneration after SMILE and the mechanism revealed by metabolomics.

Exp Eye Res 2021 Jun 9:108665. Epub 2021 Jun 9.

Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. Electronic address:

Purpose: To investigate the effect of age on wound healing after small incision lenticule extraction (SMILE) and the underlying metabolomic mechanisms.

Methods: This prospective study was conducted on 216 patients in four groups: the 18-20 (n = 38, Group I), 21-30 (n = 84, Group Ⅱ), 31-40 (n = 58, Group Ⅲ), and 41-50 (n = 36, Group IV) age groups. The density of corneal epithelial wing cells, basal cells, corneal stromal cells, endothelial cells and corneal nerves were examined with a laser confocal microscope (HRT III-RCM) before and 1 month, 3 month, 6 month and 1 year after SMILE. Read More

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Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community-Based Cohort.

Mov Disord 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.

Background: Premutation-sized (55-200) CGG repeat expansions in the FMR1 gene cause fragile X-associated tremor/ataxia syndrome (FXTAS). Most studies of premutation carriers utilized reverse ascertainment to identify patients, leading to a selection bias for larger repeats. As shorter CGG premutation repeats are common in the population, understanding their impact on health outcomes has a potentially large public health footprint. Read More

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Screening for more with less: Validation of the Global Appraisal of Individual Needs Quick v3 (GAIN-Q3) screeners.

J Subst Abuse Treat 2021 Jul 15;126:108414. Epub 2021 Apr 15.

Suzanne Dworak-Peck School of Social Work, USC Center for Artificial Intelligence in Society, USC Center for Mindfulness Science, USC Institute for Addiction Science, University of Southern California, United States of America.

Multi-morbidity is the norm among adolescents and adults with substance use and other mental disorders and warrants a multi-pronged screening approach. However, the time constraints on assessment inherent in clinical practice often temper the desire for a full understanding of multi-morbidity problems. The 15- to 25-minute Global Appraisal of Individual Needs Quick version 3 (GAIN-Q3) includes screeners for 9 common clinical problems that are short (4 to 10 items) and provide dimensional measures of problem severity in each area that are also categorized to guide clinical decision making. Read More

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FACTORS ASSOCIATED WITH INPATIENT ENDOSCOPY DELAY AND ITS IMPACT ON HOSPITAL LENGTH-OF-STAY AND 30-DAY READMISSION.

Clin Gastroenterol Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Backgrounds And Aims: Inpatient endoscopy delay (IED) negatively impacts the delivery of high-quality care. We aimed to identify factors associated with IED and evaluate its effect on hospital length-of-stay (LOS) and re-admission.

Methods: Retrospective analysis of all inpatient endoscopies performed between November 2017 to November 2019 at a tertiary care center. Read More

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Radiation Dose Reduction in Kidney Stone CT: A Randomized, Facility-Based Intervention.

J Am Coll Radiol 2021 Jun 8. Epub 2021 Jun 8.

Massachusetts General Hospital, Boston, Massachusetts.

Objective: Kidney stones are common, tend to recur, and afflict a young population. Despite evidence and recommendations, adoption of reduced-radiation dose CT (RDCT) for kidney stone CT (KSCT) is slow. We sought to design and test an intervention to improve adoption of RDCT protocols for KSCT using a randomized facility-based intervention. Read More

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Predicting ventilator-associated pneumonia with machine learning.

Medicine (Baltimore) 2021 Jun;100(23):e26246

Dascena, Inc., Houston, TX, United States.

Abstract: Ventilator-associated pneumonia (VAP) is the most common and fatal nosocomial infection in intensive care units (ICUs). Existing methods for identifying VAP display low accuracy, and their use may delay antimicrobial therapy. VAP diagnostics derived from machine learning (ML) methods that utilize electronic health record (EHR) data have not yet been explored. Read More

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Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study.

Front Med (Lausanne) 2021 25;8:644715. Epub 2021 May 25.

Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany.

Acute kidney injury (AKI) is very common in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease 2019 (COVID-19) and considered as a risk factor for COVID-19 severity. SARS-CoV-2 renal tropism has been observed in COVID-19 patients, suggesting that direct viral injury of the kidneys may contribute to AKI. We examined 20 adult cases with confirmed SARS-CoV-2 infection requiring ICU supportive care in a single-center prospective observational study and investigated whether urinary markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins (ACE2, TMPRSS2) allow identification of patients at risk for AKI and outcome of COVID-19. Read More

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Cruroplasty added to laparoscopic sleeve gastrectomy; does it decrease postoperative incidence of de-novo acid reflux?: A randomised controlled trial.

