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The NLRP3-related inflammasome modulates pain behavior in a rat model of trigeminal neuropathic pain.

Life Sci 2021 Apr 13:119489. Epub 2021 Apr 13.

Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China. Electronic address:

Aims: Nod-like receptor family pyrin domain containing 3 (NLRP3) may play an important role in neuropathic pain. Treatment for trigeminal neuropathic pain remains a challenge, as common drugs either do not demonstrate beneficial therapeutic effects or induce intolerance in patients.

Main Methods: In a rat model of trigeminal neuropathic pain, pain caused by the malpositioning of dental implants is similar to that experienced by humans. Read More

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Heart failure subtypes: pathophysiology and definitions.

Karl Swedberg

Diabetes Res Clin Pract 2021 Apr 13:108815. Epub 2021 Apr 13.

Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. Electronic address:

The diagnosis of heart failure is classified in two main types depending on left ventricular ejection fraction usually by ejection fraction < or > 40%. The division has important implications for the treatment of heart failure Type 2 diabetes is an important and common co-morbidity in chronic heart failure. It makes the prognosis of heart failure worse and chronic heart failure impacts the choice of treatment for type 2 diabetes. Read More

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Leydig Cell Tumor in a Patient with 46,XX Disorder of Sex Development (DSD), Ovotesticular: A Case Report and a Review of the Literature.

Case Rep Pathol 2021 29;2021:5552305. Epub 2021 Mar 29.

Dr. Senckenberg Institute of Pathology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.

Disorder of sex development (DSD) is a rare condition with atypical development of chromosomal, gonadal, or anatomical sex. It is classified in different subgroups based on the patient's karyotype, gonadal dysgenesis, and the appearance of the internal and external genitalia. Within the subgroups, the risk for developing neoplasms varies a lot. Read More

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Effect of various dialysis modalities on intradialytic hemodynamics, tissue injury and patient discomfort in chronic dialysis patients: design of a randomized cross-over study (HOLLANT).

BMC Nephrol 2021 Apr 15;22(1):131. Epub 2021 Apr 15.

Department of Nephrology and Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, VU University of Amsterdam, Amsterdam, The Netherlands.

Background: From a recent meta-analysis it appeared that online post-dilution hemodiafiltration (HDF), especially with a high convection volume (HV-HDF), is associated with superior overall and cardiovascular survival, if compared to standard hemodialysis (HD). The mechanism(s) behind this effect, however, is (are) still unclear. In this respect, a lower incidence of intradialytic hypotension (IDH), and hence less tissue injury, may play a role. Read More

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The impact of successful chronic total occlusion percutaneous coronary intervention on long-term clinical outcomes in real world.

BMC Cardiovasc Disord 2021 Apr 15;21(1):182. Epub 2021 Apr 15.

Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.

Background: Coronary chronic total occlusions (CTOs) are related to increased risk of adverse clinical outcomes. The optimal treatment strategy for CTO has not been well established. We sought to examine the impact of CTO percutaneous coronary intervention (PCI) on long-term clinical outcome in the real world. Read More

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Validation of Withings ScanWatch as a Wrist-Worn Reflective Pulse Oximeter: Hypoxia Study.

J Med Internet Res 2021 Apr 11. Epub 2021 Apr 11.

Withings, 2 rue Maurice Hartmann, Issy-Les-Moulineaux, FR.

Background: A decrease in the pulse oxygen saturation (SpO2) level is an indicator of hypoxemia that may occur in various respiratory diseases such as chronic obstructive pulmonary disease (COPD), sleep apnea syndrome (SAS) and COVID-19. There is currently no mass-market wrist-worn SpO2 monitor meeting the medical standards for pulse oximeters.

Objective: The main objective of this monocentric and prospective clinical study with single-blind analysis was to test and validate the accuracy of the Withings ScanWatch's reflective pulse oximeter function to measure SpO2 levels at different stages of hypoxia. Read More

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GliPR1 knockdown by RNA interference exerts anti-glioma effects in vitro and in vivo.

