32,223 results match your criteria led identification

Unusual morphology in the mid-Cretaceous lizard Oculudentavis.

Curr Biol 2021 Jun 9. Epub 2021 Jun 9.

Department of Cell and Developmental Biology, University College London, London, UK.

Oculudentavis khaungraae was described based on a tiny skull trapped in amber. The slender tapering rostrum with retracted narial openings, large eyes, and short vaulted braincase led to its identification as the smallest avian dinosaur on record, comparable to the smallest living hummingbirds. Despite its bird-like appearance, Oculudentavis showed several features inconsistent with its original phylogenetic placement. Read More

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Narrative recognition and identification: a qualitative pilot study into reading literary texts with advanced cancer patients.

J Cancer Surviv 2021 Jun 15. Epub 2021 Jun 15.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Purpose: Patients with advanced cancer can experience their disease as a contingent life event. The sudden interruption of their life stories can obscure life goals and disrupt meaning making. In the context of the research project "In search of stories," we aim to investigate the reading and discussion of selected stories which present ways of dealing with a contingent life event. Read More

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Safety and tolerability of preventive treatment options for chronic migraine.

Expert Opin Drug Saf 2021 Jun 15. Epub 2021 Jun 15.

George Washington University Medical Faculty Associates, 2150 Pennsylvania Ave, NW 7th Floor, Washington, DC 20037.

Introduction: Relative to migraine generally, chronic migraine (CM) imposes greater disability, healthcare utilization and socioeconomic burden. Six therapies currently possess a credible evidence base for prevention/suppression of CM. This review is intended to provide an assessment of their relative utility, defined as a blend of safety, tolerability and efficacy, focusing in particular on their safety and tolerability. Read More

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The early course and treatment of posttraumatic stress disorder in very young children: diagnostic prevalence and predictors in hospital-attending children and a randomized controlled proof-of-concept trial of trauma-focused cognitive therapy, for 3- to 8-year-olds.

J Child Psychol Psychiatry 2021 Jun 14. Epub 2021 Jun 14.

Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

Background: The introduction of developmentally adapted criteria for posttraumatic stress disorder (PTSD) has improved the identification of ≤6-year-old children with clinical needs. Across two studies, we assess predictors of the development of PTSD in young children (PTSD-YC), including the adult-led acute stress disorder (ASD) diagnosis, and provide proof of principle for cognitive-focused therapy for this age range, with the aim of increasing treatment options for children diagnosed with PTSD-YC.

Method: Study 1 (N = 105) assessed ASD and PTSD-YC diagnosis in 3- to 8-year-old children within one month and at around three months following attendance at an emergency room. Read More

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Post-mortem diagnosis of imported malaria in France: a case report.

Malar J 2021 Jun 14;20(1):271. Epub 2021 Jun 14.

Service de Parasitologie-Mycologie, Hôpital L'Archet, Centre Hospitalier Universitaire de Nice, UCA, 151 route de Saint Antoine de Giestière, 06000, Nice, France.

Background: Malaria is a potentially lethal parasitic disease due to infection by Plasmodium parasites, transmitted by Anopheles mosquito vectors. Various preventative measures may be recommended for travellers who visit endemic areas. The diagnosis is generally evoked in the context of a febrile patient returning from an endemic zone. Read More

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Applying the Lean Startup Method to Structure Project-Based, Student-Driven Curricular Enhancements.

Teach Learn Med 2021 Jun 14:1-10. Epub 2021 Jun 14.

Department of Medical Education, University of Illinois College of Medicine, Chicago, Illinois, USA.

Problem: Formal medical student engagement in curricular evaluation provides significant value through identification of opportunities for curricular change. Students provide diverse perspectives and have a unique vantage point, which allows them to see aspects of the curriculum that educators and administrators might not recognize. Current descriptions of student engagement are focused largely on collection, analysis, and presentation of summative feedback in the pre-clerkship curriculum. Read More

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Metabolic inhibitors of bacterial glycan biosynthesis.