Ann Med Surg (Lond) 2021 Jun 21;66:102415. Epub 2021 May 21.

Department of General Surgery, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

Background: Laparoscopic sleeve gastrectomy(LSG) is the most popular bariatric surgery worldwide. Postoperative de-novo acid reflux is one of the major common complications of the procedure. Different additive anti-reflux surgical techniques have been tried to decrease the complication although no favorable outcome is obtained. Read More

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Molecular Hallmarks, Agronomic Performances and Seed Nutraceutical Properties to Exploit Neglected Genetic Resources of Common Beans Grown by Organic Farming in Two Contrasting Environments.

Front Plant Sci 2021 25;12:674985. Epub 2021 May 25.

Department of Crop and Soil Sciences, University of Georgia, Athens, GA, United States.

Common bean ( L.) is an essential source of food proteins and an important component of sustainable agriculture systems around the world. Thus, conserving and exploiting the genetic materials of this crop species play an important role in achieving global food safety and security through the preservation of functional and serependic opportunities afforded by plant species diversity. Read More

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Feelings and Emotions of Nurses Related to Dying and Death of Patients - A Pilot Study.

Psychol Res Behav Manag 2021 4;14:705-717. Epub 2021 Jun 4.

Department of Clinical Nursing, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland.

Introduction: The aim of the study, conducted in selected inpatient units, was to evaluate and analyse the feelings and emotions which accompany nurses during their work when they face the death of patients.

Material And Methods: A total of 160 nurses were invited to participate in the study. The study group consisted of 40 nurses from each of the four departments of a municipal hospital: a surgery unit, an internal medicine unit, a hospital emergency department (ER) and an intensive care unit (ICU). Read More

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Lumbar Spine Fusion and Symptoms of Leg Length Discrepancy After Hip Arthroplasty.

J Arthroplasty 2021 May 11. Epub 2021 May 11.

Geisinger Commonwealth School of Medicine, Scranton, PA; Geisinger Orthopaedics & Sports Medicine, Scranton, PA.

Background: Hip length discrepancy (HLD) is common after total hip arthroplasty (THA); however, the effect of spinal fusion on perceived leg length discrepancy (LLD) symptoms after THA has not been examined. This study tested the hypothesis that LLD symptoms are increased in patients who underwent lumbar spinal fusion and THA, compared with patients with THA only.

Methods: This retrospective cohort study included 67 patients who underwent lumbar spinal fusion and THA, along with 78 matched control patients who underwent THA only. Read More

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Incidence, temporal trends and potential risk factors for aseptic loosening following primary unicompartmental knee arthroplasty: A meta-analysis of 96,294 knees.

Knee 2021 Jun 7;31:28-38. Epub 2021 Jun 7.

National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK; Translational Health Sciences, Bristol Medical School, Musculoskeletal Research Unit, University of Bristol, Learning & Research Building (Level 1), Southmead Hospital, Bristol BS10 5NB, UK.

Background: Aseptic loosening (AL) is among the major reasons for revision of failed primary unicompartmental knee arthroplasty (UKA). There is an ongoing temporal increase in the use of UKA with a resultant increase in the revision burden. We aimed to evaluate the incidence of, temporal trends and risk factors for AL. Read More

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Noninvasive Ventilation Use in Pediatric Status Asthmaticus.

J Asthma 2021 Jun 10:1-9. Epub 2021 Jun 10.

Department of Critical Care, New York-Presbyterian Morgan Stanley Children's Hospital.

Noninvasive ventilation (NIV) is sometimes used in refractory pediatric status asthmaticus for its potential benefits of stenting airways and dispersing albuterol. However, its effectiveness in pediatric asthma remains unproven. The usage pattern, outcomes, and safety of NIV in pediatric status asthmaticus are described. Read More

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Resurgence of regional flaps for head and neck reconstruction.

Curr Opin Otolaryngol Head Neck Surg 2021 May 17. Epub 2021 May 17.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA.

Purpose Of Review: The strain on healthcare resources in light of the COVID-19 pandemic has forced many head and neck surgeons to explore reconstructive options that may decrease length of stay. Here, we review three common and versatile regional flaps used in head and neck reconstruction that are comparable alternatives to free tissue transfer.

Recent Findings: Initial anatomic descriptions of the facial artery musculocutaneous (FAMM) flap, the supraclavicular artery island flap and the submental artery island flap were published decades ago. Read More

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Muscle architecture and passive lengthening properties of the gastrocnemius medialis and Achilles tendon in children who idiopathically toe-walk.