J Neurooncol 2021 Apr 15. Epub 2021 Apr 15.

Department of Neurosurgery, Section Experimental Neurosurgery/Tumor Immunology, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.

Introduction: In human glioblastomas, glioma pathogenesis-related protein1 (GliPR1) is overexpressed and appears to be an oncoprotein. We investigated whether GliPR1 knockdown in glioma cells by RNA interference exerts anti-glioma effects.

Methods: Experiments used human glioblastoma cell lines transduced with GliPR1 shRNA (sh#301, sh#258). Read More

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Non-intubated Robotic-Assisted Thoracic Surgery for Tracheal/Airway Resection and Reconstruction: Technique Description and Preliminary Results.

Ann Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China Department of Anesthesia, the First Affiliated Hospital of Guangzhou Medical University.

Objective: We aim to report a novel surgical technique that robotic-assisted thoracoscopic surgery combined with non-intubated spontaneous ventilation to perform tracheal/airway surgery.

Summary Background Data: Our team has demonstrated video-assisted transthoracic surgery (VATS) can be used for thoracic tracheal diseases with satisfactory outcomes. Our team has also demonstrated that tracheal/ airway resection and reconstruction under spontaneous ventilation can improve the anastomosis and operating time. Read More

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Nickel(II) Complex with a Flexidentate Ligand Derived from Acetohydrazide: Synthesis, Structural Characterization and Hirshfeld Surface Analysis.

Acta Chim Slov 2020 Jun;67(2):516-521

The mononuclear Ni(II) complex [Ni(Lp)2(CH3OH)2]Cl2 has been synthesized by reacting 1-(5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one ligand (HL) with NiCl2·6H2O in methanol solution. In the reaction, the tridentate ligand, HL, was converted in situ into 4-hydroxy-4-phenylbut-3-en-2-ylidene)acetohydrazid ligand, (pyrazole, Lp). The pyrazole ligand acts as bidentate neutral ligand and the hydroxyl group is left uncoordinated. Read More

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Characteristic differences of chest pain in male and female patients with acute coronary syndrome: A pilot study.

J Public Health Res 2021 Apr 14;10(2). Epub 2021 Apr 14.

Cardiovascular Research Group, Faculty of Medicine, Brawijaya University, Malang.

Background: The typical sign or main symptom in acute coronary syndrome (ACS) patients is chest pain, which is an initial benchmark or early sign for diagnosis. Certain factors, such as gender differences, the presence of diabetes mellitus or other clinical conditions, may make the patient not realize they have ACS. Therefore, this study aims to identify the characteristics of chest pain symptoms in male and female patients with ACS. Read More

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Male factor infertility: Initial workup and diagnosis in primary care.

Can Fam Physician 2021 Apr;67(4):248-254

Assistant Professor in the Department of Urologic Sciences at the University of British Columbia and Adjunct Assistant Professor in the Department of Urology at Weill Cornell Medicine in New York, NY.

Objective: To present a case-based discussion on the workup of male factor infertility and review currently available treatments.

Sources Of Information: This discussion is based on the current Canadian Urological Association and American Urological Association guidelines, with reference to landmark papers as appropriate from 2010 onward. All articles were retrieved through PubMed. Read More

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Surgical management of aortopulmonary window with pulmonary artery dilatation causing left main coronary compression.

Cardiol Young 2021 Apr 15:1-3. Epub 2021 Apr 15.

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Aortopulmonary window is a rare congenital heart defect. Left main coronary artery extrinsic compression by an enlarged pulmonary artery is a rare complication and a potential cause for chest pain and sudden cardiac death in patients with pulmonary hypertension. Here, we present the case of a 14-year-old boy with a large aortopulmonary window who was planned for a device closure, but during the procedure, he developed ST-T segment changes while the device was being deployed, and hence the procedure was abandoned. Read More

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Transthoracic Right Heart Echocardiography for the Intensivist.

