24,531 results match your criteria led isolation


Neolinulicin A and B from Inula japonica and their anti-inflammatory activities.

Fitoterapia 2021 Apr 10:104905. Epub 2021 Apr 10.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China. Electronic address:

A phytochemical study performed on Inula japonica led to isolation of a new 1,10-so-sesquiterpene dimer Neolinulicin A (1) and 1,10-seco-sesquiterpene Neolinulicin B (2), together with nine known sesquiterpenes (3-11). Among them, Neolinulicin A (1), which has a new carbon skeleton, was a Diels-Alder [4 + 2] adduct of two sesquiterpene moieties. Their structures were established by extensive spectroscopic analysis. Read More

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Phytochemicals from twigs of and their antioxidation kinetics of oxymyoglobin.

Nat Prod Res 2021 Apr 13:1-5. Epub 2021 Apr 13.

Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.

The phytochemical investigation of crude -hexane and ethyl acetate extracts from twigs of (Kurz) led to the isolation of 14 known compounds. Their structures were elucidated by spectroscopic techniques (IR, H NMR, C NMR, and 2D NMR) as well as mass spectrometry. These structures were characterized as -sitosterol (), lupeol (), vanilic acid (), 5,7-dihydroxychromone (), (+)-mellein (), isoliquiritigenin (), 7-hydroxyemodin (), physion (), aromadendrin (), naringenin (), apigenin (), luteolin (), chrysoeriol () and kaempferol (). Read More

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Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity.

ChemMedChem 2021 Apr 12. Epub 2021 Apr 12.

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Drug Design and Optimization, Campus E8.1, 66123, Saarbrücken, GERMANY.

Chemical decomposition of DMSO stock solutions is a common incident that can mislead biological screening campaigns. Here, we share our case study of 2-aminothiazole 1, originating from an antimalarial class that undergoes chemical decomposition in DMSO at room temperature. As previously measured biological activities observed against Plasmodium falciparum NF54 and for the target enzyme Pf IspE were not reproducible for a fresh batch, we tackled the challenge to understand where the activity originated from. Read More

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Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by .

Front Med (Lausanne) 2021 24;8:579516. Epub 2021 Mar 24.

Laboratory Analysis Unit, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", Catania, Italy.

is a filamentous fungus commonly found in the environment and is the major cause of fungal keratitis. We report a case of keratomycosis caused by in a patient using disposable soft contact lenses. A delay in diagnosis led to the initiation of an empirical antifungal treatment with the subsequent deterioration of the patient's clinical condition. Read More

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Diterpenoids from Roots of and Toxicity against Human Cancer Cell Lines.

Iran J Pharm Res 2020 ;19(4):85-94

Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Further investigations on phytochemical constituents of dichloromethane extract from roots of ( led to the isolation and identification of eight known diterpenoids from this plant for the first time. The chemical structures of the purified compounds were elucidated using spectroscopic analyses including EI-MS, H and C NMR and by comparison of the resulting spectra with those reported in the literature. Then, the cytotoxic activity of identified compounds was examined against two human cancer cell lines MCF-7 (human breast adenocarcinoma) and K562 (human chronic myelogenous leukemia). Read More

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January 2020

Direct and Indirect Somatic Embryogenesis Induction in Abel.

Front Plant Sci 2021 26;12:644389. Epub 2021 Mar 26.

Key Laboratory of Forest Silviculture and Conservation of the Ministry of Education, The College of Forestry, Beijing Forestry University, Beijing, China.

Abel. is an important woody oil species; however, the shortage of rapid and industrialized seedling culture is a large constraint on the development of the tea oil industry. Somatic embryogenesis (SE) is one of the main powerful biotechnological tools for plant mass regeneration, but the largely unknown SE in limits the scale production of clonal plants. Read More

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DNA Metabarcoding Reveals Broad Presence of Plant Pathogenic Oomycetes in Soil From Internationally Traded Plants.

Front Microbiol 2021 25;12:637068. Epub 2021 Mar 25.

Division of Biotechnology and Plant Health, Norwegian Institute of Bioeconomy Research (NIBIO), Ås, Norway.

Plants with roots and soil clumps transported over long distances in plant trading can harbor plant pathogenic oomycetes, facilitating disease outbreaks that threaten ecosystems, biodiversity, and food security. Tools to detect the presence of such oomycetes with a sufficiently high throughput and broad scope are currently not part of international phytosanitary testing regimes. In this work, DNA metabarcoding targeting the internal transcribed spacer (ITS) region was employed to broadly detect and identify oomycetes present in soil from internationally shipped plants. Read More

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Barriers to Care Experienced by Patients Who Inject Drugs During the COVID-19 Pandemic: A Qualitative Analysis.

