148 results match your criteria left-dominant hemisphere

Modality-Dependent Brain Activation Changes Induced by Acquiring a Second Language Abroad.

Front Behav Neurosci 2021 26;15:631957. Epub 2021 Mar 26.

Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.

The dynamic nature of cortical activation changes during language acquisition, including second-language learning, has not been fully elucidated. In this study, we administered two sets of reading and listening tests (Pre and Post) to participants who had begun to learn Japanese abroad. The two sets were separated by an interval of about 2 months of Japanese language training. Read More

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Decompressive Hemicraniectomy Associated With Ultrasound-Guided Minimally Invasive Puncture and Drainage Has Better Feasibility Than the Traditional Hematoma Evacuation for Deteriorating Spontaneous Intracranial Hemorrhage in the Basal Ganglia Region: A Retrospective Observational Cohort Study.

Front Neurol 2020 12;11:561781. Epub 2021 Jan 12.

Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with higher mortality and disability rates; however, ideal surgical management is still to be determined for critical ICH. The purpose of this study was to prove the feasibility and unique clinical value of a novel combination, decompressive hemicraniectomy associated with ultrasound-guided minimally invasive puncture and drainage (DH + MIPD), for deteriorating ICH in the basal ganglia region. According to the enrollment criteria, 168 ICH patients were analyzed retrospectively, of which 86 patients received DH + MIPD and 82 patients received DH associated with traditional hematoma evacuation as the control group. Read More

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January 2021

Speech-Brain Frequency Entrainment of Dyslexia with and without Phonological Deficits.

Brain Sci 2020 Nov 28;10(12). Epub 2020 Nov 28.

Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

Developmental dyslexia is a cognitive disorder characterized by difficulties in linguistic processing. Our purpose is to distinguish subtypes of developmental dyslexia by the level of speech-EEG frequency entrainment (δ: 1-4; β: 12.5-22. Read More

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November 2020

Global cortical hypoexcitability of the dominant hemisphere in major depressive disorder: A transcranial magnetic stimulation study.

Neurophysiol Clin 2020 Jul 10;50(3):175-183. Epub 2020 Mar 10.

Neuropsychiatry Department, Faculty of Medicine, Assiut University Hospital, 71511 Assiut, Egypt.

Background: Accumulating evidence suggests that major depressive disorders (MDD) are associated with an imbalance of excitation-inhibition within the prefrontal cortex (PFC), generated by a deficit of inhibitory synaptic transmission onto glutamatergic principal neurons. Transcranial magnetic stimulation (TMS) protocols can be used to measure neuronal excitability and GABAergic inhibition and thus provide additional evidence to evaluate this theory.

Objective: In the present study, TMS protocols were used to compare GABAergic function and cortical excitability of dominant hemisphere in unmedicated patients with MDD versus a control group of healthy individuals. Read More

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Eye dominance modulates visuospatial attention.

Neuropsychologia 2020 04 21;141:107314. Epub 2019 Dec 21.

Integrative Multisensory Perception Action & Cognition Team (ImpAct), INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center (CRNL), Lyon, France; University of Lyon 1, Lyon, France; Hospices Civils de Lyon, Mouvement & Handicap, Neuro-Immersion Platforms, Lyon, France; Center for Mind/Brain Sciences (CIMeC), University of Trento, Italy.

Visuospatial attention has an inherent asymmetry: the leftward bias called pseudoneglect. In typical line bisection tasks, healthy individuals tend to judge the center of a line leftward of the true center, an effect attributed to the right hemisphere dominance in visuospatial attention. Since it has been shown that information perceived by the dominant eye strongly activates the ipsilateral visual cortex, we hypothesized that eye dominance may modulate visuospatial attention bias. Read More

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Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: A Pilot MRI/MRS Study at 7 T.

Front Neurosci 2019 27;13:1260. Epub 2019 Nov 27.

Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation method commonly used in the disciplines of neuroscience, neurology, and neuropsychiatry to examine or modulate brain function. Low frequency rTMS (e.g. Read More

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November 2019

Sex, Age, and Handedness Modulate the Neural Correlates of Active Learning.