Chem Sci 2020 Jan 8;11(7):1761-1774. Epub 2020 Jan 8.

Department of Chemistry & Biochemistry, Bowdoin College 6600 College Station Brunswick ME 04011 USA

The bacterial cell wall is a quintessential drug target due to its critical role in colonization of the host, pathogen survival, and immune evasion. The dense cell wall glycocalyx contains distinctive monosaccharides that are absent from human cells, and proper assembly of monosaccharides into higher-order glycans is critical for bacterial fitness and pathogenesis. However, the systematic study and inhibition of bacterial glycosylation enzymes remains challenging. Read More

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January 2020

Identification of novel mutations contributing to azole tolerance of through exposure to tebuconazole.

Antimicrob Agents Chemother 2021 Jun 14:AAC0265720. Epub 2021 Jun 14.

Medical Mycology Research Center, Chiba University, Chiba, Chiba, Japan.

Azole resistance of is a global problem. The major resistant mechanism is a cytochrome P 14-α sterol demethylase Cyp51A alteration such as mutation(s) in the gene and the acquisition of a tandem repeat in the promoter. Although other azole tolerances and resistant mechanisms such as (a 3-hydroxy-3-methylglutaryl-coenzyme-A reductase gene) mutation are known, few reports have described studies elucidating non-Cyp51A resistance mechanisms. Read More

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Prostate Cancer Immunotherapy-Finally in From the Cold?

Curr Oncol Rep 2021 Jun 14;23(8):88. Epub 2021 Jun 14.

Division of Hematology/Oncology, New York-Presbyterian/Columbia University Medical Center, 1130 St Nicholas Avenue, Room 321A, New York, NY, 10032, USA.

Purpose Of Review: Despite significant progress, patients with metastatic prostate cancer continue to have poor prognosis. Immunotherapy has revolutionized cancer care for many tumor types but has a limited role in the treatment of prostate cancer. This review discusses the promise of immunotherapy in prostate cancer treatment with an emphasis on emerging therapeutic targets. Read More

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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions.

J Vis Exp 2021 May 27(171). Epub 2021 May 27.

Department of Internal Medicine I - Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna;

A synthetic lethal interaction between two genes is given when knock-out of either one of the two genes does not affect cell viability but knock-out of both synthetic lethal interactors leads to loss of cell viability or cell death. The best studied synthetic lethal interaction is between BRCA1/2 and PARP1, with PARP1 inhibitors being used in clinical practice to treat patients with BRCA1/2 mutated tumors. Large genetic screens in model organisms but also in haploid human cell lines have led to the identification of numerous additional synthetic lethal interaction pairs, all being potential targets of interest in the development of novel tumor therapies. Read More

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A Ligation/Recombinase Polymerase Amplification Assay for Rapid Detection of SARS-CoV-2.

Front Cell Infect Microbiol 2021 28;11:680728. Epub 2021 May 28.

Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Key Laboratory of Marine Biological Resources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, School of Pharmacy, Jiangsu Ocean University, Lianyungang, China.

The pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to more than 117 million reported cases and 2.6 million deaths. Accurate diagnosis technologies are vital for controlling this pandemic. Read More

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The Effect of a 3-Minute Mindfulness Intervention, and the Mediating Role of Maximization, on Critical Incident Decision-Making.

Front Psychol 2021 28;12:674694. Epub 2021 May 28.

Centre for Critical and Major Incident Psychology, University of Liverpool, Liverpool, United Kingdom.

Objective: In this study, we extend the impact of mindfulness to the concept of least-worst decision-making. Least-worst decisions involve high-uncertainty and require the individual to choose between a number of potentially negative courses of action. Research is increasingly exploring least-worst decisions, and real-world events (such as the COVID-19 pandemic) show the need for individuals to overcome uncertainty and commit to a least-worst course of action. Read More

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Case Report of Novel Genetic Variant in KCNT1 Channel and Pharmacological Treatment With Quinidine. Precision Medicine in Refractory Epilepsy.