J Addict Med 2021 Apr 8. Epub 2021 Apr 8.

Department of Medicine, Division of Infectious Diseases, Washington University in St. Louis School of Medicine (EG, NSN, LRM, TH, SYL, MJD); Division of Emergency Medicine, Washington University in St. Louis School of Medicine (SYL).

Objectives: To identify the barriers to accessing health care and social services faced by people who inject drugs (PWID) during the coronavirus disease 2019 (COVID-19) pandemic.

Methods: This report is a sub-analysis of a larger qualitative study. Semi-structured interviews were conducted with PWID admitted to an academic medical center from 2017 to 2020 for an invasive injection-related infection. Read More

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Xylogalacturonan-enriched pectin from the fruit pulp of Adansonia digitata: Structural characterization and antidepressant-like effect.

Carbohydr Polym 2021 Jun 15;262:117946. Epub 2021 Mar 15.

Lipetsk State Technical University, st. Moskovskaya 30, Lipetsk, 398055, Russia.

The low methyl-esterified and acetylated xylogalacturonan (DM 20 %, DA 2 %, Mw ∼ 58 kDa) was isolated by water extraction for 4 h × 2 at 50 °C (yield 23 %) from the pulp of baobab fruit (Adansonia digitata L.). Subsequent tightening of the conditions for water extraction by mean increasing the temperature to 70 °C and time to 12 h led to the co-extraction of small amounts of starch components and RG I with xylogalacturonan. Read More

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"I just keep quiet about it and act as if everything is alright" - The cascade from trauma to disengagement among adolescents living with HIV in western Kenya.

J Int AIDS Soc 2021 Apr;24(4):e25695

Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.

Introduction: There are approximately 1.7 million adolescents living with HIV (ALHIV, ages 10 to 19) globally, including 110,000 in Kenya. While ALHIV experience poor retention in care, limited data exist on factors underlying disengagement. Read More

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Anesthesia and surgery for positive COVID-19 asymptomatic pediatric patients: how long should we wait?

Paediatr Anaesth 2021 Apr 9. Epub 2021 Apr 9.

Division of Anesthesiology, Pain and Perioperative Medicine, Children's National Hospital, The George Washington University, Washington, D.C, USA.

The worldwide spread of the novel SARS-CoV-2 coronavirus (COVID-19) led to significant challenges for healthcare institutions. Our institution implemented guidelines to protect perioperative staff and patients from exposure to COVID-19, including pre-procedural testing. Patients who tested positive SARS-CoV-2 had their elective procedure postponed and quarantined as per Center for Disease Control and Prevention (CDC) guidelines. Read More

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[Impact of COVID-19 Pandemic on Medical Care of Patients with Inherited Bleeding Disorders].

Gesundheitswesen 2021 Apr 8;83(4):282-290. Epub 2021 Apr 8.

Institut für Medizinische Psychologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

Background And Objectives: Chronic diseases, such as inherited bleeding disorders (IBD) are often associated with high costs of medical care. COVID-19 containment measures, including isolation and triage, led to restrictions in the health care of chronically ill patients. The aim of the present study was to investigate the effects of the COVID-19 pandemic on the health care of IBD patients. Read More

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Applying model approaches in non-model systems: A review and case study on coral cell culture.

PLoS One 2021 8;16(4):e0248953. Epub 2021 Apr 8.

Life Science and Engineering, Virginia Commonwealth University, Richmond, Virginia, United States of America.

Model systems approaches search for commonality in patterns underlying biological diversity and complexity led by common evolutionary paths. The success of the approach does not rest on the species chosen but on the scalability of the model and methods used to develop the model and engage research. Fine-tuning approaches to improve coral cell cultures will provide a robust platform for studying symbiosis breakdown, the calcification mechanism and its disruption, protein interactions, micronutrient transport/exchange, and the toxicity of nanoparticles, among other key biological aspects, with the added advantage of minimizing the ethical conundrum of repeated testing on ecologically threatened organisms. Read More

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Novel compounds from Premna herbacea Roxb. with antidiabetic potential.

Pak J Pharm Sci 2020 Sep;33(5):1971-1979

Rajiv Gandhi Institute of Pharmacy, Trikaripur, Kasaragod, Kerala, India.

Diabetes mellitus is an epidemic that is growing worldwide at an alarming rate. The need for plant-based drugs to combat this epidemic led to the isolation of three new compounds, namely 1-Benzoyloxy-8-tetradecanoyloxy-geranilane (1), 1-Benzoyloxy-8-(octadec-9ꞌꞌ-enoyl) geranilane (2), and 1-Benzoyloxy-8-octadecanoyloxygeranilane (3), from the roots of Premnaherbacea. Their structures were deciphered by H NMR, C NMR, and 2D-NMR. Read More

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September 2020

A new diphenyl ether from Hale growing in Vietnam.