Front Neurosci 2019 11;13:961. Epub 2019 Sep 11.

Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL, United States.

Background: Self-generation of material compared to passive learning results in mproved memory performance; this may be related to recruitment of a fronto-temporal encoding network. Using a verbal paired-associate learning fMRI task, we examined the effects of sex, age, and handedness on the neural correlates of self-generation.

Methods: Data from 174 healthy English-speaking participants (78M, 56 atypically handed; ages 19-76) were preprocessed using AFNI and FSL. Read More

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September 2019

Auditory T-Complex Reveals Reduced Neural Activities in the Right Auditory Cortex in Musicians With Absolute Pitch.

Front Neurosci 2019 6;13:809. Epub 2019 Aug 6.

Center for Integrated Human Brain Science, Brain Research Institute, Niigata University, Niigata, Japan.

Absolute pitch (AP) is the ability to identify the pitch names of arbitrary musical tones without being given a reference pitch. The acquisition of AP typically requires early musical training, the critical time window for which is similar to that for the acquisition of a first language. This study investigated the left-right asymmetry of the auditory cortical functions responsible for AP by focusing on the T-complex of auditory evoked potentials (AEPs), which shows morphological changes during the critical period for language acquisition. Read More

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Shared right-hemispheric representations of sensorimotor goals in dynamic task environments.

Exp Brain Res 2019 Apr 29;237(4):977-987. Epub 2019 Jan 29.

Department of Psychology, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, M1C 1A4, Canada.

Functional behaviour affords that we form goals to integrate sensory information about the world around us with suitable motor actions, such as when we plan to grab an object with a hand. However, much research has tested grasping in static scenarios where goals are pursued with repetitive movements, whereas dynamic contexts require goals to be pursued even when changes in the environment require a change in the actions to attain them. To study grasp goals in dynamic environments here, we employed a task where the goal remained the same but the execution of the movement changed; we primed participants to grasp objects either with their right or left hand, and occasionally they had to switch to grasping with both. Read More

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Probl Radiac Med Radiobiol 2018 Dec;23:373-409

State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», Melnykova str., 53, Kyiv, 04050, Ukraine.

Relevance of the present work is determined by the considerable prevalence of both affective and cognitive disor-ders in the victims due to the Chornobyl accident, the pathogenesis of which is insufficiently studied.Objective is to identify the neuropsychiobiological mechanisms of the formation of the remote affective and cog-nitive disorders following exposure to ionizing radiation taking into account the specific gene polymorphisms.Design, object and methods of research. Read More

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December 2018

Impaired Spike Timing Dependent Cortico-Cortical Plasticity in Alzheimer's Disease Patients.

J Alzheimers Dis 2018 ;66(3):983-991

Department of Behavioural and Clinical Neurology, Non-invasive Brain Stimulation Unit, Santa Lucia Foundation IRCCS, Rome, Italy.

Background: Mechanisms of cortical plasticity have been recently investigated in Alzheimer's disease (AD) patients with transcranial magnetic stimulation protocols showing a clear impairment of long-term potentiation (LTP) cortical-like plasticity mechanisms.

Objective: We aimed to investigate mechanisms of cortico-cortical spike-timing dependent plasticity (STDP) in AD patients investigating the connections between posterior parietal cortex (PPC) and primary motor cortex (M1).

Methods: We used a cortico-cortical paired associative stimulation (cc-PAS) protocol to repeatedly activate the connection between PPC and M1 of the left-dominant hemisphere in a sample of fifteen AD patients and ten age-matched healthy subjects. Read More

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November 2019

Laterality of Poststroke Cortical Motor Activity during Action Observation Is Related to Hemispheric Dominance.

Neural Plast 2018 28;2018:3524960. Epub 2018 May 28.

University of Southern California, Los Angeles, CA, USA.

Background: Increased activity in the lesioned hemisphere has been related to improved poststroke motor recovery. However, the role of the dominant hemisphere-and its relationship to activity in the lesioned hemisphere-has not been widely explored.