Front Pharmacol 2021 28;12:648519. Epub 2021 May 28.

Department of Neurology, Garrahan Hospital, Buenos Aires City, Argentina.

In this work we present a female infant patient with epilepsy of infancy with migrating focal seizures (EIMFS). Although many pharmacological schemes were attempted, she developed an encephalopathy with poor response to antiepileptic drugs and progressive cerebral dysfunction. To present the pharmacological response and therapeutic drug monitoring of a paediatric patient with a severe encephalopathy carrying a genetic variant in KCNT1 gene, whose identification led to include quinidine (QND) in the treatment regimen as an antiepileptic drug. Read More

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Identification of mungbean yellow mosaic India virus (MYMIV) Rep interacting partners using phage display and influence of MCM3 on geminivirus DNA replication.

J Biomol Struct Dyn 2021 Jun 14:1-11. Epub 2021 Jun 14.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.

Geminiviruses consist of a single-stranded DNA genome that replicates by a rolling circle (RCR) and recombination-dependent (RDR) modes of replication. The AC1 or Rep is the indispensable viral protein required for the RCR mode of replication. Since these viruses encode only a few proteins, they depend on several host factors for replication, transcription, and other physiological processes. Read More

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Uncovering potential interspecies signaling factors in plant-derived mixed microbial culture.

Bioorg Med Chem 2021 Jun 4;42:116254. Epub 2021 Jun 4.

Biochemistry Ph.D. Program, The Graduate Center of CUNY, 365 5(th) Ave, New York, NY 10016, USA; Chemistry Ph.D. Program, The Graduate Center of CUNY, 365 5(th) Ave, New York, NY 10016, USA; Department of Chemistry, Hunter College of CUNY, 695 Park Ave, New York, NY 10065, USA.

Microbes use signaling factors for intraspecies and interspecies communications. While many intraspecies signaling factors have been found and characterized, discovery of factors for interspecies communication is lagging behind. To facilitate the discovery of such factors, we explored the potential of a mixed microbial culture (MMC) derived from wheatgrass, in which heterogeneity of this microbial community might elicit signaling factors for interspecies communication. Read More

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The impact of the molecular classification of glioblastoma on the interpretation of therapeutic clinical trial results.

Chin Clin Oncol 2021 Jun 2. Epub 2021 Jun 2.

Department of Neurological Surgery, Lurie Comprehensive Cancer Center, Chicago, IL, USA; Malnati Brain Tumor Institute and Lurie Comprehensive Cancer Center, Chicago, IL, USA; Department of Neurology, Lurie Comprehensive Cancer Center, Chicago, IL, USA; Department of Medicine (Section of Hematology & Oncology), Lurie Comprehensive Cancer Center, Chicago, IL, USA.

In 2016, the World Health Organization (WHO) released the most recent update to the classification of central nervous system tumors. This update has led to the reshaping of tumor identification and subsequently changed current understanding of treatment options for patients. Moreover, the restructuring of the classification of central nervous system tumors to include molecular markers has led to the need to re-evaluate how to interpret pivotal trials. Read More

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Sampling rate influences the regularity analysis of temporal domain measures of walking more than spatial domain measures.

Gait Posture 2021 Jun 4;88:216-220. Epub 2021 Jun 4.

Center for Research in Human Movement Variability, Department of Biomechanics, University of Nebraska at Omaha, 6160 University Drive, Omaha, NE, 68182-0860, United States; VA Nebraska-Western Iowa Health Care System, VA Research Service, 4104 Woolworth Avenue (112), Omaha, NE, 68105, United States; Department of Health and Kinesiology, Texas A&M University, 2929 Research Parkway, College Station, TX, 77843, United States. Electronic address:

Background: The spatiotemporal dynamics of stepping can provide useful information about walking performance. Most often, the identification of gait motion is performed using 3-D cinematography. The sampling rate of motion capture systems may influence the accuracy of these measures albeit in varying degrees for measures within the spatial versus temporal domain. Read More

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Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation.