J Intensive Care Med 2021 Apr 15:8850666211003475. Epub 2021 Apr 15.

Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: The impact of critical illness on the right ventricle (RV) can be profound and RV dysfunction is associated with mortality. Intensivists are becoming more facile with bedside echocardiography, however, pedagogy has largely focused on left ventricular function. Here we review measurements of right heart function by way of echocardiographic modalities and list clinical scenarios where the RV dysfunction is a salient feature. Read More

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Three concomitant locked finger metacarpophalangeal joints caused by degenerative metacarpal heads: case report.

Hand Surg Rehabil 2021 Apr 11. Epub 2021 Apr 11.

Department of Orthopedic surgery, Pontchaillou University Hospital, 2 rue Henri Le Guilloux, 35033, Rennes, France. Electronic address:

A locked metacarpophalangeal joint (LMCP) is a rare condition often confused with trigger finger. Its causes are numerous and typically divided into two broad categories: acquired LMCP in younger patients, and degenerative LMCP in older patients. This pathology usually affects only one MCP. Read More

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Clinical features and follow-up of pediatric patients hospitalized for COVID-19.

Pediatr Pulmonol 2021 Apr 14. Epub 2021 Apr 14.

Medicine Research Center, Ningbo City First Hospital, Ningbo, Zhejiang Province, China.

Objective: This report summarizes the clinical features and 1-month follow-up observations for pediatric patients who were hospitalized with coronavirus disease 2019 (COVID-19) in Wuhan Women and Children's Hospital.

Methods: The 1-month follow-up data included clinical manifestations and results from serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG and IgM tests, reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2, lung computed tomography (CT) scans, and laboratory tests.

Results: Between January 20 and March 15, 2020, 127 patients aged 0-15 years were hospitalized for COVID-19 treatment, including 3 severe cases and 124 mild or moderate cases. Read More

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Inducing lateralized phosphenes over the occipital lobe using transcranial magnetic stimulation to navigate a virtual environment.

PLoS One 2021 14;16(4):e0249996. Epub 2021 Apr 14.

Department of Life Sciences, The University of Tokyo, Tokyo, Japan.

Electrical stimulation involving visual areas of the brain produces artificial light percepts called phosphenes. These visual percepts have been extensively investigated in previous studies involving intracortical microsimulation (ICMS) and serve as the basis for developing a visual prosthesis for the blind. Although advances have been achieved, many challenges still remain with implementing a functional ICMS for visual rehabilitation purposes. Read More

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Calcium/Calmodulin-Dependent Protein Kinase II Delta Inhibition and Ventricular Remodeling After Myocardial Infarction: A Randomized Clinical Trial.

JAMA Cardiol 2021 Apr 14. Epub 2021 Apr 14.

Armaron Bio, Melbourne, Victoria, Australia.

Importance: After anterior ST-segment elevation myocardial infarction (STEMI), left ventricular (LV) remodeling results in heart failure and death. Calcium/calmodulin-dependent protein kinase II delta (CaMKIId) is a key molecular mediator of adverse LV remodeling.

Objective: To determine whether NP202, an orally active inhibitor of CaMKIId, prevents LV remodeling in patients after anterior STEMI with early residual LV dysfunction. Read More

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PCI for left main bifurcation stenting: A treatment paradigm at a crossroads?

Catheter Cardiovasc Interv 2021 Apr;97(5):786-787

Division of Cardiology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.

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Narrative review: the holy grail: update on pharmacotherapy for heart failure with preserved ejection fraction.

Ann Transl Med 2021 Mar;9(6):523

Division of Cardiovascular Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.

Heart failure with preserved ejection fraction (HFpEF) is the presence of clinical signs and/or symptoms of heart failure with a left ventricular ejection fraction (LVEF) ≥50%. Risk factors associated with this disease include hypertension, hyperlipidemia, atrial fibrillation (AF), obesity, diabetes and coronary artery disease (CAD). Despite the multiple risk factors identified for this condition, treatment and management remain challenging and a subject of ongoing research. Read More

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Early single-stage surgical revascularization of pulmonary artery in unilateral absence of a pulmonary artery.