Objective: Here, we examined whether the dominant hemisphere drives the lateralization of brain activity after stroke and whether this changes based on if the lesioned hemisphere is the dominant hemisphere or not. Read More

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December 2018

A simple magnetoencephalographic auditory paradigm may aid in confirming left-hemispheric language dominance in epilepsy patients.

PLoS One 2018 2;13(7):e0200073. Epub 2018 Jul 2.

Clinical Neurosciences, Department of Clinical Neurophysiology, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objective: The intracarotid amobarbital procedure (IAP) is the current "gold standard" in the preoperative assessment of language lateralization in epilepsy surgery candidates. It is, however, invasive and has several limitations. Here we tested a simple noninvasive language lateralization test performed with magnetoencephalography (MEG). Read More

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January 2019

Parietal association deficits in patients harboring parietal lobe gliomas: a prospective study.

J Neurosurg 2018 05;130(3):773-779

2Hellenic Center for Neurosurgical Research "Prof. Petros Kokkalis," Athens, Greece.

Objective: Although the parietal lobe is a common site for glioma formation, current literature is scarce, consists of retrospective studies, and lacks consistency with regard to the incidence, nature, and severity of parietal association deficits (PADs). The aim of this study was to assess the characteristics and incidence of PADs in patients suffering from parietal lobe gliomas through a prospective study and a battery of comprehensive neuropsychological tests.

Methods: Between 2012 and 2016 the authors recruited 38 patients with glioma confined in the parietal lobe. Read More

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The Neural Correlates of Grasping in Left-Handers: When Handedness Does Not Matter.

Front Neurosci 2018 3;12:192. Epub 2018 Apr 3.

Dipartimento di Psicologia Generale, Università degli Studi di Padova, Padua, Italy.

Neurophysiological studies showed that in macaques, grasp-related visuomotor transformations are supported by a circuit involving the anterior part of the intraparietal sulcus, the ventral and the dorsal region of the premotor area. In humans, a similar grasp-related circuit has been revealed by means of neuroimaging techniques. However, the majority of "human" studies considered movements performed by right-handers only, leaving open the question of whether the dynamics underlying motor control during grasping is simply reversed in left-handers with respect to right-handers or not. Read More

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Paradoxical Activation in the Cerebellum During Language fMRI in Patients with Brain Tumors: Possible Explanations Based on Neurovascular Uncoupling and Functional Reorganization.

Cerebellum 2018 Jun;17(3):286-293

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

The cerebellum is known for its crossed activation pattern with the contralateral cerebral hemisphere during language functional magnetic resonance imaging (fMRI) tasks in healthy patients. Crossed cerebro-cerebellar activation has been previously shown to occur in patients with brain tumors not affecting the activation areas. However, the presence of a tumor in left Broca's area in the inferior frontal gyrus is known to disrupt cerebral activation during language tasks. Read More

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Is non-awake surgery for supratentorial adult low-grade glioma treatment still feasible?

Hugues Duffau

Neurosurg Rev 2018 Jan 6;41(1):133-139. Epub 2017 Nov 6.

Department of Neurosurgery, Gui de Chauliac Hospital, CHU Montpellier, Montpellier University Medical Center, 80, Avenue Augustin Fliche, 34295, Montpellier, France.

In this short review, the author performs a database search, summarizes, and discusses studies that provide information on the need to perform awake surgery to preserve quality of life/return to work of adult patients who undergo resection for a supratentorial low-grade glioma (LGG). Based upon the currently available data, the author concludes that in LGG, patients with no or only mild deficits at diagnosis, non-awake surgery can no longer be achieved. Indeed, awake craniotomy with intrasurgical electrical mapping has resulted in an increase of the extent of resection and overall survival in LGG. Read More

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January 2018

Correlation between extreme fear and focal cortical dysplasia in anterior cingulate gyrus: Evidence from a surgical case of refractory epilepsy.

Clin Neurol Neurosurg 2017 Dec 31;163:121-123. Epub 2017 Oct 31.

Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.