Nat Prod Res 2021 Apr 7:1-7. Epub 2021 Apr 7.

Department of Chemistry, University of Education, Ho Chi Minh City, Vietnam.

Chemical investigation of the lichen Hale led to the isolation of one new diphenyl ether, parmetherine D (), along with eight known compounds (). The structures were determined by analysis of MS and NMR data and by comparison with the literature. Compounds , , and were evaluated for -glucosidase inhibition. Read More

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A Mycochemical Investigation of the Black Lingzhi Mushroom, Amauroderma rugosum (Agaricomycetes), Reveals Several Lipidic Compounds with Anti-Inflammatory and Antiproliferative Activities.

Int J Med Mushrooms 2021 ;23(4):71-80

Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Science, Guangzhou, People's Republic of China; Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, People's Republic of China.

A mycochemical investigation on the medicinal mushroom Amauroderma rugosum led to the isolation of 30 compounds, including 14 sterols, 6 phenolic constituents, 5 unsaturated fatty acids, and 5 other compounds. The structures of these compounds were elucidated by comparison of their nuclear magnetic resonance spectroscopic and mass spectrometry data with literature data. Among them, compound 27 was obtained as a new natural compound, and compounds 2-4, 7-13, and 15-30 were isolated from the genus Amauroderma for the first time. Read More

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January 2021

HPLC-ESI/MS Profiling, Phytoconstituents isolation and Evaluation of Renal Function, Oxidative Stress and Inflammation in Gentamicin-Induced Nephrotoxicity in Rats of Ficus spragueana Mildbr. & Burret.

Biomed Chromatogr 2021 Apr 5:e5135. Epub 2021 Apr 5.

Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), Dokki, Giza, Egypt.

Ficus spragueana Mildbr. & Burret, (family Moraceae), was reported to have various biological activities. However, its activity in treatment of renal injury was not investigated yet. Read More

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Stable Axially Chiral Isomers of Arylnaphthalene Lignan Glycosides with Antiviral Potential Discovered from .

J Org Chem 2021 Apr 5. Epub 2021 Apr 5.

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR People's Republic of China.

Arylnaphthalene lignans (ANLs) were known to have axial chirality due to the biphenyl skeleton with hindered rotation at the single bond. However, the stable ANL atropisomers have not been isolated from nature until the present study. Phytochemical separation of the methanol extract of the stems and barks of led to the isolation of 11 ANL glycosides including four pairs of new atropisomers with stable confirmations at room temperature. Read More

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Hydromorphone-Induced Tactile Hallucinations: Rare Opioid Side Effect.

Cureus 2021 Feb 28;13(2):e13622. Epub 2021 Feb 28.

Psychiatry, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.

Opioids are strong analgesics widely employed to treat various types of pain. In 2018, an estimated 168 million opioid prescriptions were dispensed in the United States. Opioids carry a number of side effects and up to 80% of patients treated with opioids experience a minimum of one adverse event. Read More

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February 2021

Novel flavonol-3--methylethers from Griseb. (Rutaceae).

Nat Prod Res 2021 Apr 5:1-10. Epub 2021 Apr 5.

Faculty of Natural and Exact Sciences, Pharmacy Department, University of Oriente, Santiago de Cuba, Cuba.

Griseb. is a tree endemic to Cuba, occasionally used in herbal medicine. Previously, the antitrypanosomal activity of a -hexane-2-butanone extract of leaves and of its constituent skimmianine were published. Read More

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Structurally diverse triterpenoids with cytotoxicity from Euphorbia hypericifolia.

Fitoterapia 2021 Mar 31;151:104888. Epub 2021 Mar 31.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:

Extensive phytochemical investigation on the whole herbs of Euphorbia hypericifolia led to the isolation of 18 structurally diverse tetracyclic and pentacyclic triterpenoids, including four 4α,14α-dimethyl-5α-ergostanes (1-4), two seco-adiananes (5 and 6), three dammaranes (7-9), four cycloartanes (10-13), one tirucallane (14), two fernanes (15 and 16), one ursane (17), and one oleanane (18). Among them, euphypenoids A (1) and B (5) were new triterpenoids. Their structures were elucidated on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and chemical transformation. Read More

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Social inequalities and the pandemic of COVID-19: the case of Rio de Janeiro.

J Epidemiol Community Health 2021 Apr 2. Epub 2021 Apr 2.

