128,608 results match your criteria left ventricle

Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy.

Biomed Pharmacother 2021 Jun 12;141:111780. Epub 2021 Jun 12.

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China. Electronic address:

Diabetic cardiomyopathy (DCM), one severe complication in the diabetes, leads to high mortality in the diabetic patients. However, the understanding of molecular mechanisms underlying DCM is far from completion. Herein, we investigated the disease-related differences in the proteomes of DCM based on db/db mice and verified the protective roles of peroxiredoxin-4 (Prdx4) in H9c2 cardiomyocytes treated by palmitic acid (PA). Read More

View Article and Full-Text PDF

Clinical and echocardiographic findings in a cross-sectional study of HIV-infected adults in Enugu, Nigeria.

Cardiovasc J Afr 2021 May 12;32:1-7. Epub 2021 May 12.

Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria.

Background: Human immunodeficiency virus (HIV) infection and highly active antiretroviral therapy (HAART) are implicated in cardiovascular diseases. The objective of this study was to evaluate the clinical and echocardiographic findings in HIV-infected adults.

Methods: One hundred HIV subjects on HAART, 100 HAART-naïve patients and 100 controls were recruited in this cross-sectional study. Read More

View Article and Full-Text PDF

A case report of prenatal diagnosis of fetal alloimmune thrombocytopenia: A CARE-compliant article.

Medicine (Baltimore) 2021 Jun;100(24):e26092

Department of Obstetrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Rationale: Fetal alloimmune thrombocytopenia (FAIT) is a serious life-threatening disease caused by platelet-antigen incompatibility between the mother and fetus. FAIT can lead to fetal thrombocytopenia, intracranial hemorrhage (ICH), fetal death and severe neurological disorders after birth. Noninvasive prenatal diagnosis technology has not been widely used in China, and thus few cases of FAIT can be diagnosed prenatally. Read More

View Article and Full-Text PDF

Improvement of symptoms and coronary perfusion gradient with mechanical left ventricular unloading in flow-limiting complex spontaneous coronary artery dissection, without revascularization.

Catheter Cardiovasc Interv 2021 Jun 15. Epub 2021 Jun 15.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Spontaneous coronary artery dissection (SCAD) can lead to acute coronary syndrome and sudden cardiac death, particularly in young women. Observational data show that, in SCAD patients, both percutaneous coronary intervention and coronary artery bypass grafting seem to be hampered by higher technical complexity, lower success rates, and worse outcomes. As spontaneous healing is a common occurrence, expert consensus advices medical management of the acute phase, when feasible. Read More

View Article and Full-Text PDF

Isolated ruptured dissecting aneurysm of PICA with extremely narrow neck managed by a novel endovascular technique-a case report and review of literature.

Childs Nerv Syst 2021 Jun 14. Epub 2021 Jun 14.

Department of Neuroradiology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, 600116, India.

Dissecting aneurysms of posterior inferior cerebellar artery (PICA) are usually extensions of vertebral artery dissection. Isolated dissecting aneurysms of PICA are extremely rare. A 5-month-old female child presented with history of fall from a height of around 2 ft. Read More

View Article and Full-Text PDF

Neurosurgical anatomy of the floor of the third ventricle and related vascular structures.

Surg Radiol Anat 2021 Jun 14. Epub 2021 Jun 14.

Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

Purpose: Anatomical knowledge of the floor of the third ventricle (FTV) is essential in avoiding surgical complications during endoscopic third ventriculostomy. The purpose of this study was to characterize the morphometry of FTV and related arteries, particularly the basilar artery (BA), as well as the factors that influence it.

Methods: Twenty-six formalin-fixed adult brains and two hundred adult brain MRIs were studied focusing on FTV and related arteries. Read More

View Article and Full-Text PDF

[Clinical value of left ventricular strain analysis by cardiovascular magnetic resonance in patients with coronary chronic total occlusion].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):601-609

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029,China.