J Anat 2021 Jun 9. Epub 2021 Jun 9.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.

Children who idiopathically toe-walk (ITW) habitually operate at greater plantarflexion angles and thus, at shorter muscle-tendon unit (MTU) lengths than typically developing (TD) children. Therefore, it is often assumed that habitual use of the gastrocnemius muscle in this way will cause remodelling of the muscle-tendon architecture compared to TD children. However, the gastrocnemius muscle architecture of children who ITW has never been measured. Read More

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Ultrafast-nonlinear ultraviolet pulse modulation in an AlInGaN polariton waveguide operating up to room temperature.

Nat Commun 2021 Jun 9;12(1):3504. Epub 2021 Jun 9.

Department of Physics and Astronomy, University of Sheffield, Sheffield, UK.

Ultrafast nonlinear photonics enables a host of applications in advanced on-chip spectroscopy and information processing. These rely on a strong intensity dependent (nonlinear) refractive index capable of modulating optical pulses on sub-picosecond timescales and on length scales suitable for integrated photonics. Currently there is no platform that can provide this for the UV spectral range where broadband spectra generated by nonlinear modulation can pave the way to new on-chip ultrafast (bio-) chemical spectroscopy devices. Read More

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Structural analysis of the full-length human LRRK2.

Cell 2021 Jun 3. Epub 2021 Jun 3.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

Mutations in leucine-rich repeat kinase 2 (LRRK2) are commonly implicated in the pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates critical cellular processes at membranous organelles and forms microtubule-based pathogenic filaments, yet the molecular basis underlying these biological roles of LRRK2 remains largely enigmatic. Here, we determined high-resolution structures of full-length human LRRK2, revealing its architecture and key interdomain scaffolding elements for rationalizing disease-causing mutations. Read More

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Treatment of painful median nerve neuroma using pedicled vascularized lateral antebrachial cutaneous nerve with adipofascial flap: a cadaveric study and exploration of clinical application.

J Plast Surg Hand Surg 2021 Jun 9:1-5. Epub 2021 Jun 9.

Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Japan.

The most common procedure for the treatment of painful median nerve neuroma is coverage with vascularized soft tissue following external neurolysis. However, the ideal treatment should include reconnecting the proximal and distal stumps of the damaged nerve to allow the growth of regenerating axons to their proper targets for a functional recovery. We developed a useful technique employing radial artery perforator adipofascial flap including the lateral antebrachial cutaneous nerve (LABCN) to repair the median nerve by vascularized nerve grafting and to achieve coverage of the nerve with vascularized soft tissue. Read More

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Hospital-in-the-Home as a Model for Mental Health Care Delivery: A Narrative Review.

Psychiatr Serv 2021 Jun 9:appips202000763. Epub 2021 Jun 9.

Barwon Health, Geelong, Victoria, Australia.

Objective: Hospital-in-the-home (HITH) is a service model widely adopted in medical specialties to help alleviate pressure on the availability of inpatient beds and allow patients to receive acute care in familiar surroundings. To date, such models are not widely utilized in mental health care. The authors review existing HITH-type mental health services, focusing on the domains of design, implementation, and outcomes. Read More

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Efficacy and safety of acupoint catgut embedding in treating postoperative pain of mixed hemorrhoids: A randomized controlled trial protocol.

Medicine (Baltimore) 2021 May;100(19):e25948

Department of General Surgery, Tianjin TEDA Hospital.

Background: Pain is a common complication after mixed hemorrhoids, which seriously affects the recovery of patients and prolongs the length of hospital stay. Acupoint catgut embedding has advantages in improving a variety of acute and chronic pain diseases, but there is still a lack of rigorous randomized controlled studies to verify its efficacy and safety in the treatment of postoperative pain of mixed hemorrhoids. Therefore, the purpose of this randomized controlled trial is to evaluate the clinical efficacy of acupoint catgut embedding in the treatment of postoperative pain of mixed hemorrhoids. Read More

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Influence of salinity on physiological development and zinc toxicity in the marine medaka Oryzias melastigma.

Ecotoxicology 2021 Jun 9. Epub 2021 Jun 9.

Faculty of Bioresource Sciences, Akita Prefectural University, 241-438 Kaidobata-Nishi, Nakano Shimoshinjo, Akita, 010-0195, Japan.