Laboratório de Pesquisa Clínica em DST-AIDS, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Background: The novel coronavirus (SARS-CoV-2) is a global pandemic. The lack of protective vaccine or treatment led most of the countries to follow the flattening of the infection curve with social isolation measures. There is evidence that socioeconomic inequalities have been shaping the COVID-19 burden among low and middle-income countries. Read More

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Mental Health of Children and Adolescents Amidst COVID-19 and Past Pandemics: A Rapid Systematic Review.

Int J Environ Res Public Health 2021 03 26;18(7). Epub 2021 Mar 26.

Robinson Research Institute, University of Adelaide, Adelaide, SA 5005, Australia.

The COVID‑19 pandemic and associated public health measures have disrupted the lives of people around the world. It is already evident that the direct and indirect psychological and social effects of the COVID‑19 pandemic are insidious and affect the mental health of young children and adolescents now and will in the future. The aim and objectives of this knowledge-synthesis study were to identify the impact of the pandemic on children's and adolescent's mental health and to evaluate the effectiveness of different interventions employed during previous and the current pandemic to promote children's and adolescents' mental health. Read More

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Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR).

Antibiotics (Basel) 2021 Mar 22;10(3). Epub 2021 Mar 22.

School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.

Marine natural products (MNPs) have been an important and rich source for antimicrobial drug discovery and an effective alternative to control drug resistant infections. Herein, we report bioassay guided fractionation of marine extracts from sponges , and that led us to identify novel compounds with antimicrobial properties. Tertiary amines or quaternary amine salts: aniline , benzylamine , tertiary amine and , and quaternary amine salt , along with three known compounds () were isolated from a crude extract and MeOH eluent marine extracts. Read More

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New Polyketides from the Antarctic Fungus sp. HSX2#-11.

Mar Drugs 2021 Mar 22;19(3). Epub 2021 Mar 22.

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266200, China.

The species is known as a psychrophilic pathogenic fungus with a ubiquitous distribution in Antarctica. Meanwhile, the study of its secondary metabolites is infrequent. Systematic research of the metabolites of the fungus sp. Read More

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Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber In Vitro and In Silico Studies.

Molecules 2021 Mar 12;26(6). Epub 2021 Mar 12.

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Chemical investigation of the methanolic extract of the Red Sea cucumber led to the isolation of a new cerebroside, holospiniferoside (), together with thymidine (), methyl--d-glucopyranoside (), a new triacylglycerol (), and cholesterol (). Their chemical structures were established by NMR and mass spectrometric analysis, including gas chromatography-mass spectrometry (GC-MS) and high-resolution mass spectrometry (HRMS). All the isolated compounds are reported in this species for the first time. Read More

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Cognitive Issues in Pediatric Multiple Sclerosis.

Brain Sci 2021 Mar 30;11(4). Epub 2021 Mar 30.

Section Neurosciences, Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, University of Florence, 50139 Florence, Italy.

Multiple sclerosis (MS) is one of the leading causes of disability in young adults. The onset of MS during developmental age makes pediatric patients particularly susceptible to cognitive impairment, resulting from both disease-related damage and failure of age-expected brain growth. Despite different test batteries and definitions, cognitive impairment has been consistently reported in approximately one-third of pediatric patients with MS. Read More

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Analysis of Gene Expression Changes in Plants Grown in Salty Soil in Response to Inoculation with Halophilic Bacteria.

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Department of Microbiology & Molecular Biology, Brigham Young University, Provo, UT 84602, USA.

Soil salinity is an increasing problem facing agriculture in many parts of the world. Climate change and irrigation practices have led to decreased yields of some farmland due to increased salt levels in the soil. Plants that have tolerance to salt are thus needed to feed the world's population. Read More

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Identification of Bioactive Natural Product from the Stems and Stem Barks of : Benzyl Salicylate Shows Potential Anti-Inflammatory Activity in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

Pharmaceutics 2021 Mar 25;13(4). Epub 2021 Mar 25.

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.

(Cornaceae), known as Walter's dogwood, has been used to treat dermatologic inflammation and diarrheal disease in traditional oriental medicine. As part of an ongoing research project to discover natural products with biological activities, the anti-inflammatory potential of compounds from in lipopolysaccharide (LPS)-stimulated mouse RAW 264.7 macrophages were explored. Read More

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Split Ring Resonator-Based Bandstop Filter for Improving Isolation in Compact MIMO Antenna.

Sensors (Basel) 2021 Mar 24;21(7). Epub 2021 Mar 24.

Department of Electronics and Communication Engineering, Sikkim Manipal Institute of Technology, Sikkim Manipal University, Sikkim 737136, India.

The ever-growing expectation for high data rates has led to the introduction of multiple-input multiple-output (MIMO) technologies to wireless connectivity. Such a system requires an MIMO antenna with high isolation. At the same time, the MIMO dimension should not be compromised for achieving high isolation. Read More

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