To explore the clinical value of quantitatively assessment of left ventricular strain in patients with coronary chronic total occlusion (CTO) by cardiac magnetic resonance imaging (CMR)-feature tracking (CMR-FT) technique. In this retrospective and observation study, patients with single CTO, who underwent CMR examination in Beijing Anzhen Hospital from November 2014 to January 2019, were selected as case group (CTO group), and those without cardiovascular diseases defined by echocardiography, electrocardiogram (ECG) and clinical history and with normal CMR results were selected as healthy control group (control group). General clinical data including age, gender, discharge diagnosis, and the examination results of echocardiography and ECG were obtained from the electronic medical record system. Read More

View Article and Full-Text PDF

Neonatal arrhythmias in Turner syndrome: a case report and review of the literature.

Eur Heart J Case Rep 2021 Apr 30;5(4):ytab160. Epub 2021 Apr 30.

Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA.

Background: While left-sided congenital heart defects have been well described in females with Turner syndrome (45, X), the literature is scarce regarding arrhythmias in this patient population.

Case Summary: A full-term neonate referred to cardiology was found to have a non-apex forming left ventricle and partial anomalous pulmonary venous return. During the echocardiogram, she developed atrial flutter, followed by orthodromic reentrant supraventricular tachycardia (SVT). Read More

View Article and Full-Text PDF

Surgical resection of a giant pericardial cyst: a case report.

Eur Heart J Case Rep 2021 Apr 12;5(4):ytab116. Epub 2021 Apr 12.

Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, 5-3-1 Chikami, Minami-ku, Kumamoto, Japan.

Background: Pericardial cysts are rare congenital mediastinal cysts. They are typically asymptomatic and are often discovered incidentally, although some patients may present with chest pain and dyspnoea. Asymptomatic patients are managed conservatively with multiple modalities, with surgical resection often recommended for symptomatic patients only. Read More

View Article and Full-Text PDF

Massive pulmonary embolism and thrombus-in-transit via a patent foramen ovale: a case report of successful use of extracorporeal membrane oxygenation to manage post-embolectomy severe right ventricular dysfunction.

Eur Heart J Case Rep 2021 Apr 19;5(4):ytab100. Epub 2021 Apr 19.

Department of Cardiothoracic Anaesthesia, Mohammed Bin Khalifa Bin Salman Al Khalifa Specialist Cardiac Centre, Road 4524, Block 945, Al Riffa, Awali, Kingdom of Bahrain.

Background: Pulmonary embolism with thrombus-in-transit through a patent foramen ovale is rare. It may present with neurological sequalae and rapid diagnosis is needed to prevent mortality and morbidity. The European Society of Cardiology (ESC) published guidelines in 2019 for diagnosis and management of acute pulmonary embolism which were useful in this case. Read More

View Article and Full-Text PDF

Case Report: Giant Biatrial Myxoma Mimicking Malignant Cardiac Tumor in a Patient With a Hepatic Angiomatous Mass.

Front Cardiovasc Med 2021 28;8:676807. Epub 2021 May 28.

Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Cardiac myxomas, primarily originating from the left atrium, are the most prevalent types of benign cardiac tumors; however, biatrial myxomas are extremely rare. Herein, we present a rare case of a 55-year old male with exertional dyspnea and intermittent chest discomfort due to a giant biatrial mass with concomitant atrial fibrillation and hepatic hemangioma. The giant tumor with its peduncle at the interatrial septum involved both atria; however, bulging through the tricuspid valve to the right ventricle during systole. Read More

View Article and Full-Text PDF

Cardiac Mesenchymal Cells Cultured at Physiologic Oxygen Tension Have Superior Therapeutic Efficacy in Heart Failure Caused by Myocardial Infarction.

Front Cell Dev Biol 2021 26;9:662415. Epub 2021 May 26.

Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, United States.

Stem/progenitor cells are usually cultured at atmospheric O tension (21%); however, since physiologic O tension in the heart is ∼5%, using 21% O may cause oxidative stress and toxicity. Cardiac mesenchymal cells (CMCs), a newly discovered and promising type of progenitor cells, are effective in improving left ventricle (LV) function after myocardial infarction (MI). We have previously shown that, compared with 21% O, culture at 5% O increases CMC proliferation, telomerase activity, telomere length, and resistance to severe hypoxia . Read More

View Article and Full-Text PDF

Cardiac Abnormalities in COVID-19 Patients: Should a Cardiac Echocardiogram be Routine?