To determine whether the marine medaka Oryzias melastigma is a suitable model organism for evaluating the effects of environmental chemicals on marine teleosts, we examined the effect of salinity on physiological development and zinc toxicity. Growth as measured by total body length was significantly lower in fresh water compared to brackish water. Reproductive success was also significantly reduced in fresh water, although we observed cells in the pituitary producing gonadotropins such as Gpa (common glycoprotein hormone α), Fshb (follicle stimulating hormone β), and Lhb (luteinizing hormone β) at all salinities. Read More

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Efficacy of behavioral audiological tests in identifying cochlear synaptopathy: a systematic review.

Eur Arch Otorhinolaryngol 2021 Jun 9. Epub 2021 Jun 9.

Department of Audiology, All India Institute of Speech and Hearing, Mysore, Karnataka, 570006, India.

Purpose: Cochlear synaptopathy or hidden hearing loss is difficult to assess due to the lack of sensitivity with standard audiological tests. Poor speech perception, especially in the presence of noise or tinnitus, is the most common complaint of these patients. The purpose of this systematic review is to identify articles in peer-reviewed journals that used behavioral measures in the effective assessment of cochlear synaptopathy or hidden hearing loss. Read More

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High-resolution time-of-flight PET detector with 100 ps coincidence time resolution using a side-coupled phoswich configuration.

Phys Med Biol 2021 Jun 9;66(12). Epub 2021 Jun 9.

Department of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, CA, United States of America.

Photon time-of-flight (TOF) capability in positron emission tomography (PET) enables reconstructed image signal-to-noise ratio (SNR) improvement. With the coincidence time resolution (CTR) of 100 picosecond (ps), a five-fold SNR improvement can be achieved with a 40 cm diameter imaging subject, relative to a system without TOF capability. This 100 ps CTR can be achieved for adetector design (crystal element length ≥20 mm with reasonably high crystal packing fraction) using a side-readout PET detector configuration that enables 511 keV photon interaction depth-independent light collection efficiency and lower variance in scintillation photon transit time to the silicon photomultiplier (SiPM). Read More

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One-anastomosis gastric bypass (OAGB) in patients with BMI < 30 kg/m2 and diabetes mellitus type 2 (DM2).

Nutr Hosp 2021 Jun 9. Epub 2021 Jun 9.

Instituto de Laparoscopia Avanzada del Sureste (INLAPSUR).

Introduction: type-2 diabetes mellitus (DM2) is a major health problem, as it leads to increased morbidity and mortality. Metabolic surgery has shown good results in glycemic control; however, its use has not become popular.

Objectives: to evaluate DM2 remission, as well as changes in body mass index (BMI), in overweight diabetic patients after undergoing metabolic surgery. Read More

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Preventing and managing pressure ulcers in patients receiving palliative care.

Authors:
Lynn Cornish

Nurs Older People 2021 Jun 9. Epub 2021 Jun 9.

St Margaret's Hospice Care, Somerset, England.

Pressure ulcers are more common in patients being cared for in palliative care settings than in the general population. Patients with life-limiting illnesses are living longer than ever before, and many present with multiple co-morbidities. Palliative care involves improving the patient's quality of life by achieving a balance between treatment, comfort and maintaining dignity. Read More

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Dihydroergotamine infusion for pediatric refractory headache: A retrospective chart review.

Headache 2021 May;61(5):777-789

Neuroscience Programs, Boston Children's Hospital, Boston, MA, USA.

Background: Headaches are a common symptom in children. Children with refractory headaches may be admitted for inpatient treatment with intravenous dihydroergotamine mesylate (DHE). However, very few studies have characterized these patients and their treatment outcomes using validated, self-reported, pain scales. Read More

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The complete mitochondrial genome of (Crinoidea: Comatulida: Comatulidae).

Mitochondrial DNA B Resour 2021 May 27;6(6):1777-1778. Epub 2021 May 27.

Department of Animal Biotechnology and Resource, Sahmyook University, Seoul, Korea.

(A.H. Clark, 1916) is a common crinoid found in waters along the coastlines of China, Japan, and Korea. Read More

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The complete mitochondrial genome of (Acari: Acaridae).

Mitochondrial DNA B Resour 2021 May 19;6(6):1680-1681. Epub 2021 May 19.

Department of Health Inspection and Quarantine, Wannan Medical College, Wuhu, China.

We assembled and annotated the complete mitochondrial genome of . It is the first complete mitochondrial genome sequence from the genus . The mitogenome was 13,966 bp in length and contains 37 genes (including 13 protein-coding genes, 22 transfer RNA (tRNA), and two ribosomal RNA (rRNA)), and one largest non-coding region. Read More

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