J Cardiothorac Surg 2021 Apr 13;16(1):80. Epub 2021 Apr 13.

Heart Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9# Jinsui Road, Guangzhou, 510623, China.

Background: This research aims to summarize the findings of the early single-stage revascularization of remnant pulmonary artery in unilateral absent intrapericardial pulmonary artery.

Methods: We retrospectively analyzed the medical records of 10 patients with unilateral absent pulmonary artery, in which 7 were right and 3 were left, the median age and mean weight at surgery was 4 months and 5.6 kg, respectively. Read More

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The epidemiology and clinical features of calcaneus osteomyelitis following calcaneus fracture: a retrospective study of 127 cases.

Ann Palliat Med 2021 Mar;10(3):3154-3161

Department of Orthopedics, Tongde Hospital of Zhejiang, Hangzhou, China.

Background: To analyze the epidemiology and features of calcaneus osteomyelitis following open reduction and internal fixation (ORIF) after closed calcaneus fracture.

Methods: We retrospectively analyzed 127 cases who were diagnosed with calcaneal osteomyelitis following ORIF via the extended lateral "L-shaped" approach after closed calcaneus fracture between March 2016 and August 2019 in our hospital. We analyzed participant demographics including gender, age, body mass index (BMI), trauma mechanism, Sanders classification, co-morbidity, time between initial injury and surgery, operating time, soft tissue stripping tools, tourniquet pressure, bone grafting option, internal fixation option, presence of bleeding after tourniquet deflation, and drainage option. Read More

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Age-Stratified Outcome in Treatment of Left Main Coronary Artery Stenosis: A NOBLE Trial Substudy.

Cardiology 2021 Apr 13:1-10. Epub 2021 Apr 13.

Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark.

Background: In the treatment of left main coronary artery (LMCA) disease, patients' age may affect the clinical outcome after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). This study stratified the clinical outcome according to the age of patients treated for LMCA stenosis with PCI or CABG in the Nordic-Baltic-British Left Main Revascularization (NOBLE) study.

Methods: Patients with LMCA disease were enrolled in 36 centers in northern Europe and randomized 1:1 to treatment by PCI or CABG. Read More

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Flecainide-Induced QRS Complex Widening Correlates with Negative Inotropy.

Heart Rhythm 2021 Apr 10. Epub 2021 Apr 10.

Department of Medicine, Beth Israel Deaconess Medical Center, Boston MA; Harvard Medical School, Boston MA. Electronic address:

Background: The negative inotropic effect of Class IC antiarrhythmic drugs limits their use for acute cardioversion of atrial fibrillation (AF).

Objective: In an intact porcine model, we examined effects of pulmonary and intravenous (IV) administration of flecainide on left ventricular (LV) contractility and QRS complex width at doses that are effective in converting new-onset AF to sinus rhythm.

Methods: Flecainide (1. Read More

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Treatment-Related Changes in Left Atrial Structure in Atrial Fibrillation: Findings from the CABANA Imaging Substudy.

Circ Arrhythm Electrophysiol 2021 Apr 13. Epub 2021 Apr 13.

Mayo Clinic, Rochester, MN.

- The Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) trial was a randomized, prospective trial of left atrial catheter ablation versus drug therapy for treatment of atrial fibrillation (AF). As part of CABANA, a prospective imaging sub-study was conducted. The main objectives were to describe the patterns of changes in the dimensions of the left atrium (LA) and pulmonary veins (PVs), and the relationship between these changes with treatment assignment and clinical outcomes. Read More

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Asymptomatic left isomerism with preduodenal portal vein: computed tomography appearance.

Bruno Coulier

Surg Radiol Anat 2021 Apr 13. Epub 2021 Apr 13.

Department of Diagnostic Radiology, Clinique St Luc, Bouge, 5004, Namur, Belgium.