Eur J Case Rep Intern Med 2021 14;8(5):002559. Epub 2021 May 14.

Centro Hospitalar Barreiro Montijo, Barreiro, Portugal.

Current scientific evidence shows that SARS-CoV-2 infection is associated with an increased risk of thromboembolic events. In patients with ischaemic heart disease and heart failure, thrombi of the left ventricle can increase patient mortality, mainly due to the risk of systemic embolization. Given the hypercoagulable state associated with COVID-19, such events may be more likely. Read More

View Article and Full-Text PDF

A Giant Left Intraventricular Thrombus Associated With Apical Hypertrophic Cardiomyopathy Mimics Cancer.

Cureus 2021 Jun 9;13(6):e15554. Epub 2021 Jun 9.

Cardiology, University of California, Los Angeles (UCLA) Kern Medical Center, Bakersfield, USA.

Hypertrophic cardiomyopathy (HCM) is a common disease that can be acquired due to chronic hypertension or via autosomal dominant inheritance. Several patterns of HCM have been described, of which a rare variant is apical hypertrophic cardiomyopathy (AHCM). Atrial thrombus is a well-recognized complication of HCM especially in the setting of atrial fibrillation (AF). Read More

View Article and Full-Text PDF

Dominant-Negative Effect of an Brugada Syndrome Variant.

Front Physiol 2021 28;12:661413. Epub 2021 May 28.

INSERM, UMR_S 1166 ICAN, Paris, France.

Loss-of-function mutations in the cardiac Na channel α-subunit Na1.5, encoded by , cause Brugada syndrome (BrS), a hereditary disease characterized by sudden cardiac death due to ventricular fibrillation. We previously evidenced the dominant-negative effect of the BrS Na1. Read More

View Article and Full-Text PDF

Left ventricle implantable cardioverter defibrillator: a dextro-transposition of the great arteries case.

Cardiol Young 2021 Jun 14:1-2. Epub 2021 Jun 14.

Department of Cardiology, São João Universitary Hospital, Porto, Portugal.

We present a case of a patient with dextro-transposition of the great arteries palliated with a Senning procedure and a long-term arrhythmic complication that required an intervention, with an Implantable Cardioverter Defibrillator (ICD) implantation in the sub-pulmonary ventricle (morphologically left). This case highlights the need to perform off-label procedures to deal with the long-term complications of these complex patients. Read More

View Article and Full-Text PDF

The risk factors of the early postoperative residual tricuspid regurgitation after concomitant thoracoscopic tricuspid valve repair.

J Card Surg 2021 Jun 13. Epub 2021 Jun 13.

Department of Cardiovascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Objective: Secondary tricuspid regurgitation will be aggravated if left uncorrected during the initial surgery. Recently, an aggressive strategy of routine concomitant tricuspid valve repair has been warranted. Follow this strategy, routine concomitant thoracoscopic tricuspid valve repair was performed and the surgical effect and postoperative residual TR were reviewed. Read More

View Article and Full-Text PDF

MicroRNA-17-5p Promotes Cardiac Hypertrophy by Targeting Mfn2 to Inhibit Autophagy.

Cardiovasc Toxicol 2021 Jun 12. Epub 2021 Jun 12.

Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.

Pathological cardiac hypertrophy is the leading cause of heart failure, and miRNAs have been recognized as key factors in cardiac hypertrophy. This study aimed to elucidate whether miR-17-5p affects cardiac hypertrophy by targeting the mitochondrial fusion protein mitofusin 2 (Mfn2)-mediated phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway and regulating autophagy. miR-17-5p expression was shown to be upregulated both in vivo and in vitro. Read More

View Article and Full-Text PDF

Left Ventricular Recruitment in Patients With Hypoplastic Left Heart Syndrome.