Mol Cancer 2021 Jun 11;20(1):88. Epub 2021 Jun 11.

Junior Research Group 'RNA biology and pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.

Background: Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent need. Read More

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2D-quantitative structure-activity relationships model using PLS method for anti-malarial activities of anti-haemozoin compounds.

Malar J 2021 Jun 11;20(1):264. Epub 2021 Jun 11.

Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Background: Emergence of cross-resistance to current anti-malarial drugs has led to an urgent need for identification of potential compounds with novel modes of action and anti-malarial activity against the resistant strains. One of the most promising therapeutic targets of anti-malarial agents related to food vacuole of malaria parasite is haemozoin, a product formed by the parasite through haemoglobin degradation.

Methods: With this in mind, this study developed two-dimensional-quantitative structure-activity relationships (QSAR) models of a series of 21 haemozoin inhibitors to explore the useful physicochemical parameters of the active compounds for estimation of anti-malarial activities. Read More

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Trastuzumab-induced cardiotoxicity: a review of clinical risk factors, pharmacologic prevention, and cardiotoxicity of other HER2-directed therapies.

Breast Cancer Res Treat 2021 Jun 11. Epub 2021 Jun 11.

Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd NW, Washington, DC, 20007, USA.

Purpose: Despite great success as a targeted breast cancer therapy, trastuzumab use may be complicated by heart failure and loss of left ventricular contractile function. This review summarizes the risk factors, imaging, and prevention of cardiotoxicity associated with trastuzumab and other HER2-targeted therapies.

Findings: Cardiovascular disease risk factors, advanced age, and previous anthracycline treatment predispose to trastuzumab-induced cardiotoxicity (TIC), with anthracycline exposure being the most significant risk factor. Read More

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Implants Placed in Adolescents Followed for Up to 15.5 Years: A Retrospective Case Series.

Int J Oral Maxillofac Implants 2021 May-Jun;36(3):561-568

Purpose: To evaluate the clinical outcomes of unsplinted implant-supported single crowns placed in adolescents, ages 10 to 19 years, and followed up from 5 to 15 years.

Materials And Methods: This retrospective case series evaluated the outcomes of implant-supported single crowns placed in adolescents between June 2002 and January 2015. The patients were treated with locking-taper connection implants under a two-stage rehabilitation technique. Read More

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Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias.

iScience 2021 May 28;24(5):102484. Epub 2021 Apr 28.

School of Pharmacy, University of Reading, Reading, RG6 6AX, UK.

The Hereditary Spastic Paraplegias are a group of neurodegenerative diseases characterized by spasticity and weakness in the lower body. Owing to the combination of genetic diversity and variable clinical presentation, the Hereditary Spastic Paraplegias are a strong candidate for protein-protein interaction network analysis as a tool to understand disease mechanism(s) and to aid functional stratification of phenotypes. In this study, experimentally validated human data were used to create a protein-protein interaction network based on the causative genes. Read More

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Invasive Outbreak at a Pediatric Dental Clinic.

Open Forum Infect Dis 2021 Jun 15;8(6):ofab165. Epub 2021 Apr 15.

Disease Control and Epidemiology, Orange County Health Care Agency, Santa Ana, California, USA.

Background: species, specifically and (MABs), are known to contaminate water systems and are uncommon causes of health care-associated infection, but morbidity can be significant and treatment complex.

Methods: Odontogenic MAB infections occurred in patients following pulpotomy procedures at dental clinic A from 1 January to 6 September 2016. We identified confirmed and probable cases using culture data, imaging, pathology results, and surgical findings. Read More

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Genome-Wide Identification Reveals That Hypersensitive Response (HR)-Like Lesion Inducing Protein 4 (NbHRLI4) Mediates Cell Death and Salicylic Acid-Dependent Defense Responses to Turnip Mosaic Virus.

Front Plant Sci 2021 25;12:627315. Epub 2021 May 25.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.