Left isomerism (polysplenia), one of the two major variants of heterotaxia with right isomerism (asplenia), may be rarely diagnosed in adulthood. Most cases are nevertheless asymptomatic and incidentally detected during imaging or surgery performed for unrelated conditions. We hereby report a case of left isomerism fortuitously diagnosed in a 55-year-old man with unrelated tachy-cardiomyopathy. Read More

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Squamous cell carcinoma of the tongue with cardiac metastasis on 18F-FDG PET/CT: A case report and literature review.

Medicine (Baltimore) 2021 Apr;100(15):e25529

Department of Nuclear Medicine, Centre Hospitalier Universitaire Bichat.

Introduction: The most common malignancies metastasizing to the heart are cancers of the lung, breast, mesothelioma, melanoma, leukemia, and lymphoma. Cardiac metastasis from a tongue cancer is a rare finding and only a few cases have been reported previously in the literature. In this case report and literature review, we discuss the main clinical features of patients with cardiac metastases secondary to a tongue cancer and imaging modalities performed, especially the 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Read More

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Effects of younger siblings on the brace compliance and recurrence in children with clubfoot during Ponseti treatment.

Acta Orthop Traumatol Turc 2021 Mar;55(2):102-106

Department of Orthopaedics and Traumatology, Harran University, School of Medicine, Şanlıurfa, Turkey.

Objective: This study aimed to determine the effects of the number of total siblings, younger siblings, and complex clubfoot deformity on the brace compliance and recurrence in the management of children with clubfoot deformity using the Ponseti technique.

Methods: The data from 91 children, including 22 girls and 69 boys (total 130 idiopathic clubfeet), seen from 2016 to 2019 were prospectively collected and retrospectively reviewed. The deformity was unilateral in 52 (57. Read More

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Multiple retrospective analysis of survival and evaluation of cardiac death predictors in a population of dogs affected by degenerative mitral valve disease in ACVIM class C treated with different therapeutic protocols.

Pol J Vet Sci 2021 Mar;24(1):109-118

University of Milan, University Veterinary Teaching Hospital, Via dell'Università n. 6, 26900 Lodi (LO), Italy.

Clinical records of dogs with spontaneous degenerative mitral valve disease (DMVD) with clinical signs related to congestive heart failure (CHF) recruited during routine clinical practice between 2001 and 2018 at the Cardiology Unit of the Veterinary Teaching Hospital (University of Milan) were included in this retrospective cohort study. Baseline echocardiographic data were evaluated. Median survival time (MST) was calculated. Read More

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Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling.

Lasers Surg Med 2021 Apr 13. Epub 2021 Apr 13.

Universidade Nove de Julho, Rua Vergueiro 249, Liberdade, São Paulo, SP, 01504-001, Brazil.

Background And Objectives: Induction of myocardial infarction (MI) in rats by occlusion of the left anterior descending coronary artery is an experimental model used in research to elucidate functional, structural, and molecular modifications associated with ischemic heart disease. Photobiomodulation therapy (PBMT) has become a therapeutic alternative by modulating various biological processes eliciting several effects, including anti-inflammatory and pro-proliferative actions. The main objective of this work was to evaluate the effect of PBMT in the modulation of transcriptional and post-transcriptional changes that occurred in myocardium signal transduction pathways after MI. Read More

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Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines.

BMC Cardiovasc Disord 2021 Apr 12;21(1):170. Epub 2021 Apr 12.

Department of Diagnostic Imaging, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros 800, Vila Clementino, São Paulo, 04024-002, Brazil.

Background: The use of anthracycline-based chemotherapy is associated with the development of heart failure, even years after the end of treatment. Early detection of cardiac dysfunction could identify a high-risk subset of survivors who would eventually benefit from early intervention. Cardiac magnetic resonance feature-tracking (CMR-FT) analysis offers a practical and rapid method to calculate systolic and diastolic strains from routinely acquired cine images. Read More

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