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:30-36

Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Hypoplastic left heart complex with "borderline left ventricle" and intact ventricular septum is a clinical conundrum for the congenital heart surgeon. The choice between neonatal biventricular repair and single ventricle palliation can be challenging, and the current tools to aid in the decision-making process fail to account for the morbidity associated with intermediate and late diastolic dysfunction. Staged ventricular recruitment, consisting of valvular repair techniques, resection of endocardial fibroelastosis, atrial septal restriction, and augmentation of pulmonary blood flow, has been shown to improve left ventricular size and function culminating in eventual biventricular circulation. Read More

View Article and Full-Text PDF
January 2021

Left ventricle motion estimation for cine MR images using sparse representation with shape constraint.

Phys Med 2021 Jun 9;87:49-64. Epub 2021 Jun 9.

College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, China.

Purpose: To propose a left ventricle (LV) motion estimation method based on sparse representation, in order to handle the spatial-varying intensity distortions caused by tissue deformation.

Methods: For each myocardial landmark, an adaptive dictionary was generated by learning transformations from a training dataset. Then the landmark was tracked using sparse representation. Read More

View Article and Full-Text PDF

The diagnostic value of 2D-speckle tracking echocardiography for identifying subclinical ventricular dysfunction in subjects with early repolarization pattern.

Echocardiography 2021 Jun 10. Epub 2021 Jun 10.

Cardiology Department, KBU Educational and Research Hospital, Karabük, Turkey.

Introduction: Early repolarization pattern (ERP) can exist a silent substrate for arrhytmic events in accordance with the previous studies which have shown there has been evidence of morphological changes in left ventricle (LV) in ERP subjects. Despite structural changes in ERP subjects, it has not exactly known whether a change in LV functional parameters occur in ERP. The aim of our study was to investigate LV functional parameters in ERP athletes evaluated by 2D- speckle tracking echocardiography (2D-STE). Read More

View Article and Full-Text PDF

Multimodality imaging of the ischemic right ventricle: an overview and proposal of a diagnostic algorithm.

Int J Cardiovasc Imaging 2021 Jun 10. Epub 2021 Jun 10.

Department of Cardiovascular Diseases, University of Siena, Siena, Italy.

Right ventricular (RV) involvement is frequently detected in patients presenting with acute left ventricular myocardial infarction. The ischemic right ventricle carries a dismal outcome by predisposing the heart to arrhythmic events and mechanical or hemodynamic complications. A comprehensive RV evaluation by multimodality imaging could guide clinical practice but has always been a conundrum for the imagers. Read More

View Article and Full-Text PDF

Acute effects of inhaled iloprost on intracardiac conduction in patients with pulmonary arterial hypertension.

Herz 2021 Jun 10. Epub 2021 Jun 10.

Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, University of Health Sciences, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, Istanbul, Turkey.

Background: Pulmonary arterial hypertension (PAH) is a severe, life-threatening disorder despite the availability of specific drug therapy. A lack of endogenous prostacyclin secondary to downregulation of prostacyclin synthase in PAH may contribute to vascular pathologies. Therefore, prostacyclin and its analogs including inhaled iloprost may decrease pulmonary arterial pressure and ventricular pressure. Read More

View Article and Full-Text PDF

Noninvasive electrocardiographic assessment of ventricular activation and remodeling response to cardiac resynchronization therapy.

Heart Rhythm O2 2021 Feb 12;2(1):12-18. Epub 2021 Jan 12.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Background: Cardiac resynchronization therapy (CRT) produces acute changes in electric resynchronization that can be measured noninvasively with electrocardiographic body surface mapping (ECGi). The relation between baseline acute electrophysiology metrics and their manipulation with CRT and reverse remodeling is unclear.

Objective: To test (ECGi) derived parameters of electrical activation as predictors of volumetric response to CRT. Read More

View Article and Full-Text PDF
February 2021

Cardiac arrest complicating cardiogenic shock: from pathophysiological insights to Impella-assisted cardiopulmonary resuscitation in a pheochromocytoma-induced Takotsubo cardiomyopathy-a case report.

Eur Heart J Case Rep 2021 Mar 22;5(3):ytab092. Epub 2021 Mar 22.

Department of Cardiology, Santa Chiara Hospital, 2, Largo Medaglie d'Oro, 38122 Trento, Italy.