Hypersensitive response (HR)-like cell death is an important mechanism that mediates the plant response to pathogens. In our previous study, we reported that NbHIR3s regulate HR-like cell death and basal immunity. However, the host genes involved in HR have rarely been studied. Read More

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Social Network Research contribution to evaluating process in a feasibility study of a peer-led and school-based sexual health intervention.

Sci Rep 2021 Jun 10;11(1):12244. Epub 2021 Jun 10.

MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.

There is growing interest in social network-based programmes to improve health, but rigorous methods using Social Network research to evaluate the process of these interventions is less well developed. Using data from the "STis And Sexual Health" (STASH) feasibility trial of a school-based, peer-led intervention on sexual health prevention, we illustrate how network data analysis results can address key components of process evaluations for complex interventions-implementation, mechanisms of impacts, and context. STASH trained students as Peer Supporters (PS) to diffuse sexual health messages though face-to-face interactions and online Facebook (FB) groups. Read More

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Delineation of cellular stages and identification of key proteins for reduction and biotransformation of Se(IV) by Stenotrophomonas bentonitica BII-R7.

J Hazard Mater 2021 May 24;418:126150. Epub 2021 May 24.

Department of Microbiology, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.

The widespread use of selenium (Se) in technological applications (e.g., solar cells and electronic devices) has led to an accumulation of this metalloid in the environment to toxic levels. Read More

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MiR-130b and miR-128a are essential lineage-specific co-drivers of t(4;11) MLL-AF4 acute leukemia.

Blood 2021 Jun 10. Epub 2021 Jun 10.

University of Edinburgh, Edinburgh, United Kingdom.

t(4;11) MLL-AF4 acute leukemia is one of the most aggressive malignancies in the infant and pediatric population, yet we have little information on the molecular mechanisms responsible for disease progression. This impairs the development of therapeutic regimens that can address the aggressive phenotype and lineage plasticity of MLL-AF4-driven leukemogenesis. This study highlights novel mechanisms of disease development by focusing on two microRNAs upregulated in leukemic blasts from primary patient samples: miR-130b and miR-128a. Read More

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Potent and Subtype-Selective Dopamine D Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach.

J Med Chem 2021 Jun 10. Epub 2021 Jun 10.

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Using a previously unexplored, efficient, and versatile multicomponent method, we herein report the rapid generation of novel potent and subtype-selective DRD biased partial agonists. This strategy exemplifies the search for diverse and previously unexplored moieties for the secondary/allosteric pharmacophore of the common phenyl-piperazine scaffold. The pharmacological characterization of the new compound series led to the identification of several ligands with excellent DRD affinity and subtype selectivity and remarkable functional selectivity for either the cAMP ( and ) or the β-arrestin ( and ) signaling pathways. Read More

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Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies.

Front Chem 2021 24;9:666573. Epub 2021 May 24.

Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.

A series of novel pyran-linked phthalazinone-pyrazole hybrids were designed and synthesized by a facile one-pot three-component reaction employing substituted phthalazinone, 1H-pyrazole-5-carbaldehyde, and active methylene compounds. Optimization studies led to the identification of L-proline and ethanol as efficient catalyst and solvent, respectively. This was followed by evaluation of anticancer activity against solid tumor cell lines of lung and cervical carcinoma that displayed IC values in the range of 9. Read More

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N-Methyladenine in Eukaryotic DNA: Tissue Distribution, Early Embryo Development, and Neuronal Toxicity.

Front Genet 2021 24;12:657171. Epub 2021 May 24.

Immune Endocrine Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.

DNA methylation is one of the most important epigenetic modifications and is closely related with several biological processes such as regulation of gene transcription and the development of non-malignant diseases. The prevailing dogma states that DNA methylation in eukaryotes occurs essentially through 5-methylcytosine (5mC) but recently adenine methylation was also found to be present in eukaryotes. In mouse embryonic stem cells, 6-methyladenine (6mA) was associated with the repression and silencing of genes, particularly in the X-chromosome, known to play an important role in cell fate determination. Read More

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