Localizing the semiology of ictal fear and seizure onset in epilepsy patients is commonly challenging due to limited value of routine electroencephalography (EEG) and very few surgical attempts. Here we reported a case of refractory epilepsy characterized by aura of extreme fear and hypermotor seizures, in which the left (dominant hemisphere) anterior cingulate gyrus (ACG) was determined to be the epileptogenic zone (EZ) through multiple modalities of presurgical evaluation including analysis of high frequency oscillation on intracranial EEG. Tailored resection of EZ was thus performed and pathological examination revealed focal cortical dysplasia (FCD) type IIb. Read More

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December 2017

Predicting hemispheric dominance for language production in healthy individuals using support vector machine.

Hum Brain Mapp 2017 12 3;38(12):5871-5889. Epub 2017 Sep 3.

Université de Bordeaux, Institut des Maladies Neurodégéneratives, UMR 5293, Groupe d'Imagerie Neurofonctionnelle, F-33000 Bordeaux, France.

We used a Support Vector Machine (SVM) classifier to assess hemispheric pattern of language dominance of 47 individuals categorized as non-typical for language from their hemispheric functional laterality index (HFLI) measured on a sentence minus word-list production fMRI-BOLD contrast map. The SVM classifier was trained at discriminating between Dominant and Non-Dominant hemispheric language production activation pattern on a group of 250 participants previously identified as Typicals (HFLI strongly leftward). Then, SVM was applied to each hemispheric language activation pattern of 47 non-typical individuals. Read More

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December 2017

Prevalence and predictors of post-stroke mood disorders: A meta-analysis and meta-regression of depression, anxiety and adjustment disorder.

Gen Hosp Psychiatry 2017 07 3;47:48-60. Epub 2017 Apr 3.

Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK. Electronic address:

Objective: To ascertain the prevalence and predictors of mood disorders, determined by structured clinical interviews (ICD or DSM criteria) in people after stroke.

Methods: Major electronic databases were searched from inception to June 2016 for studies involving major depression (MDD), minor depression (MnD), dysthymia, adjustment disorder, any depressive disorder (any depressive disorder) and anxiety disorders. Studies were combined using both random and fixed effects meta-analysis and results were stratified as appropriate. Read More

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rTMS treatments combined with speech training for a conduction aphasia patient: A case report with MRI study.

Medicine (Baltimore) 2017 Aug;96(32):e7399

Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University Department of Rehabilitation Medicine, Huashan Hospital Department of Rehabilitation Medicine, Shanghai Third Rehabilitation Hospital Department of Radiology, Huashan Hospital Department of Sports Medicine and Rehabilitation, Huashan Hospital State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.

Rationale: To date, little is known regarding the neural mechanisms of the functional recovery of language after repetitive transcranial magnetic stimulation (rTMS) in aphasia. Our aim was to investigate the mechanism that underlies rTMS and speech training in a case report.

Patient Concerns And Diagnoses: We report the case of a 39-year-old woman who was initially diagnosed with conduction aphasia following a left hemisphere stroke. Read More

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MEG language lateralization in partial epilepsy using dSPM of auditory event-related fields.

Epilepsy Behav 2017 08 26;73:247-255. Epub 2017 Jun 26.

Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.

Objective: Methods employed to determine hemispheric language dominance using magnetoencephalography (MEG) have differed significantly across studies in the choice of language-task, the nature of the physiological response studied, recording hardware, and source modeling methods. Our goal was to determine whether an analysis based on distributed source modeling can replicate the results of prior studies that have used dipole-modeling of event-related fields (ERFs) generated by an auditory word-recognition task to determine language dominance in patients with epilepsy.

Methods: We analyzed data from 45 adult patients with drug-resistant partial epilepsy who performed an auditory word-recognition task during MEG recording and also completed a language fMRI study as part of their evaluation for epilepsy surgery. Read More

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Inhibitory control is not lateralized in Parkinson's patients.

Neuropsychologia 2017 Jul 22;102:177-189. Epub 2017 Jun 22.

School of Innovations Sciences, Eindhoven University of Technology, Den Dolech 1, 5600 MB Eindhoven, The Netherlands.