Background: A 'catecholamine storm' in a case of pheochromocytoma can lead to a transient left ventricular dysfunction similar to Takotsubo cardiomyopathy. A cardiogenic shock can thus develop, with high left ventricular end-diastolic pressure and a reduction in coronary perfusion pressure. This scenario can ultimately lead to a cardiac arrest, in which unloading the left ventricle with a peripheral left ventricular assist device (Impella) could help in achieving the return of spontaneous circulation (ROSC). Read More

View Article and Full-Text PDF

Concept of myocardial fatigue in reversible severe left ventricular systolic dysfunction from afterload mismatch: a case series.

Eur Heart J Case Rep 2021 Mar 7;5(3):ytab089. Epub 2021 Mar 7.

Department of Cardiology, University Hospitals of Coventry & Warwickshire NHS Trust, CV2 2DX, UK.

Background : There is already extensive literature on the natural history of hypertensive heart disease (HHD) and aortic stenosis (AS). Once these patients develop severe left ventricular systolic dysfunction (LVSD) despite guideline-directed therapy for heart failure (HF), it is often thought to be end-stage from irreversible adverse remodelling. Our case series challenges this traditional paradigm. Read More

View Article and Full-Text PDF

A case of Wolff-Parkinson-White syndrome in which two-dimensional speckle-tracking echocardiography was useful for identifying the location of the accessory atrioventricular pathway.

Eur Heart J Case Rep 2021 Mar 4;5(3):ytab078. Epub 2021 Mar 4.

Division of Cardiology, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo 693-8501, Japan.

Background: In Wolff-Parkinson-White (WPW) syndrome, accessory atrioventricular pathways (AP) result in abnormal pre-excitation around the atrioventricular annuli and produce a dyssynchronous contraction of cardiac chambers. Identification of the AP affects the outcome of catheter ablation.

Case Summary: We report a case of WPW syndrome and paroxysmal atrial fibrillation in a 65-year-old man. Read More

View Article and Full-Text PDF

A case report: biventricular takotsubo cardiomyopathy with sequential ventricular recovery due to pulmonary hypertension.

Eur Heart J Case Rep 2021 Mar 16;5(3):ytab073. Epub 2021 Mar 16.

Department of Cardiology, Milton Keynes University Hospital, 8H Standing Way, Eaglestone, Milton Keynes MK6 5LD, UK.

Background: Biventricular Takotsubo cardiomyopathy (BTC) is estimated to occur in 25-42% of those with Takotsubo cardiomyopathy (TC). Little is known about which subset of patients are predisposed to having concomitant right ventricular (RV) involvement, or the pattern of recovery in BTC.

Case Summary: We describe a 69-year-old woman who presented with dyspnoea and was subsequently diagnosed with BTC. Read More

View Article and Full-Text PDF

ANG II and Aldosterone Acting Centrally Participate in the Enhanced Sodium Intake in Water-Deprived Renovascular Hypertensive Rats.

Front Pharmacol 2021 25;12:679985. Epub 2021 May 25.

Department of Physiology and Pathology, School of Dentistry, Sao Paulo State University, Araraquara, Brazil.

Renovascular hypertension is a type of secondary hypertension caused by renal artery stenosis, leading to an increase in the renin-angiotensin-aldosterone system (RAAS). Two-kidney, 1-clip (2K1C) is a model of renovascular hypertension in which rats have an increased sodium intake induced by water deprivation (WD), a common situation found in the nature. In addition, a high-sodium diet in 2K1C rats induces glomerular lesion. Read More

View Article and Full-Text PDF

Clinical Predictors of Occurrence of Ventricular Tachyarrhythmias in Patients with Reduced Left Ventricle Ejection Fraction. Results of Single-Center Prospective Study.

Kardiologiia 2021 May 31;61(5):32-40. Epub 2021 May 31.

Federal Center for Cardiovascular Surgery, Astrakhan.

Aim      To evaluate the diagnostic significance of clinical and demographic parameters for predicting a 2-year probability of ventricular tachyarrhythmias (VT) in patients with chronic heart failure and reduced left ventricular ejection fraction (CHFrLVEF).Material and methods  This single-center, prospective cohort study included 175 patients with CHFrLVEF who were implanted with a cardioverter defibrillator (CD). The endpoint was a CD-detected episode of VT. Read More

View Article and Full-Text PDF