Parkinson's disease (PD) is often characterized by asymmetrical symptoms, which are more prominent on the side of the body contralateral to the most extensively affected brain hemisphere. Therefore, lateralized PD presents an opportunity to examine the effects of asymmetric subcortical dopamine deficiencies on cognitive functioning. As it has been hypothesized that inhibitory control relies upon a right-lateralized pathway, we tested whether left-dominant PD (LPD) patients suffered from a more severe deficit in this key executive function than right-dominant PD patients (RPD). Read More

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Theory of mind performance in Parkinson's disease is associated with motor and cognitive functions, but not with symptom lateralization.

J Neural Transm (Vienna) 2017 09 5;124(9):1067-1072. Epub 2017 Jun 5.

Department of Neurology, Charité Campus Benjamin Franklin, Berlin, Germany.

Next to the typical motor signs, Parkinson's disease (PD) goes along with neuropsychiatric symptoms, amongst others affecting social cognition. Particularly, Theory of Mind (ToM) impairments have mostly been associated with right hemispherical brain dysfunction, so that it might prevail in patients with left dominant PD. Fourty-four PD patients, twenty-four with left and twenty with right dominant motor symptoms, engaged in the Reading the Mind in the Eyes (RME) and the Faux Pas Detection Test (FPD) to assess affective and cognitive ToM. Read More

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September 2017

Challenging the Myth of Right Nondominant Hemisphere: Lessons from Corticosubcortical Stimulation Mapping in Awake Surgery and Surgical Implications.

World Neurosurg 2017 Jul 15;103:449-456. Epub 2017 Apr 15.

Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France; Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors," INSERM U1051, Institute for Neurosciences of Montpellier, Montpellier, France. Electronic address:

For many years, the right hemisphere (RH) was considered as nondominant, especially in right-handers. In neurosurgical practice, this dogma resulted in the selection of awake procedure with language mapping only for lesions of the left dominant hemisphere. Conversely, surgery under general anesthesia (possibly with motor mapping) was usually proposed for right lesions. Read More

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You talkin' to me? Communicative talker gaze activates left-lateralized superior temporal cortex during perception of degraded speech.

Neuropsychologia 2017 06 8;100:51-63. Epub 2017 Apr 8.

Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK.

Neuroimaging studies of speech perception have consistently indicated a left-hemisphere dominance in the temporal lobes' responses to intelligible auditory speech signals (McGettigan and Scott, 2012). However, there are important communicative cues that cannot be extracted from auditory signals alone, including the direction of the talker's gaze. Previous work has implicated the superior temporal cortices in processing gaze direction, with evidence for predominantly right-lateralized responses (Carlin & Calder, 2013). Read More

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Three- and four-dimensional mapping of speech and language in patients with epilepsy.

Brain 2017 05;140(5):1351-1370

Department of Pediatrics, Wayne State University, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI, 48201, USA.

We have provided 3-D and 4D mapping of speech and language function based upon the results of direct cortical stimulation and event-related modulation of electrocorticography signals. Patients estimated to have right-hemispheric language dominance were excluded. Thus, 100 patients who underwent two-stage epilepsy surgery with chronic electrocorticography recording were studied. Read More

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Neurocognitive status in patients with newly-diagnosed brain tumors in good neurological condition: The impact of tumor type, volume, and location.

Clin Neurol Neurosurg 2017 May 18;156:55-62. Epub 2017 Mar 18.

Department of Psychology, Goethe-University, Frankfurt, Germany.

Objective: Neurocognitive function is of great importance in patients with brain tumors. Even patients in good neurological condition may suffer from neurocognitive dysfunction that affects their daily living. The purpose of the present study was to identify risk factors for neurocognitive dysfunction in patients suffering from common supratentorial brain tumors with minor neurological deficits. Read More

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Hemispheric asymmetries in the transition from action preparation to execution.

Neuroimage 2017 03 6;148:390-402. Epub 2017 Jan 6.

IRCCS Santa Lucia Foundation, Rome 00179, Italy; Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome 00135, Italy.

Flexible and adaptive behavior requires the ability to contextually stop inappropriate actions and select the right one as quickly as possible. Recently, it has been proposed that three brain regions, i.e. Read More

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